{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T10:06:37Z","timestamp":1791021997243,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T00:00:00Z","timestamp":1745107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y-SYBLD2022MS-0055"],"award-info":[{"award-number":["Y-SYBLD2022MS-0055"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974005"],"award-info":[{"award-number":["81974005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.intimp.2025.114696","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T07:47:14Z","timestamp":1745221634000},"page":"114696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["The lncRNA LINC02446 promotes tumor progression and HLH occurrence by regulating the expression of KLRs and IL-10 in EBV-NK-LPDs"],"prefix":"10.1016","volume":"156","author":[{"given":"Yaxian","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiachen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zetong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaolin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114696_bb0005","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.3390\/cancers15072133","article-title":"EBV and lymphomagenesis","volume":"15","author":"Sausen","year":"2023","journal-title":"Cancers"},{"key":"10.1016\/j.intimp.2025.114696_bb0010","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jcv.2018.03.001","article-title":"Primary epstein-barr virus infection","volume":"102","author":"Dunmire","year":"2018","journal-title":"J. Clin. Virol. Off. Publ. Pan Am. Soc. Clin. Virol."},{"key":"10.1016\/j.intimp.2025.114696_bb0015","article-title":"The global landscape of EBV-associated tumors","volume":"9","author":"S","year":"2019","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2025.114696_bb0020","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1146\/annurev-immunol-032414-112326","article-title":"The immunology of epstein-barr virus-induced disease","volume":"33","author":"Taylor","year":"2015","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.114696_bb0025","article-title":"Epstein-barr virus-associated T- and NK-cell lymphoproliferative diseases: a review of clinical and pathological features","volume":"13","author":"S","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.intimp.2025.114696_bb0030","first-page":"ofz171","article-title":"Determination of epstein-barr virus-infected lymphocyte cell types in peripheral blood mononuclear cells as a valuable diagnostic tool in hematological diseases, open forum","volume":"6","author":"Zhang","year":"2019","journal-title":"Infect. Dis. Ther."},{"key":"10.1016\/j.intimp.2025.114696_bb0035","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1182\/blood-2011-10-381921","article-title":"EBV-associated T\/NK-cell lymphoproliferative diseases in nonimmunocompromised hosts: prospective analysis of 108 cases","volume":"119","author":"Kimura","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2025.114696_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2328","article-title":"EBV associated T- and NK-cell lymphoproliferative diseases: a comprehensive overview of clinical manifestations and novel therapeutic insights","volume":"32","author":"Shafiee","year":"2022","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.intimp.2025.114696_bb0045","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41564-018-0334-0","article-title":"Defective epstein-barr virus in chronic active infection and haematological malignancy","volume":"4","author":"Okuno","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.intimp.2025.114696_bb0050","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13045-022-01293-5","article-title":"How we treat NK\/T-cell lymphomas, J. Hematol. Oncol","volume":"15","author":"Tse","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2025.114696_bb0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrm.2017.104","article-title":"The functions and unique features of long intergenic non-coding RNA","volume":"19","author":"Ransohoff","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2025.114696_bb0060","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12929-024-01038-1","article-title":"Pivotal functions and impact of long con-coding RNAs on cellular processes and genome integrity","volume":"31","author":"Sharma","year":"2024","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.intimp.2025.114696_bb0065","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/jmv.25516","article-title":"Differential expression profiling of lncRNAs related to epstein-barr virus infection in the epithelial cells","volume":"91","author":"Zhang","year":"2019","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.intimp.2025.114696_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/rmv.2364","article-title":"Long non-coding RNAs in virus-related cancers","volume":"32","author":"Huang","year":"2022","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.intimp.2025.114696_bb0075","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s12185-023-03660-5","article-title":"Committee for Guidelines for the Management of Chronic Active EBV disease, related disorders (the MHLW research team in Japan), updated guidelines for chronic active epstein-barr virus disease","volume":"118","author":"Kawada","year":"2023","journal-title":"Int. J. Hematol."