{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T12:48:39Z","timestamp":1793623719944,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374209"],"award-info":[{"award-number":["82374209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104570"],"award-info":[{"award-number":["82104570"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009004","name":"Anhui University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2208085Y33"],"award-info":[{"award-number":["2208085Y33"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.intimp.2025.114625","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T12:54:51Z","timestamp":1744289691000},"page":"114625","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Exploring the role of Mitoferrin-1 in Ferroptosis and mitochondrial damage in acute ischemic stroke"],"prefix":"10.1016","volume":"155","author":[{"given":"Ruijia","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114625_bb0005","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/j.amjmed.2021.07.027","article-title":"Ischemic Stroke","volume":"134","author":"Feske","year":"2021","journal-title":"Am. J. Med."},{"key":"10.1016\/j.intimp.2025.114625_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.921705","article-title":"The dual function of microglial polarization and its treatment targets in ischemic stroke","volume":"13","author":"Mo","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.intimp.2025.114625_bb0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/17474930241307876","article-title":"World stroke organization (WSO): global intracerebral hemorrhage factsheet 2025","volume":"20","author":"Parry-Jones","year":"2025","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.intimp.2025.114625_bb0020","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/17474930241308142","article-title":"World stroke organization: global stroke fact sheet 2025","volume":"20","author":"Feigin","year":"2025","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.intimp.2025.114625_bb0025","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1097\/CCM.0000000000004597","article-title":"Management of Acute Ischemic Stroke","volume":"48","author":"Herpich","year":"2020","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.114625_bb0030","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1001\/jama.2020.26867","article-title":"Diagnosis and Management of Transient Ischemic Attack and Acute Ischemic Stroke: a review","volume":"325","author":"Mendelson","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2025.114625_bb0035","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1001\/jama.2022.1420","article-title":"What is acute ischemic stroke?","volume":"327","author":"Walter","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.intimp.2025.114625_bb0040","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1161\/STROKEAHA.120.032810","article-title":"Thrombus composition and efficacy of thrombolysis and Thrombectomy in acute ischemic stroke","volume":"52","author":"Jolugbo","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.intimp.2025.114625_bb0045","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/joim.13425","article-title":"Endovascular thrombectomy for acute ischemic stroke","volume":"291","author":"Wasselius","year":"2022","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.intimp.2025.114625_bb0050","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/jnc.15807","article-title":"Iron, ferroptosis, and ischemic stroke","volume":"165","author":"Guo","year":"2023","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2025.114625_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114630","article-title":"The role of ferroptosis and its mechanism in ischemic stroke","volume":"372","author":"Hu","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2025.114625_bb0060","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4103\/1673-5374.380870","article-title":"Ferroptosis and endoplasmic reticulum stress in ischemic stroke","volume":"19","author":"Li","year":"2024","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2025.114625_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2022.101502","article-title":"Role and mechanism of ferroptosis in neurological diseases","volume":"61","author":"Ou","year":"2022","journal-title":"Mol Metab."},{"key":"10.1016\/j.intimp.2025.114625_bb0070","doi-asserted-by":"crossref","first-page":"6943438","DOI":"10.1155\/2022\/6943438","article-title":"Electroacupuncture reduces cerebral hemorrhage injury in rats by improving cerebral Iron metabolism","volume":"2022","author":"Chen","year":"2022","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.intimp.2025.114625_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114476","article-title":"Snap25 attenuates neuronal injury via reducing ferroptosis in acute ischemic stroke","volume":"367","author":"Si","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2025.114625_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118204","article-title":"Ecdysterone improves oxidative damage induced by acute ischemic stroke via inhibiting ferroptosis in neurons through ACSL4","volume":"331","author":"Sun","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.114625_bb0085","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14865","article-title":"Mechanism of ferroptosis regulating ischemic stroke and pharmacologically inhibiting ferroptosis in treatment of ischemic stroke","volume":"30","author":"Chai","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2025.114625_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102660","article-title":"The emerging role of oxygen redox in pathological progression of disorders","volume":"104","author":"Li","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2025.114625_bb0095","doi-asserted-by":"crossref","first-page":"683","DOI":"10.2174\/0113894501303824240604103732","article-title":"Targeted treatment strategies for mitochondria dysfunction: correlation with neurological disorders","volume":"25","author":"Sharma","year":"2024","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.intimp.2025.114625_bb0100","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2022.5130","article-title":"Focus on the role of mitochondria in NLRP3 inflammasome activation: a prospective target for the treatment of ischemic stroke (review)","volume":"49","author":"Zhang","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2025.114625_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134521","article-title":"Mitoferrin-1 is required for brain energy metabolism and hippocampus-dependent memory","volume":"713","author":"Baldauf","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2025.114625_bb0110","first-page":"11","article-title":"Mitoferrin, Cellular and mitochondrial Iron homeostasis","author":"Ali","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2025.114625_bb0115","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuroscience.2018.06.011","article-title":"Mitoferrin-1 is involved in the progression of Alzheimer\u2019s disease through targeting mitochondrial Iron metabolism in a Caenorhabditis elegans model of Alzheimer\u2019s disease","volume":"385","author":"Huang","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2025.114625_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2019.151058","article-title":"Mitochondria regulation in ferroptosis","volume":"99","author":"Wang","year":"2020","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.intimp.2025.114625_bb0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1538\/expanim.22-0060","article-title":"Transmembrane p24 trafficking protein 10 (TMED10) inhibits mitochondrial damage and protects neurons in ischemic stroke via the c-Jun N-terminal kinase (JNK) signaling pathway","volume":"72","author":"Li","year":"2023","journal-title":"Exp. Anim."