{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:07:09Z","timestamp":1793480829714,"version":"4.5.0"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.intimp.2025.115499","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T07:05:06Z","timestamp":1757660706000},"page":"115499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Multifunctional antibacterial micelle with targeting ability and lipase-responsibility for therapy of methicillin-resistant Staphylococcus aureus infection"],"prefix":"10.1016","volume":"165","author":[{"given":"Hua","family":"Chun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinrong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aga","family":"Erbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengui","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115499_bb0005","article-title":"Antimicrobial susceptibility testing: A comprehensive review of currently used methods","volume":"11","author":"Gajic","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.intimp.2025.115499_bb0010","first-page":"1","article-title":"Adjuvants restore colistin sensitivity in mouse models of highly colistin-resistant isolates, limiting bacterial proliferation and dissemination","volume":"68","author":"Beverly","year":"2024","journal-title":"Antimicrobial Chemotherapy"},{"key":"10.1016\/j.intimp.2025.115499_bb0015","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.micromeso.2014.10.029","article-title":"LDH and TiO2\/LDH-type nanocomposite systems: A systematic study on structural characteristics","volume":"203","author":"Seftel","year":"2015","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.intimp.2025.115499_bb0020","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.clay.2018.06.011","article-title":"Layered double hydroxides intercalated with sulfur-containing organic solutes for efficient removal of cationic and oxyanionic metal ions","volume":"162","author":"Lin","year":"2018","journal-title":"Appl. Clay Sci."},{"key":"10.1016\/j.intimp.2025.115499_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119398","article-title":"Novel H(2)S-releasing hydrogel for wound repair via in situ polarization of M2 macrophages","volume":"222","author":"Wu","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2025.115499_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2021.126236","article-title":"Antibacterial mechanism and transcriptome analysis of ultra-small gold nanoclusters as an alternative of harmful antibiotics against gram-negative bacteria","volume":"416","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.intimp.2025.115499_bb0035","first-page":"20","article-title":"Bioresponsive nano-antibacterials forH2S-sensitized hyperthermia and immunomodulation against refractory implant\u2013related infections","volume":"7","author":"Su","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.intimp.2025.115499_bb0040","first-page":"273","article-title":"A microenvironment responsive polyetheretherketone implant with antibacterial and osteoimmunomodulatory properties facilitates osseointegration","volume":"43","author":"Chen","year":"2025","journal-title":"Bioact Mater"},{"key":"10.1016\/j.intimp.2025.115499_bb0045","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1021\/acsnano.1c00204","article-title":"Dual-dynamic-bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.intimp.2025.115499_bb0050","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1021\/acsmedchemlett.9b00595","article-title":"Low-molecular-weight branched Polyethylenimine potentiates ampicillin against MRSA biofilms","volume":"11","author":"Lam","year":"2020","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.intimp.2025.115499_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113826","article-title":"Novel silver nanoparticle-antibiotic combinations as promising antibacterial and anti-biofilm candidates against multiple-antibiotic resistant ESKAPE microorganisms","volume":"236","author":"Mishra","year":"2024","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.intimp.2025.115499_bb0060","article-title":"The antibacterial activities and effects of Baicalin on ampicillin resistance of MRSA and Stenotrophomonas maltophilia","author":"Chen","year":"2024","journal-title":"Foodborne Pathog. Dis."},{"key":"10.1016\/j.intimp.2025.115499_bb0065","doi-asserted-by":"crossref","first-page":"9637","DOI":"10.2147\/IJN.S476471","article-title":"Hyaluronic acid-modified micelles of azithromycin and quercetin against infections caused by methicillin-resistant staphylococcus aureus","volume":"19","author":"Zhang","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.intimp.2025.115499_bb0070","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.actbio.2025.01.013","article-title":"Synergistic effects of NO\/H2S gases on antibacterial, anti-inflammatory, and analgesic properties in oral ulcers using a gas-releasing nanoplatform","volume":"194","author":"Chen","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.intimp.2025.115499_bb0075","doi-asserted-by":"crossref","first-page":"38989","DOI":"10.1021\/acsami.4c06322","article-title":"Bioinspired hybrid nanostructured PEEK implant with enhanced antibacterial and anti-inflammatory synergy","volume":"16","author":"Ao","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.intimp.2025.115499_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.780839","article-title":"Modulation of macrophage Immunometabolism: A new approach to fight infections","volume":"13","author":"Gauthier","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115499_bb0085","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jconrel.2021.11.027","article-title":"A spatiotemporal release platform based on pH\/ROS stimuli-responsive hydrogel in wound repairing","volume":"341","author":"Wu","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.intimp.2025.115499_bb0090","doi-asserted-by":"crossref","first-page":"11136","DOI":"10.1021\/acsnano.2c03971","article-title":"pH-Activatable organic nanoparticles for efficient Low-temperature Photothermal therapy