{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:27:21Z","timestamp":1791685641259,"version":"4.3.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160441"],"award-info":[{"award-number":["82160441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004637","name":"Nanchang University","doi-asserted-by":"publisher","award":["CDYFY-IACUC 202211 QR 007"],"award-info":[{"award-number":["CDYFY-IACUC 202211 QR 007"]}],"id":[{"id":"10.13039\/501100004637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.intimp.2025.115349","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T06:49:18Z","timestamp":1755154158000},"page":"115349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["MYCN-mediated pyroptosis and inflammation in the molecular mechanism of MicroRNA-202-3P promote functional recovery in spinal cord injury"],"prefix":"10.1016","volume":"164","author":[{"given":"Jing","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haidi","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Shuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115349_bb0005","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/s41392-022-00885-4","article-title":"Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2025.115349_bb0010","article-title":"Immune response following traumatic spinal cord injury: pathophysiology and therapies","volume":"13","author":"Sterner","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115349_bb0015","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","article-title":"Spinal cord injury: molecular mechanisms and therapeutic interventions","volume":"8","author":"Hu","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2025.115349_bb0020","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","article-title":"Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration","volume":"18","author":"Hellenbrand","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.115349_bb0025","doi-asserted-by":"crossref","first-page":"4187","DOI":"10.7150\/thno.49054","article-title":"SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-\u03baB signaling","volume":"11","author":"Liu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2025.115349_bb0030","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1111\/cns.14085","article-title":"Alpinetin inhibits neuroinflammation and neuronal apoptosis via targeting the JAK2\/STAT3 signaling pathway in spinal cord injury","volume":"29","author":"Xiao","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2025.115349_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.894","article-title":"TLR4 aggravates microglial pyroptosis by promoting DDX3X-mediated NLRP3 inflammasome activation via JAK2\/STAT1 pathway after spinal cord injury","volume":"12","author":"Wang","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.intimp.2025.115349_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102767","article-title":"Cyclic helix B peptide alleviates proinflammatory cell death and improves functional recovery after traumatic spinal cord injury","volume":"64","author":"Xu","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.115349_bb0045","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s12951-022-01724-y","article-title":"Treg cell-derived exosomes miR-709 attenuates microglia pyroptosis and promotes motor function recovery after spinal cord injury","volume":"20","author":"Xiong","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.intimp.2025.115349_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113310","article-title":"Microglia and macrophage metabolism in CNS injury and disease: the role of immunometabolism in neurodegeneration and neurotrauma","volume":"329","author":"Devanney","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2025.115349_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101932","article-title":"Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-\u03baB signaling pathway in vascular endothelial cells after traumatic spinal cord injury","volume":"41","author":"Ge","year":"2021","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0060","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-023-02255-w","article-title":"M2 microglia-derived exosome-loaded electroconductive hydrogel for enhancing neurological recovery after spinal cord injury","volume":"22","author":"Guan","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010114","article-title":"The study of cerebrospinal fluid microRNAs in spinal cord injury and neurodegenerative diseases: methodological problems and possible solutions","volume":"23","author":"Baichurina","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2025.115349_bb0070","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/s41374-021-00606-5","article-title":"Microrna-182 improves spinal cord injury in mice by modulating apoptosis and the inflammatory response via IKK\u03b2\/NF-\u03baB","volume":"101","author":"Fei","year":"2021","journal-title":"Lab. Invest."