{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:33:23Z","timestamp":1785540803823,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["13\/08216-2"],"award-info":[{"award-number":["13\/08216-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.intimp.2025.115475","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T19:13:58Z","timestamp":1757099638000},"page":"115475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Paroxetine attenuates sepsis by preserving the expression of the G protein-coupled chemokine receptor CXCR2 on neutrophils"],"prefix":"10.1016","volume":"165","author":[{"given":"Let\u00edcia Selinger","family":"Galant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"de F\u00e1tima Borges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo S\u00e9rgio","family":"de Almeida Augusto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filipe Camargo","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Martelossi","family":"Cebinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego \u00c2ngelo","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter Vinicius Silva","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Setembre","family":"Batah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Miguel","family":"da Costa-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Todorovic","family":"Fabro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Sampaio","family":"Pupo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Dal-Pizzol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago Mattar","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Carlos Farias","family":"Alves-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Kanashiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando de Queiroz","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115475_bb0005","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA - Journal of the American Medical Association"},{"key":"10.1016\/j.intimp.2025.115475_bb0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00134-012-2769-8","article-title":"Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock, 2012","volume":"39","author":"Dellinger","year":"2013","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.intimp.2025.115475_bb0015","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1097\/SHK.0000000000000457","article-title":"Advances in vascular hyporeactivity after shock: the mechanisms and managements","volume":"44","author":"Duan","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2025.115475_bb0020","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/imr.12499","article-title":"The immune system\u2019s role in sepsis progression, resolution, and long-term outcome","volume":"274","author":"Delano","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2025.115475_bb0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2025.115475_bb0030","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ni.2921","article-title":"Neutrophils at work","volume":"15","author":"Nauseef","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.115475_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2016.00155","article-title":"Paradoxical roles of the neutrophil in sepsis: protective and deleterious","volume":"7","author":"S\u00f4nego","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115475_bb0040","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1128\/IAI.70.7.3602-3610.2002","article-title":"Inhibition of leukocyte rolling by nitric oxide during sepsis leads to reduced migration of active microbicidal neutrophils","volume":"70","author":"Farias Benjamim","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.intimp.2025.115475_bb0045","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/01.shk.0000208804.34292.38","article-title":"Failure of neutrophil migration to infectious focus and cardiovascular changes on sepsis in rats: effects of the inhibition of nitric oxide production, removal of infectious focus, and antimicrobial treatment","volume":"25","author":"Torres-Due\u00f1as","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2025.115475_bb0050","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/SHK.0b013e31820e1ef0","article-title":"Divergent role of heme oxygenase inhibition in the pathogenesis of sepsis","volume":"35","author":"Freitas","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2025.115475_bb0055","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1164\/rccm.200601-103OC","article-title":"Down-regulation of CXCR2 on neutrophils in severe sepsis is mediated by inducible nitric oxide synthase-derived nitric oxide","volume":"175","author":"Rios-Santos","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.115475_bb0060","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.0900196106","article-title":"Regulation of chemokine receptor by toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis","volume":"106","author":"Alves-Filho","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.115475_bb0065","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1182\/blood-2006-05-024638","article-title":"Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation","volume":"108","author":"Arraes","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2025.115475_bb0070","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1097\/CCM.0b013e318258fb70","article-title":"Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome","volume":"40","author":"Trevelin","year":"2012","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.115475_bb0075","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nm.2156","article-title":"Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection","volume":"16","author":"Alves-Filho","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2025.115475_bb0080","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1021\/cb3003013","article-title":"Paroxetine is a direct inhibitor of G protein-coupled receptor kinase 2 and increases myocardial contractility","volume":"7","author":"Thal","year":"2012","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.intimp.2025.115475_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1161\/JAHA.120.016364","article-title":"Paroxetine attenuates cardiac hypertrophy via blocking GRK2 and ADRB1 interaction in hypertension","volume":"10","author":"Sun","year":"2021","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.intimp.2025.115475_bb0090","author":"Schumacher"},{"key":"10.1016\/j.intimp.2025.115475_bb0095","doi-asserted-by":"crossref","unstructured":"E.L. Carlson, V. Karuppagounder, W.J. Pinamont, N.K. Yoshioka, A. Ahmad, E.M. Schott, H.K. Le Bleu, M.J. Zuscik, R.A. Elbarbary, F. Kamal, Paroxetine-Mediated GRK2 Inhibition Is a Disease-Modifying Treatment for Osteoarthritis. 