{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:32:04Z","timestamp":1785202324430,"version":"3.55.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270724"],"award-info":[{"award-number":["82270724"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470722"],"award-info":[{"award-number":["82470722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200827"],"award-info":[{"award-number":["82200827"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqn202306398"],"award-info":[{"award-number":["tsqn202306398"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tstp20230665"],"award-info":[{"award-number":["tstp20230665"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019558","name":"Qingdao Key Health Discipline Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022QH037"],"award-info":[{"award-number":["ZR2022QH037"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018936","name":"Qingdao Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018936","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.intimp.2025.115300","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T22:12:43Z","timestamp":1755555163000},"page":"115300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Tectorigenin could alleviate SA-AKI via reducing M1-like polarization of macrophages through KLF4\/NF-\u03baB pathway"],"prefix":"10.1016","volume":"164","author":[{"given":"Wei","family":"Chunling","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Xiaoqian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ding","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Ningxin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yanlu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Xiaorui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gu","family":"Minghao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Ruizhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Liting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0005","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41420-023-01766-7","article-title":"Immune dysregulation in sepsis: experiences, lessons and perspectives","volume":"9","author":"Cao","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0010","first-page":"56","article-title":"Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options","volume":"9","author":"Liu","year":"2022","journal-title":"Mil. Med. Res."},{"issue":"6","key":"10.1016\/j.intimp.2025.115300_bb0015","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41581-023-00683-3","article-title":"Sepsis-associated acute kidney injury: consensus report of the 28th acute disease quality initiative workgroup","volume":"19","author":"Zarbock","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115300_bb0020","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.CCM.0000194725.48928.3A","article-title":"Sepsis in European intensive care units: results of the SOAP study","volume":"34","author":"Vincent","year":"2006","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.115300_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1053754","article-title":"CTSB promotes sepsis-induced acute kidney injury through activating mitochondrial apoptosis pathway","volume":"13","author":"Wang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115300_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115523","article-title":"Lyn attenuates sepsis-associated acute kidney injury by inhibition of phospho-STAT3 and apoptosis","volume":"211","author":"Li","year":"2023","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0035","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/ndt\/gfad142","article-title":"Sepsis-associated acute kidney injury\u2014treatment standard","volume":"39","author":"Zarbock","year":"2024","journal-title":"Nephrol. Dial. Transplant."},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0040","article-title":"Acute kidney injury","volume":"7","author":"Kellum","year":"2021","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"6","key":"10.1016\/j.intimp.2025.115300_bb0045","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202205097","article-title":"A zinc- and calcium-rich lysosomal Nanoreactor rescues monocyte\/macrophage dysfunction under Sepsis","volume":"10","author":"Zhao","year":"2023","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/biomedicines12010175","article-title":"Immunosuppression in Sepsis: biomarkers and specialized pro-resolving mediators","volume":"12","author":"Padovani","year":"2024","journal-title":"Biomedicines"},{"issue":"16","key":"10.1016\/j.intimp.2025.115300_bb0055","doi-asserted-by":"crossref","first-page":"9159","DOI":"10.3390\/ijms23169159","article-title":"Sepsis and acute kidney injury: a review focusing on the bidirectional interplay","volume":"23","author":"Chang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115300_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154484","article-title":"Koumine regulates macrophage M1\/M2 polarization via TSPO, alleviating sepsis-associated liver injury in mice","volume":"107","author":"Jin","year":"2022","journal-title":"Phytomedicine"},{"issue":"17","key":"10.1016\/j.intimp.2025.115300_bb0065","doi-asserted-by":"crossref","first-page":"9422","DOI":"10.3390\/ijms25179422","article-title":"Macrophages and gut barrier function: guardians of gastrointestinal health in post-inflammatory and post-infection responses","volume":"25","author":"Meng","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115300_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.922614","article-title":"Diabetes exacerbated sepsis-induced intestinal injury by promoting M1 macrophage polarization via miR-3061\/Snail1 signaling","volume":"13","author":"Tan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115300_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.802336","article-title":"Chronically elevated O-GlcNAcylation limits nitric oxide production and deregulates specific pro-inflammatory cytokines","volume":"13","author":"Abramowitz","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115300_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in