{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:10:25Z","timestamp":1788246625366,"version":"build-2803163510"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2025ZNSFSC1819"],"award-info":[{"award-number":["2025ZNSFSC1819"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204764"],"award-info":[{"award-number":["82204764"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274212"],"award-info":[{"award-number":["82274212"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.intimp.2025.114752","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:53:10Z","timestamp":1745859190000},"page":"114752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Tinosporine alleviates collagen-induced arthritis in rats via modulating the gut microbiota-metabolome-immunity axis"],"prefix":"10.1016","volume":"157","author":[{"given":"Chuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrui","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WenYu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114752_bb0005","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2025.114752_bb0010","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/j.immuni.2022.11.009","article-title":"The pathogenesis of rheumatoid arthritis","volume":"55","author":"Alivernini","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2025.114752_bb0015","doi-asserted-by":"crossref","first-page":"2281382","DOI":"10.1080\/19490976.2023.2281382","article-title":"The gut-joint axis mediates the TNF-induced RA process and PBMT therapeutic effects through the metabolites of gut microbiota","volume":"15","author":"Meng","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.intimp.2025.114752_bb0020","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.medj.2021.04.013","article-title":"Intestinal barrier dysfunction plays an integral role in arthritis pathology and can be targeted to ameliorate disease","volume":"2","author":"Matei","year":"2021","journal-title":"Med"},{"key":"10.1016\/j.intimp.2025.114752_bb0025","doi-asserted-by":"crossref","first-page":"1389925","DOI":"10.3389\/fcimb.2024.1389925","article-title":"Repairing gut barrier by traditional Chinese medicine: roles of gut microbiota","volume":"14","author":"Zhou","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2025.114752_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111090","article-title":"Intestinal flora, intestinal metabolism, and intestinal immunity changes in complete freud\u2019s adjuvant-rheumatoid arthritis C57BL\/6 mice","volume":"125","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.114752_bb0035","doi-asserted-by":"crossref","unstructured":"S. Wang, Y. Liu, X. Zou, M. Pan, Q. Wan, X. Chu, Exploring the pathogenesis of RA through the gut-articular axis-dysbiosis a potential factor, Clin Anat. (2024) ca.24215, doi:https:\/\/doi.org\/10.1002\/ca.24215.","DOI":"10.1002\/ca.24215"},{"key":"10.1016\/j.intimp.2025.114752_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.106563","article-title":"Associations between rheumatoid arthritis and intestinal flora, with special emphasis on RA pathologic mechanisms to treatment strategies","volume":"188","author":"Peng","year":"2024","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.intimp.2025.114752_bb0045","article-title":"The bridge of the gut\u2013joint axis: gut microbial metabolites in rheumatoid arthritis","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.114752_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113290","article-title":"Diet-gut microbiota-epigenetics in metabolic diseases: from mechanisms to therapeutics","volume":"153","author":"Li","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.114752_bb0055","doi-asserted-by":"crossref","first-page":"5879","DOI":"10.3390\/molecules28155879","article-title":"Oxymatrine alleviates collagen-induced arthritis in mice by regulating the immune balance of T cells","volume":"28","author":"Cao","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2025.114752_bb0060","doi-asserted-by":"crossref","first-page":"1475529","DOI":"10.3389\/fimmu.2024.1475529","article-title":"Butyrate: a bridge between intestinal flora and rheumatoid arthritis","volume":"15","author":"Cao","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.114752_bb0065","doi-asserted-by":"crossref","first-page":"1422245","DOI":"10.3389\/fphar.2024.1422245","article-title":"Huangqin qingre chubi capsule inhibits rheumatoid arthritis by regulating intestinal flora and improving intestinal barrier","volume":"15","author":"Peng","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.114752_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156203","article-title":"Licorice-regulated gut\u2013joint axis for alleviating collagen-induced rheumatoid arthritis","volume":"135","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.114752_bb0075","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s13075-023-03118-3","article-title":"Faecalibacterium prausnitzii alleviates inflammatory arthritis and regulates IL-17 production, short chain fatty acids, and the intestinal microbial flora in experimental mouse model for rheumatoid arthritis","volume":"25","author":"Moon","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2025.114752_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2021.123096","article-title":"Yaobitong capsules reshape and rebalance the gut microbiota and metabolites of arthritic rats: an integrated study of microbiome and fecal metabolomics analysis","volume":"1190","author":"Shi","year":"2022","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.intimp.2025.114752_bb0085","doi-asserted-by":"crossref","unstructured":"Q.Q. Xin, R. Yuan, W.L. Shi, Z.C. Zhu, Y. Wang, et al., A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders, Life Sci. 237 (2019) 116925. https:\/\/doi:https:\/\/doi.org\/10.1016\/j.lfs.2019.116925.","DOI":"10.1016\/j.lfs.2019.116925"},{"key":"10.1016\/j.intimp.2025.114752_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103001","article-title":"Gut microbiota in pre-clinical rheumatoid arthritis: from pathogenesis to preventing progression","volume":"141","author":"Lin","year":"2023","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.intimp.2025.114752_bb0095","doi-asserted-by":"crossref","unstructured":"X. Jia, X. Ma, P. Liu, Tinosporae radix: A review of traditional use, botany, phytochemistry,bioactivity, and quality marker, Comb. Chem. High Throughput Screen. 