{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:22:21Z","timestamp":1787955741375,"version":"build-2784847793"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["QN2304"],"award-info":[{"award-number":["QN2304"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024398","name":"Youth Endowment Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024398","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017128","name":"Science Fund for Distinguished Young Scholars of Anhui Province","doi-asserted-by":"publisher","award":["2208085MH212"],"award-info":[{"award-number":["2208085MH212"]}],"id":[{"id":"10.13039\/100017128","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.intimp.2025.115528","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T11:56:02Z","timestamp":1757678162000},"page":"115528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Targeting CD161 inhibitory receptors enhances NK cell-mediated changes in synovial fibroblast function in rheumatoid arthritis"],"prefix":"10.1016","volume":"165","author":[{"given":"Junqin","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangxue","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.intimp.2025.115528_bb0005","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1056\/NEJMra2103726","article-title":"Rheumatoid arthritis - common origins, divergent mechanisms","volume":"388","author":"Gravallese","year":"2023","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.intimp.2025.115528_bb0010","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/art.41752","article-title":"2021 American College of Rheumatology Guideline for the treatment of rheumatoid arthritis","volume":"73","author":"Fraenkel","year":"2021","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115528_bb0015","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/annrheumdis-2021-220973","article-title":"EULAR points to consider for the management of difficult-to-treat rheumatoid arthritis","volume":"81","author":"Nagy","year":"2022","journal-title":"Ann. Rheum. Dis."},{"issue":"10","key":"10.1016\/j.intimp.2025.115528_bb0020","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1136\/annrheumdis-2018-213378","article-title":"Biologic refractory disease in rheumatoid arthritis: results from the British Society for Rheumatology biologics register for rheumatoid arthritis","volume":"77","author":"Kearsley-Fleet","year":"2018","journal-title":"Ann. Rheum. Dis."},{"issue":"10416","key":"10.1016\/j.intimp.2025.115528_bb0025","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.intimp.2025.115528_bb0030","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1136\/annrheumdis-2020-218189","article-title":"Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis","volume":"80","author":"Tsuchiya","year":"2021","journal-title":"Ann. Rheum. Dis."},{"issue":"15","key":"10.1016\/j.intimp.2025.115528_bb0035","article-title":"An overview of multi-omics technologies in rheumatoid arthritis: applications in biomarker and pathway discovery","volume":"30","author":"Gong","year":"2024","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2025.115528_bb0040","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.4049\/jimmunol.175.12.7791","article-title":"Cutting edge: lectin-like transcript 1 is a ligand for the CD161 receptor","volume":"175","author":"Aldemir","year":"2005","journal-title":"J. Immunol."},{"issue":"September","key":"10.1016\/j.intimp.2025.115528_bb0045","article-title":"CD3D, GZMK, and KLRB1 are potential markers for early diagnosis of rheumatoid arthritis, especially in anti-Citrullinated protein antibody-negative patients","volume":"12","author":"Lu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2025.115528_bb0050","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1182\/blood.2023022882","article-title":"Targeting of the CD161 inhibitory receptor enhances T-cell-mediated immunity against hematological malignancies","volume":"143","author":"Alvarez Calderon","year":"2024","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.intimp.2025.115528_bb0055","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1026503","article-title":"Lectin-like transcript 1 is a marker of germinal center-derived B-cell non-Hodgkin\u2019s lymphomas dampening natural killer cell functions","volume":"4","author":"Germain","year":"2015","journal-title":"Oncoimmunology"},{"issue":"5","key":"10.1016\/j.intimp.2025.115528_bb0060","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.cell.2021.01.022","article-title":"Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis","volume":"184","author":"Mathewson","year":"2021","journal-title":"Cell"},{"issue":"7760","key":"10.1016\/j.intimp.2025.115528_bb0065","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-019-1263-7","article-title":"Distinct fibroblast subsets drive inflammation and damage in arthritis","volume":"570","author":"Croft","year":"2019","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2025.115528_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/jitc-2023-008694","article-title":"Poor clinical outcomes and immunoevasive contexture in CD161+CD8+ T cells barren human pancreatic cancer","volume":"12","author":"Chen","year":"2024","journal-title":"J. Immunother. Cancer"},{"issue":"8","key":"10.1016\/j.intimp.2025.115528_bb0075","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1084\/jem.20080397","article-title":"Human interleukin 17-producing cells originate from a CD161+CD4+ T cell precursor","volume":"205","author":"Cosmi","year":"2008","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.intimp.2025.115528_bb0080","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/eji.200940257","article-title":"CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC","volume":"40","author":"Maggi","year":"2010","journal-title":"Eur. J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115528_bb0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s10067-017-3800-9","article-title":"CD147-mediated chemotaxis of CD4+CD161+ T cells may contribute to local inflammation in rheumatoid arthritis","volume":"37","author":"Lv","year":"2018","journal-title":"Clin. Rheumatol."