{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:19:25Z","timestamp":1786551565538,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital of Medicine","doi-asserted-by":"publisher","award":["B18035"],"award-info":[{"award-number":["B18035"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003766","name":"Ministerul Educa\u0163iei Na\u0163ionale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003766","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.intimp.2025.115348","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:42:10Z","timestamp":1755132130000},"page":"115348","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Senkyunolide I targets CXCR4 to attenuate liver fibrosis via suppression of the NLRP3\/GSDMD pathway"],"prefix":"10.1016","volume":"164","author":[{"given":"Kexin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingjie","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junrong","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2025.115348_bb0005","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jhep.2023.03.017","article-title":"Global burden of liver disease: 2023 update","volume":"79","author":"Devarbhavi","year":"2023","journal-title":"J. Hepatol."},{"issue":"10308","key":"10.1016\/j.intimp.2025.115348_bb0010","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0140-6736(21)01374-X","article-title":"Liver cirrhosis","volume":"398","author":"Gin\u00e8s","year":"2021","journal-title":"Lancet"},{"issue":"Suppl","key":"10.1016\/j.intimp.2025.115348_bb0015","doi-asserted-by":"crossref","first-page":"S199","DOI":"10.3350\/cmh.2024.0351","article-title":"Prevalence of clinically significant liver fibrosis in the general population: a systematic review and meta-analysis","volume":"30","author":"Kim","year":"2024","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.intimp.2025.115348_bb0020","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.matbio.2018.04.006","article-title":"Liver fibrosis: direct antifibrotic agents and targeted therapies","volume":"68-69","author":"Schuppan","year":"2018","journal-title":"Matrix Biol."},{"issue":"13","key":"10.1016\/j.intimp.2025.115348_bb0025","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1080\/14656566.2020.1774553","article-title":"Current and emerging pharmacotherapeutic interventions for the treatment of liver fibrosis","volume":"21","author":"Lambrecht","year":"2020","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115348_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101809","article-title":"CXCL12\/CXCR4: An amazing challenge and opportunity in the fight against fibrosis","volume":"83","author":"Wu","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"5","key":"10.1016\/j.intimp.2025.115348_bb0035","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41422-025-01107-6","article-title":"Pyroptosis: molecular mechanisms and roles in disease","volume":"35","author":"Broz","year":"2025","journal-title":"Cell Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.115348_bb0040","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115348_bb0045","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1631\/jzus.B2300409","article-title":"Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens","volume":"25","author":"Lu","year":"2024","journal-title":"J Zhejiang Univ Sci B"},{"key":"10.1016\/j.intimp.2025.115348_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.156727","article-title":"Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-\u03baB-NLRP3-GSDMD and AMPK-PGC-1\u03b1 axes","volume":"840","author":"Zhang","year":"2022","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.intimp.2025.115348_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102691","article-title":"STING mediates hepatocyte pyroptosis in liver fibrosis by epigenetically activating the NLRP3 inflammasome","volume":"62","author":"Xiao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.115348_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102960","article-title":"CXCR4-BTK axis mediate pyroptosis and lipid peroxidation in early brain injury after subarachnoid hemorrhage via NLRP3 inflammasome and NF-\u03baB pathway","volume":"68","author":"Liu","year":"2023","journal-title":"Redox Biol."},{"issue":"Pt A","key":"10.1016\/j.intimp.2025.115348_bb0065","article-title":"Mechanisms of inhibition of nucleus pulposus cells pyroptosis through SDF1\/CXCR4-NFkB-NLRP3 axis in the treatment of intervertebral disc degeneration by Duhuo Jisheng decoction","volume":"124","author":"Guo","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115348_bb0070","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/cmi.2017.107","article-title":"The unique structural and functional features of CXCL12","volume":"15","author":"Janssens","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2025.115348_bb0075","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.biopha.2018.02.091","article-title":"Curcumin protects against hepatic stellate cells activation and migration by inhibiting the CXCL12\/CXCR4 biological axis in liver fibrosis: a study in vitro and in vivo","volume":"101","author":"Qin","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.intimp.2025.115348_bb0080","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/hep.22890","article-title":"Hepatic stellate cells express functional CXCR4: role in stromal cell-derived factor-1alpha-mediated