{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:16:34Z","timestamp":1791418594690,"version":"4.3.3"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["2023Y1390"],"award-info":[{"award-number":["2023Y1390"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.intimp.2025.115472","type":"journal-article","created":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T17:22:04Z","timestamp":1757265724000},"page":"115472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Dimethyl fumarate mitigates osteoarthritis progression through Nrf2 activation-mediated suppression of oxidative stress and subchondral osteoclastogenesis"],"prefix":"10.1016","volume":"165","author":[{"given":"Zhenyu","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziye","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.intimp.2025.115472_bb0005","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the global burden of disease study 2021","volume":"5","author":"Collaborators","year":"2023","journal-title":"Lancet Rheumatol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0010","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cger.2021.11.005","article-title":"The burden of osteoarthritis in older adults","volume":"38","author":"Hawker","year":"2022","journal-title":"Clin. Geriatr. Med."},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2023.101836","article-title":"The burden of osteoarthritis: is it a rising problem?","volume":"37","author":"Scheuing","year":"2023","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.intimp.2025.115472_bb0020","doi-asserted-by":"crossref","DOI":"10.2196\/57359","article-title":"Sex-specific trends in the prevalence of osteoarthritis and rheumatoid arthritis from 2005 to 2021 in South Korea: Nationwide cross-sectional study","volume":"10","author":"Park","year":"2024","journal-title":"JMIR Public Health Surveill."},{"issue":"10182","key":"10.1016\/j.intimp.2025.115472_bb0025","first-page":"1745","volume":"393","author":"Hunter","year":"2019","journal-title":"Osteoarthritis. Lancet."},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0030","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.mcna.2019.10.007","article-title":"Osteoarthritis: pathology, diagnosis, and treatment options","volume":"104","author":"Abramoff","year":"2020","journal-title":"Med. Clin. North Am."},{"issue":"1","key":"10.1016\/j.intimp.2025.115472_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12010005","article-title":"Osteoarthritis: pathogenesis, animal models, and new regenerative therapies","volume":"12","author":"Szponder","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2025.115472_bb0040","first-page":"1","article-title":"Cartilage-on-chip for osteoarthritis drug screening","volume":"1","author":"Zhao","year":"2025","journal-title":"OR"},{"key":"10.1016\/j.intimp.2025.115472_bb0045","first-page":"4","article-title":"Skeletal organoids","volume":"5","author":"Zhang","year":"2024","journal-title":"BMT"},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0050","article-title":"Organoid research breakthroughs in 2024: a review","volume":"1","author":"Wang","year":"2025","journal-title":"OR"},{"issue":"4","key":"10.1016\/j.intimp.2025.115472_bb0055","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.pop.2013.08.003","article-title":"Diagnosis and treatment of osteoarthritis","volume":"40","author":"Taruc-Uy","year":"2013","journal-title":"Prim. Care"},{"key":"10.1016\/j.intimp.2025.115472_bb0060","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1749-6632.2009.05240.x","article-title":"Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis","volume":"1192","author":"Goldring","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2025.115472_bb0065","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bcp.2011.09.018","article-title":"Subchondral bone as a key target for osteoarthritis treatment","volume":"83","author":"Casta\u00f1eda","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115472_bb0070","article-title":"Subchondral bone changes in hand and knee osteoarthritis detected by radiography","volume":"12 Suppl A:S10-9","author":"Buckland-Wright","year":"2004","journal-title":"Osteoarthr. Cartil."},{"issue":"7","key":"10.1016\/j.intimp.2025.115472_bb0075","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nrrheum.2012.80","article-title":"Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis","volume":"8","author":"Mapp","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115472_bb0080","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-021-00147-z","article-title":"Subchondral bone microenvironment in osteoarthritis and pain","volume":"9","author":"Hu","year":"2021","journal-title":"Bone Res"},{"issue":"10","key":"10.1016\/j.intimp.2025.115472_bb0085","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1248\/bpb.b22-00371","article-title":"V-ATPase a3 subunit in secretory lysosome trafficking in osteoclasts","volume":"45","author":"Nakanishi-Matsui","year":"2022","journal-title":"Biol. Pharm. Bull."},{"issue":"9","key":"10.1016\/j.intimp.2025.115472_bb0090","first-page":"1461","article-title":"What drives osteoarthritis?