{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:30:38Z","timestamp":1791898238178,"version":"4.3.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004263","name":"Foundation for Research Support of Rio Grande do Sul State","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018824","name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Neuroimunomodula\u00e7\u00e3o","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.intimp.2025.115518","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T19:37:37Z","timestamp":1757360257000},"page":"115518","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Accelerated T-cell senescence and persistent inflammation in older adults with rheumatoid arthritis"],"prefix":"10.1016","volume":"165","author":[{"given":"Carolina Dias","family":"Cezar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliete Nathali","family":"Scholl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Ferreira","family":"Rabelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mailton Prestes","family":"Madruga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Lu\u00eds","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Kich","family":"Grun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Engroff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusto Cesar Morioka","family":"Bressanim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Twardowski","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Helena Augustin","family":"Schwanke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia","family":"Barb\u00e9-Tuana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Kazutoshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mois\u00e9s Evandro","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115518_bb0005","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41590-021-00927-z","article-title":"Hallmarks of T cell aging","volume":"22","author":"Mittelbrunn","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0010","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1749-6632.2000.tb06651.x","article-title":"Inflamm-aging. An evolutionary perspective on immunosenescence","volume":"908","author":"Franceschi","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2025.115518_bb0015","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.intimp.2025.115518_bb0020","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0025","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00281-020-00806-z","article-title":"The interplay between immunosenescence and age-related diseases","volume":"42","author":"Barb\u00e9-Tuana","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.intimp.2025.115518_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18081742","article-title":"Markers of T cell senescence in humans","volume":"18","author":"Xu","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115518_bb0035","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0145-305X(97)00027-X","article-title":"Loss of CD28 expression on T lymphocytes: a marker of replicative senescence","volume":"21","author":"Effros","year":"1997","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0040","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1182\/blood-2002-07-2103","article-title":"Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells","volume":"101","author":"Brenchley","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2025.115518_bb0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-immunol-101721-064501","article-title":"Extremely Differentiated T Cell Subsets Contribute to Tissue Deterioration During Aging","volume":"41","author":"Soto-Heredero","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0050","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1007\/s10067-015-3031-x","article-title":"The influence of age at disease onset on disease activity and disability: results from the Ontario best practices research initiative","volume":"35","author":"Ruban","year":"2016","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.intimp.2025.115518_bb0055","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12979-020-00178-w","article-title":"Accelerated immunosenescence in rheumatoid arthritis: impact on clinical progression","volume":"17","author":"Bauer","year":"2020","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.intimp.2025.115518_bb0060","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.semarthrit.2020.03.018","article-title":"Treatment-resistant synovitis and radiographic progression are increased in elderly-onset rheumatoid arthritis patients: findings from a prospective observational longitudinal early arthritis cohort study","volume":"50","author":"Rom\u00e3o","year":"2020","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.intimp.2025.115518_bb0065","first-page":"59","article-title":"Elderly-onset rheumatoid arthritis: characteristics and treatment options","author":"Pavlov-Dolijanovic","year":"2023","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.intimp.2025.115518_bb0070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000358437","article-title":"Premature immunosenescence is associated with memory dysfunction in rheumatoid arthritis","volume":"22","author":"Petersen","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.intimp.2025.115518_bb0075","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12969-017-0165-1","article-title":"Arterial stiffness by oscillometric device and telomere lenght in juvenile idiopathic artrhitis with no cardiovascular risk factors: a cross-sectional study","volume":"15","author":"Picarelli","year":"2017","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"10.1016\/j.intimp.2025.115518_bb0080","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12979-024-00423-6","article-title":"Excess of body weight is associated with accelerated T-cell senescence in hospitalized COVID-19 patients","volume":"21","author":"Madruga","year":"2024","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.intimp.2025.115518_bb0085","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.3389\/fimmu.2018.01651","article-title":"Features of Immunosenescence in women newly diagnosed with breast Cancer","volume":"9","author":"Trintinaglia","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0090","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0047-6374(00)00199-8","article-title":"Increased expression of NK cell markers on T lymphocytes in aging and chronic activation of the immune system reflects the accumulation of effector\/senescent T cells","volume":"121","author":"Tarazona","year":"2000","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.intimp.2025.115518_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222010922","article-title":"Cytokine networks in the pathogenesis of rheumatoid arthritis","volume":"22","author":"Kondo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115518_bb0100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41584-018-0109-2","article-title":"Anti-inflammatory and immune-regulatory cytokines in rheumatoid arthritis","volume":"15","author":"Chen","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2025.115518_bb0105","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00281-017-0619-z","article-title":"Selected cytokine pathways in rheumatoid arthritis","volume":"39","author":"Noack","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.intimp.2025.115518_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020905","article-title":"Rheumatoid arthritis: pathogenic roles of diverse immune cells","volume":"23","author":"Jang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115518_bb0115","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/art.1780400615","article-title":"Expansion of unusual CD4+ T cells in severe rheumatoid arthritis","volume":"40","author":"Martens","year":"1997","journal-title":"Arthritis Rheum."