{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:39:21Z","timestamp":1791830361593,"version":"4.3.4"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160785"],"award-info":[{"award-number":["82160785"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304828"],"award-info":[{"award-number":["82304828"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360809"],"award-info":[{"award-number":["82360809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["ZYSE-2022-01"],"award-info":[{"award-number":["ZYSE-2022-01"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.intimp.2025.115165","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T19:32:40Z","timestamp":1752607960000},"page":"115165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Component characterization of Zanthoxylum nitidum extract and its anti-colitis effect through regulating PPAR\u03b3\/NF-\u03baB\/iNOS signaling pathway and gut microbiota"],"prefix":"10.1016","volume":"162","author":[{"given":"Qiang","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115165_bb0005","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41467-022-35592-9","article-title":"Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers","volume":"14","author":"Chatila","year":"2023","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2025.115165_bb0010","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.gtc.2020.07.005","article-title":"Epidemiology and pathogenesis of ulcerative colitis","volume":"49","author":"Du","year":"2020","journal-title":"Gastroenterol. Clin. N. Am."},{"key":"10.1016\/j.intimp.2025.115165_bb0015","article-title":"Trend and geographic variation in incidence and prevalence of inflammatory bowel disease in regions across China: a nationwide employee study between 2013 and 2016","volume":"9","author":"Yang","year":"2022","journal-title":"Front. Med."},{"key":"10.1016\/j.intimp.2025.115165_bb0020","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/ecco-jcc\/jjac127","article-title":"Analysis of systemic epigenetic alterations in inflammatory bowel disease: defining geographical, genetic and immune-inflammatory influences on the circulating methylome","volume":"17","author":"Kalla","year":"2022","journal-title":"J. Crohns Colitis"},{"issue":"10","key":"10.1016\/j.intimp.2025.115165_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.107883","article-title":"Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis","volume":"26","author":"Yang","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.intimp.2025.115165_bb0030","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.648915","article-title":"Repulsive guidance molecule b deficiency induces gut microbiota dysbiosis and increases the susceptibility to intestinal inflammation in mice","volume":"12","author":"Shi","year":"2021","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.intimp.2025.115165_bb0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/14728214.2020.1737009","article-title":"Emerging therapies for the treatment of ulcerative colitis","volume":"25","author":"Pugliese","year":"2020","journal-title":"Expert Opin. Emerg. Dr."},{"key":"10.1016\/j.intimp.2025.115165_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1268041","article-title":"Reviewing the potential of probiotics, prebiotics and synbiotics: advancements in treatment of ulcerative colitis","volume":"13","author":"Jadhav","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2025.115165_bb0045","first-page":"118","article-title":"Etrolizumab versus infliximab for the treatment of moderately to severely active ulcerative colitis (GARDENIA): a randomised, double-blind, double-dummy, phase 3 study, lancet","volume":"7","author":"Danese","year":"2022","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2025.115165_bb0050","doi-asserted-by":"crossref","DOI":"10.1093\/ibd\/izac260","article-title":"Induction and maintenance treatment with upadacitinib improves health-related quality of life in patients with moderately to severely active ulcerative colitis: phase 3 study results","author":"Panes","year":"2023","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2025.115165_bb0055","doi-asserted-by":"crossref","DOI":"10.1007\/s40273-023-01254-x","article-title":"Cost-effectiveness analysis of tofacitinib compared with biologics in biologic-naive patients with moderate-to-severe ulcerative colitis in Japan","author":"Kobayashi","year":"2023","journal-title":"Pharmacoeconomics"},{"key":"10.1016\/j.intimp.2025.115165_bb0060","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/00365521.2021.1998601","article-title":"Classification and clinical features of adverse drug reactions in patients with ulcerative colitis treated with 5-aminosalicylate acid: a single-center, observational study","volume":"57","author":"Tsujii","year":"2022","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.intimp.2025.115165_bb0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13020-018-0167-z","article-title":"Internationalization of traditional Chinese medicine: current international market, internationalization challenges and prospective suggestions","volume":"13","author":"Lin","year":"2018","journal-title":"Chin. Med."