{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:16:36Z","timestamp":1780362996480,"version":"3.54.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T00:00:00Z","timestamp":1741392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.intimp.2025.114383","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T05:48:01Z","timestamp":1741931281000},"page":"114383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The PM2.5 component, benzo[b]fluoranthene, may contribute to the pathogenesis of membranous nephropathy by activating phosphoinositide 3-kinase\/protein kinase B pathway and causing podocyte pyroptosis"],"prefix":"10.1016","volume":"152","author":[{"given":"Duopin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianpeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaokang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangsuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2025.114383_bb0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-021-00303-z","article-title":"Membranous nephropathy","volume":"7","author":"Ronco","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"1","key":"10.1016\/j.intimp.2025.114383_bb0010","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2478\/jtim-2020-0002","article-title":"Research Progress in the treatment of idiopathic membranous nephropathy using traditional Chinese medicine","volume":"8","author":"Lang","year":"2020","journal-title":"J. Trans. Internal Med."},{"issue":"12","key":"10.1016\/j.intimp.2025.114383_bb0015","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1681\/ASN.2016010093","article-title":"Long-term exposure to air pollution and increased risk of membranous nephropathy in China","volume":"27","author":"Xu","year":"2016","journal-title":"J. Ame. Soc. Nephrol.\u202f: JASN"},{"issue":"1","key":"10.1016\/j.intimp.2025.114383_bb0020","doi-asserted-by":"crossref","first-page":"10994","DOI":"10.1038\/s41598-020-67910-w","article-title":"Spectrum of biopsy proven renal diseases in Central China: a 10-year retrospective study based on 34,630 cases","volume":"10","author":"Hu","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2025.114383_bb0025","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1681\/ASN.2020040517","article-title":"Long-term exposure to ambient PM(2.5) and increased risk of CKD prevalence in China","volume":"32","author":"Li","year":"2021","journal-title":"J. Ame. Soc. Nephrol.\u202f: JASN"},{"issue":"4","key":"10.1016\/j.intimp.2025.114383_bb0030","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejim.2013.04.001","article-title":"Air particulate matter and cardiovascular disease: a narrative review","volume":"24","author":"Martinelli","year":"2013","journal-title":"Eur. J. Intern. Med."},{"issue":"10","key":"10.1016\/j.intimp.2025.114383_bb0035","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1001\/jama.295.10.1127","article-title":"Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases","volume":"295","author":"Dominici","year":"2006","journal-title":"Jama"},{"issue":"5","key":"10.1016\/j.intimp.2025.114383_bb0040","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1007\/s11356-014-3458-7","article-title":"Maternal exposure to fine particulate matter (PM2.5) and pregnancy outcomes: a meta-analysis","volume":"22","author":"Zhu","year":"2015","journal-title":"Environ. Sci. Pollut. Res. Int."},{"issue":"8","key":"10.1016\/j.intimp.2025.114383_bb0045","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2174\/1570179417666200713182441","article-title":"Polyaromatic hydrocarbons (PAHs): structures, synthesis and their biological profile","volume":"17","author":"Sahoo","year":"2020","journal-title":"Curr. Org. Synth."},{"issue":"20","key":"10.1016\/j.intimp.2025.114383_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph182010869","article-title":"Effects of anthropogenic emissions from different sectors on PM(2.5) concentrations in Chinese cities","volume":"18","author":"Yang","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"10.1016\/j.intimp.2025.114383_bb0055","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1289\/ehp.1003100","article-title":"Estimated reduction in cancer risk due to PAH exposures if source control measures during the 2008 Beijing Olympics were sustained","volume":"119","author":"Jia","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"11","key":"10.1016\/j.intimp.2025.114383_bb0060","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1093\/carcin\/8.11.1579","article-title":"Formation and tumorigenicity of benzo[b]fluoranthene metabolites in mouse epidermis","volume":"8","author":"Geddie","year":"1987","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.intimp.2025.114383_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110403","article-title":"The benzo[b]fluoranthene in the atmospheric fine particulate matter induces mouse glomerular podocytes injury via inhibition of autophagy","volume":"195","author":"Zhang","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"5","key":"10.1016\/j.intimp.2025.114383_bb0070","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1080\/15548627.2019.1580512","article-title":"Podocytes and autophagy: a potential therapeutic target in lupus nephritis","volume":"15","author":"Zhou","year":"2019","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.intimp.2025.114383_bb0075","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s11255-017-1555-5","article-title":"Association of podocyte autophagosome numbers with idiopathic membranous nephropathy and secondary membranous nephropathy","volume":"49","author":"Jin","year":"2017","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.intimp.2025.114383_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.152913","article-title":"Zhen-wu-tang ameliorates membranous nephropathy rats through inhibiting NF-\u03baB pathway and NLRP3 inflammasome","volume":"59","author":"Liu","year":"2019","journal-title":"Phytomed.: Int. J. Phytotherapy And Phytopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2025.114383_bb0085","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41419-020-02824-z","article-title":"TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K\/AKT pathway after spinal cord injury","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2025.114383_bb0090","article-title":"Cadmium and molybdenum co-induce pyroptosis via ROS\/PTEN\/PI3K\/AKT axis in duck renal tubular epithelial cells","volume":"272","author":"Zhang","year":"2021","journal-title":"Environ. pollution (barking, Essex\u202f: 1987)"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2025.114383_bb0095","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2007.12.002","article-title":"Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures","volume":"236","author":"Qi","year":"2008","journal-title":"Hear. Res."