},{"issue":"97","key":"10.1016\/j.intimp.2025.115518_bb0120","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1172\/JCI118638","article-title":"CD4+ CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity","author":"Schmidt","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2025.115518_bb0125","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12675","article-title":"Human CD8+ EMRA T cells display a senescence-associated secretory phenotype regulated by p38 MAPK","volume":"17","author":"Callender","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2025.115518_bb0130","first-page":"131","article-title":"CD28null T cells in aging and diseases: from biology to assessment and intervention","author":"Guan","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115518_bb0135","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00011-022-01649-0","article-title":"Immunosenescence of T cells: a key player in rheumatoid arthritis","volume":"71","author":"Gao","year":"2022","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.intimp.2025.115518_bb0140","doi-asserted-by":"crossref","first-page":"9203","DOI":"10.1073\/pnas.97.16.9203","article-title":"T cell homeostasis in patients with rheumatoid arthritis","volume":"97","author":"Koetz","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.115518_bb0145","doi-asserted-by":"crossref","first-page":"6514","DOI":"10.4049\/jimmunol.179.10.6514","article-title":"CD4+CD28null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation","volume":"179","author":"Thewissen","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0150","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.1158\/1078-0432.CCR-19-2095","article-title":"The NKG2A-HLA-E Axis as a novel checkpoint in the tumor microenvironment","volume":"26","author":"Borst","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2025.115518_bb0155","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s40425-019-0761-3","article-title":"Monalizumab: inhibiting the novel immune checkpoint NKG2A","volume":"7","author":"van Hall","year":"2019","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.intimp.2025.115518_bb0160","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s11357-010-9200-6","article-title":"NKG2D expression in CD4+ T lymphocytes as a marker of senescence in the aged immune system","volume":"33","author":"Alonso-Arias","year":"2011","journal-title":"Age (Dordr.)"},{"key":"10.1016\/j.intimp.2025.115518_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102528","article-title":"Rheumatoid arthritis in the elderly: characteristics and treatment considerations","volume":"19","author":"Serhal","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.intimp.2025.115518_bb0170","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/cmi.2017.161","article-title":"Functions of NKG2D in CD8","volume":"15","author":"Prajapati","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0175","article-title":"Human CD8","volume":"23","author":"Koh","year":"2023","journal-title":"Immune Netw."},{"key":"10.1016\/j.intimp.2025.115518_bb0180","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jbspin.2015.06.010","article-title":"Influence of CD94 and NKG2A variants on susceptibility to rheumatoid arthritis and efficacy of anti-TNF treatment","volume":"83","author":"Iwaszko","year":"2016","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.intimp.2025.115518_bb0185","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/FTD.0b013e3181679015","article-title":"CD8dim and NKG2D expression defines related subsets of CD4+ T cells in HIV-infected patients with worse prognostic factors","volume":"51","author":"Alonso-Arias","year":"2009","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.intimp.2025.115518_bb0190","doi-asserted-by":"crossref","first-page":"9452","DOI":"10.1073\/pnas.1632807100","article-title":"Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis","volume":"100","author":"Groh","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.115518_bb0195","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2025.115518_bb0200","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/eji.1830230950","article-title":"Increased cytokine production in mononuclear cells of healthy elderly people","volume":"23","author":"Fagiolo","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0205","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1159\/000327352","article-title":"Neuroimmunoendocrine interactions in patients with recurrent major depression, increased early life stress and long-standing posttraumatic stress disorder symptoms","volume":"19","author":"Lopes","year":"2012","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.intimp.2025.115518_bb0210","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbi.2015.11.016","article-title":"Peripheral leukocyte profile in people with temporal lobe epilepsy reflects the associated proinflammatory state","volume":"53","author":"Vieira","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2025.115518_bb0215","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/nyas.13712","article-title":"Inflammation in psychiatric disorders: what comes first?","volume":"1437","author":"Bauer","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.intimp.2025.115518_bb0220","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxaa078","article-title":"IL-6 in inflammation, autoimmunity and cancer","volume":"33","author":"Hirano","year":"2021","journal-title":"Int. Immunol."},{"key":"10.1016\/j.intimp.2025.115518_bb0225","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/rheumatology\/ket449","article-title":"Are there differences between young- and older-onset early inflammatory arthritis and do these impact outcomes? An analysis from the CATCH cohort","volume":"53","author":"Arnold","year":"2014","journal-title":"Rheumatology (Oxford)"},{"issue":"16","key":"10.1016\/j.intimp.2025.115518_bb0230","doi-asserted-by":"crossref","first-page":"R94","DOI":"10.1186\/ar4540","article-title":"Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study","volume":"14","author":"Innala","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2025.115518_bb0235","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/1756-185X.13428","article-title":"Elderly onset of early rheumatoid arthritis is a risk factor for bone erosions, refractory to treatment: KURAMA cohort","volume":"22","author":"Murata","year":"2019","journal-title":"Int. J. Rheum. Dis."},{"key":"10.1016\/j.intimp.2025.115518_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2020.09.017","article-title":"Elderly onset of rheumatoid arthritis is more common in males, and requires maintenance of low-dose corticosteroids along with the combination of disease modifying anti rheumatic agents","volume":"51","author":"Haroon","year":"2021","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.intimp.2025.115518_bb0245","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000164393","article-title":"Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: a comparison with younger-onset disease","volume":"55","author":"Chen","year":"2009","journal-title":"Gerontology"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925015097?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925015097?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:18:56Z","timestamp":1763047136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925015097"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":49,"alternative-id":["S1567576925015097"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115518","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accelerated T-cell senescence and persistent inflammation in older adults with rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115518","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115518"}}