{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:06:11Z","timestamp":1787753171317,"version":"build-2784847793"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772119"],"award-info":[{"award-number":["81772119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017605","name":"Shaanxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023GP41"],"award-info":[{"award-number":["2023GP41"]}],"id":[{"id":"10.13039\/501100017605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBMS-689"],"award-info":[{"award-number":["2024JC-YBMS-689"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.intimp.2025.114992","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T20:19:46Z","timestamp":1749068386000},"page":"114992","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["17\u03b2-estradiol ameliorates LPS-induced acute lung injury via mediating mitochondrial biogenesis and function in rats"],"prefix":"10.1016","volume":"161","author":[{"given":"Shaocheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhankui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.intimp.2025.114992_bb0005","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa050333","article-title":"Incidence and outcomes of acute lung injury","volume":"353","author":"Rubenfeld","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"6 Pt 1","key":"10.1016\/j.intimp.2025.114992_bb0010","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1164\/ajrccm.152.6.8520742","article-title":"Identification of patients with acute lung injury, predictors of mortality","volume":"152","author":"Doyle","year":"1995","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.intimp.2025.114992_bb0015","doi-asserted-by":"crossref","first-page":"4703","DOI":"10.1096\/fj.13-229476","article-title":"Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver","volume":"27","author":"Carchman","year":"2013","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.intimp.2025.114992_bb0020","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3892\/etm.2013.1453","article-title":"Effects and mechanisms of alveolar type II epithelial cell apoptosis in severe pancreatitis-induced acute lung injury","volume":"7","author":"Liu","year":"2014","journal-title":"Exp. Ther. Med."},{"issue":"3","key":"10.1016\/j.intimp.2025.114992_bb0025","doi-asserted-by":"crossref","first-page":"R491","DOI":"10.1152\/ajpregu.00432.2003","article-title":"Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure","volume":"286","author":"Brealey","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"16","key":"10.1016\/j.intimp.2025.114992_bb0030","doi-asserted-by":"crossref","first-page":"16224","DOI":"10.18632\/aging.103644","article-title":"SirT3 activates AMPK-related mitochondrial biogenesis and ameliorates sepsis-induced myocardial injury","volume":"12","author":"Xin","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2025.114992_bb0035","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2018.10.019","article-title":"Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress","volume":"20","author":"Bi","year":"2019","journal-title":"Redox Biol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114992_bb0040","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1074\/jbc.M608009200","article-title":"Signaling of mitochondrial biogenesis following oxidant injury","volume":"282","author":"Rasbach","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"42","key":"10.1016\/j.intimp.2025.114992_bb0045","doi-asserted-by":"crossref","first-page":"41510","DOI":"10.1074\/jbc.M304719200","article-title":"Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1","volume":"278","author":"Suliman","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2025.114992_bb0050","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.cardiores.2004.07.005","article-title":"Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis","volume":"64","author":"Suliman","year":"2004","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.intimp.2025.114992_bb0055","doi-asserted-by":"crossref","first-page":"L702","DOI":"10.1152\/ajplung.00176.2019","article-title":"17beta-Estradiol affects lung function and inflammation following ozone exposure in a sex-specific manner","volume":"317","author":"Fuentes","year":"2019","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"2","key":"10.1016\/j.intimp.2025.114992_bb0060","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1124\/jpet.108.148049","article-title":"Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis","volume":"329","author":"Lancel","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2025.114992_bb0065","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jss.2012.10.926","article-title":"Chaudry, II, role of Akt\/HO-1 pathway in estrogen-mediated attenuation of trauma-hemorrhage-induced lung injury","volume":"182","author":"Hsu","year":"2013","journal-title":"J. Surg. Res."},{"issue":"8","key":"10.1016\/j.intimp.2025.114992_bb0070","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1089\/neu.2020.7327","article-title":"Estrogen alleviates sex-dependent differences in lung bacterial clearance and mortality secondary to bacterial pneumonia after traumatic brain injury","volume":"38","author":"Pittet","year":"2021","journal-title":"J. Neurotrauma"},{"issue":"5","key":"10.1016\/j.intimp.2025.114992_bb0075","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00281-019-00754-3","article-title":"Molecular determinants for the polarization of macrophage and osteoclast","volume":"41","author":"Yang","year":"2019","journal-title":"Semin. Immunopathol."},{"issue":"2","key":"10.1016\/j.intimp.2025.114992_bb0080","first-page":"2467","article-title":"The NRF2PGC1beta pathway activates kynurenine aminotransferase 4 via attenuation of an E3 ubiquitin ligase, synoviolin, in a cecal ligation\/perforationinduced septic mouse model","volume":"18","author":"Ishida","year":"2018","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2025.114992_bb0085","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/ggi.13913","article-title":"Changes in skin temperature of ovariectomized rats under different incubation temperatures","volume":"20","author":"Sun","year":"2020","journal-title":"Geriatr. Gerontol. Int."},{"issue":"1","key":"10.1016\/j.intimp.2025.114992_bb0090","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13293-024-00633-z","article-title":"Sex differences in airway disease: estrogen and airway surface liquid dynamics","volume":"15","author":"Harvey","year":"2024","journal-title":"Biol. Sex Differ."