{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:43:21Z","timestamp":1793465001207,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.intimp.2025.114784","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T11:53:48Z","timestamp":1746186828000},"page":"114784","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["TCN1 as an inflammatory regulator in psoriasis: Activation of the NF-\u03baB pathway and potential therapeutic target"],"prefix":"10.1016","volume":"157","author":[{"given":"Jian","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanhuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuqing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqiu","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2021","key":"10.1016\/j.intimp.2025.114784_bb0005","article-title":"Study","volume":"8","author":"Damiani","year":"2019","journal-title":"Front. Med."},{"issue":"2021","key":"10.1016\/j.intimp.2025.114784_bb0010","first-page":"46","article-title":"To 2017: A systematic analysis from the global burden of disease study 2017","volume":"84","author":"Mehrmal","year":"1990","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.intimp.2025.114784_bb0015","doi-asserted-by":"crossref","DOI":"10.7326\/AITC201804030","article-title":"Psoriasis","volume":"168","author":"Lebwohl","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.intimp.2025.114784_bb0020","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/JLB.5MR0120-439R","article-title":"Keratinocyte: A trigger or an executor of psoriasis?","volume":"108","author":"Ni","year":"2020","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2025.114784_bb0025","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.biocel.2008.10.022","article-title":"Interplay between keratinocytes and immune cells\u2014recent insights into psoriasis pathogenesis","volume":"41","author":"Tonel","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.intimp.2025.114784_bb0030","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1111\/j.1365-2133.2005.06645.x","article-title":"Psoriasis: dysregulation of innate immunity","volume":"152","author":"Bos","year":"2005","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2025.114784_bb0035","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.biopha.2018.06.136","article-title":"Emerging landscape in psoriasis management: from topical application to targeting biomolecules","volume":"106","author":"Rapalli","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.114784_bb0040","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/ijd.12050","article-title":"Role of NF\u03baB in the pathogenesis of psoriasis elucidated by its staining in skin biopsy specimens","volume":"53","author":"Moorchung","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.intimp.2025.114784_bb0045","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jdermsci.2012.11.002","article-title":"NF-\u03baB: an essential transcription factor in psoriasis","volume":"69","author":"Goldminz","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.intimp.2025.114784_bb0050","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1590\/S1516-31802011000600011","article-title":"NF\u03baB inhibitors as a potential novel hypothesized treatment for psoriasis","volume":"129","author":"Derakhshan","year":"2011","journal-title":"Sao Paulo Med. J."},{"key":"10.1016\/j.intimp.2025.114784_bb0055","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2147\/ITT.S240891","article-title":"The role of IL-17 cytokines in psoriasis","volume":"10","author":"Mosca","year":"2021","journal-title":"Immunotargets Ther."},{"key":"10.1016\/j.intimp.2025.114784_bb0060","doi-asserted-by":"crossref","first-page":"138","DOI":"10.36849\/JDD.2020.4645","article-title":"Clinical and molecular effects of Interleukin-17 pathway blockade in psoriasis","volume":"19","author":"Green","year":"2020","journal-title":"J. Drugs Dermatol."},{"key":"10.1016\/j.intimp.2025.114784_bb0065","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/intimm\/dxw011","article-title":"IL-17A plays a central role in the expression of psoriasis signature genes through the induction of I\u03baB-\u03b6 in keratinocytes","volume":"28","author":"Muromoto","year":"2016","journal-title":"Int. Immunol."},{"key":"10.1016\/j.intimp.2025.114784_bb0070","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12957-022-02556-8","article-title":"TCN1 is a potential prognostic biomarker and correlates with immune infiltrates in lung adenocarcinoma","volume":"20","author":"Li","year":"2022","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.intimp.2025.114784_bb0075","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.923828","article-title":"Clinicopathological analysis and prognostic assessment of Transcobalamin I (TCN1) in patients with colorectal tumors","volume":"26","author":"Zhu","year":"2020","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.intimp.2025.114784_bb0080","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5009\/gnl210494","article-title":"TCN1 deficiency inhibits the malignancy of colorectal Cancer cells by regulating the ITGB4 pathway","volume":"17","author":"Zhu","year":"2023","journal-title":"Gut Liver"},{"key":"10.1016\/j.intimp.2025.114784_bb0085","first-page":"3122","article-title":"Immunological characterization and clinical implication of cobalamin binding protein in human gastric cancer","volume":"49","author":"Wakatsuki","year":"1989","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2025.114784_bb0090","first-page":"1","article-title":"TCN1 expression is increased in asthma","author":"Xu","year":"2023","journal-title":"Int. Arch. Allergy Immunol."