},{"issue":"11","key":"10.1016\/j.intimp.2025.114383_bb0100","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1124\/dmd.111.041160","article-title":"Effect of dimethyl sulfoxide on in vitro cytochrome P4501A2 mediated phenacetin O-deethylation in human liver microsomes","volume":"39","author":"Nirogi","year":"2011","journal-title":"Drug Metab. Dispos."},{"issue":"10","key":"10.1016\/j.intimp.2025.114383_bb0105","first-page":"e2305563","article-title":"VDR Activation Attenuates Renal Tubular Epithelial Cell Ferroptosis by Regulating Nrf2\/HO-1 Signaling Pathway in Diabetic Nephropathy","volume":"vol. 11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.intimp.2025.114383_bb0110","doi-asserted-by":"crossref","first-page":"1101408","DOI":"10.3389\/fphys.2023.1101408","article-title":"The superior cervical ganglion is involved in chronic chemoreflex sensitization during recovery from acute lung injury","volume":"14","author":"Kamra","year":"2023","journal-title":"Front. Physiol."},{"issue":"25","key":"10.1016\/j.intimp.2025.114383_bb0115","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1093\/eurheartj\/ehab139","article-title":"Association of the combined effects of air pollution and changes in physical activity with cardiovascular disease in young adults","volume":"42","author":"Kim","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.intimp.2025.114383_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107706","article-title":"Diesel exhaust PM2.5 greatly deteriorates fibrosis process in pre-existing pulmonary fibrosis via ferroptosis","volume":"171","author":"Yue","year":"2023","journal-title":"Environ. Int."},{"issue":"6","key":"10.1016\/j.intimp.2025.114383_bb0125","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/j.kint.2022.08.020","article-title":"Particulate matter of air pollution may increase risk of kidney failure in IgA nephropathy","volume":"102","author":"Luo","year":"2022","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.intimp.2025.114383_bb0130","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jamaneurol.2019.4914","article-title":"Association between cardiovascular disease and long-term exposure to air pollution with the risk of dementia","volume":"77","author":"Grande","year":"2020","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.intimp.2025.114383_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.111924","article-title":"PM2.5 exposure induces reproductive injury through IRE1\/JNK\/autophagy signaling in male rats","volume":"211","author":"Yang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"21","key":"10.1016\/j.intimp.2025.114383_bb0140","first-page":"e2101251","article-title":"An Air Particulate Pollutant Induces Neuroinflammation and Neurodegeneration in Human Brain Models","volume":"vol. 8","author":"Kang","year":"2021","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.intimp.2025.114383_bb0145","first-page":"183","article-title":"Fine particulate matter (PM(2.5)) and chronic kidney disease","volume":"254","author":"Zhang","year":"2021","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.intimp.2025.114383_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.143582","article-title":"The impact of stay-home policies during Coronavirus-19 pandemic on the chemical and toxicological characteristics of ambient PM(2.5) in the metropolitan area of Milan, Italy","volume":"758","author":"Altuwayjiri","year":"2021","journal-title":"Sci. Total Environ."},{"issue":"2018","key":"10.1016\/j.intimp.2025.114383_bb0155","doi-asserted-by":"crossref","first-page":"9098627","DOI":"10.1155\/2018\/9098627","article-title":"The kidney injury induced by short-term PM(2.5) exposure and the prophylactic treatment of essential oils in BALB\/c mice","author":"Zhang","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"9","key":"10.1016\/j.intimp.2025.114383_bb0160","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1289\/ehp.1510269","article-title":"Long-term exposure to ambient fine particulate matter and renal function in older men: the veterans administration normative aging study","volume":"124","author":"Mehta","year":"2016","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.intimp.2025.114383_bb0165","article-title":"Air pollutants and subsequent risk of chronic kidney disease and end-stage renal disease: a population-based cohort study","volume":"261","author":"Lin","year":"2020","journal-title":"Environ. Pollution (barking, Essex\u202f: 1987)"},{"key":"10.1016\/j.intimp.2025.114383_bb0170","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3389\/fendo.2018.00302","article-title":"Nephrin signaling in the podocyte: an updated view of signal regulation at the slit diaphragm and beyond","volume":"9","author":"Martin","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114383_bb0175","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0002-9440(10)64421-5","article-title":"Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation","volume":"161","author":"Saleem","year":"2002","journal-title":"Am. J. Pathol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114383_bb0180","first-page":"486","article-title":"Markers of complement-dependent and complement-independent glomerular visceral epithelial cell injury in vivo. Expression of antiadhesive proteins and cytoskeletal changes","volume":"67","author":"Floege","year":"1992","journal-title":"Lab. Invest.; J. Tech. Methods Pathol."},{"key":"10.1016\/j.intimp.2025.114383_bb0185","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.redox.2018.08.009","article-title":"iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress","volume":"19","author":"Chenxu","year":"2018","journal-title":"Redox Biol."},{"issue":"6","key":"10.1016\/j.intimp.2025.114383_bb0190","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1016\/j.kint.2019.07.014","article-title":"The anti-PLA2R antibody in membranous nephropathy: what we know and what remains a decade after its discovery","volume":"96","author":"van de Logt","year":"2019","journal-title":"Kidney Int."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692500373X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692500373X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:13:30Z","timestamp":1757913210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692500373X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":38,"alternative-id":["S156757692500373X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114383","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The PM2.5 component, benzo[b]fluoranthene, may contribute to the pathogenesis of membranous nephropathy by activating phosphoinositide 3-kinase\/protein kinase B pathway and causing podocyte pyroptosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114383","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114383"}}