-synovial versus subchondral bone pathology","volume":"56","author":"H\u00fcgle","year":"2017","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.intimp.2025.115472_bb0095","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/joa.14035","article-title":"Assessment of subchondral bone microdamage quantification using contrast-enhanced imaging techniques","volume":"245","author":"Ayodele","year":"2024","journal-title":"J. Anat."},{"issue":"7","key":"10.1016\/j.intimp.2025.115472_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271485","article-title":"Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption","volume":"17","author":"Ding","year":"2022","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.intimp.2025.115472_bb0105","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41413-022-00201-4","article-title":"PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis","volume":"10","author":"Jiang","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2025.115472_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113947","article-title":"Bafilomycin A1 mitigates subchondral bone degeneration and pain in TMJOA rats","volume":"147","author":"Jiang","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2025.115472_bb0115","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1136\/annrheumdis-2015-207923","article-title":"Halofuginone attenuates osteoarthritis by inhibition of TGF-\u03b2 activity and H-type vessel formation in subchondral bone","volume":"75","author":"Cui","year":"2016","journal-title":"Ann. Rheum. Dis."},{"issue":"10","key":"10.1016\/j.intimp.2025.115472_bb0120","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115472_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"Finkel","year":"2011","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115472_bb0130","article-title":"Oxidative-stress-related genes in osteoporosis: a systematic review","volume":"12","author":"Le\u00f3n-Reyes","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2025.115472_bb0135","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","article-title":"Redox and NF-\u03baB signaling in osteoarthritis","volume":"132","author":"Lepetsos","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2025.115472_bb0140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijbiomac.2021.06.197","article-title":"Fenugreek steroidal saponins hinder osteoclastogenic bone resorption by targeting CSF-1R which diminishes the RANKL\/OPG ratio","volume":"186","author":"Zinnia","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0145","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-023-05595-5","article-title":"PINK1\/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0150","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1080\/10641963.2020.1836191","article-title":"Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice","volume":"43","author":"Farooqui","year":"2021","journal-title":"Clin. Exp. Hypertens."},{"key":"10.1016\/j.intimp.2025.115472_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115454","article-title":"Anemoside B4 attenuates RANKL-induced osteoclastogenesis by upregulating Nrf2 and dampens ovariectomy-induced bone loss","volume":"167","author":"Cao","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.intimp.2025.115472_bb0160","article-title":"Nrf2 mitigates RANKL and M-CSF induced osteoclast differentiation via ROS-dependent mechanisms","volume":"12","author":"Yang","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2025.115472_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1027553","article-title":"Ginkgolide C slows the progression of osteoarthritis by activating Nrf2\/HO-1 and blocking the NF-\u03baB pathway","volume":"13","author":"Ma","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e13080","article-title":"Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation","volume":"9","author":"Yang","year":"2023","journal-title":"Heliyon"},{"issue":"7","key":"10.1016\/j.intimp.2025.115472_bb0175","article-title":"Antioxidant and anti-inflammatory effect of Nrf2 inducer dimethyl fumarate in neurodegenerative diseases","volume":"9","author":"Scuderi","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2025.115472_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107844","article-title":"Dimethyl fumarate improves cognitive deficits in chronic cerebral hypoperfusion rats by alleviating inflammation, oxidative stress, and ferroptosis via NRF2\/ARE\/NF-\u03baB signal pathway","volume":"98","author":"Yan","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115472_bb0185","doi-asserted-by":"crossref","DOI":"10.1177\/17448069221124920","article-title":"Dimethyl fumarate attenuates pain behaviors in osteoarthritis rats via induction of Nrf2-mediated mitochondrial biogenesis","volume":"18","author":"Gao","year":"2022","journal-title":"Mol. Pain"},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0190","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/jcmm.13367","article-title":"Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation","volume":"22","author":"Yamaguchi","year":"2018","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2025.115472_bb0195","article-title":"Biosensors