},{"key":"10.1016\/j.intimp.2025.115165_bb0070","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1002\/ptr.7561","article-title":"Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K\/AKT\/mTOR signaling pathway","volume":"36","author":"Zhai","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2025.115165_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2020.112345","article-title":"Distribution survey, phytochemical and transcriptome analysis to identify candidate genes involved in biosynthesis of functional components in Zanthoxylum nitidum","volume":"150","author":"Wang","year":"2020","journal-title":"Ind. Crop. Prod."},{"issue":"4","key":"10.1016\/j.intimp.2025.115165_bb0080","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3390\/ph17040524","article-title":"The therapeutic potential of four main compounds of Zanthoxylum nitidum (Roxb.) DC: a comprehensive study on biological processes, anti-inflammatory effects, and myocardial toxicity","volume":"17","author":"Li","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.intimp.2025.115165_bb0085","series-title":"Pharmacopoeia of the People\u2019s Republic of China","first-page":"176","volume":"vol. I","author":"Chinese Pharmacopoeia Commission","year":"2020"},{"key":"10.1016\/j.intimp.2025.115165_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2020.113232","article-title":"Rapid identification and pharmacokinetic studies of multiple active alkaloids in rat plasma through UPLC-Q-TOF-MS and UPLC-MS\/MS after the oral administration of Zanthoxylum nitidum extract","volume":"186","author":"Lin","year":"2020","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.intimp.2025.115165_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1046402","article-title":"Nitidine chloride, a benzophenanthridine alkaloid from Zanthoxylum nitidum (Roxb.) DC., exerts multiple beneficial properties, especially in tumors and inflammation-related diseases","volume":"13","author":"Lu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0100","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201098","article-title":"Zanthoxylum nitidum extract attenuates BMP-2-induced inflammation and hyperpermeability","volume":"40","author":"Hu","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.intimp.2025.115165_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112419","article-title":"Insight into the inhibitory effects of Zanthoxylum nitidum against helicobacter pylori urease and jack bean urease: kinetics and mechanism","volume":"249","author":"Lu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0110","doi-asserted-by":"crossref","first-page":"450","DOI":"10.3923\/ijp.2012.450.454","article-title":"Protective effect of Zanthoxylum nitidum bark in chemical and stress induced gastric mucosal lesions in male albino rats","volume":"8","author":"Bhattacharya","year":"2012","journal-title":"Int. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0115","first-page":"1102","article-title":"Study on the spectrum-effect relationship of Zathoxylum nitidum extracts against liver cancer","volume":"45","author":"Wang","year":"2014","journal-title":"Chin. Tradit. Herb. Drug"},{"key":"10.1016\/j.intimp.2025.115165_bb0120","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fphar.2019.00359","article-title":"Analgesic effect of Zanthoxylum nitidum extract in inflammatory pain models through targeting of ERK and NF-\u03baB signaling","volume":"10","author":"Qin","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112946","article-title":"Zanthoxylum nitidum (Roxb.) DC: traditional uses, phytochemistry, pharmacological activities and toxicology","volume":"260","author":"Lu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173912","article-title":"Coptisine ameliorates DSS-induced ulcerative colitis via improving intestinal barrier dysfunction and suppressing inflammatory response","volume":"896","author":"Wang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0135","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1002\/jsfa.11850","article-title":"Short-term treatment with zingerone ameliorates dextran sulfate sodium-induced mouse experimental colitis","volume":"102","author":"Zhang","year":"2022","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.intimp.2025.115165_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112944","article-title":"Huai hua san alleviates dextran sulphate sodium-induced colitis and modulates colonic microbiota","volume":"259","author":"Liu","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0145","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1039\/D0FO01724H","article-title":"Alleviation of DSS-induced colitis via lactobacillus acidophilus treatment in mice","volume":"12","author":"Kim","year":"2021","journal-title":"Food Funct."},{"issue":"11","key":"10.1016\/j.intimp.2025.115165_bb0150","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.3390\/microorganisms8111715","article-title":"The influence of probiotics on the Firmicutes\/Bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease","volume":"8","author":"Stojanov","year":"2020","journal-title":"Microorganisms"},{"key":"10.1016\/j.intimp.2025.115165_bb0155","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.phymed.2018.09.228","article-title":"Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo","volume":"52","author":"Li","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.115165_bb0160","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12876-019-1095-9","article-title":"Indirect costs associated with ulcerative colitis: a systematic literature review of real-world data","volume":"19","author":"Constantin","year":"2019","journal-title":"BMC Gastroenterol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115165_bb0165","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1186\/s12913-021-06816-3","article-title":"The cost burden of Crohn's disease and ulcerative colitis depending on biologic treatment status - a Danish register-based study","volume":"21","author":"Alulis","year":"2021","journal-title":"BMC Health Serv. Res."