{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:30:29Z","timestamp":1758054629799,"version":"3.44.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY22H090007"],"award-info":[{"award-number":["LY22H090007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019542","name":"Basic Research Project of Wenzhou City","doi-asserted-by":"publisher","award":["Y20220060"],"award-info":[{"award-number":["Y20220060"]}],"id":[{"id":"10.13039\/501100019542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272254"],"award-info":[{"award-number":["82272254"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.intimp.2025.115266","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T16:03:45Z","timestamp":1753459425000},"page":"115266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["ZEB2: a multifunctional regulator of neural injury repair"],"prefix":"10.1016","volume":"163","author":[{"given":"Saiqun","family":"Nie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanren","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115266_bb0005","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1093\/emboj\/cdg226","article-title":"Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins","volume":"22","author":"Postigo","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2025.115266_bb0010","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1007\/s00018-012-0935-3","article-title":"Evolutionary functional analysis and molecular regulation of the ZEB transcription factors","volume":"69","author":"Gheldof","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2025.115266_bb0015","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1091\/mbc.e07-05-0406","article-title":"Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition","volume":"18","author":"Mejlvang","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.intimp.2025.115266_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108721","article-title":"Systematic analysis of purified astrocytes after SCI unveils Zeb2os function during astrogliosis","volume":"34","author":"Wei","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2025.115266_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107834","article-title":"Zeb2 is a regulator of astrogliosis and functional recovery after CNS injury","volume":"31","author":"Vivinetto","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2025.115266_bb0030","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00018-008-8465-8","article-title":"The role of the ZEB family of transcription factors in development and disease","volume":"66","author":"Vandewalle","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2025.115266_bb0035","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2131","article-title":"Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?","volume":"7","author":"Peinado","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.intimp.2025.115266_bb0040","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1242\/dev.119.2.433","article-title":"Delta-crystallin enhancer binding protein delta EF1 is a zinc finger-homeodomain protein implicated in postgastrulation embryogenesis","volume":"2","author":"Funahashi","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.intimp.2025.115266_bb0045","doi-asserted-by":"crossref","DOI":"10.15190\/d.2018.7","article-title":"The curious case of ZEB1","volume":"6","author":"Madany","year":"2018","journal-title":"Discoveries"},{"key":"10.1016\/j.intimp.2025.115266_bb0050","doi-asserted-by":"crossref","first-page":"3490","DOI":"10.1038\/onc.2010.102","article-title":"ZEB1 represses E-cadherin and induces an EMT by recruiting the SWI\/SNF chromatin-remodeling protein BRG1","volume":"29","author":"S\u00e1nchez-Till\u00f3","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2025.115266_bb0055","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/emboj\/cdg225","article-title":"Opposing functions of ZEB proteins in the regulation of the TGFbeta\/BMP signaling pathway","volume":"22","author":"Postigo","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2025.115266_bb0060","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/ncb1998","article-title":"The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs","volume":"11","author":"Wellner","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.intimp.2025.115266_bb0065","doi-asserted-by":"crossref","first-page":"20489","DOI":"10.1074\/jbc.274.29.20489","article-title":"SIP1, a novel zinc finger\/homeodomain repressor, interacts with Smad proteins and binds to 5\u2019-CACCT sequences in candidate target genes","volume":"29","author":"Verschueren","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.115266_bb0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1242\/dev.125.1.21","article-title":"\u03b4EF1, a zinc finger and homeodomain transcription factor, is required for skeleton patterning in multiple lineages","volume":"125","author":"Takagi","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.intimp.2025.115266_bb0075","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1086\/346092","article-title":"Mice lacking Zfhx1b, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease\u2013mental retardation syndrome","volume":"72","author":"de Putte","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.intimp.2025.115266_bb0080","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1093\/emboj\/18.18.5073","article-title":"New mode of DNA binding of multi-zinc finger transcription factors: delta EF1 family members bind with two hands to two target sites","volume":"18","author":"Remacle","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2025.115266_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188886","article-title":"CtBP: a global regulator of balancing acts and