{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:53:20Z","timestamp":1790812400970,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370999"],"award-info":[{"award-number":["82370999"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tstp20221160"],"award-info":[{"award-number":["tstp20221160"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.intimp.2025.115526","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:21:21Z","timestamp":1757542881000},"page":"115526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A\u03b2 impairs bone vascular homeostasis in APP\/PS1 mice via disrupting the mitochondrial fission-efferocytosis axis in macrophages"],"prefix":"10.1016","volume":"165","author":[{"given":"Ting","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzheng","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaorui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115526_bb0005","doi-asserted-by":"crossref","first-page":"4260","DOI":"10.1016\/j.cell.2023.08.021","article-title":"Alzheimer\u2019s disease: from immunotherapy to immunoprevention","volume":"186","author":"Jucker","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2025.115526_bb0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/ageing\/afq146","article-title":"Hip fracture risk and subsequent mortality among Alzheimer\u2019s disease patients in the United Kingdom, 1988-2007","volume":"40","author":"Baker","year":"2011","journal-title":"Age Ageing"},{"key":"10.1016\/j.intimp.2025.115526_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102341","article-title":"Research progress in Alzheimer\u2019s disease and bone-brain axis","volume":"98","author":"Zhang","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2025.115526_bb0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10571-015-0319-y","article-title":"Vascular and metabolic factors in Alzheimer\u2019s disease and related dementias: introduction","volume":"36","author":"Iadecola","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2025.115526_bb0025","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12874","article-title":"Motivating role of type H vessels in bone regeneration","volume":"53","author":"Zhang","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.intimp.2025.115526_bb0030","article-title":"A\u03b2 -induced excessive mitochondrial fission drives type H blood vessels injury to aggravate bone loss in APP\/PS1 mice with Alzheimer\u2019s diseases","author":"Zhang","year":"2024","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2025.115526_bb0035","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1146\/annurev-pharmtox-032723-110507","article-title":"Targeting Efferocytosis in Inflammaging","volume":"64","author":"Poon","year":"2024","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.intimp.2025.115526_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1196033","article-title":"Monocyte-endothelial cell interactions in vascular and tissue remodeling","volume":"14","author":"Medrano-Bosch","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115526_bb0045","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41577-019-0240-6","article-title":"Efferocytosis in health and disease","volume":"20","author":"Doran","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.115526_bb0050","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/imr.13214","article-title":"The role of efferocytosis-fueled macrophage metabolism in the resolution of inflammation","volume":"319","author":"Schilperoort","year":"2023","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2025.115526_bb0055","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3389\/fimmu.2018.01645","article-title":"The role of Efferocytosis in autoimmune diseases","volume":"9","author":"Abdolmaleki","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115526_bb0060","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.jhep.2023.08.016","article-title":"A+T rich interaction domain protein 3a (Arid3a) impairs Mertk-mediated efferocytosis in cholestasis","volume":"79","author":"Chen","year":"2023","journal-title":"J. Hepatol."},{"issue":"178","key":"10.1016\/j.intimp.2025.115526_bb0065","first-page":"5635","article-title":"Macrophages and dendritic cells use different Axl\/Mertk\/Tyro3 receptors in clearance of apoptotic cells","volume":"2007","author":"Seitz","year":"1950","journal-title":"J. Immunol. (Baltimore, Md)"},{"key":"10.1016\/j.intimp.2025.115526_bb0070","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/s12276-022-00840-x","article-title":"BMS794833 inhibits macrophage efferocytosis by directly binding to MERTK and inhibiting its activity","volume":"54","author":"Bae","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2025.115526_bb0075","first-page":"25","article-title":"Regulation of Mertk surface expression via ADAM17 and \u03b3-secretase proteolytic processing","author":"Lahey","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115526_bb0080","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1161\/CIRCRESAHA.123.324011","article-title":"Macrophage heterogeneity and Efferocytosis: beyond the M1\/M2 dichotomy","volume":"134","author":"Kumar Jha","year":"2024","journal-title":"Circ. Res."},{"key":"10.1016\/j.intimp.2025.115526_bb0085","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2021.2024941","article-title":"MerTK-mediated efferocytosis promotes immune tolerance and tumor progression in osteosarcoma through enhancing M2 polarization and PD-L1 expression","volume":"11","author":"Lin","year":"2022","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.intimp.2025.115526_bb0090","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.2174\/1871527321666220616094036","article-title":"Amyloid Beta peptide-mediated alterations in mitochondrial dynamics and its implications for Alzheimer\u2019s disease","volume":"22","author":"Monsalvo-Maraver","year":"2023","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.intimp.2025.115526_bb0095","doi-asserted-by":"crossref","first-page":"10092","DOI":"10.1038\/s41598-022-13683-3","article-title":"Amyloid-\u03b2 impairs mitochondrial dynamics and autophagy in Alzheimer\u2019s disease experimental models","volume":"12","author":"de la Cueva","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115526_bb0100","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41401-020-00518-y","article-title":"Drp1-dependent mitochondrial fission in cardiovascular disease","volume":"42","author":"Jin","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2025.115526_bb0105","article-title":"Accumulation of GSK-3\u03b2 in interneurons impairs adult hippocampal neurogenesis by inhibiting GABAergic transmission","author":"Liu","year":"2025","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2025.115526_bb0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.freeradbiomed.2022.01.031","article-title":"Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3\u03b2\/Drp1-dependent mitochondrial fission and apoptosis","volume":"181","author":"Liu","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2025.115526_bb0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neurobiolaging.2014.08.005","article-title":"Blockage of GSK3\u03b2-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer\u2019s disease","volume":"36","author":"Yan","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.intimp.2025.115526_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102594","article-title":"Diminished \u03b17 nicotinic acetylcholine receptor (\u03b17nAChR) rescues amyloid-\u03b2 induced atrial remodeling by oxi-CaMKII\/MAPK\/AP-1 axis-mediated mitochondrial oxidative