{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:19:11Z","timestamp":1788830351849,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023A04J2280"],"award-info":[{"award-number":["2023A04J2280"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025A04J4109"],"award-info":[{"award-number":["2025A04J4109"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025A04J5125"],"award-info":[{"award-number":["2025A04J5125"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82403701"],"award-info":[{"award-number":["82403701"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["8220100645"],"award-info":[{"award-number":["8220100645"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202878"],"award-info":[{"award-number":["82202878"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["A20221009"],"award-info":[{"award-number":["A20221009"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","award":["2021B006"],"award-info":[{"award-number":["2021B006"]}],"id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010657"],"award-info":[{"award-number":["2022A1515010657"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515111182"],"award-info":[{"award-number":["2022A1515111182"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515012629"],"award-info":[{"award-number":["2022A1515012629"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010112","name":"Nanfang Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010112","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515030298"],"award-info":[{"award-number":["2024A1515030298"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.intimp.2025.114914","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T20:00:22Z","timestamp":1748289622000},"page":"114914","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["PFKFB3 confers cisplatin resistance in gastric cancer by inhibiting ferroptosis through SLC7A11\/xCT dephosphorylation"],"prefix":"10.1016","volume":"159","author":[{"given":"Zhanke","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiying","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiani","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huayang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaolong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2025.114914_bb0005","first-page":"209","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"10251","key":"10.1016\/j.intimp.2025.114914_bb0010","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2025.114914_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2019.102925","article-title":"Cisplatin: the first metal based anticancer drug","volume":"88","author":"Ghosh","year":"2019","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0020","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/s42003-022-04302-y","article-title":"KLF4-PFKFB3-driven glycolysis is essential for phenotypic switching of vascular smooth muscle cells","volume":"5","author":"Zhang","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.intimp.2025.114914_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100938","article-title":"Regulation of cisplatin resistance in bladder cancer by epigenetic mechanisms","volume":"68","author":"Li","year":"2023","journal-title":"Drug Resist. Updat."},{"issue":"15","key":"10.1016\/j.intimp.2025.114914_bb0030","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1038\/onc.2011.384","article-title":"Molecular mechanisms of cisplatin resistance","volume":"31","author":"Galluzzi","year":"2012","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.intimp.2025.114914_bb0035","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"35","key":"10.1016\/j.intimp.2025.114914_bb0040","article-title":"Ferroptosis detection: from approaches to applications","volume":"62","author":"Zeng","year":"2023","journal-title":"Angew. Chem. Int. Ed. Eng."},{"key":"10.1016\/j.intimp.2025.114914_bb0045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/cells12141820","article-title":"Ferroptosis in cancer progression","volume":"12","author":"Zhang","year":"2023","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.intimp.2025.114914_bb0050","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"issue":"15","key":"10.1016\/j.intimp.2025.114914_bb0055","doi-asserted-by":"crossref","first-page":"5826","DOI":"10.7150\/thno.100080","article-title":"Ferroptosis at the nexus of metabolism and metabolic diseases","volume":"14","author":"Li","year":"2024","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.intimp.2025.114914_bb0060","doi-asserted-by":"crossref","first-page":"183","DOI":"10.4196\/kjpp.2024.28.3.183","article-title":"Ferroptosis and its role in gastric and colorectal cancers","volume":"28","author":"Hou","year":"2024","journal-title":"Korean J. Physiol. Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2025.114914_bb0065","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1111\/jcmm.14511","article-title":"Molecular mechanisms of ferroptosis and its role in cancer therapy","volume":"23","author":"Xu","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0070","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2025.114914_bb0075","doi-asserted-by":"crossref","first-page":"1289335","DOI":"10.3389\/fcell.2024.1289335","article-title":"Ferroptosis and its current progress in gastric cancer","volume":"12","author":"Yue","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2025.114914_bb0080","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1146\/annurev.bi.64.070195.004055","article-title":"6-Phosphofructo-2-kinase\/fructose-2,6-bisphosphatase: a metabolic signaling enzyme","volume":"64","author":"Pilkis","year":"1995","journal-title":"Annu. Rev. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0085","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.molcel.2017.05.030","article-title":"mTORC2 regulates amino acid metabolism in Cancer by phosphorylation of the Cystine-glutamate antiporter xCT","volume":"67","author":"Gu","year":"2017","journal-title":"Mol. Cell"},{"issue":"6","key":"10.1016\/j.intimp.2025.114914_bb0090","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.ccell.2016.10.006","article-title":"Inhibition of the glycolytic activator PFKFB3 in endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy","volume":"30","author":"Cantelmo","year":"2016","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0095","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jcmgh.2022.09.009","article-title":"PFKFB3-mediated pro-glycolytic shift in hepatocellular carcinoma proliferation","volume":"15","author":"Dou","year":"2023","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"issue":"5","key":"10.1016\/j.intimp.2025.114914_bb0100","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/s41416-022-01834-2","article-title":"Inhibition of PFKFB3 in HER2-positive gastric cancer improves sensitivity to trastuzumab by inducing tumour vessel normalisation","volume":"127","author":"Yao","year":"2022","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2025.114914_bb0105","doi-asserted-by":"crossref","first-page":"445","DOI":"10.4143\/crt.2016.572","article-title":"Ferroptosis: a novel anti-tumor action for cisplatin","volume":"50","author":"Guo","year":"2018","journal-title":"Cancer Res. Treat."