{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:43:49Z","timestamp":1790657029621,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700651"],"award-info":[{"award-number":["81700651"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX25_2154"],"award-info":[{"award-number":["KYCX25_2154"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["JX12214136"],"award-info":[{"award-number":["JX12214136"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.intimp.2025.115236","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T22:46:44Z","timestamp":1753138004000},"page":"115236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["NEK7 mediates ESRD-associated endothelial injury by activating the NLRP3 inflammasome"],"prefix":"10.1016","volume":"163","author":[{"given":"Le","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songming","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanjun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115236_bb0005","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"Clinical practice guideline for the evaluation and Management of Chronic Kidney Disease","volume":"105","author":"KDIGO","year":"2024","journal-title":"Kidney Int."},{"key":"10.1016\/j.intimp.2025.115236_bb0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1056\/NEJMe2215286","article-title":"Chronic kidney disease - another step forward","volume":"388","author":"August","year":"2023","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2025.115236_bb0015","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cca.2019.08.030","article-title":"Chronic kidney disease: biomarker diagnosis to therapeutic targets","volume":"499","author":"Wang","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.intimp.2025.115236_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115407","article-title":"Chronic kidney disease-induced muscle atrophy: molecular mechanisms and promising therapies","volume":"208","author":"Wang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115236_bb0025","first-page":"e24","article-title":"Kidney fibrosis: fundamental questions, challenges, and perspectives","volume":"11","author":"Liu","year":"2024","journal-title":"Integrative Med. Nephrology Androl."},{"key":"10.1016\/j.intimp.2025.115236_bb0030","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1159\/000528560","article-title":"Cardiovascular risk prediction in chronic kidney disease","volume":"53","author":"Li","year":"2022","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.intimp.2025.115236_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000520909","article-title":"Heart failure in patients with diabetes and chronic kidney disease: challenges and opportunities","volume":"12","author":"Vijay","year":"2022","journal-title":"Cardiorenal Med."},{"key":"10.1016\/j.intimp.2025.115236_bb0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.14797\/mdcvj.1119","article-title":"Hypertension Management in Patients with chronic kidney disease","volume":"18","author":"Hebert","year":"2022","journal-title":"Methodist Debakey Cardiovasc. J."},{"key":"10.1016\/j.intimp.2025.115236_bb0045","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00059-021-05029-y","article-title":"Cardiovascular disease in patients with chronic kidney disease","volume":"46","author":"Marx","year":"2021","journal-title":"Herz"},{"key":"10.1016\/j.intimp.2025.115236_bb0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2021.09.007","article-title":"Chronic kidney disease measures for cardiovascular risk prediction","volume":"335","author":"Mok","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.intimp.2025.115236_bb0055","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1053\/j.ajkd.2018.12.044","article-title":"Hypertension in CKD: Core curriculum 2019","volume":"74","author":"Ku","year":"2019","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.intimp.2025.115236_bb0060","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.2215\/CJN.02660221","article-title":"Classification of uremic toxins and their role in kidney failure","volume":"16","author":"Rosner","year":"2021","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.intimp.2025.115236_bb0065","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1681\/ASN.2011121175","article-title":"Normal and pathologic concentrations of uremic toxins","volume":"23","author":"Duranton","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.intimp.2025.115236_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/toxins8120358","article-title":"Indoxyl sulfate-review of toxicity and therapeutic strategies","volume":"8","author":"Leong","year":"2016","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.intimp.2025.115236_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12110684","article-title":"Indoxyl sulfate, a tubular toxin, contributes to the development of chronic kidney disease","volume":"12","author":"Cheng","year":"2020","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.intimp.2025.115236_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/toxins10090367","article-title":"Impacts of Indoxyl sulfate and p-cresol sulfate on chronic kidney disease and mitigating effects of AST-120","volume":"10","author":"Liu","year":"2018","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.intimp.2025.115236_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12040229","article-title":"Indoxyl sulfate, a uremic Endotheliotoxin","volume":"12","author":"Lano","year":"2020","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.intimp.2025.115236_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/toxins11080454","article-title":"Indoxyl sulfate stimulates angiogenesis by regulating reactive oxygen species production via CYP1B1","volume":"11","author":"Pei","year":"2019","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.intimp.2025.115236_bb0095","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4174\/astr.2017.93.1.11","article-title":"The effects of indoxyl sulfate-induced endothelial microparticles on neointimal hyperplasia formation in an ex vivo model","volume":"93","author":"Ryu","year":"2017","journal-title":"Ann Surg Treat Res."},{"key":"10.1016\/j.intimp.2025.115236_bb0100","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1113\/jphysiol.2014.283887","article-title":"Effect of uraemia on endothelial cell damage is mediated by the integrin linked kinase pathway","volume":"593","author":"Garc\u00eda-J\u00e9rez","year":"2015","journal-title":"J. Physiol."