27 (2024) 1413\u20131433, doi:https:\/\/doi.org\/10.2174\/0113862073259834230920073050.","DOI":"10.2174\/0113862073259834230920073050"},{"key":"10.1016\/j.intimp.2025.114752_bb0100","article-title":"Tibetan medicine Wuwei Leze powder improves inflammatory mediated metabolic disorders and bone damage in collagen-induced arthritis rats","author":"Liu","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.114752_bb0105","doi-asserted-by":"crossref","unstructured":"S. Badavenkatappa Gari, V.K. Nelson, R. Peraman, Tinospora sinensis (lour.) merr alkaloid rich extract induces colon cancer cell death via ROS mediated, mTOR dependent apoptosis pathway: \u201can in-vitro study,\u201d BMC Complementary Med. Ther. 23 (2023) 33, doi:https:\/\/doi.org\/10.1186\/s12906-023-03849-5.","DOI":"10.1186\/s12906-023-03849-5"},{"key":"10.1016\/j.intimp.2025.114752_bb0110","first-page":"8","article-title":"Tinospora sinensis (lour.) merr. Stem modulate the TNF-alpha expression in HCT- 116 tumour cell, besides the inhibitory effect on cervical, colon and breast cancer cell lines and mycobacterium tuberculosis H37Rv","volume":"13","author":"Gari","year":"2021","journal-title":"Pharm. J."},{"key":"10.1016\/j.intimp.2025.114752_bb0115","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.phymed.2018.12.023","article-title":"Tibetan medicine kuan-jin-teng exerts anti-arthritic effects on collagen-induced arthritis rats via inhibition the production of pro-inflammatory cytokines and down-regulation of MAPK signaling pathway","volume":"57","author":"Xiong","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.114752_bb0120","doi-asserted-by":"crossref","unstructured":"C. Liu, Q. Zhao, L. Zhong, Q. Li, R. Li, S. Li, et al., W. Dhondrup, X. Meng, Y. Zhang, Y. Tu, X. Wang, Tibetan medicine ershiwuwei lvxue pill attenuates collagen-induced arthritis via inhibition of JAK2\/STAT3 signaling pathway, J. Ethnopharmacol. 270 (2021) 113820, doi:https:\/\/doi.org\/10.1016\/j.jep.2021.113820.","DOI":"10.1016\/j.jep.2021.113820"},{"key":"10.1016\/j.intimp.2025.114752_bb0125","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxlet.2023.03.003","article-title":"DNA damage and up-regulation of PARP-1 induced by columbin in vitro and in vivo","volume":"379","author":"Liao","year":"2023","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.intimp.2025.114752_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154462","article-title":"Ershiwuwei lvxue pill alleviates rheumatoid arthritis by different pathways and produces changes in the gut microbiota","volume":"107","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.114752_bb0135","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/art.20382","article-title":"Targeting osteoclasts with zoledronic acid prevents bone destruction in collagen-induced arthritis","volume":"50","author":"Sims","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2025.114752_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-021-03792-8","article-title":"TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+\/CaMKII\/Nrf2 signaling pathway","volume":"12","author":"Lv","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2025.114752_bb0145","doi-asserted-by":"crossref","first-page":"2282790","DOI":"10.1080\/19490976.2023.2282790","article-title":"Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP\/PS1 mice","volume":"15","author":"Qian","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.intimp.2025.114752_bb0150","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/13880209.2022.2056208","article-title":"Gut microbiota and metabonomics used to explore the mechanism of qing\u2019e pills in alleviating osteoporosis","volume":"60","author":"Xie","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2025.114752_bb0155","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1007\/s10787-023-01254-5","article-title":"Effect of ethyl gallate and propyl gallate on dextran sulfate sodium (DSS)-induced ulcerative colitis in C57BL\/6 J mice: preventive and protective","volume":"31","author":"Chougule","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2025.114752_bb0160","doi-asserted-by":"crossref","unstructured":"Y. Xie, D. Xu, S. Yan, X. Hu, S. Chen, K. Guo, et al., The impact of MIF deficiency on alterations of fecal microbiota in C57BL\/6 mice induced by trichinella spiralis infection, FASEB j.: Off. Publ. Fed. Am. Soc. Exp. Biol. 37 (2023) e23202, doi:https:\/\/doi.org\/10.1096\/fj.202300179RR.","DOI":"10.1096\/fj.202300179RR"},{"key":"10.1016\/j.intimp.2025.114752_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0276591","article-title":"Whole transcriptome expression profiles in kidney samples from rats with hyperuricaemic nephropathy","volume":"17","author":"Li","year":"2022","journal-title":"PloS One"},{"key":"10.1016\/j.intimp.2025.114752_bb0170","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1021\/acs.jcim.1c00203","article-title":"AutoDock vina 1.2.0: new docking methods, expanded force field, and python bindings","volume":"61","author":"Eberhardt","year":"2021","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.intimp.2025.114752_bb0175","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s10822-010-9352-6","article-title":"Ligand docking and binding site analysis with PyMOL and autodock\/vina","volume":"24","author":"Seeliger","year":"2010","journal-title":"J. Comput. Aided Mol. Des."