{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:06:09Z","timestamp":1787166369040,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T00:00:00Z","timestamp":1748476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2024AFB651"],"award-info":[{"award-number":["2024AFB651"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hubei Provincial Natural Science Foundation of China"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803917"],"award-info":[{"award-number":["81803917"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.intimp.2025.114963","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T05:02:33Z","timestamp":1749099753000},"page":"114963","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Treatment with senolytic drugs ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting osteoclastogenesis"],"prefix":"10.1016","volume":"161","author":[{"given":"Peng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2025.114963_bb0005","first-page":"787","article-title":"Avascular necrosis associated with fracture of the femoral neck after hip resurfacing: histological assessment of femoral bone from retrieval specimens, the journal of bone and joint surgery","volume":"92","author":"Steffen","year":"2010","journal-title":"British"},{"issue":"7","key":"10.1016\/j.intimp.2025.114963_bb0010","first-page":"922","article-title":"Resurfacing arthroplasty of the hip for avascular necrosis of the femoral head: a minimum follow-up of four years, the journal of bone and joint surgery","volume":"92","author":"Bose","year":"2010","journal-title":"British"},{"issue":"3","key":"10.1016\/j.intimp.2025.114963_bb0015","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jbmr.4773","article-title":"Macrophages and bone remodeling","volume":"38","author":"Weivoda","year":"2023","journal-title":"J. bone and Mineral Res.\u202f: The Official J. American Society for Bone and Mineral Res."},{"key":"10.1016\/j.intimp.2025.114963_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110639","article-title":"Early depletion of M1 macrophages retards the progression of glucocorticoid-associated osteonecrosis of the femoral head","volume":"122","author":"Cheng","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2025.114963_bb0025","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.7150\/ijbs.40917","article-title":"Steroid-induced osteonecrosis of the femoral head reveals enhanced reactive oxygen species and hyperactive osteoclasts","volume":"16","author":"Chen","year":"2020","journal-title":"Int. J. Biol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2025.114963_bb0030","doi-asserted-by":"crossref","DOI":"10.4110\/in.2022.22.e25","article-title":"IL-34 aggravates steroid-induced osteonecrosis of the femoral head via promoting osteoclast differentiation","volume":"22","author":"Wang","year":"2022","journal-title":"Immune Netw."},{"issue":"11","key":"10.1016\/j.intimp.2025.114963_bb0035","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/jbmr.2892","article-title":"Identification of senescent cells in the bone microenvironment","volume":"31","author":"Farr","year":"2016","journal-title":"J. bone and Mineral Res.\u202f: The Official J. American Society for Bone and Mineral Res."},{"issue":"9","key":"10.1016\/j.intimp.2025.114963_bb0040","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1038\/nm.4385","article-title":"Targeting cellular senescence prevents age-related bone loss in mice","volume":"23","author":"Farr","year":"2017","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.intimp.2025.114963_bb0045","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/acel.12458","article-title":"Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice","volume":"15","author":"Roos","year":"2016","journal-title":"Aging Cell"},{"issue":"7875","key":"10.1016\/j.intimp.2025.114963_bb0050","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/s41586-021-03795-7","article-title":"Aged skeletal stem cells generate an inflammatory degenerative niche","volume":"597","author":"Ambrosi","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2025.114963_bb0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2025.114963_bb0060","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41590-018-0255-3","article-title":"Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation","volume":"20","author":"Minhas","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.114963_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.103992","article-title":"Inflammation and resolution signaling in cardiac repair and heart failure","volume":"79","author":"Halade","year":"2022","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.intimp.2025.114963_bb0070","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1038\/s41598-024-53400-w","article-title":"Cellular senescence is associated with osteonecrosis of the femoral head while mesenchymal stem cell conditioned medium inhibits bone collapse","volume":"14","author":"Okamoto","year":"2024","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.intimp.2025.114963_bb0075","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13948","article-title":"Strategies for senolytic drug discovery","volume":"22","author":"Power","year":"2023","journal-title":"Aging Cell"},{"issue":"8","key":"10.1016\/j.intimp.2025.114963_bb0080","doi-asserted-by":"crossref","DOI":"10.1172\/JCI148073","article-title":"Age-associated callus senescent cells produce TGF-\u03b21 that inhibits fracture healing in aged mice","volume":"132","author":"Liu","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.intimp.2025.114963_bb0085","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.devcel.2014.11.012","article-title":"An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA","volume":"31","author":"Demaria","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.intimp.2025.114963_bb0090","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.69958","article-title":"Modulation of fracture healing by the transient accumulation of senescent cells","volume":"10","author":"Saul","year":"2021","journal-title":"eLife"},{"issue":"1","key":"10.1016\/j.intimp.2025.114963_bb0095","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41413-024-00371-3","article-title":"Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head","volume":"12","author":"Shao","year":"2024","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2025.114963_bb0100","doi-asserted-by":"crossref","first-page":"14532","DOI":"10.1038\/ncomms14532","article-title":"Cellular senescence mediates fibrotic pulmonary disease","volume":"8","author":"Schafer","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2025.114963_bb0105","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1038\/s41467-021-25453-2","article-title":"Long-term treatment with senolytic drugs Dasatinib and quercetin ameliorates age-dependent intervertebral disc degeneration in