{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:36:58Z","timestamp":1792024618085,"version":"4.4.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82305274"],"award-info":[{"award-number":["82305274"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013072","name":"Major Science and Technology Project of Hainan Province","doi-asserted-by":"publisher","award":["20210304001YY"],"award-info":[{"award-number":["20210304001YY"]}],"id":[{"id":"10.13039\/501100013072","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.intimp.2025.114785","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T17:24:56Z","timestamp":1746465896000},"page":"114785","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics"],"prefix":"10.1016","volume":"157","author":[{"given":"Yongji","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanliang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisi","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.intimp.2025.114785_bb0005","doi-asserted-by":"crossref","first-page":"246","DOI":"10.15585\/mmwr.mm6609e1","article-title":"Vital signs: prevalence of doctor-diagnosed arthritis and arthritis-attributable activity limitation - United States, 2013\u20132015","volume":"66","author":"Barbour","year":"2017","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"issue":"8","key":"10.1016\/j.intimp.2025.114785_bb0010","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.5435\/JAAOS-D-16-00160","article-title":"AAOS clinical practice guideline: surgical management of osteoarthritis of the knee: evidence-based guideline","volume":"24","author":"Weber","year":"2016","journal-title":"J. Am. Acad. Orthop. Surg."},{"issue":"10","key":"10.1016\/j.intimp.2025.114785_bb0015","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.clinbiomech.2006.07.001","article-title":"A review on the mechanical quality of articular cartilage - implications for the diagnosis of osteoarthritis","volume":"21","author":"Knecht","year":"2006","journal-title":"Clin. Biomech. (Bristol, Avon)"},{"issue":"4","key":"10.1016\/j.intimp.2025.114785_bb0020","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/jor.1100170407","article-title":"Tensile properties of articular cartilage are altered by meniscectomy in a canine model of osteoarthritis","volume":"17","author":"Elliott","year":"1999","journal-title":"J. Orthop. Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.114785_bb0025","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.coph.2013.01.010","article-title":"Targeting mechanotransduction pathways in osteoarthritis: a focus on the pericellular matrix","volume":"13","author":"Vincent","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2025.114785_bb0030","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.joca.2022.01.010","article-title":"Rodent models of knee osteoarthritis for pain research","volume":"30","author":"Alves-Sim\u00f5es","year":"2022","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.intimp.2025.114785_bb0035","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr. Cartil."},{"issue":"8","key":"10.1016\/j.intimp.2025.114785_bb0040","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.joca.2012.05.001","article-title":"Histopathology of naturally occurring and surgically induced osteoarthritis in mice","volume":"20","author":"McNulty","year":"2012","journal-title":"Osteoarthr. Cartil."},{"issue":"3","key":"10.1016\/j.intimp.2025.114785_bb0045","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/art.33388","article-title":"Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.intimp.2025.114785_bb0050","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/art.27765","article-title":"Characterizing a novel and adjustable noninvasive murine joint loading model","volume":"63","author":"Poulet","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.intimp.2025.114785_bb0055","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.joca.2015.11.007","article-title":"Importance of reference gene selection for articular cartilage mechanobiology studies","volume":"24","author":"Al-Sabah","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"6","key":"10.1016\/j.intimp.2025.114785_bb0060","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.intimp.2025.114785_bb0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"issue":"2","key":"10.1016\/j.intimp.2025.114785_bb0070","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1302\/2046-3758.132.BJR-2023-0074.R1","article-title":"Transcriptomic analyses and machine-learning methods reveal dysregulated key genes and potential pathogenesis in human osteoarthritic cartilage","volume":"13","author":"Zhao","year":"2024","journal-title":"Bone Joint Res."},{"issue":"24","key":"10.1016\/j.intimp.2025.114785_bb0075","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.2106\/JBJS.L.01497","article-title":"The effect of platelet-rich plasma on autologous osteochondral transplantation: an in vivo rabbit model","volume":"95","author":"Smyth","year":"2013","journal-title":"J. Bone Joint Surg. Am."