{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:52:53Z","timestamp":1788367973677,"version":"build-2803163510"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["HYD2020JQ0013"],"award-info":[{"award-number":["HYD2020JQ0013"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.intimp.2025.114401","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T04:13:50Z","timestamp":1742184830000},"page":"114401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA\/NF-\u03baB signaling pathway"],"prefix":"10.1016","volume":"153","author":[{"given":"Rongbao","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114401_bb0005","doi-asserted-by":"crossref","first-page":"17018","DOI":"10.1038\/nrdp.2017.18","article-title":"Traumatic spinal cord injury","volume":"3","author":"Ahuja","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"6","key":"10.1016\/j.intimp.2025.114401_bb0010","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1038\/s41591-019-0475-6","article-title":"Spinal cord repair: advances in biology and technology","volume":"25","author":"Courtine","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0015","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.intimp.2025.114401_bb0020","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/procel\/pwad003","article-title":"Recent progress and challenges in the treatment of spinal cord injury","volume":"14","author":"Tian","year":"2023","journal-title":"Protein Cell"},{"issue":"7","key":"10.1016\/j.intimp.2025.114401_bb0025","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1002\/jcp.26287","article-title":"Inflammasome: its role in traumatic brain and spinal cord injury","volume":"233","author":"Mortezaee","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.intimp.2025.114401_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.894","article-title":"TLR4 aggravates microglial pyroptosis by promoting DDX3X-mediated NLRP3 inflammasome activation via JAK2\/STAT1 pathway after spinal cord injury","volume":"12","author":"Wang","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.intimp.2025.114401_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101781","article-title":"Pyroptosis-induced inflammation and tissue damage","volume":"69","author":"Vasudevan","year":"2023","journal-title":"Semin. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2025.114401_bb0040","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2022.04.003","article-title":"NLRP3 and pyroptosis blockers for treating inflammatory diseases","volume":"43","author":"Coll","year":"2022","journal-title":"Trends Pharmacol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2025.114401_bb0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.tibs.2016.10.004","article-title":"Pyroptosis: Gasdermin-mediated programmed necrotic cell death","volume":"42","author":"Shi","year":"2017","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.intimp.2025.114401_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102160","article-title":"Modulating the polarization phenotype of microglia - a valuable strategy for central nervous system diseases","volume":"93","author":"Long","year":"2024","journal-title":"Ageing Res. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","article-title":"Microglial and macrophage polarization-new prospects for brain repair","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.intimp.2025.114401_bb0060","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41401-019-0307-8","article-title":"Kanglexin, a novel anthraquinone compound, protects against myocardial ischemic injury in mice by suppressing NLRP3 and pyroptosis","volume":"41","author":"Bian","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2025.114401_bb0065","article-title":"Kanglexin protects against cardiac fibrosis and dysfunction in mice by TGF-beta1\/ERK1\/2 noncanonical pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2025.114401_bb0070","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/s41401-021-00686-5","article-title":"Kanglexin delays heart aging by promoting mitophagy","volume":"43","author":"Li","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2025.114401_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110933","article-title":"Kanglexin accelerates diabetic wound healing by promoting angiogenesis via FGFR1\/ERK signaling","volume":"132","author":"Zhao","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.114401_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110802","article-title":"Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK\/SREBP-2\/PCSK9\/LDLR signalling pathway","volume":"133","author":"Li","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.114401_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155704","article-title":"Kanglexin counters vascular smooth muscle cell dedifferentiation and associated arteriosclerosis through inhibiting PDGFR","volume":"130","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.114401_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113138","article-title":"Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury","volume":"324","author":"Zheng","year":"2020","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.intimp.2025.114401_bb0095","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41419-022-04592-4","article-title":"Immune-responsive gene 1\/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice","volume":"13","author":"Ni","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0100","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12951-022-01522-6","article-title":"Huc-MSCs-derived exosomes attenuate inflammatory pain by regulating microglia pyroptosis and autophagy via the miR-146a-5p\/TRAF6 axis","volume":"20","author":"Hua","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0105","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13287-017-0648-5","article-title":"Exosomes secreted by stem cells from human exfoliated deciduous teeth contribute to functional recovery after traumatic brain injury by shifting microglia M1\/M2 polarization in rats","volume":"8","author":"Li","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.intimp.2025.114401_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155193","article-title":"Lupeol alleviates autoimmune myocarditis by suppressing macrophage pyroptosis and polarization via PPARalpha\/LACC1\/NF-kappaB signaling pathway","volume":"123","author":"Xiong","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.intimp.2025.114401_bb0115","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso mouse scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J. Neurotrauma"},{"issue":"5","key":"10.1016\/j.intimp.2025.114401_bb0120","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1038\/sj.bjp.0702624","article-title":"Differential inhibitory mechanism of cyclic AMP on TNF-alpha and IL-12 synthesis by macrophages exposed to microbial stimuli","volume":"127","author":"Procopio","year":"1999","journal-title":"Br. J. Pharmacol."