7(2015) 277ra31. doi: 10.1126\/scitranslmed.aaa0154.","DOI":"10.1126\/scitranslmed.aaa0154"},{"key":"10.1016\/j.intimp.2025.115475_bb0100","doi-asserted-by":"crossref","first-page":"1032497","DOI":"10.3389\/fimmu.2022.1032497","article-title":"GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2","volume":"13","author":"Thapaliya","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115475_bb0105","series-title":"Sepsis and Septic Shock-A Review of Laboratory Models and a Proposal","author":"Wichterman","year":"1980"},{"key":"10.1016\/j.intimp.2025.115475_bb0110","first-page":"214","article-title":"Role of Nitric Oxide in the Failure of Neutrophil Migration in","volume":"182","author":"Benjamim","year":"2000","journal-title":"Sepsis"},{"key":"10.1016\/j.intimp.2025.115475_bb0115","doi-asserted-by":"crossref","first-page":"12178","DOI":"10.1038\/ncomms12178","article-title":"Monitoring G protein-coupled receptor and \u03b2-arrestin trafficking in live cells using enhanced bystander BRET","volume":"7","author":"Namkung","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115475_bb0120","first-page":"643","article-title":"A new and clinically relevant murine model of solid-organ transplant aspergillosis","volume":"6","author":"Herbst","year":"2013","journal-title":"DMM Disease Models and Mechanisms"},{"key":"10.1016\/j.intimp.2025.115475_bb0125","doi-asserted-by":"crossref","first-page":"9044","DOI":"10.1073\/pnas.1711687114","article-title":"Functional New World monkey oxytocin forms elicit an altered signaling profile and promotes parental care in rats","volume":"114","author":"Parreiras-E-Silva","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.115475_bb0130","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00011-022-01669-w","article-title":"FK506 impairs neutrophil migration that results in increased polymicrobial sepsis susceptibility","volume":"72","author":"de Borges","year":"2023","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.intimp.2025.115475_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112411","article-title":"Paroxetine mitigates cardiac remodelling by doxorubicin and increases survival","volume":"145","author":"Kosi\u0107","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115475_bb0145","article-title":"Paroxetine alleviates T lymphocyte activation and infiltration to joints of collagen-induced arthritis","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115475_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417270","article-title":"Cardioprotective effects of the GRK2 inhibitor paroxetine on isoproterenol-induced cardiac remodeling by modulating NF-\u03baB mediated Prohypertrophic and Profibrotic gene expression","volume":"24","author":"Alonazi","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115475_bb0155","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/SHK.0000000000001334","article-title":"Inhibition of aerobic glycolysis promotes neutrophil to influx to the infectious site via CXCR2 in Sepsis","volume":"53","author":"Tan","year":"2020","journal-title":"Shock"},{"key":"10.1016\/j.intimp.2025.115475_bb0160","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.4049\/jimmunol.1201114","article-title":"The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions","volume":"189","author":"Raghuwanshi","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.115475_bb0165","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/01.CCM.0000198527.71819.E1","article-title":"Toll-like receptor 4 signaling leads to neutrophil migration impairment in polymicrobial sepsis","volume":"34","author":"Alves-Filho","year":"2006","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.115475_bb0170","first-page":"5696","article-title":"TLR4-Dependent Internalization of CX3CR1 Aggravates sepsis-Induced Immunoparalysis","volume":"8","author":"Ge","year":"2016"},{"key":"10.1016\/j.intimp.2025.115475_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-48949-w","article-title":"Computational study of paroxetine-like inhibitors reveals new molecular insight to inhibit GRK2 with selectivity over ROCK1","volume":"9","author":"Keretsu","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115475_bb0180","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1164\/rccm.201003-0416OC","article-title":"Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis","volume":"183","author":"Souto","year":"2011","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.115475_bb0185","doi-asserted-by":"crossref","first-page":"578654","DOI":"10.3389\/fimmu.2020.578654","article-title":"The antidepressant mirtazapine activates hepatic macrophages, facilitating pathogen clearance while limiting tissue damage in mice","volume":"11","author":"Davis","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115475_bb0190","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1096\/fj.201902542R","article-title":"Regulation of neutrophil function by selective targeting of glycan epitopes expressed on the integrin CD11b\/CD18","volume":"34","author":"Kelm","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2025.115475_bb0195","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.yjmcc.2022.07.008","article-title":"GRK2 in cardiovascular disease and its potential as a therapeutic target","volume":"172","author":"Ferrero","year":"2022","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.intimp.2025.115475_bb0200","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1152\/ajpheart.00052.2016","article-title":"Cardiac hyporesponsiveness in severe sepsis is associated with nitric oxide-dependent activation of G protein receptor kinase","volume":"313","author":"Dal-Secco","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.intimp.2025.115475_bb0205","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/1074248415587968","article-title":"Erythropoietin reverses Sepsis-induced Vasoplegia to norepinephrine through preservation of \u03b11D-adrenoceptor mRNA expression and inhibition of GRK2-mediated desensitization in mouse aorta","volume":"21","author":"Kandasamy","year":"2016","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2025.115475_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104318","article-title":"Current sepsis therapeutics","volume":"86","author":"Vincent","year":"2022","journal-title":"EBioMedicine"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925014663?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925014663?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:22:33Z","timestamp":1763047353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925014663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":41,"alternative-id":["S1567576925014663"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115475","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paroxetine attenuates sepsis by preserving the expression of the G protein-coupled chemokine receptor CXCR2 on neutrophils","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115475"}}