{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:03:40Z","timestamp":1790953420685,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T00:00:00Z","timestamp":1741824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["2021xkjT021"],"award-info":[{"award-number":["2021xkjT021"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2208085MH264"],"award-info":[{"award-number":["2208085MH264"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U24A20643"],"award-info":[{"award-number":["U24A20643"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,400,132"],"award-info":[{"award-number":["82,400,132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,100,017"],"award-info":[{"award-number":["82,100,017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82,270,015"],"award-info":[{"award-number":["82,270,015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.intimp.2025.114416","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T04:18:00Z","timestamp":1742271480000},"page":"114416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Activation of GPR35 by kynurenic acid inhibits IL-1\u03b2 secretion in macrophages during CR-hvKP-induced pneumonia"],"prefix":"10.1016","volume":"153","author":[{"given":"Qingyue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinjin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.intimp.2025.114416_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph17176278","article-title":"The characteristic of virulence, biofilm and antibiotic resistance of Klebsiella pneumoniae","volume":"17","author":"Wang","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"10.1016\/j.intimp.2025.114416_bb0010","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.02128-23","article-title":"Genome-wide screens reveal shared and strain-specific genes that facilitate enteric colonization by Klebsiella pneumoniae","volume":"14","author":"Cheung","year":"2023","journal-title":"mBio"},{"key":"10.1016\/j.intimp.2025.114416_bb0015","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.03807-23","article-title":"Klebsiella pneumoniae DedA family proteins have redundant roles in divalent cation homeostasis and resistance to phagocytosis","author":"Tiwari","year":"2024","journal-title":"Microbiology Spectrum."},{"issue":"4","key":"10.1016\/j.intimp.2025.114416_bb0020","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1128\/CMR.11.4.589","article-title":"As nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors","volume":"11","author":"Podschun","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2025.114416_bb0025","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000518679","article-title":"Innate host defense against Klebsiella pneumoniae and the outlook for development of immunotherapies","volume":"14","author":"Opoku-Temeng","year":"2022","journal-title":"J. Innate Immun."},{"issue":"2","key":"10.1016\/j.intimp.2025.114416_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/femsre\/fuy043","article-title":"Klebsiella pneumoniaeinfection biology: living to counteract host defences","volume":"43","author":"Bengoechea","year":"2018","journal-title":"FEMS Microbiol. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2025.114416_bb0035","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"issue":"7446","key":"10.1016\/j.intimp.2025.114416_bb0040","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"Wynn","year":"2013","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.intimp.2025.114416_bb0045","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1021\/acsptsci.0c00079","article-title":"Therapeutic opportunities and challenges in targeting the orphan G protein-coupled receptor GPR35","volume":"3","author":"Quon","year":"2020","journal-title":"ACS Pharmacology & Translational Science."},{"issue":"1","key":"10.1016\/j.intimp.2025.114416_bb0050","doi-asserted-by":"crossref","DOI":"10.1186\/1745-7580-4-5","article-title":"Expression analysis of G protein-coupled receptors in mouse macrophages","volume":"4","author":"Lattin","year":"2008","journal-title":"Immunome Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.114416_bb0055","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.apsb.2022.10.011","article-title":"G protein-coupled receptor 35 attenuates nonalcoholic steatohepatitis by reprogramming cholesterol homeostasis in hepatocytes","volume":"13","author":"Wei","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"issue":"5","key":"10.1016\/j.intimp.2025.114416_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107979","article-title":"Lysophosphatidic acid-mediated GPR35 signaling in CX3CR1+ macrophages regulates intestinal homeostasis","volume":"32","author":"Kaya","year":"2020","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.intimp.2025.114416_bb0065","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00587-20","article-title":"Microbiota-Derived Short-Chain Fatty Acids Promote LAMTOR2-Mediated Immune Responses in Macrophages","volume":"5","author":"Wu","year":"2020","journal-title":"mSystems"},{"issue":"5","key":"10.1016\/j.intimp.2025.114416_bb0070","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tips.2023.03.001","article-title":"GPR35: from enigma to therapeutic target","volume":"44","author":"Milligan","year":"2023","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2025.114416_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.12.013","article-title":"Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming","volume":"172","author":"Christ","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2025.114416_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00276","article-title":"NLRP3 Inflammasome and inflammatory bowel disease","volume":"10","author":"Zhen","year":"2019","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2025.114416_bb0085","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"7434","key":"10.1016\/j.intimp.2025.114416_bb0090","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature11729","article-title":"NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice","volume":"493","author":"Heneka","year":"2012","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2025.114416_bb0095","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-019-2157-1","article-title":"NEK7 interacts with NLRP3 to modulate the pyroptosis in inflammatory bowel disease via NF-\u03baB signaling","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.intimp.2025.114416_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/cells9041047","article-title":"The P2X7 receptor and NLRP3 Axis in non-alcoholic fatty liver disease: a brief