{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:48:34Z","timestamp":1792270114751,"version":"4.4.0"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273006"],"award-info":[{"award-number":["82273006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.intimp.2025.115230","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T01:27:00Z","timestamp":1753234020000},"page":"115230","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Hernandezine alleviates inflammatory bowel disease by enhancing gut barrier integrity via the AMPK\/NRF2 pathway and regulating immune-metabolic balance"],"prefix":"10.1016","volume":"163","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7353-0262","authenticated-orcid":false,"given":"Tianyu","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuheng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingye","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyang","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115230_bb0005","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cyto.2004.07.012","article-title":"New cytokine therapeutics for inflammatory bowel disease","volume":"28","author":"Stokkers","year":"2004","journal-title":"Cytokine"},{"issue":"301\u2013318","key":"10.1016\/j.intimp.2025.115230_bb0010","first-page":"ix","article-title":"Inflammatory bowel disease","volume":"19","author":"Szigethy","year":"2010","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.intimp.2025.115230_bb0015","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2025.115230_bb0020","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/brv.12608","article-title":"Exosome-mediated effects and applications in inflammatory bowel disease","volume":"95","author":"Ocansey","year":"2020","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.intimp.2025.115230_bb0025","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2025.115230_bb0030","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease","volume":"448","author":"Xavier","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115230_bb0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/ajg.2014.357","article-title":"Treatment of IBD: where we are and where we are going","volume":"110","author":"Bernstein","year":"2015","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.intimp.2025.115230_bb0040","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2036.2010.04489.x","article-title":"Review article: explaining risks of inflammatory bowel disease therapy to patients","volume":"33","author":"Siegel","year":"2011","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2025.115230_bb0045","doi-asserted-by":"crossref","first-page":"5389","DOI":"10.2147\/JIR.S470520","article-title":"Restore intestinal barrier integrity: an approach for inflammatory bowel disease therapy","volume":"17","author":"Kong","year":"2024","journal-title":"JIR"},{"key":"10.1016\/j.intimp.2025.115230_bb0050","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/all.15683","article-title":"BTEX exposure and its body burden pose differential risks for asthma and its phenotypic clusters","volume":"78","author":"Hsu","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2025.115230_bb0055","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.2147\/IJN.S370784","article-title":"Extracellular vesicles: the next generation Theranostic nanomedicine for inflammatory bowel disease","volume":"17","author":"Li","year":"2022","journal-title":"IJN"},{"key":"10.1016\/j.intimp.2025.115230_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115084","article-title":"Potential activity of traditional Chinese medicine against ulcerative colitis: a review","volume":"289","author":"Liu","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115230_bb0065","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s12224-018-9326-3","article-title":"Thalictrum nainitalense (Ranunculaceae), a new species from the Uttarakhand Himalaya, India","volume":"53","author":"Singh","year":"2018","journal-title":"Folia Geobot."},{"key":"10.1016\/j.intimp.2025.115230_bb0070","series-title":"Presented at the proceedings of SPIE \u2013 the International Society for Optical Engineering","first-page":"58","article-title":"Parallelism analysis of memory system in single-chip VLIW video signal processors","author":"Wu","year":"1998"},{"key":"10.1016\/j.intimp.2025.115230_bb0075","first-page":"57","article-title":"The alkaloids of the roots of Thalictrum flavum L","volume":"4","author":"Velcheva","year":"1992","journal-title":"Acta Pharm. Nord."},{"key":"10.1016\/j.intimp.2025.115230_bb0080","doi-asserted-by":"crossref","first-page":"8090","DOI":"10.18632\/oncotarget.6980","article-title":"Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers","volume":"7","author":"Law","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.intimp.2025.115230_bb0085","doi-asserted-by":"crossref","first-page":"67218","DOI":"10.18632\/oncotarget.18365","article-title":"A novel AMPK activator hernandezine inhibits LPS-induced TNF\u03b1 production","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.intimp.2025.115230_bb0090","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/cdd.2017.14","article-title":"AMPK improves gut epithelial differentiation and barrier function via regulating Cdx2 expression","volume":"24","author":"Sun","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2025.115230_bb0095","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1136\/gut.2005.085373","article-title":"Alterations in intestinal permeability","volume":"55","author":"Arrieta","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2025.115230_bb0100","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1161\/CIRCULATIONAHA.111.078212","article-title":"Rheb is a critical regulator of autophagy during myocardial ischemia","volume":"125","author":"Sciarretta","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2025.115230_bb0105","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/labinvest.2012.75","article-title":"Metformin protects against the development of fructose-induced steatosis in mice: role of the intestinal barrier function","volume":"92","author":"Spruss","year":"2012","journal-title":"Lab. Investig."