},{"issue":"D1","key":"10.1016\/j.intimp.2025.114752_bb0180","doi-asserted-by":"crossref","first-page":"D480","DOI":"10.1093\/nar\/gkaa1100","article-title":"UniProt: the universal protein knowledgebase in 2021","volume":"49","author":"UniProt Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2025.114752_bb0185","doi-asserted-by":"crossref","first-page":"1805418","DOI":"10.1155\/2020\/1805418","article-title":"An integrated fecal microbiome and metabolomics in T2DM rats reveal antidiabetes effects from host-microbial metabolic axis of EtOAc extract from sophora flavescens","volume":"2020","author":"Shao","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2025.114752_bb0190","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/s41577-022-00685-5","article-title":"Intestinal barrier protection","volume":"22","author":"Minton","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.114752_bb0195","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1146\/annurev-immunol-042718-041841","article-title":"Gut microbiota regulation of T cells during inflammation and autoimmunity","volume":"37","author":"Brown","year":"2019","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.114752_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117316","article-title":"Kuijie decoction ameliorates ulcerative colitis by affecting intestinal barrier functions, gut microbiota, metabolic pathways and treg\/Th17 balance in mice","volume":"319","author":"Peng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.114752_bb0205","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.741934","article-title":"Stigmasterol restores the balance of treg\/Th17 cells by activating the butyrate-PPAR\u03b3 axis in colitis","volume":"12","author":"Wen","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.114752_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.136","article-title":"Intraspecific difference of Latilactobacillus sakei in inflammatory bowel diseases: insights into potential mechanisms through comparative genomics and metabolomics analyses","volume":"2","author":"Liu","year":"2023","journal-title":"iMeta"},{"key":"10.1016\/j.intimp.2025.114752_bb0215","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1039\/C9FO02556A","article-title":"The prophylactic effects of different lactobacilli on collagen-induced arthritis in rats","volume":"11","author":"Fan","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2025.114752_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108644","article-title":"Effect of potato fiber on survival of lactobacillus species at simulated gastric conditions and composition of the gut microbiota in vitro","volume":"125","author":"Larsen","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.intimp.2025.114752_bb0225","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1039\/D3FO05212E","article-title":"Bifidobacterium improves oestrogen-deficiency-induced osteoporosis in mice by modulating intestinal immunity","volume":"15","author":"Zhang","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2025.114752_bb0230","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1146\/annurev-micro-032421-111819","article-title":"Essential amino acid metabolites as chemical mediators of host-microbe interaction in the gut","volume":"77","author":"McCann","year":"2023","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.intimp.2025.114752_bb0235","doi-asserted-by":"crossref","first-page":"761","DOI":"10.2174\/1389203721666200219100216","article-title":"Amino acids regulate glycolipid metabolism and alter intestinal microbial composition","volume":"21","author":"Xie","year":"2020","journal-title":"CPPS"},{"key":"10.1016\/j.intimp.2025.114752_bb0240","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12934-024-02307-2","article-title":"Intestinal mucosal microbiota mediate amino acid metabolism involved in the gastrointestinal adaptability to cold and humid environmental stress in mice","volume":"23","author":"Zhang","year":"2024","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.intimp.2025.114752_bb0245","article-title":"Metabolomics in rheumatoid arthritis: advances and review","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.114752_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.162910","article-title":"Flammulina velutipes polysaccharide counteracts cadmium-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier","volume":"877","author":"Hao","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.intimp.2025.114752_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115109","article-title":"Metabonomics and 16S rRNA gene sequencing to study the therapeutic mechanism of danggui sini decoction on collagen-induced rheumatoid arthritis rats with cold bi syndrome","volume":"222","author":"He","year":"2023","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.intimp.2025.114752_bb0260","article-title":"Jingfang granules ameliorate inflammation and immune disorders in mice exposed to low temperature and high humidity by restoring the dysregulation of gut microbiota and fecal metabolites","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.114752_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114034","article-title":"Gut microbiota and their metabolites in the immune response of rheumatoid arthritis: therapeutic potential and future directions","volume":"147","author":"Cai","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.114752_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156150","article-title":"Rebalancing immune homeostasis in combating disease: the impact of medicine food homology plants and gut microbiome","volume":"136","author":"Xia","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.114752_bb0275","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.tem.2022.01.002","article-title":"Gut barrier disruption and chronic disease","volume":"33","author":"Martel","year":"2022","journal-title":"Trends Endocrinol. Metab."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925007428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925007428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:50:16Z","timestamp":1762552216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925007428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":55,"alternative-id":["S1567576925007428"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114752","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tinosporine alleviates collagen-induced arthritis in rats via modulating the gut microbiota-metabolome-immunity axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114752"}}