homeostases","volume":"1878","author":"Jaiswal","year":"2023","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.intimp.2025.115266_bb0090","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuropharm.2014.01.003","article-title":"Transcriptional co-repressors and memory storage","volume":"80","author":"Schoch","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.intimp.2025.115266_bb0095","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nature01550","article-title":"Coordinated histone modifications mediated by a CtBP co-repressor complex","volume":"422","author":"Shi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115266_bb0100","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0888-7543(03)00169-1","article-title":"Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1","volume":"82","author":"Nelles","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.intimp.2025.115266_bb0105","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1073\/pnas.97.12.6391","article-title":"Differential expression and function of members of the zfh-1 family of zinc finger\/homeodomain repressors","volume":"97","author":"Postigo","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.intimp.2025.115266_bb0110","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.7150\/thno.109091","article-title":"Neural-enhancing PRP\/Alg\/GelMA triple-network hydrogel for neurogenesis and angiogenesis after spinal cord injury via PI3K\/AKT\/mTOR signaling pathway","volume":"15","author":"Yun","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2025.115266_bb0115","doi-asserted-by":"crossref","first-page":"6300","DOI":"10.1007\/s12035-024-03964-5","article-title":"HIF-1\u03b1 induced by hypoxia promotes peripheral nerve injury recovery through regulating ferroptosis in DRG neuron","volume":"61","author":"An","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2025.115266_bb0120","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jhep.2023.10.006","article-title":"Endothelial DGKG promotes tumor angiogenesis and immune evasion in hepatocellular carcinoma","volume":"80","author":"Zhang","year":"2024","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2025.115266_bb0125","article-title":"Protocatechuic acid suppresses ferroptosis to protect against hypoxic-ischemic encephalopathy by targeting the HIF-1\u03b1\/VEGFA axis","volume":"143","author":"Zhang","year":"2025","journal-title":"Phytomed. Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.intimp.2025.115266_bb0130","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.12659\/MSM.904678","article-title":"Zinc finger E-box binding protein 2 (ZEB2) suppress apoptosis of vascular endothelial cells induced by high glucose through mitogen-activated protein kinases (MAPK) pathway activation","volume":"23","author":"Wang","year":"2017","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.intimp.2025.115266_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111778","article-title":"MicroRNA-200c-3p inhibits proliferation and migration of renal artery endothelial cells by directly targeting ZEB2","volume":"387","author":"Liu","year":"2020","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.intimp.2025.115266_bb0140","first-page":"3515","article-title":"Comprehensive strategy of conduit guidance combined with VEGF producing schwann cells accelerates peripheral nerve repair","volume":"6","author":"Wu","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.intimp.2025.115266_bb0145","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/s41467-020-20361-3","article-title":"Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner","volume":"12","author":"Gladka","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115266_bb0150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0925-4773(00)00318-X","article-title":"XSIP1, a Xenopus zinc finger\/homeodomain encoding gene highly expressed during early neural development","volume":"94","author":"Van Grunsven","year":"2000","journal-title":"Mech. Dev."},{"key":"10.1016\/j.intimp.2025.115266_bb0155","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0925-4773(01)00599-8","article-title":"Dynamic regulation of Brachyury expression in the amphibian embryo by XSIP1","volume":"111","author":"Papin","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.intimp.2025.115266_bb0160","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1002\/dvdy.20727","article-title":"\u03b4EF1 and SIP1 are differentially expressed and have overlapping activities during Xenopus embryogenesis","volume":"235","author":"van Grunsven","year":"2006","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.intimp.2025.115266_bb0165","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.nbd.2003.10.004","article-title":"Pleiotropic and diverse expression of ZFHX1B gene transcripts during mouse and human development supports the various clinical manifestations of the \u201cMowat\u2013Wilson\u201d syndrome","volume":"15","author":"Bassez","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.intimp.2025.115266_bb0170","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.pneurobio.2013.07.002","article-title":"BMP-Smad 1\/5\/8 signalling in the development of the nervous system","volume":"109","author":"Hegarty","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.intimp.2025.115266_bb0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pneurobio.2015.07.001","article-title":"Zeb2: a multifunctional regulator of nervous system development","volume":"132","author":"Hegarty","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.intimp.2025.115266_bb0180","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ydbio.2004.08.010","article-title":"XSIP1 is essential for early neural gene expression and neural differentiation by suppression of BMP signaling","volume":"275","author":"Nitta","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.intimp.2025.115266_bb0185","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/nrm3758","article-title":"Molecular