{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T01:51:08Z","timestamp":1777600268371,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2022CFA027"],"award-info":[{"award-number":["2022CFA027"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"publisher","award":["32125037"],"award-info":[{"award-number":["32125037"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32102652"],"award-info":[{"award-number":["32102652"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.intimp.2025.115342","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T13:42:49Z","timestamp":1754919769000},"page":"115342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Sclareol can effectively ameliorate Feline calicivirus induced lung injury via the inhibition of inflammation and apoptosis"],"prefix":"10.1016","volume":"164","author":[{"given":"Yuanyuan","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengfang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zirui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisha","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuzhou","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengxia","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huaibing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guiqing","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115342_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/v14050937","article-title":"Calicivirus infection in cats","volume":"14","author":"Hofmann-Lehmann","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.intimp.2025.115342_bb0010","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.3389\/fimmu.2019.02334","article-title":"Immune response modulation by caliciviruses","volume":"10","author":"Penaflor-Tellez","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115342_bb0015","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1099\/vir.0.059634-0","article-title":"Norovirus gene expression and replication","volume":"95","author":"Thorne","year":"2014","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.intimp.2025.115342_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/v13102040","article-title":"Feline calicivirus virulent systemic disease: clinical epidemiology, analysis of viral isolates and in vitro efficacy of novel antivirals in Australian outbreaks","volume":"13","author":"Bordicchia","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.intimp.2025.115342_bb0025","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.rvsc.2019.02.008","article-title":"Feline calicivirus infection in cats with virulent systemic disease, Italy","volume":"124","author":"Caringella","year":"2019","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.intimp.2025.115342_bb0030","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.meegid.2018.08.029","article-title":"Isolation and molecular characterization of a virulent systemic feline calicivirus isolated in China","volume":"65","author":"Guo","year":"2018","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.intimp.2025.115342_bb0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1354\/vp.41-3-257","article-title":"Pathologic, immunohistochemical, and electron microscopic findings in naturally occurring virulent systemic feline calicivirus infection in cats","volume":"41","author":"Pesavento","year":"2004","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.intimp.2025.115342_bb0040","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1002\/ptr.7635","article-title":"Sclareol attenuates angiotensin II-induced cardiac remodeling and inflammation via inhibiting MAPK signaling","volume":"37","author":"Yang","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2025.115342_bb0045","article-title":"The bioactivities of sclareol: a mini review","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115342_bb0050","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1002\/ptr.7465","article-title":"Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK\/NF-kappaB signaling pathway","volume":"36","author":"Han","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2025.115342_bb0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.intimp.2016.12.026","article-title":"Sclareol ameliorate lipopolysaccharide-induced acute lung injury through inhibition of MAPK and induction of HO-1 signaling","volume":"44","author":"LHsieh","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115342_bb0060","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/10286020.2019.1681407","article-title":"Discovery of sclareol and sclareolide as filovirus entry inhibitors","volume":"22","author":"Chen","year":"2020","journal-title":"J. Asian Nat. Prod. Res."},{"key":"10.1016\/j.intimp.2025.115342_bb0065","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12906-021-03214-4","article-title":"Allergen fragrance molecules: a potential relief for COVID-19","volume":"21","author":"Aydin","year":"2021","journal-title":"BMC Complement Med Ther"},{"key":"10.1016\/j.intimp.2025.115342_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2020.108849","article-title":"Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo","volume":"249","author":"Xu","year":"2020","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.intimp.2025.115342_bb0075","doi-asserted-by":"crossref","DOI":"10.1099\/jgv.0.001936","article-title":"Drug screening identified that handelin inhibits feline calicivirus infection by inhibiting HSP70 expression in vitro","volume":"105","author":"Yan","year":"2024","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.intimp.2025.115342_bb0080","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1186\/1478-811X-11-84","article-title":"A systems biology approach to suppress TNF-induced proinflammatory gene expressions","volume":"11","author":"Hayashi","year":"2013","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.intimp.2025.115342_bb0085","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1182\/blood.V99.5.1666","article-title":"Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1(TNFR1)\u2013 and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3","author":"Pinto","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2025.115342_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2021.198595","article-title":"Caliciviruses induce mRNA of tumor necrosis factor alpha via their protease activity","volume":"306","author":"Sekiguchi","year":"2021","journal-title":"Virus Res."