of ocular bacterial infection","volume":"16","author":"Zhu","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.intimp.2025.115499_bb0095","doi-asserted-by":"crossref","first-page":"36814","DOI":"10.1021\/acsami.8b16092","article-title":"Antibacterial micelles with vancomycin-mediated targeting and pH\/lipase-triggered release of antibiotics","volume":"10","author":"Chen","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.intimp.2025.115499_bb0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1574-6976.1994.tb00121.x","article-title":"Bacterial lipase","volume":"15","author":"KE","year":"1994","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.intimp.2025.115499_bb0105","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1021\/ja111110e","article-title":"Bacterial toxin-triggered drug release from gold nanoparticle-stabilized liposomes for the treatment of bacterial infection","volume":"133","author":"Pornpattananangkul","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.intimp.2025.115499_bb0110","first-page":"254","article-title":"pH and lipase-responsive nanocarrier-mediated dual drug delivery system to treat periodontitis in diabetic rats","volume":"18","author":"Wang","year":"2022","journal-title":"Bioact Mater"},{"key":"10.1016\/j.intimp.2025.115499_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110230","article-title":"Evaluation of hypocrellin A-loaded lipase sensitive polymer micelles for intervening methicillin-resistant staphylococcus aureus antibiotic-resistant bacterial infection","volume":"106","author":"Guo","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.intimp.2025.115499_bb0120","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1021\/ja211279u","article-title":"Lipase-sensitive polymeric triple-layered nanogel for \u201con-demand\u201d drug delivery","volume":"134","author":"Xiong","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.intimp.2025.115499_bb0125","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jconrel.2020.06.002","article-title":"Liposomal delivery of antibiotic loaded nucleic acid nanogels with enhanced drug loading and synergistic anti-inflammatory activity against S. Aureus intracellular infections","volume":"324","author":"Obuobi","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.intimp.2025.115499_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/polym16182647","article-title":"Preparation and characterization of chitosan\/starch nanocomposites loaded with ampicillin to enhance antibacterial activity against Escherichia coli","volume":"16","author":"Nguyen","year":"2024","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.intimp.2025.115499_bb0135","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s12866-023-03034-1","article-title":"Synergistic antibacterial action of the iron complex and ampicillin against Staphylococcus aureus","volume":"23","author":"Kosaristanova","year":"2023","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.intimp.2025.115499_bb0140","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.colsurfb.2018.06.040","article-title":"Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects","volume":"170","author":"Roxana Jijie","year":"2018","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.intimp.2025.115499_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114502","article-title":"Strategies and progresses for enhancing targeted antibiotic delivery","volume":"189","author":"Nazli","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.intimp.2025.115499_bb0150","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41551-022-00903-4","article-title":"Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis","volume":"6","author":"Zhang","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.intimp.2025.115499_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.112770","article-title":"Modified porous starches loading curcumin and improving the free radical scavenging ability and release properties of curcumin","volume":"168","author":"Han","year":"2023","journal-title":"Food Res. Int."},{"key":"10.1016\/j.intimp.2025.115499_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/ph14040309","article-title":"The immunomodulatory and anti-inflammatory effect of curcumin on immune cell populations, cytokines, and in vivo models of rheumatoid arthritis","volume":"14","author":"Makuch","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.intimp.2025.115499_bb0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010142","article-title":"Effects of quercetin and curcumin combination on antibacterial, antioxidant, in vitro wound healing and migration of human dermal fibroblast cells","volume":"23","author":"Chittasupho","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115499_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120852","article-title":"Preparation and characterization of curcumin\/chitosan conjugate as an efficient photodynamic antibacterial agent","volume":"313","author":"Zhao","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.intimp.2025.115499_bb0175","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1021\/acsabm.3c00316","article-title":"Reprogramming M1-to-M2 phenotype to alleviate inflammation: using liposomal curcumin as a tool to redefine macrophage functionality","volume":"6","author":"Nasra","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.intimp.2025.115499_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.153284","article-title":"Indicative bacterial cellulose films incorporated with curcumin-embedded Pickering emulsions: preparation, antibacterial performance, and mechanism","volume":"495","author":"Miao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.intimp.2025.115499_bb0185","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1021\/acsabm.4c01657","article-title":"Amphiphilic poly(ethylene glycol)-cholesterol conjugate: stable micellar formulation for efficient loading and effective intracellular delivery of