mechanisms of epithelial-mesenchymal transition","volume":"15","author":"Lamouille","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2025.115266_bb0190","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1091\/mbc.e11-02-0103","article-title":"An autocrine TGF-beta\/ZEB\/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition","volume":"22","author":"Gregory","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.intimp.2025.115266_bb0195","doi-asserted-by":"crossref","first-page":"14910","DOI":"10.1074\/jbc.C800074200","article-title":"The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2","volume":"283","author":"Korpal","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.115266_bb0200","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1091\/mbc.e07-03-0249","article-title":"Differential regulation of epithelial and mesenchymal markers by \u03b4EF1 proteins in epithelial\u2013mesenchymal transition induced by TGF-\u03b2","volume":"18","author":"Shirakihara","year":"2007","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.intimp.2025.115266_bb0205","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.4103\/1673-5374.306078","article-title":"Zeb2 directs EMT-like processes that underlies the glial response to injury","volume":"16","author":"Vivinetto","year":"2021","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2025.115266_bb0210","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1007\/s00018-020-03516-9","article-title":"Mechanisms of Schwann cell plasticity involved in peripheral nerve repair after injury","volume":"77","author":"Nocera","year":"2020","journal-title":"Cell. Mol. Life Sci. CMLS"},{"key":"10.1016\/j.intimp.2025.115266_bb0215","article-title":"Zeb2: Inhibiting the inhibitors in Schwann cells","volume":"4","author":"Brinkmann","year":"2017","journal-title":"Neurogenesis Austin Tex"},{"key":"10.1016\/j.intimp.2025.115266_bb0220","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nature02006","article-title":"Smad-dependent and Smad-independent pathways in TGF-beta family signalling","volume":"425","author":"Derynck","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115266_bb0225","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.stem.2009.11.015","article-title":"SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells","volume":"6","author":"Chng","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.intimp.2025.115266_bb0230","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/pro.3519","article-title":"The molecular details of cytokine signaling via the JAK\/STAT pathway","volume":"27","author":"Morris","year":"2018","journal-title":"Protein Sci. Publ. Protein Soc."},{"key":"10.1016\/j.intimp.2025.115266_bb0235","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S1050-1738(02)00230-X","article-title":"Role of the JAK\u2013STAT pathway in protection against myocardial ischemia\/reperfusion injury","volume":"13","author":"Bolli","year":"2003","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.intimp.2025.115266_bb0240","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.201809665","article-title":"Inhibition of Stat3-mediated astrogliosis ameliorates pathology in an Alzheimer\u2019s disease model","volume":"11","author":"Reichenbach","year":"2019","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.intimp.2025.115266_bb0245","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.adf8531","article-title":"The transcription factor ZEB2 drives the formation of age-associated B cells","volume":"383","author":"Dai","year":"2024","journal-title":"Science"},{"key":"10.1016\/j.intimp.2025.115266_bb0250","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1182\/blood-2016-05-714659","article-title":"The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling","volume":"129","author":"Li","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2025.115266_bb0255","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrn3024","article-title":"Not(ch) just development: Notch signalling in the adult brain","volume":"12","author":"Ables","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0260","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ydbio.2020.09.006","article-title":"Zeb2 regulates the balance between retinal interneurons and M\u00fcller glia by inhibition of BMP\u2013Smad signaling","volume":"468","author":"Menuchin-Lasowski","year":"2020","journal-title":"Dev. Biol."},{"key":"10.1016\/j.intimp.2025.115266_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148365","article-title":"ZEB2 alleviates Hirschsprung\u2019s-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1\/Jagged-2 pathway","volume":"912","author":"Feng","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2025.115266_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105952","article-title":"Schwann cell functions in peripheral nerve development and repair","volume":"176","author":"Bosch-Queralt","year":"2023","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.intimp.2025.115266_bb0275","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nn.2323","article-title":"Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity","volume":"12","author":"Woodhoo","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0280","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nn.4322","article-title":"Zeb2 recruits HDAC-NuRD to inhibit Notch and controls Schwann cell differentiation and remyelination","volume":"19","author":"Wu","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0285","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.brainres.2018.09.034","article-title":"Role of Zeb2\/Sip1 in neuronal development","volume":"1705","author":"Epifanova","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2025.115266_bb0290","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nature17623","article-title":"Astrocyte