{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:20:22Z","timestamp":1791724822867,"version":"4.3.4"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071189"],"award-info":[{"award-number":["82071189"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271222"],"award-info":[{"award-number":["82271222"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101265"],"award-info":[{"award-number":["82101265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401505"],"award-info":[{"award-number":["82401505"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023\\u202FM740142"],"award-info":[{"award-number":["2023\\u202FM740142"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20230143"],"award-info":[{"award-number":["GZC20230143"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.intimp.2025.114508","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:18:31Z","timestamp":1743142711000},"page":"114508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A novel postoperative delayed neurocognitive recovery model established based on preoperative rapid eye movement sleep deprivation in adult mice"],"prefix":"10.1016","volume":"153","author":[{"given":"Kaixi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingshu","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengqian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114508_bb0005","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.bja.2017.11.087","article-title":"Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018","volume":"121","author":"Evered","year":"2018","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.intimp.2025.114508_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111772","article-title":"The activation of RAR\u03b1 prevents surgery-induced cognitive impairments via the inhibition of neuroinflammation and the restoration of synaptic proteins in elderly mice","volume":"130","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.114508_bb0015","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1111\/cns.13718","article-title":"Cholecystokinin octapeptide improves hippocampal glutamatergic synaptogenesis and postoperative cognition by inhibiting induction of A1 reactive astrocytes in aged mice","volume":"27","author":"Chen","year":"2021","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2025.114508_bb0020","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/cns.13784","article-title":"Electroacupuncture ameliorates postoperative cognitive dysfunction and associated neuroinflammation via NLRP3 signal inhibition in aged mice","volume":"28","author":"Sun","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2025.114508_bb0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1538\/expanim.22-0053","article-title":"A modified mouse model of perioperative neurocognitive disorders exacerbated by sleep fragmentation","volume":"72","author":"Wu","year":"2023","journal-title":"Exp. Anim."},{"key":"10.1016\/j.intimp.2025.114508_bb0030","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/ALN.0000000000004046","article-title":"Sleep, pain, and cognition: modifiable targets for optimal perioperative brain health","volume":"135","author":"O\u2019Gara","year":"2021","journal-title":"Anesthesiology"},{"key":"10.1016\/j.intimp.2025.114508_bb0035","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S1474-4422(14)70172-3","article-title":"Connections between sleep and cognition in older adults","volume":"13","author":"Yaffe","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.intimp.2025.114508_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.smrv.2023.101786","article-title":"The prevalence and risk factors of sleep disturbances in surgical patients: a systematic review and meta-analysis","volume":"69","author":"Butris","year":"2023","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.intimp.2025.114508_bb0045","doi-asserted-by":"crossref","first-page":"170","DOI":"10.7326\/0003-4819-156-12-201208070-00472","article-title":"Sleep disruption due to hospital noises: a prospective evaluation","volume":"157","author":"Buxton","year":"2012","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.intimp.2025.114508_bb0050","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1213\/ANE.0000000000005323","article-title":"Sleep loss in the hospitalized patient and its influence on recovery from illness and operation","volume":"132","author":"Hillman","year":"2021","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.intimp.2025.114508_bb0055","doi-asserted-by":"crossref","first-page":"766","DOI":"10.12968\/bjon.2008.17.12.30306","article-title":"Sleep disruption experienced by surgical patients in an acute hospital","volume":"17","author":"Lane","year":"2008","journal-title":"Br. J. Nurs."},{"key":"10.1016\/j.intimp.2025.114508_bb0060","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/AIA.0000000000000391","article-title":"Sleep disruption in older surgical patients and its important implications","volume":"61","author":"Butris","year":"2023","journal-title":"Int. Anesthesiol. Clin."},{"key":"10.1016\/j.intimp.2025.114508_bb0065","first-page":"604","article-title":"Sleep disturbances in the critically ill patients: role of delirium and sedative agents","volume":"77","author":"Trompeo","year":"2011","journal-title":"Minerva Anestesiol."