curcumin","volume":"8","author":"Pradhan","year":"2025","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.intimp.2025.115499_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.119080","article-title":"Preparation, characterization and antioxidant properties of curcumin encapsulated chitosan\/lignosulfonate micelles","volume":"281","author":"Lin","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.intimp.2025.115499_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.123147","article-title":"Photodynamic therapy combined with quaternized chitosan antibacterial strategy for instant and prolonged bacterial infection treatment","volume":"352","author":"Luo","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.intimp.2025.115499_bb0200","article-title":"The mitochondria-targeted micelle inhibits Alzheimer\u2019s disease progression by alleviating neuronal mitochondrial dysfunction and Neuroinflammation","volume":"21","author":"Qian","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.intimp.2025.115499_bb0205","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13603","article-title":"Engineering a pH-responsive polymeric micelle co-loaded with paclitaxel and triptolide for breast cancer therapy","volume":"57","author":"Zhang","year":"2024","journal-title":"Cell Prolif."},{"key":"10.1016\/j.intimp.2025.115499_bb0210","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.addr.2020.09.009","article-title":"Polymeric micelles for the delivery of poorly soluble drugs: from nanoformulation to clinical approval","volume":"156","author":"Duhyeong Hwang","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.intimp.2025.115499_bb0215","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.3748\/wjg.v28.i25.2867","article-title":"Micelles as potential drug delivery systems for colorectal cancer treatment","volume":"28","author":"Fatfatz","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.intimp.2025.115499_bb0220","first-page":"135","article-title":"Polymeric micelles and cancer therapy: an ingenious multimodaltumor-targeted drug delivery system. Drug Deliv","volume":"13","author":"SK","year":"2023","journal-title":"Transl. Res."},{"key":"10.1016\/j.intimp.2025.115499_bb0225","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.biomaterials.2015.02.077","article-title":"Roles of ligand and TPGS of micelles in regulating internalization, penetration and accumulation against sensitive or resistant tumor and therapy for multidrug resistant tumors","volume":"53","author":"Wang","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2025.115499_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29051155","article-title":"Cationic vitamin E-TPGS mixed micelles of Berberine to neutralize doxorubicin-induced cardiotoxicity via amelioration of mitochondrial dysfunction and impeding apoptosis","volume":"29","author":"Metwally","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2025.115499_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120390","article-title":"Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and re-polarization","volume":"264","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2025.115499_bb0240","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.819163","article-title":"Folate receptor Beta for macrophage imaging in rheumatoid arthritis","volume":"13","author":"Steinz","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115499_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.121683","article-title":"Folate decorated chitosan-chondroitin sulfate nanoparticles loaded hydrogel for targeting macrophages against rheumatoid arthritis","volume":"327","author":"Siddiqui","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.intimp.2025.115499_bb0250","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12951-019-0537-4","article-title":"Targeted delivery of antibiotics to the infected pulmonary tissues using ROS-responsive nanoparticles","volume":"17","author":"Wang","year":"2019","journal-title":"J Nanobiotechnol."},{"key":"10.1016\/j.intimp.2025.115499_bb0255","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.2147\/IJN.S507038","article-title":"Inhibition of ovarian Cancer growth, metastasis and reverse the tumor microenvironment by dual drug-loaded polymer micelle targeting tumor microenvironment","volume":"20","author":"Zhang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.intimp.2025.115499_bb0260","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/jac\/dkae382","article-title":"Antimicrobial activity of ceftibuten\/polymyxin B combination against polymyxin\/carbapenem-resistant Klebsiella pneumoniae","volume":"80","author":"Sturaro","year":"2025","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.intimp.2025.115499_bb0265","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.gpb.2022.01.004","article-title":"SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets","volume":"20","author":"Zheng","year":"2022","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.intimp.2025.115499_bb0270","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00203-025-04251-0","article-title":"Standardizing biofilm quantification: harmonizing crystal violet absorbance measurements through extinction coefficient ratio adjustment","volume":"207","author":"George","year":"2025","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.intimp.2025.115499_bb0275","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/nature12479","article-title":"Bacteria activate sensory neurons that modulate pain and inflammation","volume":"501","author":"Chiu","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115499_bb0280","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1111\/bph.16344","article-title":"Synergism between remdesivir and ribavirin leads to SARS-CoV-2 extinction in cell culture","volume":"181","author":"Garcia-Crespo","year":"2024","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115499_bb0285","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac382","article-title":"SynergyFinder 3.0: an interactive analysis and consensus interpretation of multi-drug synergies across multiple samples","volume":"50","author":"Ianevski","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2025.115499_bb0290","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1109\/JBHI.2021.3126339","article-title":"Trustworthy deep neural network for inferring anticancer synergistic combinations","volume":"27","author":"Alsherbiny","year":"2023","journal-title":"IEEE J. Biomed. Health Inform."