},{"issue":"4","key":"10.1016\/j.intimp.2025.115230_bb0110","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3109\/10409238.2010.488215","article-title":"AMPK inhibition in health and disease","volume":"45","author":"Viollet","year":"2010","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.intimp.2025.115230_bb0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41575-020-00399-w","article-title":"The intestinal barrier, an arbitrator turned provocateur in IBD","volume":"18","author":"Mehandru","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2025.115230_bb0120","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s10787-022-00980-6","article-title":"The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases","volume":"30","author":"Hasanvand","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2025.115230_bb0125","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.intimp.2025.115230_bb0130","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/s41419-018-1223-4","article-title":"Mast cells are essential intermediaries in regulating IL-33\/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons","volume":"9","author":"He","year":"2018","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.115230_bb0400","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-32505-8","article-title":"Mannose ameliorates experimental colitis by protecting intestinal barrier integrity","volume":"13","author":"Dong","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115230_bb0135","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1007\/s10753-022-01704-2","article-title":"Effects of resveratrol on tight junction proteins and the Notch1 pathway in an HT-29 cell model of inflammation induced by lipopolysaccharide","volume":"45","author":"Luo","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2025.115230_bb0140","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1097\/MIB.0000000000000421","article-title":"Syndecan-1 acts in synergy with tight junction through Stat3 signaling to maintain intestinal mucosal barrier and prevent bacterial translocation","volume":"21","author":"Wang","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2025.115230_bb0145","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1128\/MCB.00118-16","article-title":"AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at serine 550","volume":"36","author":"Joo","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.intimp.2025.115230_bb0150","doi-asserted-by":"crossref","first-page":"3272","DOI":"10.1021\/acs.molpharmaceut.8b00332","article-title":"Metformin protects against LPS-induced intestinal barrier dysfunction by activating AMPK pathway","volume":"15","author":"Wu","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.intimp.2025.115230_bb0155","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1089\/ars.2012.4530","article-title":"Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets","volume":"19","author":"Biasi","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2025.115230_bb0160","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ijbiomac.2017.02.024","article-title":"Astragalus polysaccharides protect against dextran sulfate sodium-induced colitis by inhibiting NF-\u03ba\u0412 activation","volume":"98","author":"Lv","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.115230_bb0410","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3748\/wjg.v26.i1.55","article-title":"Synergistic protection of astragalus polysaccharides and matrine against ulcerative colitis and associated lung injury in rats","volume":"26","author":"Yan","year":"2020","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2025.115230_bb0165","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1021\/acs.jnatprod.6b00597","article-title":"Hernandezine, a Bisbenzylisoquinoline alkaloid with selective inhibitory activity against multidrug-resistance-linked ATP-binding cassette drug transporter ABCB1","volume":"79","author":"Hsiao","year":"2016","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.intimp.2025.115230_bb0170","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.3390\/molecules24193622","article-title":"Interaction effects between doxorubicin and Hernandezine on the pharmacokinetics by liquid chromatography coupled with mass spectrometry","volume":"24","author":"Song","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2025.115230_bb0175","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41401-022-01006-1","article-title":"Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS\/AMPK signaling pathway","volume":"44","author":"Song","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2025.115230_bb0180","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.bcp.2010.08.009","article-title":"AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis","volume":"80","author":"Bai","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115230_bb0185","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-018-07859-7","article-title":"Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway","volume":"10","author":"Singh","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115230_bb0190","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1083\/jcb.134.4.1031","article-title":"Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by expression of a mutant tight junction membrane protein","volume":"134","author":"Balda","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.intimp.2025.115230_bb0195","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1083\/jcb.143.2.391","article-title":"A single gene product, claudin-1 or \u22122, reconstitutes tight junction strands and recruits occludin in fibroblasts","volume":"143","author":"Furuse","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.intimp.2025.115230_bb0200","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3945\/jn.110.125633","article-title":"Kaempferol enhances intestinal barrier function through the cytoskeletal association and expression of tight junction proteins in Caco-2 cells","volume":"141","author":"Suzuki","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.intimp.2025.115230_bb0205","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3945\/jn.110.135657","article-title":"Regulation of tight junction permeability by intestinal bacteria and dietary components","volume":"141","author":"Ulluwishewa","year":"2011","journal-title":"J. Nutr."