},{"issue":"18","key":"10.1016\/j.intimp.2025.114401_bb0125","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1046\/j.1432-1033.2002.03157.x","article-title":"Inhibition of the NF-kappaB transcriptional activity by protein kinase a","volume":"269","author":"Takahashi","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.intimp.2025.114401_bb0130","series-title":"Transcriptional Gene Regulation in Health and Disease","first-page":"41","article-title":"NF-\u03baB and the transcriptional control of inflammation","author":"Mitchell","year":"2018"},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2025.114401_bb0140","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12992","article-title":"Programmed cell death in spinal cord injury pathogenesis and therapy","volume":"54","author":"Shi","year":"2021","journal-title":"Cell Prolif."},{"issue":"20","key":"10.1016\/j.intimp.2025.114401_bb0145","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1001\/jama.1997.03540440031029","volume":"277","author":"Bracken","year":"1997","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.intimp.2025.114401_bb0150","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.phrs.2009.01.018","article-title":"PPAR-alpha modulate the anti-inflammatory effect of glucocorticoids in the secondary damage in experimental spinal cord trauma","volume":"59","author":"Genovese","year":"2009","journal-title":"Pharmacol. Res."},{"issue":"17\u201318","key":"10.1016\/j.intimp.2025.114401_bb0155","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1089\/neu.2022.0409","article-title":"Trends in the use of corticosteroids in the Management of Acute Spinal Cord Injury in north American clinical trials network sites","volume":"40","author":"Hejrati","year":"2023","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0160","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12974-020-01735-2","article-title":"Macrophage MSR1 promotes the formation of foamy macrophage and neuronal apoptosis after spinal cord injury","volume":"17","author":"Kong","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.intimp.2025.114401_bb0165","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1007\/s00401-019-01992-3","article-title":"The origin, fate, and contribution of macrophages to spinal cord injury pathology","volume":"137","author":"Milich","year":"2019","journal-title":"Acta Neuropathol."},{"issue":"7575","key":"10.1016\/j.intimp.2025.114401_bb0170","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0175","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41392-021-00507-5","article-title":"Pyroptosis: mechanisms and diseases","volume":"6","author":"Yu","year":"2021","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0180","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12974-017-0980-9","article-title":"Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice","volume":"14","author":"Jiang","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.114401_bb0185","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jare.2020.08.004","article-title":"Role of pyroptosis in spinal cord injury and its therapeutic implications","volume":"28","author":"Al Mamun","year":"2021","journal-title":"J. Adv. Res."},{"issue":"12","key":"10.1016\/j.intimp.2025.114401_bb0190","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.7150\/ijbs.45467","article-title":"Role of Pyroptosis in traumatic brain and spinal cord injuries","volume":"16","author":"Hu","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2025.114401_bb0195","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.intimp.2025.114401_bb0200","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1552127","article-title":"Curcumin ameliorates white matter injury after ischemic stroke by inhibiting microglia\/macrophage Pyroptosis through NF-kappaB suppression and NLRP3 Inflammasome inhibition","volume":"2021","author":"Ran","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.269","article-title":"CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K\/AKT\/Foxo1 signaling","volume":"11","author":"Xu","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.intimp.2025.114401_bb0210","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.freeradbiomed.2021.03.037","article-title":"Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs-NF-kappaB signaling pathway and pyroptosis after secondary spinal cord injury","volume":"168","author":"Liu","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.intimp.2025.114401_bb0215","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1093\/brain\/awab250","article-title":"Macrophage phagocytosis after spinal cord injury: when friends become foes","volume":"144","author":"Van Broeckhoven","year":"2021","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.intimp.2025.114401_bb0220","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglial M1\/M2 polarization and metabolic states","volume":"173","author":"Orihuela","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.114401_bb0225","article-title":"Immune response following traumatic spinal cord injury: pathophysiology and therapies","volume":"13","author":"Sterner","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2025.114401_bb0230","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.4103\/1673-5374.389302","article-title":"Lupenone improves motor dysfunction in spinal cord injury mice through inhibiting the inflammasome activation and pyroptosis in microglia via the nuclear factor kappa B pathway","volume":"19","author":"Li","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2025.114401_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in rheumatoid arthritis synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2025.114401_bb0240","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/cns.13839","article-title":"Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial\/macrophage polarization","volume":"28","author":"Xue","year":"2022","journal-title":"CNS Neurosci. