{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:25:04Z","timestamp":1786991104462,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21961142009"],"award-info":[{"award-number":["21961142009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1271"],"award-info":[{"award-number":["2024KY1271"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY20H070004"],"award-info":[{"award-number":["LY20H070004"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.intimp.2025.114570","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T02:01:50Z","timestamp":1743991310000},"page":"114570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Compound J27 alleviates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease by targeting JNK"],"prefix":"10.1016","volume":"154","author":[{"given":"Jiaxi","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiming","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengsha","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2025.114570_bb0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"10","key":"10.1016\/j.intimp.2025.114570_bb0010","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S2468-1253(21)00183-7","article-title":"Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement","volume":"6","author":"Eslam","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.intimp.2025.114570_bb0015","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12072-020-10094-2","article-title":"The Asian Pacific Association for the Study of the liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease","volume":"14","author":"Eslam","year":"2020","journal-title":"Hepatol. Int."},{"issue":"7","key":"10.1016\/j.intimp.2025.114570_bb0020","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S2468-1253(22)00127-3","article-title":"Promoting the term MAFLD: China in action","volume":"7","author":"Zhang","year":"2022","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.intimp.2025.114570_bb0025","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.tem.2024.02.007","article-title":"Current status and future trends of the global burden of MASLD","volume":"35","author":"Miao","year":"2024","journal-title":"Trends Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.intimp.2025.114570_bb0030","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/HEP.0000000000000004","article-title":"The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review","volume":"77","author":"Younossi","year":"2023","journal-title":"Hepatology"},{"issue":"12","key":"10.1016\/j.intimp.2025.114570_bb0035","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1002\/hep4.1599","article-title":"The growing burden of disability related to nonalcoholic fatty liver disease: data from the global burden of disease 2007-2017","volume":"4","author":"Paik","year":"2020","journal-title":"Hepatol. Commun."},{"issue":"5","key":"10.1016\/j.intimp.2025.114570_bb0040","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41575-023-00888-8","article-title":"Hepatic glucose metabolism in the steatotic liver","volume":"21","author":"Scoditti","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2025.114570_bb0045","article-title":"Human-induced pluripotent stem cell based hepatic-modeling of lipid metabolism-associated TM6SF2-E167K variant","author":"Faccioli","year":"2024","journal-title":"Hepatology"},{"issue":"11","key":"10.1016\/j.intimp.2025.114570_bb0050","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1111\/liv.16086","article-title":"Metabolic syndrome traits differentially and cumulatively influence micro- and macrovascular disease risk in patients with MASLD","volume":"44","author":"Henney","year":"2024","journal-title":"Liver Int"},{"issue":"10","key":"10.1016\/j.intimp.2025.114570_bb0055","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S2468-1253(24)00193-6","article-title":"Natural history and progression of metabolic dysfunction-associated steatotic liver disease","volume":"9","author":"Hagstrom","year":"2024","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"1 Suppl","key":"10.1016\/j.intimp.2025.114570_bb0060","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.jhep.2015.02.041","article-title":"Current efforts and trends in the treatment of NASH","volume":"62","author":"Ratziu","year":"2015","journal-title":"J. Hepatol."},{"issue":"1","key":"10.1016\/j.intimp.2025.114570_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jnutbio.2013.09.001","article-title":"Novel insights of dietary polyphenols and obesity","volume":"25","author":"Wang","year":"2014","journal-title":"J. Nutr. Biochem."},{"issue":"7968","key":"10.1016\/j.intimp.2025.114570_bb0070","first-page":"E25","article-title":"Author correction: a central role for JNK in obesity and insulin resistance","volume":"619","author":"Hirosumi","year":"2023","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2025.114570_bb0075","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ceb.2007.02.001","article-title":"The JNK signal transduction pathway","volume":"19","author":"Weston","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.intimp.2025.114570_bb0080","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5762395","article-title":"Lipid-induced mechanisms of metabolic syndrome","volume":"2020","author":"Denisenko","year":"2020","journal-title":"J. Obes."},{"issue":"1","key":"10.1016\/j.intimp.2025.114570_bb0085","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/alz.12370","article-title":"Hypothesis: JNK signaling is a therapeutic target of neurodegenerative diseases","volume":"18","author":"Zhao","year":"2022","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.intimp.2025.114570_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126172","article-title":"Auricularia auricula-judae (bull.) polysaccharides improve obesity in mice by regulating gut microbiota and TLR4\/JNK signaling pathway","volume":"250","author":"Zhou","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114570_bb0095","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.ccell.2024.03.004","article-title":"Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer","volume":"42","author":"Yang","year":"2024","journal-title":"Cancer Cell"},{"issue":"11","key":"10.1016\/j.intimp.2025.114570_bb0100","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.1172\/JCI136363","article-title":"Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity","volume":"130","author":"Schriever","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.intimp.2025.114570_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/cells9081802","article-title":"Biological properties of JNK3 and its function in neurons, astrocytes, pancreatic beta-cells and cardiovascular cells","volume":"9","author":"Nakano","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2025.114570_bb0110","doi-asserted-by":"crossref","first-page":"8186","DOI":"10.1038\/s41467-023-43783-1","article-title":"Puckered and JNK signaling in pioneer neurons coordinates the motor activity of the Drosophila embryo","volume":"14","author":"Karkali","year":"2023","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2025.114570_bb0115","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1042\/CS20210964","article-title":"Nicotinamide