scar formation aids central nervous system axon regeneration","volume":"532","author":"Anderson","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115266_bb0295","doi-asserted-by":"crossref","first-page":"853","DOI":"10.3390\/cells12060853","article-title":"Current advancements in spinal cord injury research-glial scar formation and neural regeneration","volume":"12","author":"Clifford","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2025.115266_bb0300","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12264-013-1358-3","article-title":"The glial scar in spinal cord injury and repair","volume":"29","author":"Yuan","year":"2013","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.intimp.2025.115266_bb0305","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109099","article-title":"Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury","volume":"9","author":"Watson","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.intimp.2025.115266_bb0310","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neuron.2011.12.021","article-title":"Dual-mode modulation of Smad signaling by Smad-interacting protein Sip1 is required for myelination in the central nervous system","volume":"73","author":"Weng","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2025.115266_bb0315","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.neuron.2012.11.009","article-title":"Directed migration of cortical interneurons depends on the cell-autonomous action of Sip1","volume":"77","author":"van den Berghe","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.intimp.2025.115266_bb0320","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.4103\/1673-5374.213537","article-title":"Transcriptional inhibition in Schwann cell development and nerve regeneration","volume":"12","author":"Quintes","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2025.115266_bb0325","doi-asserted-by":"crossref","first-page":"22347","DOI":"10.1073\/pnas.1910292116","article-title":"Myelin sheath structure and regeneration in peripheral nerve injury repair","volume":"116","author":"Liu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.intimp.2025.115266_bb0330","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nn.4321","article-title":"Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair","volume":"19","author":"Quintes","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0335","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3390\/cells10071587","article-title":"Epithelial-mesenchymal transition (EMT): the type-2 EMT in wound healing, tissue regeneration and organ fibrosis","volume":"10","author":"Marconi","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2025.115266_bb0340","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/glia.23532","article-title":"Repair Schwann cell update: adaptive reprogramming, EMT, and stemness in regenerating nerves","volume":"67","author":"Jessen","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.intimp.2025.115266_bb0345","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.celrep.2017.08.064","article-title":"Changes in the coding and non-coding transcriptome and DNA Methylome that define the Schwann cell repair phenotype after nerve injury","volume":"20","author":"Arthur-Farraj","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2025.115266_bb0350","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.devcel.2021.01.017","article-title":"Localized EMT reprograms glial progenitors to promote spinal cord repair","volume":"56","author":"Klatt Shaw","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.intimp.2025.115266_bb0355","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1038\/s41467-022-33382-x","article-title":"Lesion environments direct transplanted neural progenitors towards a wound repair astroglial phenotype in mice","volume":"13","author":"O\u2019Shea","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115266_bb0360","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s41593-024-01684-6","article-title":"Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice","volume":"27","author":"O\u2019Shea","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0365","doi-asserted-by":"crossref","first-page":"1097880","DOI":"10.3389\/fimmu.2023.1097880","article-title":"Epithelial-mesenchymal transition is the main way in which glioma-associated microglia\/macrophages promote glioma progression","volume":"14","author":"He","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115266_bb0370","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1053\/jhsu.2000.4165","article-title":"A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance","volume":"25","author":"Lundborg","year":"2000","journal-title":"J. Hand Surg."},{"key":"10.1016\/j.intimp.2025.115266_bb0375","doi-asserted-by":"crossref","first-page":"1594435","DOI":"10.3389\/fnins.2025.1594435","article-title":"Unlocking nerve regeneration: electrical stimulation and bioscaffolds to enhance peripheral nerve regeneration","volume":"19","author":"Thakkar","year":"2025","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113794","article-title":"Strategies to neutralize RhoA\/ROCK pathway after spinal cord injury","volume":"343","author":"Roy","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2025.115266_bb0385","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.4103\/1673-5374.335823","article-title":"Basic mechanisms of peripheral nerve injury and treatment via electrical stimulation","volume":"17","author":"Chu","year":"2022","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2025.115266_bb0390","doi-asserted-by":"crossref","first-page":"1368630","DOI":"10.3389\/fncel.2024.1368630","article-title":"Emerging role of extracellular vesicles and exogenous stimuli in