stellate cell activation","volume":"49","author":"Hong","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2025.115348_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107717","article-title":"Senkyunolide I attenuates hepatic ischemia\/reperfusion injury in mice via anti-oxidative, anti-inflammatory and anti-apoptotic pathways","volume":"97","author":"Yang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115348_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108393","article-title":"Senkyunolide I alleviates renal ischemia-reperfusion injury by inhibiting oxidative stress, endoplasmic reticulum stress and apoptosis","volume":"102","author":"Zhu","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2025.115348_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28083636","article-title":"Senkyunolide I: a review of its phytochemistry, pharmacology, pharmacokinetics, and drug-likeness","volume":"28","author":"Huang","year":"2023","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.intimp.2025.115348_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166819","article-title":"Senkyunolide I ameliorates thoracic aortic aneurysm and dissection in mice via inhibiting the oxidative stress and apoptosis of endothelial cells","volume":"1869","author":"Zhao","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"5","key":"10.1016\/j.intimp.2025.115348_bb0105","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00204-015-1543-4","article-title":"Experimental models of liver fibrosis","volume":"90","author":"Yanguas","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115348_bb0110","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41419-022-04802-z","article-title":"MyD88 in hepatic stellate cells enhances liver fibrosis via promoting macrophage M1 polarization","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.intimp.2025.115348_bb0115","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41419-020-2664-0","article-title":"Induction of ASC pyroptosis requires gasdermin D or caspase-1\/11-dependent mediators and IFN\u03b2 from pyroptotic macrophages","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.intimp.2025.115348_bb0120","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41423-023-00983-5","article-title":"Mesenchymal stromal cells in hepatic fibrosis\/cirrhosis: from pathogenesis to treatment","volume":"20","author":"Yang","year":"2023","journal-title":"Cell. Mol. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115348_bb0125","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.143018","article-title":"A single-domain i-body, AD-114, attenuates renal fibrosis through blockade of CXCR4","volume":"7","author":"Cao","year":"2022","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.intimp.2025.115348_bb0130","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1002\/hep.26790","article-title":"Differential effects of sorafenib on liver versus tumor fibrosis mediated by stromal-derived factor 1 alpha\/C-X-C receptor type 4 axis and myeloid differentiation antigen-positive myeloid cell infiltration in mice","volume":"59","author":"Chen","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2025.115348_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121492","article-title":"Synergetic regulation of kupffer cells, extracellular matrix and hepatic stellate cells with versatile CXCR4-inhibiting nanocomplex for magnified therapy in liver fibrosis","volume":"284","author":"Wu","year":"2022","journal-title":"Biomaterials"},{"issue":"8","key":"10.1016\/j.intimp.2025.115348_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28083636","article-title":"Senkyunolide I: a review of its phytochemistry, pharmacology, pharmacokinetics, and drug-likeness","volume":"28","author":"Huang","year":"2023","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.intimp.2025.115348_bb0145","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1021\/acs.analchem.9b05479","article-title":"Surface plasmon resonance-based membrane protein-targeted active ingredients recognition strategy: construction and implementation in ligand screening from herbal medicines","volume":"92","author":"Chen","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.intimp.2025.115348_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110180","article-title":"Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis","volume":"367","author":"Yin","year":"2022","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.intimp.2025.115348_bb0155","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jhep.2020.07.041","article-title":"Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis","volume":"74","author":"Gaul","year":"2021","journal-title":"J. Hepatol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925013396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925013396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:45:41Z","timestamp":1758786341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925013396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":31,"alternative-id":["S1567576925013396"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115348","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Senkyunolide I targets CXCR4 to attenuate liver fibrosis via suppression of the NLRP3\/GSDMD pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115348","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115348"}}