},{"issue":"2","key":"10.1016\/j.intimp.2025.114785_bb0080","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bone.2012.12.044","article-title":"Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats","volume":"53","author":"Zhu","year":"2013","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.intimp.2025.114785_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12010005","article-title":"Osteoarthritis: pathogenesis, animal models, and new regenerative therapies","volume":"12","author":"Szponder","year":"2022","journal-title":"J. Clin. Med."},{"issue":"03","key":"10.1016\/j.intimp.2025.114785_bb0090","first-page":"114","article-title":"Biomechanical modeling of knee joint load bearing","volume":"39","author":"Tang","year":"2017","journal-title":"Sichuan J Physiol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2025.114785_bb0095","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11626-016-0090-5","article-title":"The effect of mechanical stretch stress on the differentiation and apoptosis of human growth plate chondrocytes","volume":"53","author":"Sun","year":"2017","journal-title":"In Vitro Cell. Dev. Biol. Anim."},{"issue":"12","key":"10.1016\/j.intimp.2025.114785_bb0100","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1089\/jir.2019.0029","article-title":"High-density lipoproteins decrease Proinflammatory activity and modulate the innate immune response","volume":"39","author":"Taborda","year":"2019","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.intimp.2025.114785_bb0105","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41413-019-0066-7","article-title":"Bench-to-bedside strategies for osteoporotic fracture: from osteoimmunology to mechanosensation","volume":"7","author":"Xie","year":"2019","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2025.114785_bb0110","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbrc.2022.03.119","article-title":"High expression of Piezo1 induces senescence in chondrocytes through calcium ions accumulation","volume":"607","author":"Ren","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2025.114785_bb0115","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41413-020-0099-y","article-title":"Molecular mechanosensors in osteocytes","volume":"8","author":"Qin","year":"2020","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2025.114785_bb0120","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8538463","article-title":"Mechanism of abnormal chondrocyte proliferation induced by Piezo1-siRNA exposed to mechanical stretch","volume":"2020","author":"Sun","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"13","key":"10.1016\/j.intimp.2025.114785_bb0125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2001611118","article-title":"Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis","volume":"118","author":"Lee","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2025.114785_bb0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jare.2023.09.040","article-title":"Piezo1 activation accelerates osteoarthritis progression and the targeted therapy effect of artemisinin","volume":"62","author":"Gan","year":"2023","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.114785_bb0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1124\/jpet.104.065151","article-title":"Regulation of kinase cascades and transcription factors by a poly(ADP-ribose) polymerase-1 inhibitor, 4-hydroxyquinazoline, in lipopolysaccharide-induced inflammation in mice","volume":"310","author":"Veres","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2025.114785_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156727","article-title":"Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-\u03baB-NLRP3-GSDMD and AMPK-PGC-1\u03b1 axes","volume":"840","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.intimp.2025.114785_bb0145","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.fsi.2022.03.018","article-title":"NLRP3 inflammasome is involved in the mechanism of the mitigative effect of lycopene on sulfamethoxazole-induced inflammatory damage in grass carp kidneys","volume":"123","author":"Lu","year":"2022","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.intimp.2025.114785_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2021.105986","article-title":"Zinc antagonizes common carp (Cyprinus carpio) intestinal arsenic poisoning through PI3K\/AKT\/mTOR signaling cascade and MAPK pathway","volume":"240","author":"Guo","year":"2021","journal-title":"Aquat. Toxicol. (Amsterdam, Netherlands)."},{"issue":"1","key":"10.1016\/j.intimp.2025.114785_bb0155","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/jcmm.16104","article-title":"Maltol prevents the progression of osteoarthritis by targeting PI3K\/Akt\/NF-\u03baB pathway: in vitro and in vivo studies","volume":"25","author":"Lu","year":"2021","journal-title":"J. Cell. Mol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925007751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925007751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:50:42Z","timestamp":1762552242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925007751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":31,"alternative-id":["S1567576925007751"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114785","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the mechanisms of mechanical loading-induced knee osteoarthritis through transcriptomics","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114785","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114785"}}