},{"key":"10.1016\/j.intimp.2025.115165_bb0170","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.carbpol.2018.01.013","article-title":"Therapeutic roles of polysaccharides from Dendrobium officinale on colitis and its underlying mechanisms","volume":"185","author":"Liang","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.intimp.2025.115165_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.112775","article-title":"Total alkaloids of Sophora alopecuroides L. ameliorated murine colitis by regulating bile acid metabolism and gut microbiota","volume":"255","author":"Jia","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0180","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8893621","article-title":"Anti-inflammatory effects of Heritiera littoralis fruits on dextran sulfate sodium- (DSS-) induced ulcerative colitis in mice by regulating gut microbiota and suppressing NF-\u03baB pathway","volume":"2020","author":"Lin","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2025.115165_bb0185","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1002\/cbdv.200690108","article-title":"Benzophenanthridine alkaloids from Zanthoxylum nitidum (Roxb.) DC, and their analgesic and anti-inflammatory activities","volume":"3","author":"Hu","year":"2006","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.intimp.2025.115165_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.794277","article-title":"Spectrum-effect relationship analysis of bioactive compounds in Zanthoxylum nitidum (Roxb.) DC. By ultra-high performance liquid chromatography mass spectrometry coupled with comprehensive filtering approaches","volume":"13","author":"Rao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0195","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00018-022-04471-3","article-title":"5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism","volume":"79","author":"Huang","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2025.115165_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118131","article-title":"Sarcandra glabra (Thunb.) Nakai alleviates DSS-induced ulcerative colitis by promoting restitution, restoring barrier function, and modulating IL-17\/ Notch1\/FoxP3 pathway in intestinal cells","volume":"328","author":"Zhang","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0205","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/bcpt.13720","article-title":"Fingolimod ameliorates acetic acid-induced ulcerative colitis: an insight into its modulatory impact on pro\/anti-inflammatory cytokines and AKT\/mTOR signalling","volume":"130","author":"Makled","year":"2022","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2025.115165_bb0210","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1155090","article-title":"CD73 mediated host purinergic metabolism in intestine contributes to the therapeutic efficacy of a novel mesenchymal-like endometrial regenerative cells against experimental colitis","volume":"14","author":"Shao","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115165_bb0215","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/diagnostics7020021","article-title":"Salivary IL-8, IL-6 and TNF-\u03b1 as potential diagnostic biomarkers for oral cancer","volume":"7","author":"Sahibzada","year":"2017","journal-title":"Diagnostics"},{"issue":"9","key":"10.1016\/j.intimp.2025.115165_bb0220","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.3390\/biomedicines11092511","article-title":"Fucoidan from Ericaria crinita alleviates inflammation in rat paw edema, downregulates pro-inflammatory cytokine levels, and shows antioxidant activity","volume":"11","author":"Lukova","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.intimp.2025.115165_bb0225","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1124\/jpet.301.1.59","article-title":"New cytokine delivery system using gelatin microspheres containing interleukin-10 for experimental inflammatory bowel disease","volume":"301","author":"Nakase","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2025.115165_bb0230","article-title":"Th2 cells lacking T-bet suppress naive and memory T cell responses via IL-10","volume":"USA.18(6)","author":"Mu\u00f1oz","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2025.115165_bb0235","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1556\/1886.2024.00009","article-title":"Carvacrol prophylaxis improves clinical outcome and dampens apoptotic and pro-inflammatory immune responses upon campylobacter jejuni infection of human microbiota-associated IL-10\u2212\/\u2212 mice","volume":"14","author":"Heimesaat","year":"2024","journal-title":"Eur. J. Microbiol. Immunol."