rheumatoid arthritis synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115300_bb0085","doi-asserted-by":"crossref","first-page":"521","DOI":"10.7150\/ijbs.80200","article-title":"Neuropeptide Y protects kidney from acute kidney injury by inactivating M1 macrophages via the Y1R-NF-\u03baB-Mincle-dependent mechanism","volume":"19","author":"Tan","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0090","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/15548627.2024.2393926","article-title":"Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1","volume":"21","author":"Huang","year":"2024","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0095","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/s12964-024-01841-1","article-title":"STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation","volume":"22","author":"Lee","year":"2024","journal-title":"Cell Commun. Signaling"},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13020-024-00918-w","article-title":"Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis","volume":"19","author":"Chen","year":"2024","journal-title":"Chin. Med."},{"issue":"12","key":"10.1016\/j.intimp.2025.115300_bb0105","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1038\/s41401-022-00990-8","article-title":"Mass spectrometry imaging: new eyes on natural products for drug research and development","volume":"43","author":"Hou","year":"2022","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2025.115300_bb0110","first-page":"8","article-title":"Tectorigenin alleviates inflammation, apoptosis, and ossification in rat tendon-derived stem cells via modulating NF-kappa B and MAPK pathways","author":"Moqbel","year":"2020","journal-title":"Front. Cell Devel. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115300_bb0115","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/ptr.6299","article-title":"Tectorigenin protects against experimental fulminant hepatic failure by regulating the TLR4\/mitogen-activated protein kinase and TLR4\/nuclear factor-\u03baB pathways and autophagy","volume":"33","author":"Zhang","year":"2019","journal-title":"Phytother. Res."},{"issue":"11","key":"10.1016\/j.intimp.2025.115300_bb0120","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s12272-001-2129-7","article-title":"Tectorigenin inhibits IFN-\u03b3\/LPS-induced inflammatory responses in murine macrophage RAW 264.7 cells","volume":"31","author":"Pan","year":"2008","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.intimp.2025.115300_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2022.112948","article-title":"Tectorigenin ameliorated high-fat diet-induced nonalcoholic fatty liver disease through anti-inflammation and modulating gut microbiota in mice","volume":"164","author":"Duan","year":"2022","journal-title":"Food Chem. Toxicol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115300_bb0130","first-page":"841","article-title":"Tectorigenin inhibits the inflammation of LPS-induced acute lung injury in mice","volume":"12","author":"Ma","year":"2014","journal-title":"Chin. J. Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1099\/00222615-21-1-59","article-title":"Interactions of virulent and avirulent leptospires with primary cultures of renal epithelial cells","volume":"21","author":"Ballard","year":"1986","journal-title":"J. Med. Microbiol."},{"key":"10.1016\/j.intimp.2025.115300_bb0140","article-title":"Calycosin attenuates renal ischemia\/reperfusion injury by suppressing NF-\u03baB mediated inflammation via PPAR\u03b3\/EGR1 pathway","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115300_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.114202","article-title":"Immunoregulatory mechanism of acute kidney injury in sepsis: a narrative review","volume":"159","author":"Sun","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115300_bb0150","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbi.2024.02.016","article-title":"The miR-25802\/KLF4\/NF-\u03baB signaling axis regulates microglia-mediated neuroinflammation in Alzheimer\u2019s disease","volume":"118","author":"Zhao","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.intimp.2025.115300_bb0155","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1172\/JCI45444","article-title":"Kr\u00fcppel-like factor 4 regulates macrophage polarization","volume":"121","author":"Liao","year":"2011","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0160","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1186\/s13054-020-03327-1","article-title":"Gut-liver crosstalk in sepsis-induced liver injury","volume":"24","author":"Sun","year":"2020","journal-title":"Crit. Care"},{"issue":"19","key":"10.1016\/j.intimp.2025.115300_bb0165","doi-asserted-by":"crossref","first-page":"4722","DOI":"10.1111\/bph.15902","article-title":"A non-retinol retinoic acid receptor-\u03b3 (RAR-\u03b3\/NR1B3) selective agonist, tectorigenin, can effectively inhibit the ultraviolet A-induced skin damage","volume":"179","author":"Dai","year":"2022","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115300_bb0170","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.freeradbiomed.2023.12.031","article-title":"Tectorigenin inhibits oxidative stress by activating the Keap1\/Nrf2\/HO-1 signaling pathway in Th2-mediated allergic asthmatic mice","volume":"212","author":"Jiang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"14","key":"10.1016\/j.intimp.2025.115300_bb0175","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.158571","article-title":"JAML promotes acute kidney injury mainly through a macrophage-dependent mechanism","volume":"7","author":"Huang","year":"2022","journal-title":"JCI Insight"},{"issue":"10","key":"10.1016\/j.intimp.2025.115300_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/eji.202250071","article-title":"DsbA-L deletion attenuates LPS-induced acute kidney injury by modulating macrophage polarization","volume":"53","author":"Cui","year":"2023","journal-title":"Eur. J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115300_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e14006","article-title":"Embelin