},{"key":"10.1016\/j.intimp.2025.114508_bb0070","first-page":"1251","article-title":"Correlation between preoperative sleep disorders and postoperative delayed neurocognitive recovery in elderly patients","volume":"46","author":"Li","year":"2021","journal-title":"Zhong Nan Da Xue Xue Bao Yi Xue Ban"},{"key":"10.1016\/j.intimp.2025.114508_bb0075","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/jgs.14685","article-title":"Sleep disruption at home as an independent risk factor for postoperative delirium","volume":"65","author":"Todd","year":"2017","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.intimp.2025.114508_bb0080","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1213\/ANE.0000000000006768","article-title":"Melanin-concentrating hormone is associated with delayed neurocognitive recovery in older adult patients with preoperative sleep disorders undergoing spinal anesthesia","volume":"138","author":"Gao","year":"2024","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.intimp.2025.114508_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2019.110791","article-title":"The potential mechanism of postoperative cognitive dysfunction in older people","volume":"130","author":"Lin","year":"2020","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.intimp.2025.114508_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111290","article-title":"Rutin prevents pyroptosis and M1 microglia via Nrf2\/mac-1\/caspase-1-mediated inflammasome axis to improve POCD","volume":"127","author":"Ji","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.114508_bb0095","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.bbi.2019.01.020","article-title":"MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice","volume":"78","author":"Chen","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2025.114508_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115582","article-title":"Neuroinflammation: the central enabler of postoperative cognitive dysfunction","volume":"167","author":"Liu","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.114508_bb0105","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12974-019-1695-x","article-title":"Dysregulation of BDNF\/TrkB signaling mediated by NMDAR\/ca(2+)\/calpain might contribute to postoperative cognitive dysfunction in aging mice","volume":"17","author":"Qiu","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.114508_bb0110","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1177\/0271678X20943823","article-title":"The ARRIVE guidelines 2.0: updated guidelines for reporting animal research","volume":"40","author":"Percie du Sert","year":"2020","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.intimp.2025.114508_bb0115","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.bbi.2021.12.006","article-title":"TNF signaling pathway-mediated microglial activation in the PFC underlies acute paradoxical sleep deprivation-induced anxiety-like behaviors in mice","volume":"100","author":"Liu","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2025.114508_bb0120","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1111\/cns.14261","article-title":"Reciprocal interaction between mitochondrial fission and mitophagy in postoperative delayed neurocognitive recovery in aged rats","volume":"29","author":"Li","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2025.114508_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112744","article-title":"3-Methyladenine attenuates neuroinflammation and improves cognitive function in sepsis-associated encephalopathy by inhibiting autophagy","volume":"139","author":"Zhu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.114508_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113464","article-title":"Effects of remimazolam and surgery on cognition in a tibia fracture mouse model","volume":"143","author":"Zhao","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.114508_bb0135","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1097\/ALN.0b013e31820ad3ce","article-title":"Heat shock protein 72 overexpression prevents early postoperative memory decline after orthopedic surgery under general anesthesia in mice","volume":"114","author":"Vizcaychipi","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.intimp.2025.114508_bb0140","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1213\/ANE.0000000000003514","article-title":"Postoperative cognitive dysfunction and noncardiac surgery","volume":"127","author":"Evered","year":"2018","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.intimp.2025.114508_bb0145","article-title":"Activation of the lateral Habenula-ventral tegmental area neural circuit contributes to postoperative cognitive dysfunction in mice","volume":"9","author":"Xin","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.intimp.2025.114508_bb0150","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1097\/ALN.0000000000000045","article-title":"High-mobility group box 1 protein initiates postoperative cognitive decline by engaging bone marrow-derived macrophages","volume":"120","author":"Vacas","year":"2014","journal-title":"Anesthesiology"},{"key":"10.1016\/j.intimp.2025.114508_bb0155","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/00000542-200509000-00028","article-title":"Abdominal surgery decreases food-reinforced operant responding in rats: relevance of incisional pain","volume":"103","author":"Martin","year":"2005","journal-title":"Anesthesiology"},{"key":"10.1016\/j.intimp.2025.114508_bb0160","doi-asserted-by":"crossref","first-page":"14641","DOI":"10.1523\/JNEUROSCI.2173-12.2012","article-title":"Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats","volume":"32","author":"Barrientos","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.intimp.2025.114508_bb0165","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1007\/s12035-023-03651-x","article-title":"Urolithin a prevents sleep-deprivation-induced Neuroinflammation and mitochondrial dysfunction in young and aged mice","volume":"61","author":"Misrani","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2025.114508_bb0170","doi-asserted-by":"crossref","first-page":"e1204","DOI":"10.1097\/CCM.0000000000003400","article-title":"A systematic review and Meta-analysis examining the impact of sleep disturbance on