{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T07:30:00Z","timestamp":1794036600662,"version":"4.8.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009103","name":"Education Department of Shaanxi Province","doi-asserted-by":"publisher","award":["23JK0581"],"award-info":[{"award-number":["23JK0581"]}],"id":[{"id":"10.13039\/501100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBQN-0880"],"award-info":[{"award-number":["2024JC-YBQN-0880"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024SF-YBXM-217"],"award-info":[{"award-number":["2024SF-YBXM-217"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2023-JC-QN-0932"],"award-info":[{"award-number":["2023-JC-QN-0932"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82072229"],"award-info":[{"award-number":["82072229"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.intimp.2025.115471","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T11:46:52Z","timestamp":1757159212000},"page":"115471","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Tauroursodeoxycholic acid modulates neuroinflammation via STING\/NF-\u03baB inhibition after traumatic brain injury"],"prefix":"10.1016","volume":"165","author":[{"given":"Jiawei","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianlin","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115471_bb0235","doi-asserted-by":"crossref","first-page":"eadj4260","DOI":"10.1126\/sciadv.adj4260","article-title":"Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury","volume":"10","author":"Zhang","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2025.115471_bb0130","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic brain injury: progress and challenges in prevention, clinical care, and research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.intimp.2025.115471_bb0135","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00134-022-06702-4","article-title":"Management of moderate to severe traumatic brain injury: an update for the intensivist","volume":"48","author":"Meyfroidt","year":"2022","journal-title":"Intensive Care Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115471_bb0030","doi-asserted-by":"crossref","DOI":"10.31083\/JIN25292","article-title":"Mitochondria as a therapeutic target: focusing on traumatic brain injury","volume":"24","author":"Carteri","year":"2025","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.intimp.2025.115471_bb0095","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.neuron.2017.07.010","article-title":"Neuroimmunology of traumatic brain injury: time for a paradigm shift","volume":"95","author":"Jassam","year":"2017","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.intimp.2025.115471_bb0150","doi-asserted-by":"crossref","first-page":"81","DOI":"10.31083\/j.jin2204081","article-title":"Nrf2 as a potential therapeutic target for traumatic brain injury","volume":"22","author":"Muneer","year":"2023","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.intimp.2025.115471_bb0025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.25259\/SNI_774_2023","article-title":"Neuroprotection: surgical approaches in traumatic brain injury","volume":"15","author":"Buccilli","year":"2024","journal-title":"Surg. Neurol. Int."},{"key":"10.1016\/j.intimp.2025.115471_bb0190","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s40478-023-01635-5","article-title":"Selective neuroimmune modulation by type I interferon drives neuropathology and neurologic dysfunction following traumatic brain injury","volume":"11","author":"Todd","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.intimp.2025.115471_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.111066","article-title":"Neuroimmune and neuroinflammation response for traumatic brain injury","volume":"217","author":"Wu","year":"2024","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.intimp.2025.115471_bb0225","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2100225118","article-title":"TBK1 recruitment to STING activates both IRF3 and NF-\u03baB that mediate immune defense against tumors and viral infections","volume":"118","author":"Yum","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.115471_bb0185","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/jb\/mvad064","article-title":"Membrane traffic governs the STING inflammatory signalling","volume":"174","author":"Taguchi","year":"2023","journal-title":"J Biochem (Tokyo)"},{"key":"10.1016\/j.intimp.2025.115471_bb0005","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12974-018-1354-7","article-title":"STING-mediated type-I interferons contribute to the neuroinflammatory process and detrimental effects following traumatic brain injury","volume":"15","author":"Abdullah","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.115471_bb0060","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 Inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.115471_bb0195","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41573-023-00822-2","article-title":"Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets","volume":"23","author":"Vande Walle","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.intimp.2025.115471_bb0160","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/bph.16001","article-title":"Drug repurposing for cardiovascular diseases: new targets and indications for probenecid","volume":"180","author":"On\u00f3di","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115471_bb0105","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.3390\/cells8121471","article-title":"Tauroursodeoxycholate-bile acid with chaperoning activity: molecular and cellular effects and therapeutic perspectives","volume":"8","author":"Kusaczuk","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2025.115471_bb0065","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41575-021-00566-7","article-title":"Role of bile acids and their receptors in gastrointestinal and hepatic pathophysiology","volume":"19","author":"Fuchs","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2025.115471_bb0110","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1136\/gutjnl-2021-325013","article-title":"NFATc1 signaling drives chronic ER stress responses to promote NAFLD progression","volume":"71","author":"Latif","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2025.115471_bb0085","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41580-020-0250-z","article-title":"Mechanism, regulation and functions of the unfolded protein response","volume":"21","author":"Hetz","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2025.115471_bb0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s00401-016-1655-9","article-title":"Tauroursodeoxycholic bile acid arrests axonal degeneration by inhibiting the unfolded protein response in X-linked adrenoleukodystrophy","volume":"133","author":"Launay","year":"2017","journal-title":"Acta Neuropathol (Berl)"},{"key":"10.1016\/j.intimp.2025.115471_bb0210","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s13578-023-01053-z","article-title":"Roles of bile acids signaling in neuromodulation under physiological and pathological conditions","volume":"13","author":"Xing","year":"2023","journal-title":"Cell Biosci."