riboside kinase-2 inhibits JNK pathway and limits dilated cardiomyopathy in mice with chronic pressure overload","volume":"136","author":"Shahzadi","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"issue":"3","key":"10.1016\/j.intimp.2025.114570_bb0120","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1053\/j.gastro.2019.10.038","article-title":"ZIP4 increases expression of transcription factor ZEB1 to promote integrin alpha3beta1 signaling and inhibit expression of the gemcitabine transporter ENT1 in pancreatic Cancer cells","volume":"158","author":"Liu","year":"2020","journal-title":"Gastroenterology"},{"issue":"28","key":"10.1016\/j.intimp.2025.114570_bb0125","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1073\/pnas.0603509103","article-title":"Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance","volume":"103","author":"Tuncman","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.intimp.2025.114570_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10082035","article-title":"Mechanism and therapeutic targets of c-Jun-N-terminal kinases activation in nonalcoholic fatty liver disease","volume":"10","author":"Min","year":"2022","journal-title":"Biomedicines"},{"issue":"17","key":"10.1016\/j.intimp.2025.114570_bb0135","doi-asserted-by":"crossref","first-page":"12304","DOI":"10.1021\/acs.jmedchem.3c00832","article-title":"Discovery of the diphenyl 6-Oxo-1,6-dihydropyridazine-3-carboxylate\/carboxamide analogue J27 for the treatment of acute lung injury and Sepsis by targeting JNK2 and inhibiting the JNK2-NF-kappaB\/MAPK pathway","volume":"66","author":"Liao","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.intimp.2025.114570_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109587","article-title":"A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice","volume":"115","author":"Jin","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"Pt 22","key":"10.1016\/j.intimp.2025.114570_bb0145","doi-asserted-by":"crossref","first-page":"5197","DOI":"10.1242\/jcs.01483","article-title":"Linking JNK signaling to NF-kappaB: a key to survival","volume":"117","author":"Papa","year":"2004","journal-title":"J. Cell Sci."},{"issue":"7","key":"10.1016\/j.intimp.2025.114570_bb0150","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41419-023-05960-4","article-title":"Macrophage DCLK1 promotes obesity-induced cardiomyopathy via activating RIP2\/TAK1 signaling pathway","volume":"14","author":"Yang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.intimp.2025.114570_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.777","article-title":"MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease","volume":"12","author":"Luo","year":"2022","journal-title":"Clin. Transl. Med."},{"issue":"11","key":"10.1016\/j.intimp.2025.114570_bb0160","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1101\/gad.7.11.2135","article-title":"Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain","volume":"7","author":"Hibi","year":"1993","journal-title":"Genes Dev."},{"issue":"10","key":"10.1016\/j.intimp.2025.114570_bb0165","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.celrep.2016.02.026","article-title":"Fibroblast growth factor 21 mediates glycemic regulation by hepatic JNK","volume":"14","author":"Vernia","year":"2016","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.intimp.2025.114570_bb0170","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.cmet.2014.06.010","article-title":"The PPARalpha-FGF21 hormone axis contributes to metabolic regulation by the hepatic JNK signaling pathway","volume":"20","author":"Vernia","year":"2014","journal-title":"Cell Metab."},{"issue":"2","key":"10.1016\/j.intimp.2025.114570_bb0175","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.molmet.2016.12.001","article-title":"JNK at the crossroad of obesity, insulin resistance, and cell stress response","volume":"6","author":"Solinas","year":"2017","journal-title":"Mol. Metab."},{"issue":"3","key":"10.1016\/j.intimp.2025.114570_bb0180","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2174\/0929867327666200210144114","article-title":"Recent advances in c-Jun N-terminal kinase (JNK) inhibitors","volume":"28","author":"Li","year":"2021","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2025.114570_bb0185","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1186\/s13046-019-1467-6","article-title":"SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells","volume":"38","author":"Yu","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"2 Pt B","key":"10.1016\/j.intimp.2025.114570_bb0190","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.molimm.2015.06.016","article-title":"SP600125 promotes resolution of allergic airway inflammation via TLR9 in an OVA-induced murine acute asthma model","volume":"67","author":"Wu","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2025.114570_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105412","article-title":"Posttranslational modifications as therapeutic targets for intestinal disorders","volume":"165","author":"Choo","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"9","key":"10.1016\/j.intimp.2025.114570_bb0200","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1001\/jama.2020.12567","article-title":"Benefits and risks of bariatric surgery in adults: a review","volume":"324","author":"Arterburn","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2025.114570_bb0205","article-title":"Safety of Semaglutide","volume":"12","author":"Smits","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"19","key":"10.1016\/j.intimp.2025.114570_bb0210","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1001\/jama.2019.3805","article-title":"Metformin in 2019","volume":"321","author":"Flory","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2025.114570_bb0215","article-title":"First US drug approved for a liver disease surging around the world","author":"Ledford","year":"2024","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.intimp.2025.114570_bb0220","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1056\/NEJMoa2309000","article-title":"A phase 3, randomized, controlled trial of Resmetirom in NASH with liver fibrosis","volume":"390","author":"Harrison","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.intimp.2025.114570_bb0225","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0016-5085(98)70599-2","article-title":"Steatohepatitis: a tale of two \u201chits\u201d?","volume":"114","author":"Day","year":"1998","journal-title":"Gastroenterology"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925005600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925005600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:49:00Z","timestamp":1762552140000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925005600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":45,"alternative-id":["S1567576925005600"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114570","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Compound J27 alleviates high-fat diet-induced metabolic dysfunction-associated steatotic liver disease by targeting JNK","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114570"}}