{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:56:05Z","timestamp":1790520965635,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017290","name":"Technology Bureau of Zhanjiang Municipality","doi-asserted-by":"publisher","award":["2021A05055"],"award-info":[{"award-number":["2021A05055"]}],"id":[{"id":"10.13039\/501100017290","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024A1515013013"],"award-info":[{"award-number":["2024A1515013013"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.intimp.2025.115072","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:30:46Z","timestamp":1750077046000},"page":"115072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["IGF2BP2 regulates inflammation in ulcerative colitis through N6-methyladenosine-dependent modulation of CBR1"],"prefix":"10.1016","volume":"161","author":[{"given":"Weiyun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuliang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shicai","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Hua","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanjin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenkai","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.intimp.2025.115072_bb0005","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3390\/biomedicines10071695","article-title":"RNA modification in inflammatory bowel diseases","volume":"10","author":"Nakayama","year":"2022","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0010","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2019.11.003","article-title":"The microbiome and inflammatory bowel disease","volume":"145","author":"Glassner","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0015","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/nrgastro.2017.136","article-title":"Environmental triggers in IBD: a review of progress and evidence","volume":"15","author":"Ananthakrishnan","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2025.115072_bb0020","article-title":"Treatment of inflammatory bowel disease: a comprehensive review","volume":"8","author":"Cai","year":"2021","journal-title":"Front Med. (Lausanne)."},{"key":"10.1016\/j.intimp.2025.115072_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2023.106502","article-title":"Epigenetic modification of m6A methylation: regulatory factors, functions and mechanism in inflammatory bowel disease","volume":"166","author":"Wang","year":"2024","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0030","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41392-020-00450-x","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2025.115072_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103295","article-title":"WTAP promotes the progression of ulcerative colitis by silencing the expression of CES2 through m6A modification","volume":"148","author":"Xie","year":"2024","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0040","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10565-024-09944-8","article-title":"METTL14 regulates inflammation in ulcerative colitis via the lncRNA DHRS4-AS1\/miR-206\/A3AR axis","volume":"40","author":"Wu","year":"2024","journal-title":"Cell Biol. Toxicol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115072_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.111812","article-title":"The m6A reader HNRNPC is a key regulator in DSS-induced colitis by modulating macrophage phenotype","volume":"28","author":"Fang","year":"2025","journal-title":"iScience"},{"issue":"7","key":"10.1016\/j.intimp.2025.115072_bb0050","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.7150\/ijbs.70458","article-title":"The role of insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer","volume":"18","author":"Sun","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2025.115072_bb0055","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3892\/etm.2023.12273","article-title":"IGF2BP2-dependent STIM1 inhibition protects against LPS-induced pneumonia in vitro by alleviating endoplasmic reticulum stress and the inflammatory response","volume":"26","author":"Zhou","year":"2023","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0060","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41420-024-01988-3","article-title":"IGF2BP2 regulates the inflammation of fibroblast-like synoviocytes via GSTM5 in rheumatoid arthritis","volume":"10","author":"Nan","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2025.115072_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinsp.2025.100637","article-title":"RBBP4 downregulation increases the sensitivity of A549 and HeLa cells to cisplatin by inhibiting cyclin D1 expression","volume":"80","author":"Zeng","year":"2025","journal-title":"Clinics (Sao Paulo)"},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100838","article-title":"Choice of selectable marker affects recombinant protein expression in cells and exosomes","volume":"297","author":"Guo","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.115072_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.649463","article-title":"Tiliroside ameliorates ulcerative colitis by restoring the M1\/M2 macrophage balance via the HIF-1\u03b1\/glycolysis pathway","volume":"12","author":"Zhuang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115072_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.pestbp.2024.106153","article-title":"New insights into zinc alleviating renal toxicity of arsenic-exposed carp (Cyprinus carpio) through YAP-TFR\/ROS signaling pathway","volume":"205","author":"Lu","year":"2024","journal-title":"Pestic. Biochem. Physiol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115072_bb0085","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.gtc.2020.08.002","article-title":"Osterman. biologic therapy for ulcerative colitis","volume":"49","author":"Bhattacharya","year":"2020","journal-title":"Gastroenterol. Clin. N. Am."},{"issue":"7","key":"10.1016\/j.intimp.2025.115072_bb0090","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1002\/ddr.21706","article-title":"Flufenamic acid alleviates sepsis-induced lung injury by up-regulating CBR1","volume":"81","author":"Jiang","year":"2020","journal-title":"Drug Dev. Res."},{"issue":"2","key":"10.1016\/j.intimp.2025.115072_bb0095","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.taap.2015.03.020","article-title":"Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-\u03baB and MAPK activation in macrophages and TPA-induced ear edema in mice","volume":"286","author":"Kim","year":"2015","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115072_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109634","article-title":"Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2 cells","volume":"348","author":"Endo","year":"2021","journal-title":"Chem. Biol. Interact."},{"issue":"10401","key":"10.1016\/j.intimp.2025.115072_bb0105","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.intimp.2025.115072_bb0110","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl5723","article-title":"m6A mRNA modification maintains colonic epithelial cell homeostasis via NF-\u03baB-mediated antiapoptotic pathway","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci. Adv."},{"issue":"14","key":"10.1016\/j.intimp.2025.115072_bb0115","article-title":"The loss of YTHDC1 in gut macrophages exacerbates inflammatory bowel disease","volume":"10","author":"Ge","year":"2023","journal-title":"Adv Sci (Weinh)."