},{"key":"10.1016\/j.intimp.2025.115165_bb0240","doi-asserted-by":"crossref","first-page":"730","DOI":"10.3389\/fphar.2020.00730","article-title":"Peroxisome proliferator-activated receptors: experimental targeting for the treatment of inflammatory bowel diseases","volume":"11","author":"Decara","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121766","article-title":"Polydatin ameliorates inflammation and oxidative stress associated with MSU-induced gouty arthritis in mice by regulating PPAR-\u03b3 and ferritin activation","volume":"326","author":"Du","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.115165_bb0250","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.03227-20","article-title":"5-aminosalicylic acid ameliorates colitis and checks dysbiotic Escherichia coli expansion by activating PPAR-\u03b3 signaling in the intestinal epithelium","volume":"12","author":"Cevallos","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.intimp.2025.115165_bb0255","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/932530","article-title":"Peroxisome proliferator-activated receptors family is involved in the response to treatment and mild clinical course in patients with ulcerative colitis","volume":"2014","author":"Yamamoto-Furusho","year":"2014","journal-title":"Dis. Markers"},{"key":"10.1016\/j.intimp.2025.115165_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109058","article-title":"Honokiol alleviates ulcerative colitis by targeting PPAR-\u03b3\u2013TLR4\u2013NF-\u03baB signaling and suppressing gasdermin-D-mediated pyroptosis in vivo and in vitro","volume":"111","author":"Wang","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105681","article-title":"Unripe Citrus unshiu peel inhibited pre-adipocyte's differentiation via leptin-PPAR\u03b3\/FAS pathway and pro-inflammatory cytokines' release","volume":"107","author":"Lee","year":"2023","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.intimp.2025.115165_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116293","article-title":"Ethanol extract of Piper wallichii ameliorates DSS-induced ulcerative colitis in mice: involvement of TLR4\/NF-\u03baB\/COX-2 signaling pathway","volume":"308","author":"Zhao","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2025.115165_bb0275","doi-asserted-by":"crossref","first-page":"6171","DOI":"10.1021\/acs.est.1c00515","article-title":"ROS-induced hepatotoxicity under cypermethrin: involvement of the crosstalk between Nrf2\/Keap1 and NF-\u03baB\/i\u03baB-\u03b1 pathways regulated by proteasome","volume":"55","author":"Zhao","year":"2021","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.intimp.2025.115165_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153631","article-title":"Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice","volume":"90","author":"Li","year":"2021","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2025.115165_bb0285","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00018-023-05051-9","article-title":"Calcium-sensing receptor and NF-\u03baB pathways in TN breast cancer contribute to cancer-induced cardiomyocyte damage via activating neutrophil extracellular traps formation","volume":"81","author":"Zeng","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2025.115165_bb0290","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.18632\/aging.202469","article-title":"Inhibiting TLR4 signaling by linarin for preventing inflammatory response in osteoarthritis","volume":"13","author":"Qi","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.intimp.2025.115165_bb0295","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10565-020-09563-z","article-title":"Systems pharmacology approach uncovers Ligustilide attenuates experimental colitis in mice by inhibiting PPAR\u03b3-mediated inflammation pathways","volume":"37","author":"Huang","year":"2021","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.intimp.2025.115165_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104355","article-title":"Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-\u03baB signaling through activation of PPAR\u03b3","volume":"147","author":"Li","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2025.115165_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172453","article-title":"Aesculin protects against DSS-induced colitis though activating PPAR\u03b3 and inhibiting NF-\u043aB pathway","volume":"857","author":"Tian","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0310","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bcp.2016.02.019","article-title":"Oroxyloside prevents dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-\u03baB pathway through PPAR\u03b3 activation","volume":"106","author":"Wang","year":"2016","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115165_bb0315","doi-asserted-by":"crossref","first-page":"18232","DOI":"10.1038\/s41598-023-45354-2","article-title":"Skimmianine attenuates liver ischemia\/reperfusion injury by regulating PI3K-AKT signaling pathway-mediated inflammation, apoptosis and oxidative stress","volume":"13","author":"Huo","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115165_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154394","article-title":"Sanguinarine ameliorates DSS induced ulcerative colitis by inhibiting NLRP3 inflammasome activation and modulating intestinal microbiota in C57BL\/6 mice","volume":"106","author":"Li","year":"2022","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.intimp.2025.115165_bb0325","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1002\/ptr.8271","article-title":"Magnoflorine alleviates dextran sulfate sodium-induced ulcerative colitis via inhibiting JAK2\/STAT3 signaling pathway","volume":"38","author":"Wen","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2025.115165_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104603","article-title":"Oxyberberine, a