},{"key":"10.1016\/j.intimp.2025.114784_bb0095","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.intimp.2025.114784_bb0100","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2025.114784_bb0105","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/bioinformatics\/btr709","article-title":"Robust rank aggregation for gene list integration and meta-analysis","volume":"28","author":"Kolde","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.intimp.2025.114784_bb0110","article-title":"A comprehensive analysis of genes associated with hypoxia and cuproptosis in pulmonary arterial hypertension using machine learning methods and immune infiltration analysis: AHR is a key gene in the cuproptosis process","volume":"11","author":"Chen","year":"2024","journal-title":"Front Med. (Lausanne)"},{"key":"10.1016\/j.intimp.2025.114784_bb0115","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1186\/s12885-022-10452-3","article-title":"A pan-cancer analysis of the oncogenic role of ERCC6L","volume":"22","author":"Lu","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.intimp.2025.114784_bb0120","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s12882-021-02447-2","article-title":"Comprehensive analysis of diabetic nephropathy expression profile based on weighted gene co-expression network analysis algorithm","volume":"22","author":"Gholaminejad","year":"2021","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.intimp.2025.114784_bb0125","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.8505","article-title":"Identification and validation of key modules and hub genes associated with the pathological stage of oral squamous cell carcinoma by weighted gene co-expression network analysis","volume":"8","author":"Hu","year":"2020","journal-title":"PeerJ"},{"key":"10.1016\/j.intimp.2025.114784_bb0130","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1038\/s41598-025-86170-0","article-title":"Integrated bioinformatics analysis identified cuproptosis-related hub gene Mpeg1 as potential biomarker in spinal cord injury","volume":"15","author":"Mao","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.114784_bb0135","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.114784_bb0140","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.2147\/IJGM.S457577","article-title":"LARS1 is a prognostic biomarker and exhibits a correlation with immune infiltrates in hepatocellular carcinoma","volume":"17","author":"Fan","year":"2024","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.intimp.2025.114784_bb0145","doi-asserted-by":"crossref","first-page":"12029","DOI":"10.18632\/aging.206079","article-title":"UBR1 is a prognostic biomarker and therapeutic target associated with immune cell infiltration in gastric cancer","volume":"16","author":"Yuan","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2025.114784_bb0150","article-title":"Yu, clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"10.1016\/j.intimp.2025.114784_bb0155","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2025.114784_bb0160","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.intimp.2025.114784_bb0165","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.celrep.2016.12.019","article-title":"Pan-cancer Immunogenomic analyses reveal genotype-Immunophenotype relationships and predictors of response to checkpoint blockade","volume":"18","author":"Charoentong","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2025.114784_bb0170","doi-asserted-by":"crossref","first-page":"9775","DOI":"10.7150\/thno.61677","article-title":"Identification of three tumor antigens and immune subtypes for mRNA vaccine development in diffuse glioma","volume":"11","author":"Zhou","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2025.114784_bb0175","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.3390\/cancers14194713","article-title":"Identification of essential tumor-infiltrating immune cells and relevant genes in left-sided and right-sided Colon cancers","volume":"14","author":"Su","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.intimp.2025.114784_bb0180","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/j.jaci.2020.11.028","article-title":"Single-cell RNA sequencing of psoriatic skin identifies pathogenic Tc17 cell subsets and reveals distinctions between CD8+ T cells in autoimmunity and cancer","volume":"147","author":"Liu","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.114784_bb0185","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.jaci.2021.04.021","article-title":"Single-cell transcriptomics applied to emigrating cells from psoriasis elucidate pathogenic versus regulatory immune cell subsets","volume":"148","author":"Kim","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.114784_bb0190","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-immunol-032713-120225","article-title":"Immunology of psoriasis","volume":"32","author":"Lowes","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.114784_bb0195","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/bioinformatics\/btm254","article-title":"GEOquery: a bridge between the gene expression omnibus (GEO) and BioConductor","volume":"23","author":"Davis","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.intimp.2025.114784_bb0200","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.intimp.2025.114784_bb0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/7651_2013_42","article-title":"Growth and differentiation of HaCaT keratinocytes","volume":"1195","author":"Wilson","year":"2014","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.intimp.2025.114784_bb0210","series-title":"Purification