},{"key":"10.1016\/j.intimp.2025.114696_bb0080","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/hon.2998","article-title":"The superiority of epstein-barr virus DNA in plasma over in peripheral blood mononuclear cells for monitoring EBV-positive NK-cell lymphoproliferative diseases","volume":"40","author":"Zheng","year":"2022","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.intimp.2025.114696_bb0085","first-page":"136","article-title":"Detection of epstein-barr virus genome in natural-killer-like cell line, YT","volume":"6","author":"Yoneda","year":"1992","journal-title":"Leukemia"},{"key":"10.1016\/j.intimp.2025.114696_bb0090","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1046\/j.1365-2141.2003.04359.x","article-title":"Common cytological and cytogenetic features of epstein-barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T\/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions","volume":"121","author":"Zhang","year":"2003","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.intimp.2025.114696_bb0095","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1046\/j.1365-2249.1999.00836.x","article-title":"Characterization of epstein-barr virus (EBV)-infected natural killer (NK) cell proliferation in patients with severe mosquito allergy; establishment of an IL-2-dependent NK-like cell line","volume":"115","author":"Tsuge","year":"1999","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2025.114696_bb0100","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1158\/0008-5472.CAN-03-1562","article-title":"Epstein-barr virus infection of human natural killer cell lines and peripheral blood natural killer cells","volume":"64","author":"Isobe","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2025.114696_bb0105","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/sj.leu.2401769","article-title":"A novel natural killer cell line (KHYG-1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation","volume":"14","author":"Yagita","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.intimp.2025.114696_bb0110","first-page":"1","volume":"24","year":"1996","journal-title":"J. Cell. Biochem. Suppl."},{"key":"10.1016\/j.intimp.2025.114696_bb0115","first-page":"547","article-title":"Morphological and virological investigations on cultured burkitt tumor lymphoblasts (strain raji)","volume":"37","author":"Epstein","year":"1966","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.intimp.2025.114696_bb0120","first-page":"23","article-title":"The establishment of cell lines from chronic B cell leukaemias: evidence of leukaemic origin by karyotypic abnormalities and ig gene rearrangement","volume":"73","author":"Melo","year":"1988","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2025.114696_bb0125","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0145-2126(88)90037-9","article-title":"Establishment and characterization of a human lymphoma cell line (WSU-NHL) with 14;18 translocation","volume":"12","author":"Mohamed","year":"1988","journal-title":"Leuk. Res."},{"key":"10.1016\/j.intimp.2025.114696_bb0130","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1002\/1097-0142(197811)42:5<2379::AID-CNCR2820420539>3.0.CO;2-4","article-title":"Biology of the human malignant lymphomas. IV. Functional characterization of ten diffuse histiocytic lymphoma cell lines","volume":"42","author":"Epstein","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/j.intimp.2025.114696_bb0135","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1046\/j.1365-2141.1998.00911.x","article-title":"Establishment and characterization of a mantle cell lymphoma cell line","volume":"102","author":"Jeon","year":"1998","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.intimp.2025.114696_bb0140","first-page":"891","article-title":"Rosette-forming human lymphoid cell lines. I. Establishment and evidence for origin of thymus-derived lymphocytes","volume":"49","author":"Minowada","year":"1972","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.intimp.2025.114696_bb0145","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/ijc.2910180405","article-title":"Properties of the K562 cell line, derived from a patient with chronic myeloid leukemia","volume":"18","author":"Klein","year":"1976","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.intimp.2025.114696_bb0150","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1365-2141.1993.tb03334.x","article-title":"Establishment of a leukaemic cell line from a patient with acquisition of chromosomal abnormalities during disease progression in myelodysplastic syndrome","volume":"85","author":"Nakagawa","year":"1993","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.intimp.2025.114696_bb0155","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1182\/blood.V70.1.192.192","article-title":"Growth