stress","volume":"59","author":"Zhao","year":"2023","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.115526_bb0125","first-page":"11","article-title":"Beta-amyloid instigates dysfunction of mitochondria in cardiac cells","author":"Jang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2025.115526_bb0130","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1038\/s41467-024-46735-5","article-title":"CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer","volume":"15","author":"Cheng","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115526_bb0135","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s40035-024-00434-9","article-title":"Trajectory of brain-derived amyloid beta in Alzheimer\u2019s disease: where is it coming from and where is it going?","volume":"13","author":"Liu","year":"2024","journal-title":"Translational Neurodegeneration"},{"key":"10.1016\/j.intimp.2025.115526_bb0140","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111038","article-title":"Erythropoietin signaling in peripheral macrophages is required for systemic \u03b2-amyloid clearance","volume":"41","author":"Xu","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.intimp.2025.115526_bb0145","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13251","article-title":"Macrophage efferocytosis in atherosclerosis","volume":"97","author":"Baraniecki","year":"2023","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.intimp.2025.115526_bb0150","first-page":"59","article-title":"Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL-6\/STAT3 signaling pathway","author":"Shi","year":"2021","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.intimp.2025.115526_bb0155","first-page":"1310","article-title":"Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression","volume":"29","author":"Zeng","year":"2013","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.intimp.2025.115526_bb0160","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13287-022-02800-8","article-title":"Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K\/AKT pathway","volume":"13","author":"Lu","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.intimp.2025.115526_bb0165","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s11914-024-00878-y","article-title":"Efferocytosis and bone dynamics","volume":"22","author":"Batoon","year":"2024","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.intimp.2025.115526_bb0170","first-page":"12","article-title":"Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis","author":"Yao","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.intimp.2025.115526_bb0175","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.1093\/rheumatology\/keab900","article-title":"Perivascular and endomysial macrophages expressing VEGF and CXCL12 promote angiogenesis in anti-HMGCR immune-mediated necrotizing myopathy","volume":"61","author":"Lia","year":"2022","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2025.115526_bb0180","first-page":"132","article-title":"Macrophage-produced VEGFC is induced by efferocytosis to ameliorate cardiac injury and inflammation","author":"Glinton","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2025.115526_bb0185","first-page":"131","article-title":"Myeloid cell-derived PROS1 inhibits tumor metastasis by regulating inflammatory and immune responses via IL-10","author":"Maimon","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2025.115526_bb0190","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1074\/jbc.M706906200","article-title":"Autophosphorylation docking site Tyr-867 in Mer receptor tyrosine kinase allows for dissociation of multiple signaling pathways for phagocytosis of apoptotic cells and down-modulation of lipopolysaccharide-inducible NF-kappaB transcriptional activation","volume":"283","author":"Tibrewal","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.115526_bb0195","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s12974-018-1112-x","article-title":"Sulforaphane rescues amyloid-\u03b2 peptide-mediated decrease in MerTK expression through its anti-inflammatory effect in human THP-1 macrophages","volume":"15","author":"Jhang","year":"2018","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.intimp.2025.115526_bb0200","article-title":"ADAM17 orchestrates Interleukin-6, TNF\u03b1 and EGF-R signaling in inflammation and cancer. Biochimica et biophysica acta","volume":"1869","author":"Schumacher","year":"2022","journal-title":"Mol. Cell Res."},{"key":"10.1016\/j.intimp.2025.115526_bb0205","first-page":"11","article-title":"ADAM17 activity and IL-6 trans-signaling in inflammation and Cancer","author":"Schumacher","year":"2019","journal-title":"Cancers"},{"key":"10.1016\/j.intimp.2025.115526_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116281","article-title":"Retinoic acid tiers mitochondrial metabolism to Sertoli cell-mediated efferocytosis via a non-RAR-dependent mechanism","volume":"225","author":"Wu","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115526_bb0215","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.molcel.2023.02.012","article-title":"Determinants and outcomes of mitochondrial dynamics","volume":"83","author":"Quintana-Cabrera","year":"2023","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2025.115526_bb0220","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41420-023-01497-9","article-title":"Defective efferocytosis by aged macrophages promotes STING signaling mediated inflammatory liver injury","volume":"9","author":"Hu","year":"2023","journal-title":"Cell Death Discovery"},{"key":"10.1016\/j.intimp.2025.115526_bb0225","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41420-023-01563-2","article-title":"Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4\/ROS signalling pathway through inhibiting BRD4","volume":"9","author":"Zhou","year":"2023","journal-title":"Cell Death Discovery"},{"key":"10.1016\/j.intimp.2025.115526_bb0230","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cell.2017.08.041","article-title":"Mitochondrial fission promotes the continued clearance of apoptotic cells by macrophages","volume":"171","author":"Wang","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2025.115526_bb0235","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.bbagrm.2015.10.017","article-title":"Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells","volume":"1849","author":"Park","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2025.115526_bb0240","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.neurobiolaging.2011.02.003","article-title":"AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation","volume":"33","author":"Li","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.intimp.2025.115526_bb0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117031","article-title":"Qingxin Kaiqiao fang decreases tau hyperphosphorylation in Alzheimer\u2019s disease via the PI3K\/Akt\/GSK3\u03b2 pathway in vitro and in vivo","volume":"318","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925015176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925015176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:59:22Z","timestamp":1778619562000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925015176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":49,"alternative-id":["S1567576925015176"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115526","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A\u03b2 impairs bone vascular homeostasis in APP\/PS1 mice via disrupting the mitochondrial fission-efferocytosis axis in macrophages","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115526"}}