of RNA Using TRIzol (TRI Reagent)","author":"Rio","year":"2010"},{"key":"10.1016\/j.intimp.2025.114784_bb0215","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.tibtech.2018.12.002","article-title":"The ultimate qPCR experiment: producing publication quality, reproducible data the first time","volume":"37","author":"Taylor","year":"2019","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.intimp.2025.114784_bb0220","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1354\/vp.42-4-405","article-title":"Technical aspects of immunohistochemistry","volume":"42","author":"Ramos-Vara","year":"2005","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.intimp.2025.114784_bb0225","doi-asserted-by":"crossref","first-page":"429","DOI":"10.4103\/1947-2714.100998","article-title":"Western blot: technique, theory, and trouble shooting","volume":"4","author":"Yang","year":"2012","journal-title":"North Am. J. Med. Sci."},{"key":"10.1016\/j.intimp.2025.114784_bb0230","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12943-018-0861-6","article-title":"Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1\u03b2\/VEGFA signalling","volume":"17","author":"Hu","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2025.114784_bb0235","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1158\/1535-7163.MCT-12-0920","article-title":"PI3K stimulates DNA synthesis and cell-cycle progression via its p55PIK regulatory subunit interaction with PCNA","volume":"12","author":"Wang","year":"2013","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.intimp.2025.114784_bb0240","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0888-7543(92)90435-U","article-title":"Genomic structure and mapping of the chromosomal gene for transcobalamin I (TCN1): comparison to human intrinsic factor","volume":"12","author":"Johnston","year":"1992","journal-title":"Genomics"},{"key":"10.1016\/j.intimp.2025.114784_bb0245","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.53165","article-title":"Keratin 14-dependent disulfides regulate epidermal homeostasis and barrier function via 14-3-3\u03c3 and YAP1","volume":"9","author":"Guo","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.intimp.2025.114784_bb0250","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.cytogfr.2016.01.002","article-title":"S100A7: A rAMPing up AMP molecule in psoriasis","volume":"32","author":"D'Amico","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.intimp.2025.114784_bb0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2016.82","article-title":"Psoriasis","volume":"2","author":"Greb","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.intimp.2025.114784_bb0260","first-page":"39","article-title":"Biologic treatments of psoriasis: an update for the clinician","volume":"15","author":"Brownstone","year":"2021","journal-title":"Biologics"},{"key":"10.1016\/j.intimp.2025.114784_bb0265","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/1097-0142(197709)40:3<1348::AID-CNCR2820400352>3.0.CO;2-Q","article-title":"Serum vitamin B12 and transcobalamin abnormalities in patients with cancer","volume":"40","author":"Carmel","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.intimp.2025.114784_bb0270","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10549-011-1555-6","article-title":"Keratin 15, transcobalamin I and homeobox gene Hox-B13 expression in breast phyllodes tumors: novel markers in biological classification","volume":"132","author":"Chong","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.intimp.2025.114784_bb0275","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/15533506211045318","article-title":"Xing PhD, Clinicopathological analysis and prognostic assessment of TCN1 in patients with gastric Cancer","volume":"29","author":"Zhu","year":"2022","journal-title":"Surg. Innov."},{"key":"10.1016\/j.intimp.2025.114784_bb0280","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1002\/ijc.24748","article-title":"Akt-mediated regulation of NF\u03baB and the essentialness of NF\u03baB for the oncogenicity of PI3K and Akt","volume":"125","author":"Bai","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.intimp.2025.114784_bb0285","doi-asserted-by":"crossref","first-page":"18934","DOI":"10.1074\/jbc.M101103200","article-title":"Akt stimulates the transactivation potential of the RelA\/p65 subunit of NF-\u03baB through utilization of the I\u03baB kinase and activation of the mitogen-activated protein kinase p38","volume":"276","author":"Madrid","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.114784_bb0290","doi-asserted-by":"crossref","first-page":"36076","DOI":"10.1074\/jbc.M111.259549","article-title":"Akt fine-tunes NF-\u03baB-dependent gene expression during T cell activation","volume":"286","author":"Cheng","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.114784_bb0295","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1056\/NEJM199704103361506","article-title":"Nuclear factor-\u03baB \u2014 A pivotal transcription factor in chronic inflammatory diseases","volume":"336","author":"Barnes","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2025.114784_bb0300","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/bjd.14106","article-title":"Nuclear factor-\u03baB pathway activation and phosphatase and tensin homolog downregulation in psoriasis","volume":"174","author":"Hong","year":"2016","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2025.114784_bb0305","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/ng.311","article-title":"genome-wide scan reveals association of psoriasis with IL-23 and NF-\u03baB pathways","volume":"41","author":"Nair","year":"2009","journal-title":"Nat. Genet."