},{"key":"10.1016\/j.intimp.2025.115499_bb0295","article-title":"Combining SNAPs with antibiotics shows enhanced synergistic efficacy against S. aureus and P. aeruginosa biofilms","volume":"9","author":"Maset","year":"2023","journal-title":"npj Biofilms and Microbiomes"},{"key":"10.1016\/j.intimp.2025.115499_bb0300","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00719-25","article-title":"VLX600, an anticancer iron chelator, exerts antimicrobial effects on mycobacterium abscessus infections","volume":"13","author":"Oh","year":"2025","journal-title":"Microbiol Spectr."},{"key":"10.1016\/j.intimp.2025.115499_bb0305","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-019-1038-x","article-title":"Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells","volume":"38","author":"Margue","year":"2019","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2025.115499_bb0310","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12247-022-09619-z","article-title":"Improving antibacterial efficiency of curcumin in magnetic polymeric nanocomposites","volume":"18","author":"Sadeghi-Ghadi","year":"2022","journal-title":"J. Pharm. Innov."},{"key":"10.1016\/j.intimp.2025.115499_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.130117","article-title":"Preparation and photodynamic bactericidal effects of curcumin-beta-cyclodextrin complex","volume":"361","author":"Lai","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.intimp.2025.115499_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.127893","article-title":"Preparation and characterization of zein\/carboxymethyl dextrin nanoparticles to encapsulate curcumin: physicochemical stability, antioxidant activity and controlled release properties","volume":"340","author":"Meng","year":"2021","journal-title":"Food Chem."},{"key":"10.1016\/j.intimp.2025.115499_bb0325","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s00604-024-06849-5","article-title":"Ampicillin-derived carbon dots as the sensitive probe for the detection of Fe(3+) and cu(2+) in living cells and water samples","volume":"191","author":"Dong","year":"2024","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.intimp.2025.115499_bb0330","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1208\/s12249-021-02047-1","article-title":"Evaluation of the antitumor effect and immune response of micelles modified with a Polysialic acid-D-alpha-Tocopheryl polyethylene glycol 1000 succinate conjugate","volume":"22","author":"Sun","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.intimp.2025.115499_bb0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124837","article-title":"Design and development of DSPE-PEG2000\/DPPC disk-like micelles for targeted delivery of icariin phytochemical in pulmonary fibrosis","volume":"667","author":"Jiang","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.intimp.2025.115499_bb0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.124675","article-title":"Investigating the influence of molybdenum disulfide quantum dots coated with DSPE-PEG-TPP on molecular structures of liver lipids and proteins: An in vivo study","volume":"320","author":"Ageeli","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.intimp.2025.115499_bb0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123787","article-title":"Targeted delivery and apoptosis induction of CDK-4\/6 inhibitor loaded folic acid decorated lipid-polymer hybrid nanoparticles in breast cancer cells","volume":"651","author":"Rajana","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.intimp.2025.115499_bb0350","doi-asserted-by":"crossref","first-page":"2460666","DOI":"10.1080\/10717544.2025.2460666","article-title":"Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility","volume":"32","author":"Jurgelane","year":"2025","journal-title":"Drug Deliv."},{"key":"10.1016\/j.intimp.2025.115499_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.130330","article-title":"Light-triggerable and pH\/lipase-responsive release of antibiotics and \u03b2-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria","volume":"424","author":"Chen","year":"2021","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.intimp.2025.115499_bb0360","doi-asserted-by":"crossref","first-page":"5856","DOI":"10.1039\/D3TB00227F","article-title":"A calcium hydroxide\/oleic acid\/phospholipid nanoparticle induced cancer cell apoptosis by the combination of intracellular calcium overload and lactic acidosis elimination","volume":"11","author":"Zhou","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.intimp.2025.115499_bb0365","doi-asserted-by":"crossref","first-page":"14299","DOI":"10.1021\/acsami.7b15678","article-title":"Bacteria-targeting nanoparticles with microenvironment-responsive antibiotic release to eliminate intracellular Staphylococcus aureus and associated infection","volume":"10","author":"Yang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.intimp.2025.115499_bb0370","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s10895-023-03297-x","article-title":"Illuminating bacterial contamination in water sources: the power of fluorescence-based methods","volume":"34","author":"Modi","year":"2023","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.intimp.2025.115499_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2021.112225","article-title":"Acid-activated ROS generator with folic acid targeting for bacterial biofilm elimination","volume":"127","author":"Yu","year":"2021","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"10.1016\/j.intimp.2025.115499_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124129","article-title":"Ampicillin-resistant bacterial pathogens targeted chitosan nano-drug delivery system (CS-AMP-P-ZnO) for combinational