{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T11:25:07Z","timestamp":1794569107454,"version":"4.9.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300682"],"award-info":[{"award-number":["32300682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["FRF-TP-22-007A1"],"award-info":[{"award-number":["FRF-TP-22-007A1"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.intimp.2025.114550","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:54:23Z","timestamp":1744289663000},"page":"114550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway"],"prefix":"10.1016","volume":"155","author":[{"given":"Chunbin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubang","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cencan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114550_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25031631","article-title":"Inhibition of the RAF\/MEK\/ERK signaling Cascade in pancreatic Cancer: recent advances and future perspectives","volume":"25","author":"Adamopoulos","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.114550_bb0010","doi-asserted-by":"crossref","first-page":"D789","DOI":"10.1093\/nar\/gku1205","article-title":"OMIM.org: online Mendelian inheritance in man (OMIM(R)), an online catalog of human genes and genetic disorders","volume":"43","author":"Amberger","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2025.114550_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113270","article-title":"Caffeic acid loaded into engineered lipid nanoparticles for Alzheimer's disease therapy","volume":"225","author":"Andrade","year":"2023","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.intimp.2025.114550_bb0020","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.snb.2016.07.181","article-title":"Alzheimer's disease: development of a sensitive label-free electrochemical immunosensor for detection of amyloid beta peptide","volume":"239","author":"Carneiro","year":"2017","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.intimp.2025.114550_bb0025","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/rej.2022.0023","article-title":"Berberine ameliorates lipopolysaccharide-induced cognitive impairment through SIRT1\/NRF2\/NF-\u03baB signaling pathway in C57BL\/6J mice","volume":"25","author":"Chen","year":"2022","journal-title":"Rejuvenation Res."},{"key":"10.1016\/j.intimp.2025.114550_bb0030","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.1039\/D1FO01360B","article-title":"Protective effects of berberine against MPTP-induced dopaminergic neuron injury through promoting autophagy in mice","volume":"12","author":"Deng","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2025.114550_bb0035","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.apsb.2021.12.009","article-title":"Pharmacological modulation of autophagy for Alzheimer's disease therapy: opportunities and obstacles","volume":"12","author":"Deng","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.intimp.2025.114550_bb0040","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fnins.2018.00255","article-title":"Association between autophagy and neurodegenerative diseases","volume":"12","author":"Fujikake","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2025.114550_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131755","article-title":"Integrated network pharmacology and cellular assay for the investigation of an anti-obesity effect of 6-shogaol","volume":"374","author":"Jiao","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.intimp.2025.114550_bb0050","doi-asserted-by":"crossref","first-page":"D1388","DOI":"10.1093\/nar\/gkaa971","article-title":"PubChem in 2021: new data content and improved web interfaces","volume":"49","author":"Kim","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2025.114550_bb0055","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/cns.13216","article-title":"Exploring the bi-directional relationship between autophagy and Alzheimer's disease","volume":"26","author":"Kuang","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2025.114550_bb0060","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuron.2020.10.005","article-title":"Neuronal autophagy regulates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum","volume":"109","author":"Kuijpers","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2025.114550_bb0065","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.intimp.2025.114550_bb0070","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/j.csbj.2022.03.006","article-title":"INPUT: an intelligent network pharmacology platform unique for traditional Chinese medicine","volume":"20","author":"Li","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.intimp.2025.114550_bb0075","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1021\/acschemneuro.0c00808","article-title":"Berberine improves behavioral and cognitive deficits in a mouse model of Alzheimer's disease via regulation of \u03b2-amyloid production and endoplasmic reticulum stress","volume":"12","author":"Liang","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.intimp.2025.114550_bb0080","article-title":"Asiaticoside mitigates Alzheimer's disease pathology by attenuating inflammation and enhancing synaptic function","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.114550_bb0085","article-title":"Integrating network pharmacology and animal experimental validation to investigate the action mechanism of oleanolic acid in obesity","volume":"22","author":"Liu","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2025.114550_bb0090","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1016\/j.scib.2022.12.006","article-title":"Alzheimer's disease: current status and perspective","volume":"67","author":"Liu","year":"2022","journal-title":"Sci. Bull. (Beijing)"},{"key":"10.1016\/j.intimp.2025.114550_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2024.106144","article-title":"Exploration of anti-osteoporotic peptides from Moringa oleifera leaf proteins by network pharmacology, molecular docking, molecular dynamics and cellular assay