{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:14:11Z","timestamp":1792512851190,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019542","name":"Basic Research Project of Wenzhou City","doi-asserted-by":"publisher","award":["Y20220937"],"award-info":[{"award-number":["Y20220937"]}],"id":[{"id":"10.13039\/501100019542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019542","name":"Basic Research Project of Wenzhou City","doi-asserted-by":"publisher","award":["Y20240649"],"award-info":[{"award-number":["Y20240649"]}],"id":[{"id":"10.13039\/501100019542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.intimp.2025.114630","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T09:16:01Z","timestamp":1744622161000},"page":"114630","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Therapeutic potential of Sweroside in postmenopausal osteoporosis: Inhibition of osteoclast differentiation and promotion of osteoclast apoptosis via NF-\u03baB and MAPK pathways"],"prefix":"10.1016","volume":"155","author":[{"given":"Zhipeng","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114630_bb0005","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1056\/NEJMcp2307353","article-title":"Postmenopausal Osteoporosis","volume":"389","author":"Walker","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2025.114630_bb0010","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1056\/NEJMc2314624","article-title":"Postmenopausal Osteoporosis","volume":"390","author":"Silverstein","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2025.114630_bb0015","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41574-020-0339-7","article-title":"A broader strategy for osteoporosis interventions","volume":"16","author":"Reid","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.intimp.2025.114630_bb0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jbmr.4773","article-title":"Macrophages and bone remodeling","volume":"38","author":"Weivoda","year":"2023","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.intimp.2025.114630_bb0025","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1476-4598-13-238","article-title":"Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL\/OPG ratio in human breast cancer cells generating bone metastases","volume":"13","author":"Arrigoni","year":"2014","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2025.114630_bb0030","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1172\/JCI35711","article-title":"NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism","volume":"118","author":"Aliprantis","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2025.114630_bb0035","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/416744a","article-title":"RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta","volume":"416","author":"Takayanagi","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.114630_bb0040","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1111\/jcmm.15052","article-title":"Integrin-associated molecules and signalling cross talking in osteoclast cytoskeleton regulation","volume":"24","author":"Kong","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2025.114630_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129357","article-title":"VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production","volume":"260","author":"Miao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.114630_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115817","article-title":"Inhibition of KIF11 ameliorates osteoclastogenesis via regulating mTORC1-mediated NF-\u03baB signaling","volume":"217","author":"Miao","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2025.114630_bb0055","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/aps.2015.85","article-title":"Aconine inhibits RANKL-induced osteoclast differentiation in RAW264.7 cells by suppressing NF-\u03baB and NFATc1 activation and DC-STAMP expression","volume":"37","author":"Zeng","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2025.114630_bb0060","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/s41418-017-0048-5","article-title":"STAC2 negatively regulates osteoclast formation by targeting the RANK signaling complex","volume":"25","author":"Jeong","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2025.114630_bb0065","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/cdd.2017.153","article-title":"A vitronectin-derived peptide reverses ovariectomy-induced bone loss via regulation of osteoblast and osteoclast differentiation","volume":"25","author":"Min","year":"2018","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2025.114630_bb0070","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41368-023-00272-x","article-title":"CD97 inhibits osteoclast differentiation via Rap1a\/ERK pathway under compression","volume":"16","author":"Wang","year":"2024","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.intimp.2025.114630_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118366","article-title":"Siwu decoction exerts a phytoestrogenic osteoprotective effect on postmenopausal osteoporosis via the estrogen receptor\/phosphatidylinositol 3-kinase\/serine\/threonine protein kinase pathway","volume":"332","author":"Yang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.114630_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118873","article-title":"Multi-omics and bioinformatics for the investigation of therapeutic mechanism of roucongrong pill against postmenopausal osteoporosis","volume":"337","author":"Jiang","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.114630_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153146","article-title":"Sweroside promotes osteoblastic differentiation and mineralization via interaction of membrane estrogen receptor-\u03b1 and GPR30 mediated p38 signalling pathway on MC3T3-E1 cells","volume":"68","author":"Wu","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.114630_bb0090","doi-asserted-by":"crossref","first-page":"7050","DOI":"10.1002\/ptr.7336","article-title":"Promotion of osteogenesis by Sweroside via BMP2-involved signaling in postmenopausal osteoporosis","volume":"35","author":"Choi","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2025.114630_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103223","article-title":"Sweroside alleviates pressure overload-induced heart failure through targeting CaMKII\u03b4 to inhibit ROS-mediated NF-\u03baB\/NLRP3 in cardiomyocytes","volume":"74","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.114630_bb0100","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.biopha.2017.08.007","article-title":"Sweroside eradicated leukemia cells and attenuated pathogenic processes in mice by inducing apoptosis","volume":"95","author":"Han","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.114630_bb0105","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbad518","article-title":"Network pharmacology: towards the artificial intelligence-based precision traditional Chinese medicine","volume":"25","author":"Zhang","year":"2023","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.intimp.2025.114630_bb0110","doi-asserted-by":"crossref","first-page":"20383","DOI":"10.1021\/acs.jafc.4c02982","article-title":"Tetrahydroberberine prevents Ovariectomy-induced bone loss by inhibiting RANKL-induced Osteoclastogenesis and promoting osteoclast apoptosis","volume":"72","author":"Wu","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2025.114630_bb0115","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.7150\/thno.30206","article-title":"Pseurotin a inhibits Osteoclastogenesis and prevents Ovariectomized-induced bone loss by suppressing reactive oxygen species","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2025.114630_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154739","article-title":"Safranal inhibits estrogen-deficiency osteoporosis by targeting Sirt1 to interfere with NF-\u03baB acetylation","volume":"114","author":"Sheng","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.114630_bb0125","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/ncb1747","article-title":"Nitric oxide-induced nuclear GAPDH activates p300\/CBP and mediates apoptosis","volume":"10","author":"Sen","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.intimp.2025.114630_bb0130","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1001\/jama.286.22.2865","article-title":"Osteoporosis, an underdiagnosed disease","volume":"286","author":"Chesnut","year":"2001","journal-title":"Jama"},{"key":"10.1016\/j.intimp.2025.114630_bb0135","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S2213-8587(17)30184-5","article-title":"Use of bone turnover markers in postmenopausal osteoporosis","volume":"5","author":"Eastell","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.intimp.2025.114630_bb0140","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1056\/NEJMcp1513724","article-title":"Clinical Practice. Postmenopausal Osteoporosis","volume":"374","author":"Black","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.intimp.2025.114630_bb0145","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMc1615367","article-title":"Romosozumab Treatment in Postmenopausal Osteoporosis","volume":"376","author":"Banhidy","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2025.114630_bb0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijsu.2019.03.004","article-title":"Teriparatide versus bisphosphonates for treatment of postmenopausal osteoporosis: a meta-analysis","volume":"66","author":"Yuan","year":"2019","journal-title":"Int. J. Surg."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925006204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925006204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T07:30:46Z","timestamp":1778052646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925006204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":30,"alternative-id":["S1567576925006204"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114630","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of Sweroside in postmenopausal osteoporosis: Inhibition of osteoclast differentiation and promotion of osteoclast apoptosis via NF-\u03baB and MAPK pathways","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114630","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114630"}}