novel gut microbiota-mediated metabolite of berberine, possesses superior anti-colitis effect: impact on intestinal epithelial barrier, gut microbiota profile and TLR4-MyD88-NF-\u03baB pathway","volume":"152","author":"Li","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2025.115165_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.104110","article-title":"Tectochrysin ameliorates dextran sulfate sodium-induced chronic colitis by regulating the intestinal flora and inflammatory responses","volume":"60","author":"Yu","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.intimp.2025.115165_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114260","article-title":"\u0392-Patchoulene simultaneously ameliorated dextran sulfate sodium-induced colitis and secondary liver injury in mice via suppressing colonic leakage and flora imbalance","volume":"182","author":"Liu","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2023.105646","article-title":"Kaempferol relieves the DSS-induced chronic colitis in C57BL\/6J mice, alleviates intestinal angiogenesis, and regulates colonic microflora structure","volume":"107","author":"Yu","year":"2023","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.intimp.2025.115165_bb0350","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.intimp.2019.05.008","article-title":"Kakkalide and irisolidone alleviate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice by inhibiting lipopolysaccharide binding to toll-like receptor-4 and proteobacteria population","volume":"73","author":"Jang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115165_bb0355","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nutres.2021.04.008","article-title":"A rise in Proteobacteria is an indicator of gut-liver axis-mediated nonalcoholic fatty liver disease in high-fructose-fed adult mice","volume":"91","author":"Vasques-Monteiro","year":"2021","journal-title":"Nutr. Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.115165_bb0360","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13568-020-01114-3","article-title":"Nigella a ameliorates inflammation and intestinal flora imbalance in DSS induced colitis mice","volume":"10","author":"Hu","year":"2020","journal-title":"AMB Express"},{"issue":"25","key":"10.1016\/j.intimp.2025.115165_bb0365","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.3748\/wjg.v25.i25.3242","article-title":"Gut microbiota contributes to the distinction between two traditional Chinese medicine syndromes of ulcerative colitis","volume":"25","author":"Zhang","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"8","key":"10.1016\/j.intimp.2025.115165_bb0370","doi-asserted-by":"crossref","first-page":"6987","DOI":"10.1039\/C9FO02772F","article-title":"Sturgeon hydrolysates alleviate DSS-induced colon colitis in mice by modulating NF-\u03baB, MAPK, and microbiota composition","volume":"11","author":"Gao","year":"2020","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2025.115165_bb0375","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1089600","article-title":"The role of Akkermansia muciniphila in inflammatory bowel disease: current knowledge and perspectives","volume":"13","author":"Zheng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115165_bb0380","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41575-022-00631-9","article-title":"Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms","volume":"19","author":"Cani","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2025.115165_bb0385","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1126\/science.aam9949","article-title":"Microbiota-activated PPAR-\u03b3 signaling inhibits dysbiotic Enterobacteriaceae expansion","volume":"357","author":"Byndloss","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.intimp.2025.115165_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113571","article-title":"Gegen Qinlian decoction ameliorates murine colitis by inhibiting the expansion of Enterobacteriaceae through activating PPAR-\u03b3 signaling","volume":"154","author":"Hu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115165_bb0395","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1126\/science.1232467","article-title":"Host-derived nitrate boosts growth of E. Coli in the inflamed gut","volume":"339","author":"Winter","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.intimp.2025.115165_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154106","article-title":"Emodin targeting the colonic metabolism via PPAR\u03b3 alleviates UC by inhibiting facultative anaerobe","volume":"104","author":"Luo","year":"2022","journal-title":"Phytomedicine"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925011555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925011555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T03:33:08Z","timestamp":1786159988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925011555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":80,"alternative-id":["S1567576925011555"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115165","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Component characterization of Zanthoxylum nitidum extract and its anti-colitis effect through regulating PPAR\u03b3\/NF-\u03baB\/iNOS signaling pathway and gut microbiota","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115165"}}