analyses","volume":"116","author":"Men","year":"2024","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.intimp.2025.114550_bb0100","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2025.114550_bb0105","doi-asserted-by":"crossref","first-page":"616","DOI":"10.2174\/1386207324666210804122539","article-title":"Berberine in the treatment of neurodegenerative diseases and nanotechnology enabled targeted delivery","volume":"25","author":"Mohi-Ud-Din","year":"2022","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.intimp.2025.114550_bb0110","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.jalz.2018.06.3040","article-title":"The antimicrobial protection hypothesis of Alzheimer's disease","volume":"14","author":"Moir","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.intimp.2025.114550_bb0115","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1586\/ern.09.107","article-title":"MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE","volume":"9","author":"Origlia","year":"2009","journal-title":"Expert. Rev. Neurother."},{"key":"10.1016\/j.intimp.2025.114550_bb0120","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1038\/s41591-021-01456-w","article-title":"Microglial activation and tau propagate jointly across Braak stages","volume":"27","author":"Pascoal","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2025.114550_bb0125","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1515\/revneuro-2017-0063","article-title":"Amyloid toxicity in Alzheimer's disease","volume":"29","author":"Reiss","year":"2018","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.intimp.2025.114550_bb0130","article-title":"Evidence of tau hyperphosphorylation and dystrophic microglia in the common marmoset. Frontiers in aging","volume":"8","author":"Rodriguez-Callejas","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2025.114550_bb0135","doi-asserted-by":"crossref","first-page":"3961","DOI":"10.1096\/fj.201600698R","article-title":"LC3\/GABARAP family proteins: autophagy-(un)related functions","volume":"30","author":"Schaaf","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2025.114550_bb0140","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.intimp.2025.114550_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards suite: from gene data mining to disease genome sequence analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinformatics"},{"key":"10.1016\/j.intimp.2025.114550_bb0150","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2025.114550_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.763866","article-title":"TRPV1-mediated microglial autophagy attenuates Alzheimer's disease-associated pathology and cognitive decline","volume":"12","author":"Wang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.114550_bb0160","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-024-06423-0","article-title":"Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control","volume":"15","author":"Wible","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2025.114550_bb0165","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1474-4422(12)70136-9","article-title":"Active immunotherapy for Alzheimer's disease","volume":"11","author":"Wisniewski","year":"2012","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.intimp.2025.114550_bb0170","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.redox.2016.12.022","article-title":"The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2\/PINK1","volume":"11","author":"Xiao","year":"2017","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.114550_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/biom14020243","article-title":"The role of the dysregulated JNK signaling pathway in the pathogenesis of human diseases and its potential therapeutic strategies: a comprehensive review","volume":"14","author":"Yan","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.intimp.2025.114550_bb0180","doi-asserted-by":"crossref","DOI":"10.7555\/JBR.36.20220145","article-title":"Impaired autophagy in amyloid-beta pathology: a traditional review of recent Alzheimer's research. The","volume":"37","author":"Yuan","year":"2023","journal-title":"J. Biomed. Res."},{"key":"10.1016\/j.intimp.2025.114550_bb0185","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12906-019-2510-z","article-title":"Neuroprotective effects of berberine in animal models of Alzheimer's disease: a systematic review of pre-clinical studies","volume":"19","author":"Yuan","year":"2019","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.intimp.2025.114550_bb0190","doi-asserted-by":"crossref","DOI":"10.15252\/embj.201798308","article-title":"p62 filaments capture and present ubiquitinated cargos for autophagy","volume":"37","author":"Zaffagnini","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2025.114550_bb0195","article-title":"Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway","volume":"15","author":"Zhang","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.114550_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101464","article-title":"Autophagy in Alzheimer's disease pathogenesis: therapeutic potential and future perspectives","volume":"72","author":"Zhang","year":"2021","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2025.114550_bb0205","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.7150\/ijbs.81900","article-title":"\u0392-Amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease","volume":"19","author":"Zhao","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2025.114550_bb0210","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/alz.12370","article-title":"Hypothesis: JNK signaling is a therapeutic target of neurodegenerative diseases","volume":"18","author":"Zhao","year":"2022","journal-title":"Alzheimers Dement."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925005405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925005405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:27:55Z","timestamp":1778052475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925005405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":42,"alternative-id":["S1567576925005405"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114550","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114550","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114550"}}