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2025.114401_bb0245","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/s41401-021-00759-5","article-title":"Metformin promotes microglial cells to facilitate myelin debris clearance and accelerate nerve repairment after spinal cord injury","volume":"43","author":"Wu","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2025.114401_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113310","article-title":"Microglia and macrophage metabolism in CNS injury and disease: the role of immunometabolism in neurodegeneration and neurotrauma","volume":"329","author":"Devanney","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2025.114401_bb0255","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jconrel.2023.08.025","article-title":"Targeted delivery of CD163(+) macrophage-derived small extracellular vesicles via RGD peptides promote vascular regeneration and stabilization after spinal cord injury","volume":"361","author":"Peng","year":"2023","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0260","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12964-022-01036-6","article-title":"Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury","volume":"21","author":"Chang","year":"2023","journal-title":"Cell Commun. Signal"},{"issue":"9","key":"10.1016\/j.intimp.2025.114401_bb0265","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.1007\/s12035-024-04026-6","article-title":"M2 microglia-derived exosomes promote spinal cord injury recovery in mice by alleviating A1 astrocyte activation","volume":"61","author":"Zhang","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.intimp.2025.114401_bb0270","doi-asserted-by":"crossref","DOI":"10.1093\/jmcb\/mjac077","article-title":"Argon mitigates post-stroke neuroinflammation by regulating M1\/M2 polarization and inhibiting NF-kappaB\/NLRP3 inflammasome signaling","volume":"14","author":"Xue","year":"2023","journal-title":"J. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114401_bb0275","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1182\/blood.2019003990","article-title":"The gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice","volume":"136","author":"Wu","year":"2020","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.intimp.2025.114401_bb0280","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1038\/s41423-020-00567-7","article-title":"USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy","volume":"18","author":"Liu","year":"2021","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114401_bb0285","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.tibs.2024.01.004","article-title":"cAMP signaling: a remarkably regional affair","volume":"49","author":"Bock","year":"2024","journal-title":"Trends Biochem. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0290","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13045-024-01524-x","article-title":"cAMP-PKA\/EPAC signaling and cancer: the interplay in tumor microenvironment","volume":"17","author":"Zhang","year":"2024","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2025.114401_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105030","article-title":"Blame the signaling: role of cAMP for the resolution of inflammation","volume":"159","author":"Tavares","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0300","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-kappaB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2025.114401_bb0305","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.it.2022.07.004","article-title":"NF-kappaB: blending metabolism, immunity, and inflammation","volume":"43","author":"Capece","year":"2022","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.114401_bb0310","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41522-023-00374-8","article-title":"Gut microbiota-mediated secondary bile acid alleviates Staphylococcus aureus-induced mastitis through the TGR5-cAMP-PKA-NF-kappaB\/NLRP3 pathways in mice","volume":"9","author":"Zhao","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"10","key":"10.1016\/j.intimp.2025.114401_bb0315","doi-asserted-by":"crossref","DOI":"10.1038\/nmicrobiol.2016.132","article-title":"Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-mediated immune activation and infiltration","volume":"1","author":"Li","year":"2016","journal-title":"Nat. Microbiol."},{"issue":"12","key":"10.1016\/j.intimp.2025.114401_bb0320","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2174\/1389450124666230818092506","article-title":"A comprehensive review on therapeutic potential of a natural Anthraquinone derivative Emodin in brain-related disorders","volume":"24","author":"Goyal","year":"2023","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.intimp.2025.114401_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155578","article-title":"Aloe-emodin alleviates cerebral ischemia-reperfusion injury by regulating microglial polarization and pyroptosis through inhibition of NLRP3 inflammasome activation","volume":"129","author":"Li","year":"2024","journal-title":"Phytomedicine"},{"issue":"26","key":"10.1016\/j.intimp.2025.114401_bb0330","doi-asserted-by":"crossref","first-page":"22577","DOI":"10.1021\/acsomega.2c01897","article-title":"Network pharmacology experiments show that Emodin can exert a protective effect on MCAO rats by regulating Hif-1alpha\/VEGF-A signaling","volume":"7","author":"Lv","year":"2022","journal-title":"ACS Omega"},{"issue":"17","key":"10.1016\/j.intimp.2025.114401_bb0335","doi-asserted-by":"crossref","first-page":"8056","DOI":"10.1039\/D1FO01144H","article-title":"Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K\/AKT\/mTOR and NF-kappaB pathway","volume":"12","author":"Xian","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2025.114401_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117583","article-title":"Aloe-emodin from Sanhua decoction inhibits neuroinflammation by regulating microglia polarization after subarachnoid hemorrhage","volume":"322","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925003911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925003911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:50:10Z","timestamp":1762552210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925003911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":68,"alternative-id":["S1567576925003911"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114401","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kanglexin attenuates spinal cord injury by modulating pyroptosis and polarization via the PKA\/NF-\u03baB signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114401"}}