},{"key":"10.1016\/j.intimp.2025.115230_bb0210","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1128\/MCB.24.16.7130-7139.2004","article-title":"Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2","volume":"24","author":"Kobayashi","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.intimp.2025.115230_bb0215","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.tips.2013.04.005","article-title":"Toward clinical application of the Keap1-Nrf2 pathway","volume":"34","author":"Suzuki","year":"2013","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2025.115230_bb0220","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00394-011-0269-1","article-title":"Procyanidin B2 induces Nrf2 translocation and glutathione S-transferase P1 expression via ERKs and p38-MAPK pathways and protect human colonic cells against oxidative stress","volume":"51","author":"Rodr\u00edguez-Ramiro","year":"2012","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.intimp.2025.115230_bb0225","doi-asserted-by":"crossref","first-page":"11580","DOI":"10.1158\/0008-5472.CAN-06-3562","article-title":"Nrf2-deficient mice have an increased susceptibility to dextran sulfate sodium-induced colitis","volume":"66","author":"Khor","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2025.115230_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108710","article-title":"Maackiain protects against sepsis via activating AMPK\/Nrf2\/HO-1 pathway","volume":"108","author":"Bai","year":"2022","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115230_bb0235","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3389\/fnmol.2018.00267","article-title":"Trilobatin protects against oxidative injury in neuronal PC12 cells through regulating mitochondrial ROS homeostasis mediated by AMPK\/Nrf2\/Sirt3 signaling pathway","volume":"11","author":"Gao","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2025.115230_bb0240","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3389\/fphar.2020.00662","article-title":"Dihydroquercetin activates AMPK\/Nrf2\/HO-1 signaling in macrophages and attenuates inflammation in LPS-induced Endotoxemic mice","volume":"11","author":"Lei","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115230_bb0245","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1089\/neu.2016.4764","article-title":"Extracellular signal-regulated kinase\/nuclear factor-Erythroid2-like2\/Heme Oxygenase-1 pathway-mediated Mitophagy alleviates traumatic brain injury-induced intestinal mucosa damage and epithelial barrier dysfunction","volume":"34","author":"Liu","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.intimp.2025.115230_bb0250","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s10620-014-3428-4","article-title":"Role of Nrf2 dysfunction in uremia-associated intestinal inflammation and epithelial barrier disruption","volume":"60","author":"Lau","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.intimp.2025.115230_bb0255","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.taap.2014.07.011","article-title":"Upregulation of heme oxygenase-1 expression by dehydrodiconiferyl alcohol (DHCA) through the AMPK-Nrf2 dependent pathway","volume":"281","author":"Lee","year":"2014","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115230_bb0260","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1189\/jlb.0109006","article-title":"All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg\/Th17 profile in human ulcerative and murine colitis","volume":"86","author":"Bai","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2025.115230_bb0405","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8813558","article-title":"The function and role of the Th17\/Treg cell balance in inflammatory bowel disease","volume":"2020","author":"Yan","year":"2020","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.intimp.2025.115230_bb0265","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2007.11.016","article-title":"T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma","volume":"28","author":"Yang","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2025.115230_bb0270","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1172\/JCI25112","article-title":"Defective regulatory and effector T cell functions in patients with FOXP3 mutations","volume":"116","author":"Bacchetta","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2025.115230_bb0275","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/ni904","article-title":"Foxp3 programs the development and function of CD4+CD25+ regulatory T cells","volume":"4","author":"Fontenot","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.115230_bb0280","doi-asserted-by":"crossref","first-page":"6323","DOI":"10.4049\/jimmunol.171.12.6323","article-title":"The regulatory T cell family: distinct subsets and their interrelations","volume":"171","author":"Jonuleit","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.115230_bb0285","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ibd.20753","article-title":"Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis","volume":"15","author":"Alex","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2025.115230_bb0290","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1074-7613(03)00208-5","article-title":"Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6","volume":"19","author":"Jego","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2025.115230_bb0295","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/gutjnl-2016-312135","article-title":"Interplay of host genetics and gut microbiota underlying the onset and clinical presentation of inflammatory bowel disease","volume":"67","author":"Imhann","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2025.115230_bb0300","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-230X-13-20","article-title":"Clostridium leptum group bacteria abundance and diversity in the fecal microbiota of patients with inflammatory bowel disease: a case-control study in India","volume":"13","author":"Kabeerdoss","year":"2013","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.intimp.2025.115230_bb0305","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/gut.2003.025403","article-title":"Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease","volume":"53","author":"Ott","year":"2004","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2025.115230_bb0310","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nri3661","article-title":"Cytokines