molecular mechanisms of peripheral nerve regeneration","volume":"18","author":"Izhiman","year":"2024","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0395","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1161\/CIRCRESAHA.121.319949","article-title":"Cerebral hemorrhage: pathophysiology, treatment, and future directions","volume":"130","author":"Magid-Bernstein","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2025.115266_bb0400","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3389\/fnmol.2018.00176","article-title":"Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against neuronal apoptosis via activation of Akt\/MDM2\/p53 signaling pathway in a rat model of intracerebral hemorrhage","volume":"11","author":"Xu","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0405","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1080\/15384101.2021.1959702","article-title":"ZEB2, interacting with MDM2, contributes to the dysfuntion of brain microvascular endothelial cells and brain injury after intracerebral hemorrhage","volume":"20","author":"Guo","year":"2021","journal-title":"Cell Cycle Georget. Tex"},{"key":"10.1016\/j.intimp.2025.115266_bb0410","first-page":"253","article-title":"miR-141-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting ZEB2","volume":"99","author":"Yu","year":"2022","journal-title":"J. Clin. Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"10.1016\/j.intimp.2025.115266_bb0415","doi-asserted-by":"crossref","first-page":"20041","DOI":"10.1074\/jbc.RA118.001858","article-title":"miR-27a-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11","volume":"293","author":"Xi","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.115266_bb0420","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s12031-021-01887-7","article-title":"Zeb2\/Axin2-enriched BMSC-derived exosomes promote post-stroke functional recovery by enhancing neurogenesis and neural plasticity","volume":"72","author":"Wei","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0425","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41593-020-0597-7","article-title":"Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2","volume":"23","author":"Zhou","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.intimp.2025.115266_bb0430","unstructured":"R.C, Zhang, R. Chen, H. Li, X.Y.Chen, Y. Tu, Zeb2 regulates the increase of astrocytes and recovery of motorfunction after spinal cord injury in mice by EMT process, J. Hainan Med. Univ. 27 (2021) 161\u2013167. doi:10.13210\/j.cnki.jhmu.20200824.003."},{"key":"10.1016\/j.intimp.2025.115266_bb0435","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s43587-024-00792-z","article-title":"Modulating mTOR-dependent astrocyte substate transitions to alleviate neurodegeneration","volume":"5","author":"Zhang","year":"2025","journal-title":"Nat. Aging"},{"key":"10.1016\/j.intimp.2025.115266_bb0440","doi-asserted-by":"crossref","first-page":"982","DOI":"10.3390\/genes12070982","article-title":"Neurological phenotype of Mowat-Wilson syndrome","volume":"12","author":"Cordelli","year":"2021","journal-title":"Genes"},{"key":"10.1016\/j.intimp.2025.115266_bb0445","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.3390\/ijms25052838","article-title":"Mowat-Wilson syndrome: case report and review of ZEB2 gene variant types, protein defects and molecular interactions","volume":"25","author":"St Peter","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115266_bb0450","article-title":"Successful treatment of drug-resistant status epilepticus in an adult patient with Mowat-Wilson syndrome: a case report","volume":"14","author":"Nosaki","year":"2020","journal-title":"Epilepsy Behav. Rep."},{"key":"10.1016\/j.intimp.2025.115266_bb0455","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.stemcr.2023.10.002","article-title":"Mowat-Wilson syndrome factor ZEB2 controls early formation of human neural crest through BMP signaling modulation","volume":"11","author":"Charney","year":"2023","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.intimp.2025.115266_bb0460","doi-asserted-by":"crossref","first-page":"eadj4748","DOI":"10.1126\/sciimmunol.adj4748","article-title":"Zeb2 drives the formation of CD11c+ atypical B cells to sustain germinal centers that control persistent infection","volume":"9","author":"Gao","year":"2024","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.intimp.2025.115266_bb0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2025.03.021","article-title":"ZEB2 is a master switch controlling the tumor-associated macrophage program","author":"Sheban","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2025.115266_bb0470","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1093\/hmg\/ddm093","article-title":"Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome","volume":"16","author":"Van de Putte","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.intimp.2025.115266_bb0475","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1159\/000487464","article-title":"Altered long noncoding RNA and messenger RNA expression in experimental intracerebral hemorrhage - a preliminary study","volume":"45","author":"Hanjin","year":"2018","journal-title":"Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925012561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925012561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T05:13:05Z","timestamp":1757913185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925012561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":95,"alternative-id":["S1567576925012561"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115266","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ZEB2: a multifunctional regulator of neural injury repair","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115266","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115266"}}