factor requirements of childhood acute leukemia: establishment of GM-CSF-dependent cell lines","volume":"70","author":"Lange","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2025.114696_bb0160","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/cr.2017.146","article-title":"Integrated genomic analysis identifies deregulated JAK\/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia","volume":"28","author":"Huang","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/j.intimp.2025.114696_bb0165","article-title":"Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer\/T-cell lymphoma and establishes MIR155HG as a target of PRDM1, tumour biol","volume":"39","author":"Baytak","year":"2017","journal-title":"J. Int. Soc. Oncodevelopmental Biol. Med."},{"key":"10.1016\/j.intimp.2025.114696_bb0170","first-page":"124","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis, Pediatr. Blood","volume":"48","author":"Henter","year":"2007","journal-title":"Cancer"},{"key":"10.1016\/j.intimp.2025.114696_bb0175","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1182\/blood.2023021074","article-title":"Chronic active epstein-barr virus disease originates from infected hematopoietic stem cells","volume":"143","author":"Wang","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2025.114696_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166722","article-title":"A nuclear NKRF interacting long noncoding RNA controls EBV eradication and suppresses tumor progression in natural killer\/T-cell lymphoma","volume":"1869","author":"Wang","year":"2023","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.intimp.2025.114696_bb0185","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41423-019-0206-4","article-title":"Human NK cells: surface receptors, inhibitory checkpoints, and translational applications","volume":"16","author":"Sivori","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2025.114696_bb0190","article-title":"Implications of NKG2A in immunity and immune-mediated diseases","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.114696_bb0195","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3390\/vaccines10121993","article-title":"Disruption of the NKG2A:HLA-E immune checkpoint axis to enhance NK cell activation against cancer","volume":"10","author":"Fisher","year":"2022","journal-title":"Vaccines"},{"key":"10.1016\/j.intimp.2025.114696_bb0200","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1158\/1078-0432.CCR-19-2095","article-title":"The NKG2A-HLA-E axis as a novel checkpoint in the tumor microenvironment, Clin. Cancer res","volume":"26","author":"Borst","year":"2020","journal-title":"Off. J. Am. Assoc. Cancer Res."},{"key":"10.1016\/j.intimp.2025.114696_bb0205","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.jaci.2022.11.012","article-title":"Clinical and genetic characterization of epstein-barr virus\u2013associated T\/NK-cell lymphoproliferative diseases","volume":"151","author":"Luo","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.114696_bb0210","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1007\/s12026-022-09285-w","article-title":"Cytokine storm and targeted therapy in hemophagocytic lymphohistiocytosis","volume":"70","author":"Zhang","year":"2022","journal-title":"Immunol. Res."},{"key":"10.1016\/j.intimp.2025.114696_bb0215","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1186\/s13023-021-01973-4","article-title":"Increased levels of serum interleukin-10 are associated with poor outcome in adult hemophagocytic lymphohistiocytosis patients","volume":"16","author":"Zhou","year":"2021","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.intimp.2025.114696_bb0220","doi-asserted-by":"crossref","first-page":"2342276","DOI":"10.1080\/21505594.2024.2342276","article-title":"Comprehensive evaluation of immune dysregulation in secondary hemophagocytic lymphohistiocytosis","volume":"15","author":"Wang","year":"2024","journal-title":"Virulence"},{"key":"10.1016\/j.intimp.2025.114696_bb0225","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.jaci.2022.06.017","article-title":"Excessive IL-10 and IL-18 trigger hemophagocytic lymphohistiocytosis-like hyperinflammation and enhanced myelopoiesis","volume":"150","author":"Tang","year":"2022","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925006861?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925006861?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:49:37Z","timestamp":1762552177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925006861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":45,"alternative-id":["S1567576925006861"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114696","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The lncRNA LINC02446 promotes tumor progression and HLH occurrence by regulating the expression of KLRs and IL-10 in EBV-NK-LPDs","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114696","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114696"}}