in inflammatory bowel disease","volume":"14","author":"Neurath","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.115230_bb0315","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/imm.12231","article-title":"The microbiome and regulation of mucosal immunity","volume":"142","author":"McDermott","year":"2014","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2025.115230_bb0320","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1096\/fj.201801897R","article-title":"Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity","volume":"33","author":"Kayser","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2025.115230_bb0325","doi-asserted-by":"crossref","first-page":"2902","DOI":"10.1074\/jbc.M114.610733","article-title":"A gut microbial metabolite of linoleic acid, 10-hydroxy-cis-12-octadecenoic acid, ameliorates intestinal epithelial barrier impairment partially via GPR40-MEK-ERK pathway","volume":"290","author":"Miyamoto","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.115230_bb0330","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.biopha.2018.10.112","article-title":"Gambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-\u03baB and MAPK activation to reduce inflammation in LPS-activated RAW264.7 cells","volume":"109","author":"Ren","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115230_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2024.105328","article-title":"Attenuation by Zhiqiao neohesperidin on dextran sulfate sodium-induced colitis in mice through inhibition of the TLR4\/NF-\u03baB pathway","volume":"62","author":"Li","year":"2024","journal-title":"Food Biosci."},{"key":"10.1016\/j.intimp.2025.115230_bb0340","article-title":"The neuroprotective effect of Isotetrandrine on Parkinson's disease via anti-inflammation and Antiapoptosis in vitro and in vivo","volume":"2023","author":"Wu","year":"2023","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.intimp.2025.115230_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e12344","article-title":"Fluvoxamine ameliorates oxidative stress and inflammation induced by bile-duct ligation in male rats","volume":"8","author":"Barmoudeh","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.intimp.2025.115230_bb0350","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1038\/s41598-017-04968-z","article-title":"Fluvoxamine stimulates oligodendrogenesis of cultured neural stem cells and attenuates inflammation and demyelination in an animal model of multiple sclerosis","volume":"7","author":"Ghareghani","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115230_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2023.104252","article-title":"Chemical components and health benefits of Rubus suavissimus S. Lee (Chinese sweet tea) and the production method of rubusoside","volume":"143","author":"Liu","year":"2024","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.intimp.2025.115230_bb0360","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1124\/jpet.117.244319","article-title":"Adenosine A2A receptor agonist, 2-p-(2-Carboxyethyl)phenethylamino-5\u2019-N-ethylcarboxamidoadenosine hydrochloride hydrate, inhibits inflammation and increases fibroblast growth Factor-2 tissue expression in carrageenan-induced rat paw edema","volume":"364","author":"Ialenti","year":"2018","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.intimp.2025.115230_bb0365","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj7666","article-title":"Disruption of epithelium integrity by inflammation-associated fibroblasts through prostaglandin signaling","volume":"10","author":"Dong","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2025.115230_bb0370","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ebiom.2019.03.071","article-title":"Inflammation associated ethanolamine facilitates infection by Crohn's disease-linked adherent-invasive Escherichia coli","volume":"43","author":"Ormsby","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2025.115230_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118587","article-title":"Changes in serum inflammatory cytokine levels and intestinal flora in a self-healing dextran sodium sulfate-induced ulcerative colitis murine model","volume":"263","author":"Jialing","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.115230_bb0380","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2297831","article-title":"DSS treatment does not affect murine colonic microbiota in absence of the host","volume":"16","author":"Krause","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.intimp.2025.115230_bb0385","article-title":"Clostridium butyricum and Chitooligosaccharides in Synbiotic combination ameliorate symptoms in a DSS-induced ulcerative colitis mouse model by modulating gut microbiota and enhancing intestinal barrier function","volume":"11","author":"Huang","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.intimp.2025.115230_bb0390","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1021\/jf803638d","article-title":"Effect of a low dose of dietary resveratrol on colon microbiota, inflammation and tissue damage in a DSS-induced colitis rat model","volume":"57","author":"Larrosa","year":"2009","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2025.115230_bb0395","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1248\/bpb.b22-00612","article-title":"Inhibitory effect of Hernandezine on the proliferation of hepatocellular carcinoma","volume":"46","author":"Kuok","year":"2023","journal-title":"Biol. Pharm. Bull."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925012202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925012202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:10:47Z","timestamp":1757913047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925012202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":82,"alternative-id":["S1567576925012202"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115230","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hernandezine alleviates inflammatory bowel disease by enhancing gut barrier integrity via the AMPK\/NRF2 pathway and regulating immune-metabolic balance","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115230","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115230"}}