},{"issue":"6","key":"10.1016\/j.intimp.2025.114914_bb0110","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/s41580-024-00703-5","article-title":"The cell biology of ferroptosis","volume":"25","author":"Dixon","year":"2024","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0115","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1186\/s12885-018-4521-4","article-title":"Expression of glycolytic enzymes in ovarian cancers and evaluation of the glycolytic pathway as a strategy for ovarian cancer treatment","volume":"18","author":"Xintaropoulou","year":"2018","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0120","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/s41467-020-15112-3","article-title":"Long noncoding RNA AGPG regulates PFKFB3-mediated tumor glycolytic reprogramming","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.114914_bb0125","doi-asserted-by":"crossref","first-page":"17044","DOI":"10.1038\/sigtrans.2017.44","article-title":"Roles of PFKFB3 in cancer","volume":"2","author":"Shi","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"8021","key":"10.1016\/j.intimp.2025.114914_bb0130","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/s41586-024-07620-9","article-title":"NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance","volume":"631","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.114914_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111215","article-title":"The liquid-liquid phase separation in programmed cell death","volume":"120","author":"Yin","year":"2024","journal-title":"Cell. Signal."},{"issue":"2","key":"10.1016\/j.intimp.2025.114914_bb0140","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1021\/jacs.3c10132","article-title":"Lipid peroxidation drives liquid-liquid phase separation and disrupts raft protein partitioning in biological membranes","volume":"146","author":"Balakrishnan","year":"2024","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0145","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.canlet.2016.07.035","article-title":"Induction of ferroptotic cell death for overcoming cisplatin resistance of head and neck cancer","volume":"381","author":"Roh","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2025.114914_bb0150","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.canlet.2018.06.018","article-title":"CISD2 inhibition overcomes resistance to sulfasalazine-induced ferroptotic cell death in head and neck cancer","volume":"432","author":"Kim","year":"2018","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2025.114914_bb0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.canlet.2018.04.021","article-title":"Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT","volume":"428","author":"Wang","year":"2018","journal-title":"Cancer Lett."},{"issue":"7545","key":"10.1016\/j.intimp.2025.114914_bb0160","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.114914_bb0165","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.2147\/OTT.S254995","article-title":"The role of Erastin in Ferroptosis and its prospects in Cancer therapy","volume":"13","author":"Zhao","year":"2020","journal-title":"Onco Targets Ther"},{"key":"10.1016\/j.intimp.2025.114914_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112612","article-title":"PFKFB3 inhibitors as potential anticancer agents: mechanisms of action, current developments, and structure-activity relationships","volume":"203","author":"Wang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2025.114914_bb0175","doi-asserted-by":"crossref","unstructured":"Redman RA, Pohlmann PR, Kurman MR et al. A phase I, dose-escalation, multi-center study of PFK-158 in patients with advanced solid malignancies explores a first-in-man inhbibitor of glycolysis. J. Clin. Oncol.; 33 (15_suppl): TPS2606-TPS2606.","DOI":"10.1200\/jco.2015.33.15_suppl.tps2606"},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0180","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00018-024-05257-5","article-title":"Cardiac-specific PFKFB3 overexpression prevents diabetic cardiomyopathy via enhancing OPA1 stabilization mediated by K6-linked ubiquitination","volume":"81","author":"Luo","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"issue":"11","key":"10.1016\/j.intimp.2025.114914_bb0185","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1002\/glia.24248","article-title":"Differential role of neuronal glucose and PFKFB3 in memory formation during development","volume":"70","author":"Cruz","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2025.114914_bb0190","article-title":"SIRT3 deficiency reduces PFKFB3-driven T-cell glycolysis and promotes arthritic inflammation. Sci China","author":"Wang","year":"2025","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.114914_bb0195","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1158\/1535-7163.MCT-07-0482","article-title":"Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth","volume":"7","author":"Clem","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.intimp.2025.114914_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156436","article-title":"Unveiling polysaccharides of Houttuynia cordata Thunb.: extraction, purification, structure, bioactivities, and structure-activity relationships","volume":"138","author":"Gao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.114914_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.119200","article-title":"Rabdosia rubescens (Hemsl.) H. Hara: a potent anti-tumor herbal remedy - botany, phytochemistry, and clinical applications and insights","volume":"340","author":"Gao","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"Pt 4","key":"10.1016\/j.intimp.2025.114914_bb0210","article-title":"Polysaccharides from Lonicera japonica Thunb.: extraction, purification, structural features and biological activities-a review","volume":"281","author":"Gao","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692500904X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692500904X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:59:29Z","timestamp":1778619569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692500904X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":42,"alternative-id":["S156757692500904X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114914","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PFKFB3 confers cisplatin resistance in gastric cancer by inhibiting ferroptosis through SLC7A11\/xCT dephosphorylation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114914","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114914"}}