},{"issue":"3","key":"10.1016\/j.intimp.2025.115349_bb0075","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10142-023-01220-y","article-title":"The dysregulation of miRNAs in epilepsy and their regulatory role in inflammation and apoptosis","volume":"23","author":"Xie","year":"2023","journal-title":"Funct. Integr. Genomics"},{"issue":"2","key":"10.1016\/j.intimp.2025.115349_bb0080","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01127-22","article-title":"A novel synbiotic alleviates autoimmune hepatitis by modulating the gut microbiota-liver axis and inhibiting the hepatic TLR4\/NF-\u03baB\/NLRP3 signaling pathway","volume":"8","author":"Kang","year":"2023","journal-title":"mSystems"},{"key":"10.1016\/j.intimp.2025.115349_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115999","article-title":"Huangqin decoction mitigates hepatic inflammation in high-fat diet-challenged rats by inhibiting TLR4\/NF-\u03baB\/NLRP3 pathway","volume":"303","author":"Yan","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115349_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117712","article-title":"Qingda granule alleviates cerebral ischemia\/reperfusion injury by inhibiting TLR4\/NF-\u03baB\/NLRP3 signaling in microglia","volume":"324","author":"Cai","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115349_bb0095","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.yjmcc.2020.02.007","article-title":"M2 macrophage-derived exosomes carry microRNA-148a to alleviate myocardial ischemia\/reperfusion injury via inhibiting TXNIP and the TLR4\/NF-\u03baB\/NLRP3 inflammasome signaling pathway","volume":"142","author":"Dai","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0100","doi-asserted-by":"crossref","first-page":"11860","DOI":"10.1038\/s41598-024-62733-5","article-title":"miRNA-206-3p alleviates LPS-induced acute lung injury via inhibiting inflammation and pyroptosis through modulating TLR4\/NF-\u03baB\/NLRP3 pathway","volume":"14","author":"Chen","year":"2024","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.intimp.2025.115349_bb0105","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.4103\/1673-5374.335164","article-title":"Microrna-101a-3p mimic ameliorates spinal cord ischemia\/reperfusion injury","volume":"17","author":"Zhang","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0110","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/15476286.2020.1804698","article-title":"MCPIP1 ribonuclease can bind and cleave AURKA mRNA in MYCN-amplified neuroblastoma cells","volume":"18","author":"Nowak","year":"2021","journal-title":"RNA Biol."},{"issue":"49","key":"10.1016\/j.intimp.2025.115349_bb0115","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2213146119","article-title":"Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors","volume":"119","author":"Novototskaya-Vlasova","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"8","key":"10.1016\/j.intimp.2025.115349_bb0120","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.3390\/ijms26083600","article-title":"Pomiferin induces Antiproliferative and pro-death effects in high-risk neuroblastoma cells by modulating multiple cell death pathways","volume":"26","author":"Gnanamony","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0125","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12868-022-00698-9","article-title":"Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury of rat","volume":"23","author":"Zhao","year":"2022","journal-title":"BMC Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12974-020-01973-4","article-title":"Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages\/microglia polarization and affords neuroprotection after spinal cord injury","volume":"17","author":"Fan","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0135","article-title":"Schwann cell-derived exosomes containing MFG-E8 modify macrophage\/microglial polarization for attenuating inflammation via the SOCS3\/STAT3 pathway after spinal cord injury","volume":"14","author":"Jie","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0140","doi-asserted-by":"crossref","first-page":"30099","DOI":"10.1038\/s41598-024-81332-y","article-title":"Bone marrow mesenchymal stem cells modulate miR-202-3p to suppress neuronal apoptosis following spinal cord injury through autophagy activation via the AMPK, MAPK, and PI3K\/AKT\/mTOR signaling pathway","volume":"14","author":"Huang","year":"2024","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0145","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00401-024-02758-2","article-title":"Ferroptosis inhibitor improves outcome after early and delayed treatment in mild spinal cord injury","volume":"147","author":"Ryan","year":"2024","journal-title":"Acta Neuropathol."},{"issue":"8","key":"10.1016\/j.intimp.2025.115349_bb0150","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1007\/s12035-024-03954-7","article-title":"Spinal cord injury: from MicroRNAs to Exosomal MicroRNAs","volume":"61","author":"Xu","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115349_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e17852","article-title":"lncRNA XIST inhibition promotes M2 polarization of microglial and aggravates the spinal cord injury via regulating miR-124-3p \/ IRF1 axis","volume":"9","author":"Yang","year":"2023","journal-title":"Heliyon"},{"issue":"2","key":"10.1016\/j.intimp.2025.115349_bb0160","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2021.4979","article-title":"Gypenoside XVII protects against spinal cord injury in mice by regulating the microRNA-21-mediated PTEN\/AKT\/mTOR pathway","volume":"48","author":"Sun","year":"2021","journal-title":"Int. J. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12974-021-02342-5","article-title":"MicroRNA-155-5p promotes neuroinflammation and central sensitization via inhibiting SIRT1 in a nitroglycerin-induced chronic migraine mouse model","volume":"18","author":"Wen","year":"2021","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.intimp.2025.115349_bb0170","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/cns.14113","article-title":"Exosomal miR-128-3p reversed fibrinogen-mediated inhibition of oligodendrocyte progenitor cell differentiation and remyelination after cerebral ischemia","volume":"29","author":"Hou","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2025.115349_bb0175","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.celrep.2019.09.020","article-title":"Oligodendrocyte intrinsic miR-27a controls myelination and Remyelination","volume":"29","author":"Tripathi","year":"2019","journal-title":"Cell Rep."},{"issue":"7","key":"10.1016\/j.intimp.2025.115349_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0254921","article-title":"Impact of microRNA-210 on wound healing among the patients with diabetic foot ulcer","volume":"16","author":"Pichu","year":"2021","journal-title":"PloS One"},{"issue":"7","key":"10.1016\/j.intimp.2025.115349_bb0185","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/cns.13839","article-title":"Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial\/macrophage polarization","volume":"28","author":"Xue","year":"2022","journal-title":"CNS Neurosci. Ther."},{"issue":"7","key":"10.1016\/j.intimp.2025.115349_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/biom13071029","article-title":"Tanshinone IIA and cryptotanshinone counteract inflammation by regulating gene and miRNA expression in human SGBS adipocytes","volume":"13","author":"Carpi","year":"2023","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0195","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12964-024-01803-7","article-title":"The role of miR-155-5p in inflammation and mechanical loading during intervertebral disc degeneration","volume":"22","author":"Cazzanelli","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"6","key":"10.1016\/j.intimp.2025.115349_bb0200","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1159\/000526666","article-title":"Upregulation of miRNA-26a enhances the apoptosis of cerebral neurons by targeting EphA2 and inhibiting the MAPK pathway","volume":"44","author":"Chi","year":"2022","journal-title":"Dev. Neurosci."},{"issue":"5","key":"10.1016\/j.intimp.2025.115349_bb0205","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1002\/ehf2.14493","article-title":"miRNA-103-3p-Hlf regulates apoptosis and autophagy by targeting hepatic leukaemia factor in heart failure","volume":"10","author":"Xue","year":"2023","journal-title":"ESC Heart Fail."},{"issue":"4","key":"10.1016\/j.intimp.2025.115349_bb0210","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1111\/jcmm.16139","article-title":"The miRNA-15b\/USP7\/KDM6B axis engages in the initiation of osteoporosis by modulating osteoblast differentiation and autophagy","volume":"25","author":"Lu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0215","doi-asserted-by":"crossref","DOI":"10.1080\/13510002.2023.2224607","article-title":"Inhibition of MEG3 ameliorates cardiomyocyte apoptosis and autophagy by regulating the expression of miRNA-129-5p in a mouse model of heart failure","volume":"28","author":"Mi","year":"2023","journal-title":"Redox Rep."},{"key":"10.1016\/j.intimp.2025.115349_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2024.1429977","article-title":"Neuroinflammation in Parkinson\u2019s disease: focus on the relationship between miRNAs and microglia","volume":"18","author":"Xu","year":"2024","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0225","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1213\/ANE.0000000000007239","article-title":"The effect of Pexidartinib on neuropathic pain via influences on microglia and neuroinflammation in mice","volume":"141","author":"Yang","year":"2025","journal-title":"Anesth. Analg."},{"issue":"19","key":"10.1016\/j.intimp.2025.115349_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914771","article-title":"Ursolic acid alleviates Neuroinflammation after intracerebral hemorrhage by mediating microglial Pyroptosis via the NF-\u03baB\/NLRP3\/GSDMD pathway","volume":"24","author":"Lei","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0235","doi-asserted-by":"crossref","DOI":"10.1111\/imr.13406","article-title":"Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis","volume":"329","author":"Pandey","year":"2025","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2025.115349_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116673","article-title":"The interplay between mitochondrial dysfunction and NLRP3 inflammasome in multiple sclerosis: therapeutic implications and animal model