},{"key":"10.1016\/j.intimp.2025.115236_bb0105","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jfma.2019.03.005","article-title":"Serum indoxyl sulfate predicts adverse cardiovascular events in patients with chronic kidney disease","volume":"118","author":"Fan","year":"2019","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.intimp.2025.115236_bb0110","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1007\/s00204-015-1652-0","article-title":"Indoxyl sulfate enhances IL-1\u03b2-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS\/MAPKs\/NF\u03baB\/AP-1 pathway","volume":"90","author":"Shen","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.intimp.2025.115236_bb0115","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1189\/jlb.0112023","article-title":"Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease","volume":"93","author":"Ito","year":"2013","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2025.115236_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118807","article-title":"Indoxyl sulfate induces ROS production via the aryl hydrocarbon receptor-NADPH oxidase pathway and inactivates NO in vascular tissues","volume":"265","author":"Nakagawa","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.115236_bb0125","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10456-013-9339-8","article-title":"In acute kidney injury, indoxyl sulfate impairs human endothelial progenitor cells: modulation by statin","volume":"16","author":"Wu","year":"2013","journal-title":"Angiogenesis"},{"key":"10.1016\/j.intimp.2025.115236_bb0130","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1080\/13880209.2023.2208617","article-title":"Qiqilian ameliorates vascular endothelial dysfunction by inhibiting NLRP3-ASC inflammasome activation in vivo and in vitro","volume":"61","author":"Luo","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2025.115236_bb0135","article-title":"Sinapine thiocyanate ameliorates vascular endothelial dysfunction in hypertension by inhibiting activation of the NLRP3 Inflammasome","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115236_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154131","article-title":"Berberine alleviates NLRP3 inflammasome induced endothelial junction dysfunction through ca(2+) signalling in inflammatory vascular injury","volume":"101","author":"Dai","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.115236_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2022.104384","article-title":"NLRP3 inflammasome contributes to endothelial dysfunction in angiotensin II-induced hypertension in mice","volume":"143","author":"Li","year":"2022","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.intimp.2025.115236_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.128867","article-title":"NLRP3 inflammasome-mediated endothelial cells pyroptosis is involved in decabromodiphenyl ethane-induced vascular endothelial injury","volume":"267","author":"Zheng","year":"2021","journal-title":"Chemosphere"},{"key":"10.1016\/j.intimp.2025.115236_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108334","article-title":"iNOS regulates activation of the NLRP3 inflammasome through the sGC\/cGMP\/PKG\/TACE\/TNF-\u03b1 axis in response to cigarette smoke resulting in aortic endothelial pyroptosis and vascular dysfunction","volume":"101","author":"Liao","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115236_bb0160","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.4049\/jimmunol.2000217","article-title":"NLRP3 Inflammasome activation in lung vascular endothelial cells contributes to intestinal ischemia\/reperfusion-induced acute lung injury","volume":"205","author":"Ito","year":"2020","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.115236_bb0165","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.apsb.2019.02.008","article-title":"Aspirin alleviates endothelial gap junction dysfunction through inhibition of NLRP3 inflammasome activation in LPS-induced vascular injury","volume":"9","author":"Zhou","year":"2019","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.intimp.2025.115236_bb0170","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000484623","article-title":"Trimethylamine-N-oxide instigates NLRP3 Inflammasome activation and endothelial dysfunction","volume":"44","author":"Boini","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.intimp.2025.115236_bb0175","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbrc.2016.11.017","article-title":"Trimethylamine N-oxide induces inflammation and endothelial dysfunction in human umbilical vein endothelial cells via activating ROS-TXNIP-NLRP3 inflammasome","volume":"481","author":"Sun","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2025.115236_bb0180","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 Inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.115236_bb0185","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10787-022-01026-7","article-title":"NEK7: a new target for the treatment of multiple tumors and chronic inflammatory diseases","volume":"30","author":"Wang","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2025.115236_bb0190","doi-asserted-by":"crossref","first-page":"4074","DOI":"10.1021\/pr500437x","article-title":"Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6","volume":"13","author":"de Souza","year":"2014","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.intimp.2025.115236_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2023.11.015","article-title":"ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation","volume":"83","author":"Zheng","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2025.115236_bb0200","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115236_bb0205","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115236_bb0210","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ni.3333","article-title":"NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component","volume":"17","author":"Shi","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.115236_bb0215","doi-asserted-by":"crossref","first-page":"F1081","DOI":"10.1152\/ajprenal.00534.2015","article-title":"NLRP3 deletion protects against renal fibrosis and attenuates mitochondrial abnormality in mouse with 5\/6 nephrectomy","volume":"310","author":"Gong","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.intimp.2025.115236_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109819","article-title":"Carnosic acid inhibits NLRP3 inflammasome activation by targeting both priming and assembly steps","volume":"116","author":"Lin","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115236_bb0225","doi-asserted-by":"crossref","first-page":"8396","DOI":"10.1038\/s41467-023-44203-0","article-title":"Acetylation is required for full activation of the NLRP3 inflammasome","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115236_bb0230","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4049\/immunohorizons.2200058","article-title":"NLRP3 Inflammasome priming and activation are regulated by a