for detection of biochemical markers relevant to osteoarthritis","volume":"11","author":"Longo","year":"2021","journal-title":"Biosensors (Basel)"},{"key":"10.1016\/j.intimp.2025.115472_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.900344","article-title":"Development of nanomaterials to target articular cartilage for osteoarthritis therapy","volume":"9","author":"Rao","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"4","key":"10.1016\/j.intimp.2025.115472_bb0205","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s40266-024-01108-x","article-title":"Patterns of comorbidities and prescribing and dispensing of non-steroidal anti-inflammatory drugs (NSAIDs) among patients with osteoarthritis in the USA: real-world study","volume":"41","author":"Ide","year":"2024","journal-title":"Drugs Aging"},{"issue":"7","key":"10.1016\/j.intimp.2025.115472_bb0210","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1080\/09168451.2020.1738912","article-title":"Puerarin inhibits the migration of osteoclast precursors and osteoclastogenesis by inhibiting MCP-1 production","volume":"84","author":"Lin","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2025.115472_bb0215","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1038\/s41598-020-59363-y","article-title":"C-phycocyanin attenuates RANKL-induced osteoclastogenesis and bone resorption in vitro through inhibiting ROS levels, NFATc1 and NF-\u03baB activation","volume":"10","author":"AlQranei","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2025.115472_bb0220","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/JCMA.0000000000001096","article-title":"Suppression of bone resorption by Mori Radicis cortex through NFATc1 and c-Fos signaling-mediated inhibition of osteoclast differentiation","volume":"87","author":"Hong","year":"2024","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.intimp.2025.115472_bb0225","doi-asserted-by":"crossref","DOI":"10.1038\/srep38014","article-title":"NADPH oxidase gp91(phox) contributes to RANKL-induced osteoclast differentiation by upregulating NFATc1","volume":"6","author":"Kang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115472_bb0230","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13018-016-0346-5","article-title":"Animal models of osteoarthritis: classification, update, and measurement of outcomes","volume":"11","author":"Kuyinu","year":"2016","journal-title":"J. Orthop. Surg. Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.115472_bb0235","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s12891-021-04180-1","article-title":"The burden of chronic pain for patients with osteoarthritis in Germany: a retrospective cohort study of claims data","volume":"22","author":"Schild","year":"2021","journal-title":"BMC Musculoskelet. Disord."},{"issue":"3","key":"10.1016\/j.intimp.2025.115472_bb0240","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1172\/JCI121561","article-title":"Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain","volume":"129","author":"Zhu","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.intimp.2025.115472_bb0245","first-page":"335","article-title":"Organoids: the future of disease modelling and therapeutics","volume":"5","author":"Zhou","year":"2024","journal-title":"Biomater Transl"},{"key":"10.1016\/j.intimp.2025.115472_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.117865","article-title":"Dimethyl fumarate attenuates synovial inflammation, reduces nociception, and inhibits the development of post-traumatic osteoarthritis","volume":"183","author":"Khan","year":"2025","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.intimp.2025.115472_bb0255","doi-asserted-by":"crossref","first-page":"17932","DOI":"10.1021\/acsami.4c19160","article-title":"Reprogramming macrophage phenotype using a reactive oxygen species-responsive liposome delivery system for inflammation microenvironment remodeling and osteoarthritis treatment","volume":"17","author":"Lai","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.intimp.2025.115472_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101845","article-title":"NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression","volume":"40","author":"S\u00e1nchez-de-Diego","year":"2021","journal-title":"Redox Biol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925014638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925014638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:10:40Z","timestamp":1763046640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925014638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":52,"alternative-id":["S1567576925014638"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115472","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dimethyl fumarate mitigates osteoarthritis progression through Nrf2 activation-mediated suppression of oxidative stress and subchondral osteoclastogenesis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115472","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115472"}}