mice","volume":"12","author":"Novais","year":"2021","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.intimp.2025.114963_bb0110","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"7589","key":"10.1016\/j.intimp.2025.114963_bb0115","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"issue":"7372","key":"10.1016\/j.intimp.2025.114963_bb0120","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2025.114963_bb0125","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202101483","article-title":"Local delivery of Senolytic drug inhibits intervertebral disc degeneration and restores intervertebral disc structure","volume":"11","author":"Lim","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"11","key":"10.1016\/j.intimp.2025.114963_bb0130","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13979","article-title":"Senolytic treatment reduces oxidative protein stress in an aging male murine model of post-traumatic osteoarthritis","volume":"22","author":"Chin","year":"2023","journal-title":"Aging Cell"},{"issue":"1","key":"10.1016\/j.intimp.2025.114963_bb0135","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41584-020-00533-7","article-title":"Mechanisms and therapeutic implications of cellular senescence in osteoarthritis","volume":"17","author":"Coryell","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2025.114963_bb0140","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3389\/fcell.2020.00354","article-title":"The Senolytic drug Navitoclax (ABT-263) causes trabecular bone loss and impaired Osteoprogenitor function in aged mice","volume":"8","author":"Sharma","year":"2020","journal-title":"Front. Cell and Develop. Biol."},{"issue":"23","key":"10.1016\/j.intimp.2025.114963_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222313173","article-title":"Mechanisms and regulation of cellular senescence","volume":"22","author":"Roger","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2025.114963_bb0150","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1136\/gutjnl-2016-312940","article-title":"Age-dependent shift in macrophage polarisation causes inflammation-mediated degeneration of enteric nervous system","volume":"67","author":"Becker","year":"2018","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.intimp.2025.114963_bb0155","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.immuni.2024.01.001","article-title":"Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging","volume":"57","author":"Zhou","year":"2024","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.intimp.2025.114963_bb0160","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat. Med."},{"issue":"10","key":"10.1016\/j.intimp.2025.114963_bb0165","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1172\/JCI134091","article-title":"IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis","volume":"130","author":"Faust","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"14","key":"10.1016\/j.intimp.2025.114963_bb0170","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.1073\/pnas.1810692116","article-title":"Age-related inflammation triggers skeletal stem\/progenitor cell dysfunction","volume":"116","author":"Josephson","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.114963_bb0175","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2025.114963_bb0180","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"issue":"3","key":"10.1016\/j.intimp.2025.114963_bb0185","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.joca.2020.11.006","article-title":"Senolytic agent quercetin ameliorates intervertebral disc degeneration via the Nrf2\/NF-\u03baB axis","volume":"29","author":"Shao","year":"2021","journal-title":"Osteoarthr. Cartil."},{"issue":"5484","key":"10.1016\/j.intimp.2025.114963_bb0190","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone Resorption by Osteoclasts","volume":"vol. 289","author":"Teitelbaum","year":"2000","journal-title":"Science (New York, N.Y.)"},{"issue":"2","key":"10.1016\/j.intimp.2025.114963_bb0195","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11420-016-9487-7","article-title":"The efficacy of bisphosphonates with Core decompression and mesenchymal stem cells compared with bisphosphonates alone in the treatment of osteonecrosis of the hip: a retrospective study","volume":"12","author":"Gianakos","year":"2016","journal-title":"HSS J.\u202f: the Musculoskeletal J. Hospital for Special Surgery"},{"issue":"1","key":"10.1016\/j.intimp.2025.114963_bb0200","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1080\/14756366.2017.1302440","article-title":"Hyperbaric oxygen therapy modulates serum OPG\/RANKL in femoral head necrosis patients","volume":"32","author":"Vezzani","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"8","key":"10.1016\/j.intimp.2025.114963_bb0205","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1002\/jbmr.85","article-title":"The tyrosine kinase inhibitor dasatinib dysregulates bone remodeling through inhibition of osteoclasts in vivo","volume":"25","author":"Vandyke","year":"2010","journal-title":"J. bone and Mineral Res.\u202f: The Official J. American Society for Bone and Mineral Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.114963_bb0210","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14072","article-title":"Lipoteichoic acid restrains macrophage senescence via \u03b2-catenin\/FOXO1\/REDD1 pathway in age-related osteoporosis","volume":"23","author":"Cheng","year":"2024","journal-title":"Aging Cell"},{"issue":"5","key":"10.1016\/j.intimp.2025.114963_bb0215","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41584-023-00935-3","article-title":"Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone","volume":"19","author":"Ferrari","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"issue":"11","key":"10.1016\/j.intimp.2025.114963_bb0220","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/nm.3668","article-title":"PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis","volume":"20","author":"Xie","year":"2014","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.114963_bb0225","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1038\/s41467-021-22131-1","article-title":"Osteoclasts protect bone blood vessels against senescence through the angiogenin\/plexin-B2 axis","volume":"12","author":"Liu","year":"2021","journal-title":"Nat. Commun."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925009531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925009531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T19:52:36Z","timestamp":1775764356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925009531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":45,"alternative-id":["S1567576925009531"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114963","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treatment with senolytic drugs ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting osteoclastogenesis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114963","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114963"}}