studies","volume":"175","author":"Shadab","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.intimp.2025.115349_bb0245","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001335","article-title":"Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma","volume":"9","author":"Seier","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0250","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00383-024-05788-9","article-title":"Systemic inflammation enhances metastatic growth in a syngeneic neuroblastoma mouse model","volume":"40","author":"Mimura","year":"2024","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.intimp.2025.115349_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112068","article-title":"Reniformin a suppresses non-small cell lung cancer progression by inducing TLR4\/NLRP3\/caspase-1\/GSDMD-dependent pyroptosis","volume":"133","author":"Zhu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0260","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-023-02721-0","article-title":"Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4\/MyD88\/NF-\u03baB pathway in LPC-induced demyelination","volume":"20","author":"Wang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.115349_bb0265","doi-asserted-by":"crossref","first-page":"6561048","DOI":"10.1155\/2022\/6561048","article-title":"Yanghe Pingchuan granules alleviate airway inflammation in bronchial asthma and inhibit Pyroptosis by blocking the TLR4\/NF-\u03baB\/NRLP3 signaling pathway","volume":"2022","author":"Pan","year":"2022","journal-title":"Mediators Inflamm."},{"issue":"6","key":"10.1016\/j.intimp.2025.115349_bb0270","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.70372","article-title":"Elucidation of dexmedetomidine-induced analgesic tolerance mechanisms in neuropathic pain with modulation of SGK1, NR2A, and NR2B expression via the spinal SGK1\/NF-\u03baB signalling pathway","volume":"29","author":"Huikang","year":"2025","journal-title":"J. Cell. Mol. Med."},{"issue":"12","key":"10.1016\/j.intimp.2025.115349_bb0275","doi-asserted-by":"crossref","first-page":"52","DOI":"10.14715\/cmb\/2024.70.12.7","article-title":"Inhibition of RIPK1-driven necroptosis ameliorates inflammatory hyperalgesia caused by lipopolysaccharide: involvement of TLR-, NLRP3-, and caspase-11-mediated signaling pathways","volume":"70","author":"Kurt","year":"2025","journal-title":"Cell. Mol. Biol. (Noisy-le-Grand)"},{"issue":"1","key":"10.1016\/j.intimp.2025.115349_bb0280","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s10571-024-01519-9","article-title":"The role of inflammatory Cascade and reactive Astrogliosis in glial scar formation post-spinal cord injury","volume":"44","author":"Bhatt","year":"2024","journal-title":"Cell. Mol. Neurobiol."},{"issue":"15","key":"10.1016\/j.intimp.2025.115349_bb0285","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1021\/acs.nanolett.2c02259","article-title":"Three-dimensional-cultured MSC-derived exosome-hydrogel hybrid microneedle Array patch for spinal cord repair","volume":"22","author":"Han","year":"2022","journal-title":"Nano Lett."},{"issue":"22","key":"10.1016\/j.intimp.2025.115349_bb0290","doi-asserted-by":"crossref","first-page":"22928","DOI":"10.1021\/acsnano.3c08046","article-title":"Schwann cell-derived exosomes and methylprednisolone composite patch for spinal cord injury repair","volume":"17","author":"Zhu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.intimp.2025.115349_bb0295","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.2147\/JIR.S428425","article-title":"Mesenchymal stem cell transplantation: neuroprotection and nerve regeneration after spinal cord injury","volume":"16","author":"Chen","year":"2023","journal-title":"J. Inflamm. Res."},{"issue":"11","key":"10.1016\/j.intimp.2025.115349_bb0300","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12137","article-title":"Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF-\u03b2 upregulation, microvascular stabilization and functional recovery in a rodent model of severe spinal cord injury","volume":"10","author":"Nakazaki","year":"2021","journal-title":"J. Extracell. Vesicles"},{"issue":"18","key":"10.1016\/j.intimp.2025.115349_bb0305","doi-asserted-by":"crossref","first-page":"13849","DOI":"10.3390\/ijms241813849","article-title":"Role of stem cell-derived exosomes and microRNAs in spinal cord injury","volume":"24","author":"Hwang","year":"2023","journal-title":"Int. J. Mol. Sci."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925013402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925013402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T07:45:49Z","timestamp":1758786349000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925013402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":61,"alternative-id":["S1567576925013402"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115349","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MYCN-mediated pyroptosis and inflammation in the molecular mechanism of MicroRNA-202-3P promote functional recovery in spinal cord injury","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115349","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115349"}}