},{"key":"10.1016\/j.intimp.2025.114625_bb0130","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jss.2023.05.006","article-title":"Ferrostatin-1 ameliorated oxidative lipid damage in LPS-induced acute lung injury","volume":"290","author":"Liu","year":"2023","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.intimp.2025.114625_bb0135","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s40001-023-01264-7","article-title":"Ferrostatin-1 facilitated neurological functional rehabilitation of spinal cord injury mice by inhibiting ferroptosis","volume":"28","author":"Zhou","year":"2023","journal-title":"Eur. J. Med. Res."},{"key":"10.1016\/j.intimp.2025.114625_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2024.150452","article-title":"The role of LCN2 in exacerbating ferroptosis levels in acute ischemic stroke injury","volume":"733","author":"Si","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2025.114625_bb0145","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12011-012-9596-1","article-title":"Trace element, antioxidant activity, and lipid peroxidation levels in brain cortex of gerbils after cerebral ischemic injury","volume":"152","author":"Fang","year":"2013","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.intimp.2025.114625_bb0150","first-page":"11","article-title":"Gamma-Glutamylcysteine exerts neuroprotection effects against cerebral ischemia\/reperfusion injury through inhibiting lipid peroxidation and Ferroptosis","author":"Zhang","year":"2022","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.intimp.2025.114625_bb0155","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s12951-023-01862-x","article-title":"Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia\/reperfusion injury mice inhibiting neuron ferroptosis","volume":"21","author":"Wang","year":"2023","journal-title":"J Nanobiotechnology."},{"key":"10.1016\/j.intimp.2025.114625_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.116795","article-title":"The neuroprotective effects of carvacrol on ischemia\/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation","volume":"235","author":"Guan","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.114625_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118305","article-title":"LncRNA PVT1 regulates ferroptosis through miR-214-mediated TFR1 and p53","volume":"260","author":"Lu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.114625_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112842","article-title":"Structure-activity relationship studies of phenothiazine derivatives as a new class of ferroptosis inhibitors together with the therapeutic effect in an ischemic stroke model","volume":"209","author":"Yang","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2025.114625_bb0175","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1111\/j.1460-9568.2006.04699.x","article-title":"Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat","volume":"23","author":"Freret","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"628\u201341","key":"10.1016\/j.intimp.2025.114625_bb0180","article-title":"PEBP1 wardens Ferroptosis by enabling lipoxygenase generation of lipid death signals","volume":"171","author":"Wenzel","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2025.114625_bb0185","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.bbi.2021.01.003","article-title":"ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation","volume":"93","author":"Cui","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2025.114625_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105933","article-title":"Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke","volume":"174","author":"Li","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2025.114625_bb0195","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s11010-023-04793-1","article-title":"The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)","volume":"479","author":"AlRuwaili","year":"2024","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.intimp.2025.114625_bb0200","first-page":"12","article-title":"Mitoferrin-1 promotes proliferation and abrogates protein oxidation via the glutathione pathway in glioblastoma","author":"Ali","year":"2023","journal-title":"Antioxidants (Basel)."},{"key":"10.1016\/j.intimp.2025.114625_bb0205","first-page":"12","article-title":"Role of mitochondrial Iron overload in mediating cell death in H9c2 cells","author":"Tam","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2025.114625_bb0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3389\/fphys.2019.00139","article-title":"Mechanisms of Ferroptosis and relations with regulated cell death: a review","volume":"10","author":"Lei","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2025.114625_bb0215","article-title":"Ferroptosis: biochemistry and biology in cancers","volume":"11","author":"Shi","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2025.114625_bb0220","doi-asserted-by":"crossref","first-page":"1290234","DOI":"10.3389\/fphys.2024.1290234","article-title":"Mechanistic elucidation of ferroptosis and ferritinophagy: implications for advancing our understanding of arthritis","volume":"15","author":"Guo","year":"2024","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2025.114625_bb0225","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1681\/ASN.2013080838","article-title":"Iron sucrose accelerates early atherogenesis by increasing superoxide production and upregulating adhesion molecules in CKD","volume":"25","author":"Kuo","year":"2014","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.intimp.2025.114625_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102357","article-title":"MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress","volume":"54","author":"Gumpper-Fedus","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.114625_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102305","article-title":"XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury","volume":"52","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.114625_bb0240","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.freeradbiomed.2024.07.006","article-title":"Role of mitochondrial reactive oxygen species in chemically-induced ferroptosis","volume":"223","author":"Song","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2025.114625_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24020922","article-title":"Synaptic activity regulates mitochondrial Iron metabolism to enhance neuronal bioenergetics","volume":"24","author":"Tena-Morraja","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.114625_bb0250","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12943-024-02140-6","article-title":"Artificial intelligence alphafold model for molecular biology and drug discovery: a machine-learning-driven informatics investigation","volume":"23","author":"Guo","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2025.114625_bb0255","doi-asserted-by":"crossref","first-page":"eadn6354","DOI":"10.1126\/science.adn6354","article-title":"AlphaFold2 structures guide prospective ligand discovery","volume":"384","author":"Lyu","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.intimp.2025.114625_bb0260","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ymgme.2018.10.005","article-title":"Strong correlation of ferrochelatase enzymatic activity with Mitoferrin-1 mRNA in lymphoblasts of patients with protoporphyria","volume":"128","author":"Phillips","year":"2019","journal-title":"Mol. Genet. Metab."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925006150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925006150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:33:10Z","timestamp":1778052790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925006150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":52,"alternative-id":["S1567576925006150"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114625","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring the role of Mitoferrin-1 in Ferroptosis and mitochondrial damage in acute ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114625","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114625"}}