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0120","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41420-022-00849-1","article-title":"METTL3 overexpression aggravates LPS-induced cellular inflammation in mouse intestinal epithelial cells and DSS-induced IBD in mice","volume":"8","author":"Yang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.intimp.2025.115072_bb0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/s41419-024-06509-9","article-title":"The m6A reader IGF2BP2 regulates glycolytic metabolism and mediates histone lactylation to enhance hepatic stellate cell activation and liver fibrosis","volume":"15","author":"Zhou","year":"2024","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.intimp.2025.115072_bb0130","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1007\/s12265-023-10478-3","article-title":"CaMKII\u03b4, stabilized by RNA N6-Methyladenosine reader IGF2BP2, boosts Coxsackievirus B3-induced myocardial inflammation via interacting with TIRAP","volume":"17","author":"Xiao","year":"2024","journal-title":"J. Cardiovasc. Transl. Res."},{"key":"10.1016\/j.intimp.2025.115072_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110471","article-title":"Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K\/ Akt\/ NF-\u03baB pathway","volume":"129","author":"Ju","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115072_bb0140","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jare.2022.10.015","article-title":"Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): multi-omics reveals critical role of gut-liver axis","volume":"52","author":"Yin","year":"2023","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.115072_bb0145","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s10787-022-00955-7","article-title":"Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K\/AKT\/NF-\u03baB signaling pathways","volume":"30","author":"Ni","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2025.115072_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.880589","article-title":"Renshen Baidu powder protects ulcerative colitis via inhibiting the PI3K\/Akt\/NF-\u03baB signaling pathway","volume":"13","author":"Ye","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115072_bb0155","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ejphar.2014.04.024","article-title":"Protective effect of 7-O-succinyl macrolactin a against intestinal inflammation is mediated through PI3-kinase\/Akt\/mTOR and NF-\u03baB signaling pathways","volume":"735","author":"Park","year":"2014","journal-title":"Eur. J. Pharmacol."},{"issue":"Pt A","key":"10.1016\/j.intimp.2025.115072_bb0160","article-title":"The improved effect and its mechanism of phytic acid on DSS-induced UC mice","volume":"311","author":"Hou","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.115072_bb0165","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3389\/fphar.2020.01036","article-title":"Kuijieyuan decoction improved intestinal barrier injury of ulcerative colitis by affecting TLR4-dependent PI3K\/AKT\/NF-\u03baB oxidative and inflammatory signaling and gut microbiota","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115072_bb0170","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/MIB.0000000000000655","article-title":"Natural nuclear factor kappa Beta inhibitors: safe therapeutic options for inflammatory bowel disease","volume":"22","author":"Tambuwala","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"10.1016\/j.intimp.2025.115072_bb0175","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1631\/jzus.B2300409","article-title":"Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens","volume":"25","author":"Lu","year":"2024","journal-title":"J Zhejiang Univ Sci B"},{"issue":"7","key":"10.1016\/j.intimp.2025.115072_bb0180","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1093\/cvr\/cvab160","article-title":"mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification","volume":"118","author":"Kumari","year":"2022","journal-title":"Cardiovasc. Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.115072_bb0185","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"Huang","year":"2018","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0190","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-021-02212-1","article-title":"RNA N6-methyladenosine reader IGF2BP2 promotes lymphatic metastasis and epithelial-mesenchymal transition of head and neck squamous carcinoma cells via stabilizing slug mRNA in an m6A-dependent manner","volume":"41","author":"Yu","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"4","key":"10.1016\/j.intimp.2025.115072_bb0195","doi-asserted-by":"crossref","first-page":"4405","DOI":"10.1002\/cam4.5096","article-title":"IGF2BP2 promotes pancreatic carcinoma progression by enhancing the stability of B3GNT6 mRNA via m6A methylation","volume":"12","author":"Cao","year":"2023","journal-title":"Cancer Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0200","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13046-024-02996-y","article-title":"KLF7 regulates super-enhancer-driven IGF2BP2 overexpression to promote the progression of head and neck squamous cell carcinoma","volume":"43","author":"Cai","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0205","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12943-019-1105-0","article-title":"LncRNA LINRIS stabilizes IGF2BP2 and promotes the aerobic glycolysis in colorectal cancer","volume":"18","author":"Wang","year":"2019","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0210","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12943-022-01608-7","article-title":"CircEZH2\/miR-133b\/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA","volume":"21","author":"Yao","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2025.115072_bb0215","article-title":"Natural compounds target programmed cell death (PCD) signaling mechanism to treat ulcerative colitis: a review","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115072_bb0220","article-title":"IGF2BP2 regulates the progression of Alzheimer\u2019s disease through m6A-mediated NLRP3 Inflammasome","volume":"13","author":"Wu","year":"2025","journal-title":"Immun. Inflamm. Dis."},{"issue":"5","key":"10.1016\/j.intimp.2025.115072_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2025.167797","article-title":"The IGF2BP2-circ-DAPK1 axis promotes high-glucose-induced ferroptosis of HUVECs by decreasing NQO1 expression","volume":"1871","author":"Qiu","year":"2025","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"20","key":"10.1016\/j.intimp.2025.115072_bb0230","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1080\/15384101.2023.2283328","article-title":"IGF2BP2 promotes glycolysis and hepatocellular carcinoma stemness by stabilizing CDC45 mRNA via m6A modification","volume":"22","author":"Wu","year":"2023","journal-title":"Cell Cycle"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925010628?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925010628?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T19:59:30Z","timestamp":1775764770000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925010628"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":46,"alternative-id":["S1567576925010628"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115072","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGF2BP2 regulates inflammation in ulcerative colitis through N6-methyladenosine-dependent modulation of CBR1","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115072"}}