{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T04:12:32Z","timestamp":1792469552699,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085QH250"],"award-info":[{"award-number":["2308085QH250"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2023AH050570"],"award-info":[{"award-number":["2023AH050570"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Provincial Department of Education","doi-asserted-by":"publisher","award":["2023AH053398"],"award-info":[{"award-number":["2023AH053398"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","award":["YXCX202203"],"award-info":[{"award-number":["YXCX202203"]}],"id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.intimp.2025.114463","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T21:08:51Z","timestamp":1742418531000},"page":"114463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Vaccarin alleviates renal ischemia-reperfusion injury by inhibiting inflammation and ferroptosis"],"prefix":"10.1016","volume":"153","author":[{"given":"Qianwen","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiagen","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.intimp.2025.114463_bb0005","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41581-021-00410-w","article-title":"Conceptual advances and evolving terminology in acute kidney disease","volume":"17","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.intimp.2025.114463_bb0010","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.kint.2017.08.014","article-title":"Neutrophil peptidyl arginine deiminase-4 has a pivotal role in ischemia\/reperfusion-induced acute kidney injury","volume":"93","author":"Raup-Konsavage","year":"2018","journal-title":"Kidney Int."},{"issue":"4","key":"10.1016\/j.intimp.2025.114463_bb0015","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneph.2017.184","article-title":"Paradigms of acute kidney injury in the intensive care setting","volume":"14","author":"Kellum","year":"2018","journal-title":"Nature Reviews Nephrology"},{"issue":"6","key":"10.1016\/j.intimp.2025.114463_bb0020","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00134-017-4809-x","article-title":"Renal recovery after acute kidney injury","volume":"43","author":"Forni","year":"2017","journal-title":"Intensive Care Medicine"},{"issue":"15","key":"10.1016\/j.intimp.2025.114463_bb0025","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1111\/jcmm.17444","article-title":"Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4\/NOX4 pathway in mice","volume":"26","author":"Feng","year":"2022","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"2","key":"10.1016\/j.intimp.2025.114463_bb0030","first-page":"273","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism","volume":"171","author":"Stockwell","year":"2017","journal-title":"Redox Biology, and Disease, Cell"},{"key":"10.1016\/j.intimp.2025.114463_bb0035","doi-asserted-by":"crossref","first-page":"1065867","DOI":"10.3389\/fphar.2022.1065867","article-title":"Ferroptosis: A new insight for treatment of acute kidney injury","volume":"13","author":"Li","year":"2022","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"10.1016\/j.intimp.2025.114463_bb0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/cells12010016","article-title":"Myo-Inositol Supplementation Alleviates Cisplatin-Induced Acute Kidney Injury via Inhibition of Ferroptosis","volume":"12","author":"Qi","year":"2023","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.intimp.2025.114463_bb0045","doi-asserted-by":"crossref","first-page":"6583","DOI":"10.3390\/ijms23126583","article-title":"Ferroptosis: a potential therapeutic target in acute kidney injury","volume":"23","author":"Hosohata","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.114463_bb0050","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000517723","article-title":"Targeting Ferroptosis Attenuates Interstitial Inflammation and Kidney Fibrosis","volume":"8","author":"Zhou","year":"2021","journal-title":"Kidney Diseases"},{"issue":"5","key":"10.1016\/j.intimp.2025.114463_bb0055","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/bph.15364","article-title":"Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis","volume":"178","author":"Li","year":"2021","journal-title":"British Journal of Pharmacology"},{"issue":"15","key":"10.1016\/j.intimp.2025.114463_bb0060","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1111\/bph.15834","article-title":"Leonurine alleviates ferroptosis in cisplatin-induced acute kidney injury by activating the Nrf2 signalling pathway","volume":"179","author":"Hu","year":"2022","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.intimp.2025.114463_bb0065","doi-asserted-by":"crossref","first-page":"113468","DOI":"10.1016\/j.fct.2022.113468","article-title":"Asiatic acid alleviates LPS-induced acute kidney injury in broilers by inhibiting oxidative stress and ferroptosis via activation of the Nrf2 pathway","volume":"170","author":"Qiu","year":"2022","journal-title":"Food and Chemical Toxicology"},{"key":"10.1016\/j.intimp.2025.114463_bb0070","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.seppur.2014.06.002","article-title":"Microwave-assisted extraction and antioxidant activity of vaccarin from the seeds of Vaccaria segetalis","volume":"133","author":"Yuan","year":"2014","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.intimp.2025.114463_bb0075","doi-asserted-by":"crossref","first-page":"956247","DOI":"10.3389\/fphar.2022.956247","article-title":"Vaccarin alleviates endothelial inflammatory injury in diabetes by mediating miR-570-3p\/HDAC1 pathway","volume":"13","author":"Li","year":"2022","journal-title":"Frontiers in Pharmacology"},{"issue":"8","key":"10.1016\/j.intimp.2025.114463_bb0080","doi-asserted-by":"crossref","first-page":"13832","DOI":"10.1002\/jcp.28063","article-title":"Vaccarin prevents titanium particle-induced osteolysis and inhibits RANKL-induced osteoclastogenesis by blocking NF-\u03baB and MAPK signaling pathways","volume":"234","author":"Liu","year":"2019","journal-title":"Journal of Cellular Physiology"},{"issue":"1","key":"10.1016\/j.intimp.2025.114463_bb0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3892\/ijmm.2014.1977","article-title":"Vaccarin attenuates the human EA.hy926 endothelial cell oxidative stress injury through inhibition of Notch