},{"issue":"3","key":"10.1016\/j.intimp.2025.114992_bb0095","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1165\/rcmb.2024-0042OC","article-title":"Estrogen oppositely regulates pulmonary hypertension via METTL3\/PFKFB3 under Normoxia and hypoxia","volume":"72","author":"Li","year":"2025","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"Pt 1","key":"10.1016\/j.intimp.2025.114992_bb0100","article-title":"Extract of Nanhaia speciosa J. Compton & Schrire alleviates LPS-induced acute lung injury via the NF-kappaB\/Nrf2\/AQPs pathway","volume":"337","author":"Zhou","year":"2025","journal-title":"J. Ethnopharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2025.114992_bb0105","doi-asserted-by":"crossref","first-page":"L878","DOI":"10.1152\/ajplung.00008.2013","article-title":"Estradiol activates epithelial sodium channels in rat alveolar cells through the G protein-coupled estrogen receptor","volume":"305","author":"Greenlee","year":"2013","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.intimp.2025.114992_bb0110","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/B978-0-12-394816-8.00010-6","article-title":"Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer\u2019s disease","volume":"64","author":"Yao","year":"2012","journal-title":"Adv. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2025.114992_bb0115","article-title":"Mitochondrial dysfunction in acute kidney injury and sex-specific implications","volume":"7","author":"Pan","year":"2019","journal-title":"Med. Res. Arch."},{"issue":"5","key":"10.1016\/j.intimp.2025.114992_bb0120","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1007\/s10753-020-01255-4","article-title":"Overexpression of peroxisome proliferator-activated receptor gamma coactivator 1-alpha protects cardiomyocytes from lipopolysaccharide-induced mitochondrial damage and apoptosis","volume":"43","author":"Zhang","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2025.114992_bb0125","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/nyas.12872","article-title":"Estrogen receptor-beta in mitochondria: implications for mitochondrial bioenergetics and tumorigenesis","volume":"1350","author":"Liao","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2025.114992_bb0130","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11010-010-0668-2","article-title":"Muscle regeneration occurs to coincide with mitochondrial biogenesis","volume":"349","author":"Wagatsuma","year":"2011","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.intimp.2025.114992_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101771","article-title":"Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis","volume":"38","author":"Li","year":"2021","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.intimp.2025.114992_bb0140","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1152\/physrev.00025.2007","article-title":"Transcriptional paradigms in mammalian mitochondrial biogenesis and function","volume":"88","author":"Scarpulla","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.intimp.2025.114992_bb0145","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.freeradbiomed.2021.01.045","article-title":"MitoQ alleviates LPS-mediated acute lung injury through regulating Nrf2\/Drp1 pathway","volume":"165","author":"Hou","year":"2021","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2025.114992_bb0150","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.semcdb.2019.05.022","article-title":"Mitochondria as playmakers of apoptosis, autophagy and senescence","volume":"98","author":"Abate","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2025.114992_bb0155","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1097\/01.TA.0000051939.95039.E6","article-title":"The association between gender and mortality among trauma patients as modified by age","volume":"54","author":"George","year":"2003","journal-title":"J. Trauma"},{"key":"10.1016\/j.intimp.2025.114992_bb0160","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.12659\/MSM.916254","article-title":"Estrogen modulates cartilage and subchondral bone Remodeling in an ovariectomized rat model of postmenopausal osteoarthritis","volume":"25","author":"Xu","year":"2019","journal-title":"Med. Sci. Monit."},{"issue":"3","key":"10.1016\/j.intimp.2025.114992_bb0165","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0890-6238(03)00011-X","article-title":"Multiple mechanisms are involved in apoptotic cell death in the mouse uterus and vagina after ovariectomy","volume":"17","author":"Sato","year":"2003","journal-title":"Reprod. Toxicol."},{"issue":"3","key":"10.1016\/j.intimp.2025.114992_bb0170","first-page":"141","article-title":"Paraquat-induced lipid peroxidation: effects of ovariectomy and estrogen receptor antagonist","volume":"49","author":"Huang","year":"2006","journal-title":"Chin. J. Physiol."},{"key":"10.1016\/j.intimp.2025.114992_bb0175","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jare.2023.08.006","article-title":"Forsythiaside a alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-gamma\/RXR-alpha complex","volume":"60","author":"Wang","year":"2024","journal-title":"J. Adv. Res."},{"issue":"5","key":"10.1016\/j.intimp.2025.114992_bb0180","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1165\/rcmb.2023-0251OC","article-title":"FTO deficiency alleviates LPS-induced acute lung injury by TXNIP\/NLRP3-mediated alveolar epithelial cell Pyroptosis","volume":"70","author":"Xie","year":"2024","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"Pt A","key":"10.1016\/j.intimp.2025.114992_bb0185","article-title":"Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1alpha\/HO-1 pathway","volume":"142","author":"Shi","year":"2024","journal-title":"Int. Immunopharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925009828?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925009828?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:58:45Z","timestamp":1778619525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925009828"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":37,"alternative-id":["S1567576925009828"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114992","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"17\u03b2-estradiol ameliorates LPS-induced acute lung injury via mediating mitochondrial biogenesis and function in rats","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114992","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114992"}}