},{"key":"10.1016\/j.intimp.2025.115471_bb0045","article-title":"Akkermansia muciniphila-Nlrp3 is involved in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115471_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146566","article-title":"Tauroursodeoxycholic acid prevents ER stress-induced apoptosis and improves cerebral and vascular function in mice subjected to subarachnoid hemorrhage","volume":"1727","author":"Chen","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2025.115471_bb0075","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting STING with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115471_bb0170","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1111\/cns.14278","article-title":"Single-cell RNA-sequencing analysis reveals enhanced non-canonical neurotrophic factor signaling in the subacute phase of traumatic brain injury","volume":"29","author":"Qiu","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2025.115471_bb0050","doi-asserted-by":"crossref","DOI":"10.1097\/JS9.0000000000001794","article-title":"WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury","author":"Chen","year":"2024","journal-title":"Int J Surg Lond Engl."},{"key":"10.1016\/j.intimp.2025.115471_bb0220","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3390\/biom14030350","article-title":"Exploration of the binding mechanism of cyclic dinucleotide analogs to stimulating factor proteins and the implications for subsequent analog drug design","volume":"14","author":"Yuan","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/j.intimp.2025.115471_bb0165","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.wneu.2024.01.084","article-title":"Traumatic brain injury: a comprehensive review of biomechanics and molecular pathophysiology","volume":"185","author":"Orr","year":"2024","journal-title":"World Neurosurg."},{"key":"10.1016\/j.intimp.2025.115471_bb0215","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2147\/DDDT.S450895","article-title":"A novel network pharmacology strategy based on the universal effectiveness-common mechanism of medical herbs uncovers therapeutic targets in traumatic brain injury","volume":"18","author":"Yu","year":"2024","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2025.115471_bb0070","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1007\/s12035-022-02822-6","article-title":"A literature review of traumatic brain injury biomarkers","volume":"59","author":"Ghaith","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2025.115471_bb0010","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/brainsci12050527","article-title":"Current clinical trials in traumatic brain injury","volume":"12","author":"Ahmed","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.intimp.2025.115471_bb0020","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.biopsych.2021.05.025","article-title":"Traumatic brain injury and risk of neurodegenerative disorder","volume":"91","author":"Brett","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2025.115471_bb0175","doi-asserted-by":"crossref","first-page":"9279","DOI":"10.3390\/ijms25179279","article-title":"Emerging roles of bile acids and TGR5 in the central nervous system: molecular functions and therapeutic implications","volume":"25","author":"Romero-Ram\u00edrez","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115471_bb0055","article-title":"Bile acid metabolites predict multiple sclerosis progression and supplementation is safe in progressive disease","author":"Dc","year":"2024","journal-title":"MedRxiv Prepr Serv Health Sci."},{"key":"10.1016\/j.intimp.2025.115471_bb0090","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.biopsych.2021.09.024","article-title":"Mental health consequences of traumatic brain injury","volume":"91","author":"Howlett","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.intimp.2025.115471_bb0015","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.4103\/NRR.NRR-D-23-01424","article-title":"Hypidone hydrochloride (YL-0919) ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation","volume":"20","author":"Bai","year":"2025","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2025.115471_bb0120","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1484742","article-title":"Changes in serum concentration of perioperative inflammatory cytokines following the timing of surgery among mild-moderate traumatic brain injury patients and factors associated","volume":"15","author":"Lekuya","year":"2024","journal-title":"Front. Neurol."},{"key":"10.1016\/j.intimp.2025.115471_bb0245","article-title":"Relationship between the cGAS-STING and NF-\u03baB pathways-role in neurotoxicity","volume":"175","author":"Zhong","year":"2024","journal-title":"Biomed Pharmacother Biomedecine Pharmacother"},{"key":"10.1016\/j.intimp.2025.115471_bb0155","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41420-023-01360-x","article-title":"XBP1 modulates endoplasmic reticulum and mitochondria crosstalk via regulating NLRP3 in renal ischemia\/reperfusion injury","volume":"9","author":"Ni","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2025.115471_bb0240","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13287-020-02091-x","article-title":"Exosomal microRNA-22-3p alleviates cerebral ischemic injury by modulating KDM6B\/BMP2\/BMF axis","volume":"12","author":"Zhang","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.intimp.2025.115471_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2023.115401","article-title":"Aluminum exposure induces central nervous system impairment via activating NLRP3-medicated pyroptosis pathway","volume":"264","author":"Hao","year":"2023","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.intimp.2025.115471_bb0230","article-title":"Stress granule-localized USP8 potentiates cGAS-mediated type I interferonopathies through deubiquitination of DDX3X","volume":"43","author":"Zhang","year":"2024","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2025.115471_bb0145","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.molcel.2017.06.020","article-title":"HEXIM1 and NEAT1 Long non-coding RNA form a multi-subunit complex that regulates DNA-mediated innate immune response","volume":"67","author":"Morchikh","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2025.115471_bb0140","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01209-24","article-title":"IFI207, a young and fast-evolving protein, controls retroviral replication via the STING pathway","volume":"15","author":"Moran","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.intimp.2025.115471_bb0125","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41586-022-04559-7","article-title":"Activation of STING by targeting a pocket in the transmembrane domain","volume":"604","author":"Lu","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115471_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114934","article-title":"Second messenger 2\u20323\u2019-cyclic GMP-AMP (2\u20323\u2019-cGAMP): synthesis, transmission, and degradation","volume":"198","author":"Su","year":"2022","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115471_bb0205","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.it.2023.04.006","article-title":"Structure-based mechanisms of 2\u20323\u2019-cGAMP intercellular transport in the cGAS-STING immune pathway","volume":"44","author":"Xie","year":"2023","journal-title":"Trends Immunol."},{"key":"10.1016\/j.intimp.2025.115471_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104866","article-title":"Regulation of cGAS and STING signaling during inflammation and infection","volume":"299","author":"Chauvin","year":"2023","journal-title":"J. Biol. Chem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925014626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925014626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:55:29Z","timestamp":1778820929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925014626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":48,"alternative-id":["S1567576925014626"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115471","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tauroursodeoxycholic acid modulates neuroinflammation via STING\/NF-\u03baB inhibition after traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115471","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115471"}}