review","volume":"9","author":"Rossato","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2025.114416_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105885","article-title":"NLRP3 inflammasome and IL-1\u03b2 pathway in type 2 diabetes and atherosclerosis: friend or foe?","volume":"173","author":"Chen","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"12","key":"10.1016\/j.intimp.2025.114416_bb0110","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/CIRCRESAHA.118.311362","article-title":"NLRP3 Inflammasome and the IL-1 pathway in atherosclerosis","volume":"122","author":"Grebe","year":"2018","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.intimp.2025.114416_bb0115","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5582\/bst.2020.01029","article-title":"NEK7: a potential therapy target for NLRP3-related diseases","volume":"14","author":"Liu","year":"2020","journal-title":"Biosci. Trends"},{"issue":"1","key":"10.1016\/j.intimp.2025.114416_bb0120","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 Inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"issue":"13","key":"10.1016\/j.intimp.2025.114416_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 Inflammasome: An overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1019365","key":"10.1016\/j.intimp.2025.114416_bb0130","article-title":"Kynurenic acid ameliorates NLRP3 inflammasome activation by blocking calcium mobilization via GPR35","volume":"13","author":"Sun","year":"2022","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2025.114416_bb0135","doi-asserted-by":"crossref","first-page":"5271","DOI":"10.4049\/jimmunol.0903035","article-title":"Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury","volume":"184","author":"Schingnitz","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.114416_bb0140","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fphar.2015.00041","article-title":"G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease","volume":"6","author":"Divorty","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.114416_bb0145","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1254446","article-title":"GPR35 acts a dual role and therapeutic target in inflammation","volume":"14","author":"Wu","year":"2023","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2025.114416_bb0150","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cell.2022.01.010","article-title":"GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA","volume":"185","author":"De Giovanni","year":"2022","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.intimp.2025.114416_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113005","article-title":"The gut microbiota-induced kynurenic acid recruits GPR35-positive macrophages to promote experimental encephalitis","volume":"42","author":"Miyamoto","year":"2023","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.intimp.2025.114416_bb0160","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1016\/j.immuni.2023.05.006","article-title":"Platelets and mast cells promote pathogenic eosinophil recruitment during invasive fungal infection via the 5-HIAA-GPR35 ligand-receptor system","volume":"56","author":"Giovanni","year":"2023","journal-title":"Immunity"},{"issue":"31","key":"10.1016\/j.intimp.2025.114416_bb0165","doi-asserted-by":"crossref","first-page":"22021","DOI":"10.1074\/jbc.M603503200","article-title":"Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35","volume":"281","author":"Wang","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.114416_bb0170","doi-asserted-by":"crossref","first-page":"19189","DOI":"10.1074\/jbc.M109.024042","article-title":"Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions","volume":"284","author":"Barth","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2025.114416_bb0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000314164","article-title":"G-protein-coupled receptor 35 is a target of the asthma drugs cromolyn disodium and nedocromil sodium","volume":"86","author":"Yang","year":"2010","journal-title":"Pharmacology"},{"key":"10.1016\/j.intimp.2025.114416_bb0180","article-title":"Inducible antibacterial responses in macrophages","author":"MJ., S.; D., R.; A., S.; R., K","year":"2024","journal-title":"Nat. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2025.114416_bb0185","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2025.114416_bb0190","first-page":"1","article-title":"Macrophage Proinflammatory activation and deactivation","author":"Valledor","year":"2010","journal-title":"Adv. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114416_bb0195","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cmet.2011.11.013","article-title":"Orchestration of metabolism by macrophages","volume":"15","author":"SK., B.; A., M","year":"2012","journal-title":"Cell Metab."},{"issue":"7","key":"10.1016\/j.intimp.2025.114416_bb0200","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"B., K.; LA., O. N","year":"2015","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.114416_bb0205","article-title":"Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription. Nature","volume":"5","author":"Huai","year":"2014","journal-title":"Communications"},{"issue":"5","key":"10.1016\/j.intimp.2025.114416_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/cells12050793","article-title":"Gut-microbiota-derived metabolites maintain gut and systemic immune homeostasis","volume":"12","author":"Wang","year":"2023","journal-title":"Cells"},{"issue":"6145","key":"10.1016\/j.intimp.2025.114416_bb0215","first-page":"569","article-title":"The microbial metabolites, short-chain fatty acids","volume":"341","author":"Smith","year":"2013","journal-title":"Regulate Colonic Treg Cell Homeostasis. Science."},{"issue":"1","key":"10.1016\/j.intimp.2025.114416_bb0220","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-022-01458-x","article-title":"Gut microbiota-derived ursodeoxycholic acid alleviates low birth weight-induced colonic inflammation by enhancing M2 macrophage polarization","volume":"11","author":"Pi","year":"2023","journal-title":"Microbiome"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925004060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925004060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:58:09Z","timestamp":1778619489000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925004060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":44,"alternative-id":["S1567576925004060"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114416","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Activation of GPR35 by kynurenic acid inhibits IL-1\u03b2 secretion in macrophages during CR-hvKP-induced pneumonia","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114416"}}