},{"key":"10.1016\/j.intimp.2025.114784_bb0310","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cyto.2017.05.018","article-title":"IL-17A causes depression-like symptoms via NF\u03baB and p38MAPK signaling pathways in mice: implications for psoriasis associated depression","volume":"97","author":"Nadeem","year":"2017","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2025.114784_bb0315","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3390\/medicina57080754","article-title":"The role of chemokines in psoriasis\u2014an overview","volume":"57","author":"Zdanowska","year":"2021","journal-title":"Medicina"},{"key":"10.1016\/j.intimp.2025.114784_bb0320","first-page":"169","article-title":"Chemokines and chemokine receptors as targets in the therapy of psoriasis, Curr drug targets Inflamm","volume":"3","author":"Homey","year":"2004","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2025.114784_bb0325","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jdermsci.2011.11.007","article-title":"Chemokine receptors in the pathogenesis and therapy of psoriasis","volume":"65","author":"Mabuchi","year":"2012","journal-title":"J. Dermatol. Sci."},{"key":"10.1016\/j.intimp.2025.114784_bb0330","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.3390\/ijms23031840","article-title":"The role of the neutrophilic network in the pathogenesis of psoriasis","volume":"23","author":"Czerwi\u0144ska","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.114784_bb0335","doi-asserted-by":"crossref","DOI":"10.1111\/srt.13404","article-title":"Research progress on the neutrophil components and their interactions with immune cells in the development of psoriasis","volume":"29","author":"Wang","year":"2023","journal-title":"Skin Res. Technol."},{"key":"10.1016\/j.intimp.2025.114784_bb0340","doi-asserted-by":"crossref","first-page":"49253","DOI":"10.18632\/oncotarget.17534","article-title":"Oscillating expression of interleukin-16 in multiple myeloma is associated with proliferation, clonogenic growth, and PI3K\/NFKB\/MAPK activation","volume":"8","author":"Templin","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.intimp.2025.114784_bb0345","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1016\/j.celrep.2017.11.014","article-title":"Noncanonical pathway for regulation of CCL2 expression by an mTORC1-FOXK1 Axis promotes recruitment of tumor-associated macrophages","volume":"21","author":"Nakatsumi","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2025.114784_bb0350","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1016\/j.celrep.2019.10.090","article-title":"Sustained secretion of the antimicrobial peptide S100A7 is dependent on the downregulation of Caspase-8","volume":"29","author":"Bhatt","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2025.114784_bb0355","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-065X.2008.00699.x","article-title":"The roles of IL-17A in inflammatory immune responses and host defense against pathogens","volume":"226","author":"Iwakura","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2025.114784_bb0360","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cyto.2013.07.022","article-title":"IL-17 family: cytokines, receptors and signaling","volume":"64","author":"Gu","year":"2013","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2025.114784_bb0365","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1159\/000217736","article-title":"Blood transcobalamin levels in malignant hepatoma","volume":"12","author":"Fr\u00e9mont","year":"1991","journal-title":"Tumour Biol."},{"key":"10.1016\/j.intimp.2025.114784_bb0370","first-page":"1303","article-title":"Signaling pathways mediated by tumor necrosis factor alpha","volume":"15","author":"Leong","year":"2000","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.intimp.2025.114784_bb0375","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2017.8015","article-title":"Differential expression of cyclin D1, Ki-67, pRb, and p53 in psoriatic skin lesions and normal skin","author":"Kim","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2025.114784_bb0380","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1365-2230.2009.03774.x","article-title":"Expression of cyclin D1 and p16 in psoriasis before and after phototherapy","volume":"35","author":"El-Ela","year":"2010","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.intimp.2025.114784_bb0385","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/bjd.18713","article-title":"Psoriatic epidermis expresses high level of inflammatory mediators and the CDK2\/4 cyclin-dependent kinases are involved in the regulation of cell-cycle progression in epidermal cells","volume":"182","author":"Gesser","year":"2020","journal-title":"Br. J. Dermatol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692500774X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692500774X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:51:46Z","timestamp":1762552306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692500774X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":77,"alternative-id":["S156757692500774X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114784","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TCN1 as an inflammatory regulator in psoriasis: Activation of the NF-\u03baB pathway and potential therapeutic target","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114784","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114784"}}