phosphatidylinositol-dependent mechanism","volume":"6","author":"Hamilton","year":"2022","journal-title":"Immunohorizons"},{"key":"10.1016\/j.intimp.2025.115236_bb0235","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.765477","article-title":"Intracellular NAD(+) depletion confers a priming signal for NLRP3 Inflammasome activation","volume":"12","author":"Shim","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115236_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153521","article-title":"Baeckein E suppressed NLRP3 inflammasome activation through inhibiting both the priming and assembly procedure: implications for gout therapy","volume":"84","author":"Lin","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.115236_bb0245","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.bbrc.2020.06.075","article-title":"Aldehyde dehydrogenase 2 inhibited oxidized LDL-induced NLRP3 inflammasome priming and activation via attenuating oxidative stress","volume":"529","author":"Xu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2025.115236_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109937","article-title":"ROS-induced NLRP3 inflammasome priming and activation mediate PCB 118- induced pyroptosis in endothelial cells","volume":"189","author":"Long","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.intimp.2025.115236_bb0255","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.565924","article-title":"Priming is dispensable for NLRP3 Inflammasome activation in human monocytes in vitro","volume":"11","author":"Gritsenko","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115236_bb0260","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.3389\/fimmu.2019.01108","article-title":"Chemotherapeutic agent paclitaxel mediates priming of NLRP3 Inflammasome activation","volume":"10","author":"Son","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115236_bb0265","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s41423-021-00670-3","article-title":"An update on the regulatory mechanisms of NLRP3 inflammasome activation","volume":"18","author":"Paik","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2025.115236_bb0270","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/s42003-023-05426-5","article-title":"MafB regulates NLRP3 inflammasome activation by sustaining p62 expression in macrophages","volume":"6","author":"Cui","year":"2023","journal-title":"Commun Biol."},{"key":"10.1016\/j.intimp.2025.115236_bb0275","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s10495-019-01582-4","article-title":"MicroRNA-214 targets COX-2 to antagonize indoxyl sulfate (IS)-induced endothelial cell apoptosis","volume":"25","author":"Li","year":"2020","journal-title":"Apoptosis"},{"key":"10.1016\/j.intimp.2025.115236_bb0280","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ekir.2023.01.008","article-title":"The transcriptomics of the human vein transformation after arteriovenous fistula anastomosis uncovers layer-specific remodeling and hallmarks of maturation failure","volume":"8","author":"Martinez","year":"2023","journal-title":"Kidney Int Rep."},{"key":"10.1016\/j.intimp.2025.115236_bb0285","doi-asserted-by":"crossref","first-page":"F477","DOI":"10.1152\/ajprenal.00472.2015","article-title":"Effect of chronic uremia on the transcriptional profile of the calcified aorta analyzed by RNA sequencing","volume":"310","author":"Rukov","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.intimp.2025.115236_bb0290","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/apha.12724","article-title":"Adenine-induced chronic renal failure in rats decreases aortic relaxation rate and alters expression of proteins involved in vascular smooth muscle calcium handling","volume":"218","author":"Nguy","year":"2016","journal-title":"Acta Physiol (Oxford)"},{"key":"10.1016\/j.intimp.2025.115236_bb0295","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1159\/000112823","article-title":"Indoxyl sulfate reduces superoxide scavenging activity in the kidneys of normal and uremic rats","volume":"28","author":"Owada","year":"2008","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.intimp.2025.115236_bb0300","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9082359","article-title":"Endothelial dysfunction in chronic kidney disease, from biology to clinical outcomes: a 2020 update","volume":"9","author":"Roumeliotis","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2025.115236_bb0305","doi-asserted-by":"crossref","first-page":"iii28","DOI":"10.1093\/ndt\/gfy174","article-title":"Cardiovascular disease in dialysis patients","volume":"33","author":"Cozzolino","year":"2018","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.intimp.2025.115236_bb0310","doi-asserted-by":"crossref","first-page":"416","DOI":"10.3390\/toxins6020416","article-title":"Binding affinity and capacity for the uremic toxin indoxyl sulfate","volume":"6","author":"Devine","year":"2014","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.intimp.2025.115236_bb0315","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26040976","article-title":"NLRP3 Inflammasome inhibitors in cardiovascular diseases","volume":"26","author":"Mezzaroma","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2025.115236_bb0320","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fimmu.2015.00155","article-title":"Pro-coagulant endothelial dysfunction results from EHEC Shiga toxins and host damage-associated molecular patterns","volume":"6","author":"Mayer","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115236_bb0325","doi-asserted-by":"crossref","DOI":"10.3390\/toxins12060361","article-title":"Endothelial damage, inflammation and immunity in chronic kidney disease","volume":"12","author":"Diaz-Ricart","year":"2020","journal-title":"Toxins (Basel)."},{"key":"10.1016\/j.intimp.2025.115236_bb0330","doi-asserted-by":"crossref","first-page":"348","DOI":"10.2741\/4595","article-title":"Uremic toxins are conditional danger- or homeostasis-associated molecular patterns","volume":"23","author":"Sun","year":"2018","journal-title":"Front Biosci (Landmark Ed)."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925012263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925012263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:09:27Z","timestamp":1757912967000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925012263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":66,"alternative-id":["S1567576925012263"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115236","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NEK7 mediates ESRD-associated endothelial injury by activating the NLRP3 inflammasome","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115236","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115236"}}