},{"key":"10.1016\/j.intimp.2025.115342_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110031","article-title":"Coixol ameliorates toxoplasma gondii infection-induced lung injury by interfering with T. Gondii HSP70\/TLR4\/NF-kappaB signaling pathway","volume":"118","author":"Shen","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115342_bb0100","doi-asserted-by":"crossref","first-page":"15935","DOI":"10.1073\/pnas.2004615117","article-title":"TNF deficiency dysregulates inflammatory cytokine production, leading to lung pathology and death during respiratory poxvirus infection","volume":"117","author":"Tuazon Kels","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.115342_bb0105","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3389\/fimmu.2019.00452","article-title":"Contribution of cytokines to tissue damage during human respiratory syncytial virus infection","volume":"10","author":"Bohmwald","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115342_bb0110","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.4049\/jimmunol.1701543","article-title":"Inflammatory monocytes drive influenza a virus-mediated lung injury in juvenile mice","volume":"200","author":"Coates","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.115342_bb0115","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.fm.2010.01.001","article-title":"The effect of cranberry juice and cranberry proanthocyanidins on the infectivity of human enteric viral surrogates","volume":"27","author":"Su","year":"2010","journal-title":"Food Microbiol."},{"key":"10.1016\/j.intimp.2025.115342_bb0120","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.foodcont.2014.07.056","article-title":"Protective effects of red wine and resveratrol for foodborne virus surrogates","volume":"47","author":"Oh","year":"2015","journal-title":"Food Control"},{"key":"10.1016\/j.intimp.2025.115342_bb0125","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1006\/jmcc.2002.2003","article-title":"Characterisation of murine cytomegalovirus myocarditis: cellular infiltration of the heart and virus persistence","volume":"34","author":"Lenzo","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.intimp.2025.115342_bb0130","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1172\/JCI22428","article-title":"Organ-specific roles for transcription factor NF-\u03baB in reovirus-induced apoptosis and disease","volume":"115","author":"O\u2019Donnell","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2025.115342_bb0135","first-page":"2341","article-title":"Coxsackievirus B3-induced apoptosis and Caspase-3","volume":"115","author":"Jingling Yuan","year":"2003","journal-title":"Cell Res."},{"key":"10.1016\/j.intimp.2025.115342_bb0140","doi-asserted-by":"crossref","first-page":"13203","DOI":"10.1128\/JVI.77.24.13203-13213.2003","article-title":"Infection and injury of neurons by west NileEncephalitisVirus","volume":"77","author":"Shrestha","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.intimp.2025.115342_bb0145","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nrmicro2071","article-title":"Apoptosis in animal models of virus-induced disease","volume":"7","author":"Clarke","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.intimp.2025.115342_bb0150","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1101\/gad.1188204","article-title":"Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling","volume":"18","author":"Ran","year":"2004","journal-title":"Genes Dev."},{"key":"10.1016\/j.intimp.2025.115342_bb0155","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1196\/annals.1299.110","article-title":"Apoptosis in cultured cells infected with feline calicivirus","volume":"1010","author":"Roberts","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2025.115342_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104761","article-title":"Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2)","volume":"156","author":"Runfeng","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2025.115342_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154786","article-title":"Isoliquiritigenin inhibits virus replication and virus-mediated inflammation via NRF2 signaling","volume":"114","author":"Wang","year":"2023","journal-title":"Phytomedicine"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925013335?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925013335?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:47:09Z","timestamp":1772891229000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925013335"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":33,"alternative-id":["S1567576925013335"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115342","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sclareol can effectively ameliorate Feline calicivirus induced lung injury via the inhibition of inflammation and apoptosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115342"}}