attenuates lipopolysaccharide-induced acute kidney injury through the inhibition of M1 macrophage activation and NF-\u03baB signaling in mice","volume":"9","author":"Tang","year":"2023","journal-title":"Heliyon"},{"issue":"27","key":"10.1016\/j.intimp.2025.115300_bb0190","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301243","article-title":"A Cyclodextrin-based pH-responsive MicroRNA delivery platform targeting polarization of M1 to M2 macrophages for Sepsis therapy","volume":"12","author":"Ding","year":"2023","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.intimp.2025.115300_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155502","article-title":"Jaceosidin attenuates the progression of hepatic fibrosis by inhibiting the VGLL3\/HMGB1\/TLR4 signaling pathway","volume":"128","author":"Yao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.115300_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104678","article-title":"Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1\/2 pathway","volume":"153","author":"Yang","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"5","key":"10.1016\/j.intimp.2025.115300_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1077","article-title":"Tectorigenin inhibits inflammatory responses in murine inflammatory bowel disease and LPS-stimulated macrophages via inactivating MAPK signaling pathway","volume":"12","author":"Huang","year":"2024","journal-title":"Immunity, Inflammation and Disease"},{"issue":"22","key":"10.1016\/j.intimp.2025.115300_bb0210","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.3390\/ijms21228843","article-title":"Recent discoveries on the involvement of Kr\u00fcppel-like factor 4 in the Most common Cancer types","volume":"21","author":"Taracha-Wisniewska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"21","key":"10.1016\/j.intimp.2025.115300_bb0215","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1161\/CIRCULATIONAHA.120.046672","article-title":"Stem cell pluripotency genes Klf4 and Oct4 regulate complex SMC phenotypic changes critical in late-stage atherosclerotic lesion pathogenesis","volume":"142","author":"Alencar","year":"2020","journal-title":"Circulation"},{"issue":"7836","key":"10.1016\/j.intimp.2025.115300_bb0220","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41586-020-2975-4","article-title":"Reprogramming to recover youthful epigenetic information and restore vision","volume":"588","author":"Lu","year":"2020","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.intimp.2025.115300_bb0225","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/j.cell.2016.11.052","article-title":"In vivo amelioration of age-associated hallmarks by partial reprogramming","volume":"167","author":"Ocampo","year":"2016","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.intimp.2025.115300_bb0230","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1172\/JCI123069","article-title":"Adipocyte-secreted exosomal microRNA-34a inhibits M2 macrophage polarization to promote obesity-induced adipose inflammation","volume":"129","author":"Pan","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.intimp.2025.115300_bb0235","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1681\/ASN.2019020111","article-title":"KLF4 in macrophages attenuates TNF\u03b1-mediated kidney injury and fibrosis","volume":"30","author":"Wen","year":"2019","journal-title":"J. Am. Soc. Nephrol."},{"issue":"28","key":"10.1016\/j.intimp.2025.115300_bb0240","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202307216","article-title":"Histone H3K18 and Ezrin Lactylation promote renal dysfunction in Sepsis-associated acute kidney injury","volume":"11","author":"Qiao","year":"2024","journal-title":"Adv. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2025.115300_bb0245","first-page":"L371","article-title":"Toll-like receptor 4 is not targeted to the lysosome in cystic fibrosis airway epithelial cells","volume":"304","author":"Kelly","year":"2013","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0250","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"issue":"23","key":"10.1016\/j.intimp.2025.115300_bb0255","article-title":"Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors","volume":"117","author":"Kristi","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0260","article-title":"The anti-tumor function of the IKK inhibitor PS1145 and high levels of p65 and KLF4 are associated with the drug resistance in nasopharyngeal carcinoma cells","volume":"9","author":"Hong Lok","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2025.115300_bb0265","doi-asserted-by":"crossref","DOI":"10.1172\/JCI139927","article-title":"Biomarkers of inflammation and repair in kidney disease progression","volume":"131","author":"Puthumana","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.intimp.2025.115300_bb0270","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.2337\/dc23-2196","article-title":"Associations of kidney tubular biomarkers with incident macroalbuminuria and sustained low eGFR in DCCT\/EDIC","volume":"47","author":"Limonte","year":"2024","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.intimp.2025.115300_bb0275","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/15548627.2024.2393926","article-title":"Macrophage autophagy protects against acute kidney injury by inhibiting renal inflammation through the degradation of TARM1","volume":"21","author":"Huang","year":"2025","journal-title":"Autophagy"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925012913?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925012913?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:50:27Z","timestamp":1762552227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925012913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":55,"alternative-id":["S1567576925012913"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115300","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tectorigenin could alleviate SA-AKI via reducing M1-like polarization of macrophages through KLF4\/NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115300"}}