signaling","volume":"35","author":"Xie","year":"2015","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.intimp.2025.114463_bb0090","first-page":"924","article-title":"Vaccarin alleviates hypertension and nephropathy in renovascular hypertensive rats","volume":"15","author":"Cai","year":"2018","journal-title":"Exp Ther Med"},{"issue":"11","key":"10.1016\/j.intimp.2025.114463_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e21231","article-title":"Vaccarin alleviates cisplatin-induced acute kidney injury via decreasing NOX4-derived ROS","volume":"9","author":"Wu","year":"2023","journal-title":"Heliyon"},{"issue":"640","key":"10.1016\/j.intimp.2025.114463_bb0105","doi-asserted-by":"crossref","first-page":"eabk2709","DOI":"10.1126\/scitranslmed.abk2709","article-title":"Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms","volume":"14","author":"Jia-Nan","year":"2022","journal-title":"Science Translational Medicine"},{"issue":"W1","key":"10.1016\/j.intimp.2025.114463_bb0110","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein\u2013ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Research"},{"issue":"9","key":"10.1016\/j.intimp.2025.114463_bb0115","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1080\/15548627.2020.1810918","article-title":"Ferroptosis: machinery and regulation","volume":"17","author":"Chen","year":"2021","journal-title":"Autophagy"},{"issue":"10","key":"10.1016\/j.intimp.2025.114463_bb0120","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1080\/15548627.2023.2218764","article-title":"GPX4 in cell death, autophagy, and disease","volume":"19","author":"Xie","year":"2023","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.intimp.2025.114463_bb0125","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1089\/ars.2007.1892","article-title":"Mitochondria-Targeted Cytoprotective Peptides for Ischemia\u2013Reperfusion Injury","volume":"10","author":"Szeto","year":"2007","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/j.intimp.2025.114463_bb0130","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s13613-021-00849-x","article-title":"Outcome of acute kidney injury: how to make a difference?","volume":"11","author":"Matthieu","year":"2021","journal-title":"Annals of Intensive Care"},{"issue":"7","key":"10.1016\/j.intimp.2025.114463_bb0135","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.drudis.2006.02.010","article-title":"Ischemic acute tubular necrosis models and drug discovery: a focus on cellular inflammation","volume":"11","author":"Ikeda","year":"2006","journal-title":"Drug discovery today"},{"issue":"2","key":"10.1016\/j.intimp.2025.114463_bb0140","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0306-4522(99)00569-2","article-title":"Mitochondrial porin required for ischemia-induced mitochondrial dysfunction and neuronal damage","volume":"97","author":"Perez Velazquez","year":"2000","journal-title":"Neuroscience"},{"issue":"24","key":"10.1016\/j.intimp.2025.114463_bb0145","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1111\/febs.17130","article-title":"Role of mitochondria in renal ischemia\u2013reperfusion injury","volume":"291","author":"Huang","year":"2024","journal-title":"The FEBS Journal"},{"issue":"1","key":"10.1016\/j.intimp.2025.114463_bb0155","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s10020-024-00785-z","article-title":"Porous Se@SiO2 nanospheres alleviate diabetic retinopathy by inhibiting excess lipid peroxidation and inflammation","volume":"30","author":"Niu","year":"2024","journal-title":"Molecular Medicine"},{"key":"10.1016\/j.intimp.2025.114463_bb0160","doi-asserted-by":"crossref","first-page":"102436","DOI":"10.1016\/j.redox.2022.102436","article-title":"Evolutionary and structural analyses of the NADPH oxidase family in eukaryotes reveal an initial calcium dependency","volume":"56","author":"Massari","year":"2022","journal-title":"Redox Biology"},{"key":"10.1016\/j.intimp.2025.114463_bb0165","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.sbi.2019.03.001","article-title":"Structure and mechanisms of ROS generation by NADPH oxidases","volume":"59","author":"Magnani","year":"2019","journal-title":"Current Opinion in Structural Biology"},{"issue":"1","key":"10.1016\/j.intimp.2025.114463_bb0170","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cellsig.2005.03.023","article-title":"Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases","volume":"18","author":"Martyn","year":"2006","journal-title":"Cellular Signalling"},{"key":"10.1016\/j.intimp.2025.114463_bb0175","doi-asserted-by":"crossref","first-page":"101479","DOI":"10.1016\/j.redox.2020.101479","article-title":"Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production","volume":"32","author":"Wang","year":"2020","journal-title":"Redox Biology"},{"issue":"1","key":"10.1016\/j.intimp.2025.114463_bb0180","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/labinvest.2017.120","article-title":"NADPH oxidase 4 promotes cisplatin-induced acute kidney injury via ROS-mediated programmed cell death and inflammation","volume":"98","author":"Meng","year":"2018","journal-title":"Laboratory Investigation"},{"key":"10.1016\/j.intimp.2025.114463_bb0185","doi-asserted-by":"crossref","first-page":"112303","DOI":"10.1016\/j.intimp.2024.112303","article-title":"Hederagenin improves renal fibrosis in diabetic nephropathy by regulating Smad3\/NOX4\/SLC7A11 signaling-mediated tubular cell ferroptosis","volume":"135","author":"jia","year":"2024","journal-title":"International Immunopharmacology"},{"issue":"26","key":"10.1016\/j.intimp.2025.114463_bb0190","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.1073\/pnas.1702293114","article-title":"Crystal structures and atomic model of NADPH oxidase","volume":"114","author":"Magnani","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925004539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925004539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:47:49Z","timestamp":1762552069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925004539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":36,"alternative-id":["S1567576925004539"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114463","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vaccarin alleviates renal ischemia-reperfusion injury by inhibiting inflammation and ferroptosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114463","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114463"}}