antibacterial treatment","volume":"237","author":"Sathiyaseelan","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.115499_bb0385","first-page":"14","article-title":"Dual elemental doping activated signaling pathway of angiogenesis and defective heterojunction engineering for effective therapy of MRSA-infected wounds","volume":"37","author":"Huang","year":"2024","journal-title":"Bioact Mater"},{"key":"10.1016\/j.intimp.2025.115499_bb0390","doi-asserted-by":"crossref","first-page":"17902","DOI":"10.1021\/acsami.9b05787","article-title":"Local Photothermal\/photodynamic synergistic therapy by disrupting bacterial membrane to accelerate reactive oxygen species permeation and protein leakage","volume":"11","author":"Mao","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.intimp.2025.115499_bb0395","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.131248","article-title":"Curcumin and silver nanoparticles loaded antibacterial multifunctional pectin\/gelatin films for food packaging applications","volume":"266","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.115499_bb0400","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202311967","article-title":"Seeking cells, targeting Bacteria: A Cascade-targeting Bacteria-responsive Nanosystem for combating intracellular bacterial infections","volume":"20","author":"Tang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.intimp.2025.115499_bb0405","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.7150\/thno.66663","article-title":"Ferroptotic stress promotes macrophages against intracellular bacteria","volume":"12","author":"Ma","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2025.115499_bb0410","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1039\/D2BM01489K","article-title":"Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection","volume":"11","author":"Wang","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.intimp.2025.115499_bb0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120344","article-title":"Antibacterial nanotruffles for treatment of intracellular bacterial infection","volume":"262","author":"Elnaggar","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2025.115499_bb0420","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02494-5","article-title":"Baicalin nanodelivery system based on functionalized metal-organic framework for targeted therapy of osteoarthritis by modulating macrophage polarization","volume":"22","author":"Huang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.intimp.2025.115499_bb0425","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1164\/rccm.200708-1261OC","article-title":"Lung inflammation induced by Lipoteichoic acid or lipopolysaccharide in humans","volume":"178","author":"Hoogerwerf","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2025.115499_bb0430","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.joen.2020.07.028","article-title":"Immunomodulation mediated by azithromycin in experimental periapical inflammation","volume":"46","author":"Andrada","year":"2020","journal-title":"J Endodont"},{"key":"10.1016\/j.intimp.2025.115499_bb0435","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/biof.1716","article-title":"Experimental and clinical reports on anti-inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review","volume":"47","author":"Memarzia","year":"2021","journal-title":"Biofactors"},{"key":"10.1016\/j.intimp.2025.115499_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131499","article-title":"Curcumin analogues with improved antioxidant properties: A theoretical exploration","volume":"373","author":"Purushothaman","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.intimp.2025.115499_bb0445","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1021\/acsabm.4c01579","article-title":"Zwitterionic, stimuli-responsive liposomes for curcumin drug delivery: enhancing M2 macrophage polarization and reducing oxidative stress through enzyme-specific and hyperthermia-triggered release","volume":"8","author":"Basak","year":"2024","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.intimp.2025.115499_bb0450","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3496043","article-title":"Oxidative stress in infection and consequent disease","volume":"2017","author":"Ivanov","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2025.115499_bb0455","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1039\/D1TB00156F","article-title":"Tannic acid-inspired, self-healing, and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties","volume":"9","author":"Shi","year":"2021","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.intimp.2025.115499_bb0460","doi-asserted-by":"crossref","first-page":"4453","DOI":"10.1021\/acs.molpharmaceut.3c00062","article-title":"Curcumin-loaded macrophage-derived exosomes effectively improve wound healing","volume":"20","author":"Li","year":"2023","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.intimp.2025.115499_bb0465","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jconrel.2024.07.027","article-title":"Lipid nanoparticles encapsulating curcumin for imaging and stabilization of vulnerable atherosclerotic plaques via phagocytic \u201ceat-me\u201d signals","volume":"373","author":"Shi","year":"2024","journal-title":"J. Control. Release"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925014900?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925014900?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:14:29Z","timestamp":1763046869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925014900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":93,"alternative-id":["S1567576925014900"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115499","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multifunctional antibacterial micelle with targeting ability and lipase-responsibility for therapy of methicillin-resistant Staphylococcus aureus infection","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115499","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115499"}}