postoperative delirium","volume":"46","author":"Fadayomi","year":"2018","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.114508_bb0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbr.2019.01.038","article-title":"REM sleep deprivation-induced circadian clock gene abnormalities participate in hippocampal-dependent memory impairment by enhancing inflammation in rats undergoing sevoflurane inhalation","volume":"364","author":"Hou","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.intimp.2025.114508_bb0180","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1111\/bph.14626","article-title":"Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation","volume":"176","author":"Cao","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.114508_bb0185","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s43440-020-00161-8","article-title":"The effect of alpha lipoic acid on passive avoidance and social interaction memory, pain perception, and locomotor activity in REM sleep-deprived rats","volume":"73","author":"Mahdavi","year":"2021","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.intimp.2025.114508_bb0190","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.intimp.2019.03.003","article-title":"Methane ameliorates post-operative cognitive dysfunction by inhibiting microglia NF-\u03baB\/MAPKs pathway and promoting IL-10 expression in aged mice","volume":"71","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.114508_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114577","article-title":"Formyl peptide receptor 1 is involved in surgery-induced neuroinflammation and dysfunction of learning and memory in mice","volume":"452","author":"Ma","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.intimp.2025.114508_bb0200","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1002\/anie.201802309","article-title":"Custom-made ceria nanoparticles show a neuroprotective effect by modulating phenotypic polarization of the microglia","volume":"57","author":"Zeng","year":"2018","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.intimp.2025.114508_bb0205","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s10787-023-01216-x","article-title":"Microglia polarization in nociplastic pain: mechanisms and perspectives","volume":"31","author":"Atta","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2025.114508_bb0210","doi-asserted-by":"crossref","first-page":"eabq7806","DOI":"10.1126\/sciadv.abq7806","article-title":"Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy","volume":"9","author":"Chung","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2025.114508_bb0215","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1126\/science.aad8373","article-title":"Complement and microglia mediate early synapse loss in Alzheimer mouse models","volume":"352","author":"Hong","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.intimp.2025.114508_bb0220","doi-asserted-by":"crossref","first-page":"714","DOI":"10.3390\/antiox12030714","article-title":"Caffeic acid Phenethyl Ester suppresses oxidative stress and regulates M1\/M2 microglia polarization via Sirt6\/Nrf2 pathway to mitigate cognitive impairment in aged mice following anesthesia and surgery","volume":"12","author":"Wang","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2025.114508_bb0225","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.bja.2022.08.019","article-title":"Interleukin-6 trans-signalling in hippocampal CA1 neurones mediates perioperative neurocognitive disorders in mice","volume":"129","author":"Hu","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.intimp.2025.114508_bb0230","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2019.03.020","article-title":"IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation","volume":"50","author":"Ouyang","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2025.114508_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102982","article-title":"IL-10 protects against OPC ferroptosis by regulating lipid reactive oxygen species levels post stroke","volume":"69","author":"Wu","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.114508_bb0240","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.bja.2017.11.096","article-title":"Interleukin-6 is both necessary and sufficient to produce perioperative neurocognitive disorder in mice","volume":"120","author":"Hu","year":"2018","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.intimp.2025.114508_bb0245","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2025.114508_bb0250","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12974-020-01891-5","article-title":"Microglia induce the transformation of A1\/A2 reactive astrocytes via the CXCR7\/PI3K\/Akt pathway in chronic post-surgical pain","volume":"17","author":"Li","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.114508_bb0255","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.neubiorev.2020.08.006","article-title":"Associations between sex hormones, sleep problems and depression: a systematic review","volume":"118","author":"Morssinkhof","year":"2020","journal-title":"Neurosci. Biobehav. Rev."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925004989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925004989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:58:28Z","timestamp":1778619508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925004989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":51,"alternative-id":["S1567576925004989"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114508","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel postoperative delayed neurocognitive recovery model established based on preoperative rapid eye movement sleep deprivation in adult mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114508"}}