},{"issue":"9","key":"10.1016\/j.intimp.2025.115528_bb0090","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European league against rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.intimp.2025.115528_bb0095","article-title":"Regulatory fibroblast-like Synoviocytes cell membrane coated nanoparticles: a novel targeted therapy for rheumatoid arthritis","volume":"10","author":"Liu","year":"2023","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Ger)"},{"issue":"5","key":"10.1016\/j.intimp.2025.115528_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051118","article-title":"Impact of \u03949-tetrahydrocannabinol on rheumatoid arthritis synovial fibroblasts alone and in co-culture with peripheral blood mononuclear cells","volume":"10","author":"Lowin","year":"2022","journal-title":"Biomedicines"},{"issue":"17","key":"10.1016\/j.intimp.2025.115528_bb0105","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.intimp.2025.115528_bb0110","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.intimp.2025.115528_bb0115","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","article-title":"Improving RNA-Seq expression estimates by correcting for fragment bias","volume":"12","author":"Roberts","year":"2011","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115528_bb0120","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"issue":"12","key":"10.1016\/j.intimp.2025.115528_bb0125","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"Database issue","key":"10.1016\/j.intimp.2025.115528_bb0130","first-page":"D480","article-title":"KEGG for linking genomes to life and the environment","volume":"36","author":"Kanehisa","year":"2008","journal-title":"Nucleic Acids Res."},{"issue":"43","key":"10.1016\/j.intimp.2025.115528_bb0135","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"16","key":"10.1016\/j.intimp.2025.115528_bb0140","first-page":"1","article-title":"Single-cell RNA-Seq analysis reveals cell subsets and gene signatures associated with rheumatoid arthritis disease activity","volume":"9","author":"Binvignat","year":"2024","journal-title":"JCI Insight"},{"issue":"6621","key":"10.1016\/j.intimp.2025.115528_bb0145","doi-asserted-by":"crossref","DOI":"10.1126\/science.abl7207","article-title":"Aberrant hyperexpression of the RNA binding protein FMRP in tumors mediates immune evasion","volume":"378","author":"Zeng","year":"2022","journal-title":"Science (80-)"},{"issue":"7811","key":"10.1016\/j.intimp.2025.115528_bb0150","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41586-020-2222-z","article-title":"Notch signalling drives synovial fibroblast identity and arthritis pathology","volume":"582","author":"Wei","year":"2020","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.intimp.2025.115528_bb0155","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.autrev.2011.04.017","article-title":"Emerging role for NK cells in the pathogenesis of inflammatory arthropathies","volume":"10","author":"Conigliaro","year":"2011","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2025.115528_bb0160","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/cmi.2016.60","article-title":"UPAR promotes tumor-like biologic behaviors of fibroblast-like synoviocytes through PI3K\/Akt signaling pathway in patients with rheumatoid arthritis","volume":"15","author":"Liu","year":"2018","journal-title":"Cell. Mol. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115528_bb0165","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41584-022-00793-5","article-title":"Mechanisms of joint destruction in rheumatoid arthritis - immune cell-fibroblast-bone interactions","volume":"18","author":"Komatsu","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"issue":"7987","key":"10.1016\/j.intimp.2025.115528_bb0170","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2025.115528_bb0175","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/BOR.0000000000000978","article-title":"Recent developments in the synovial fibroblast pathobiology field in rheumatoid arthritis","volume":"36","author":"Neumann","year":"2024","journal-title":"Curr. Opin. Rheumatol."},{"issue":"10","key":"10.1016\/j.intimp.2025.115528_bb0180","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1182\/blood-2008-05-155846","article-title":"Mechanisms and pathologic significances in increase in serum interleukin-6 (IL-6) and soluble IL-6 receptor after administration of an anti-IL-6 receptor antibody, tocilizumab, in patients with rheumatoid arthritis and Castleman disease","volume":"112","author":"Nishimoto","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2025.115528_bb0185","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-immunol-101220-023458","article-title":"IL-6 revisited: from rheumatoid arthritis to CAR T cell therapy and COVID-19","volume":"40","author":"Kishimoto","year":"2022","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115528_bb0190","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/annrheumdis-2020-217844","article-title":"In vitro elimination of autoreactive B cells from rheumatoid arthritis patients by universal chimeric antigen receptor T cells","volume":"80","author":"Zhang","year":"2021","journal-title":"Ann. Rheum. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2025.115528_bb0195","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1002\/art.41812","article-title":"Is there a place for chimeric antigen receptor-T cells in the treatment of chronic autoimmune rheumatic diseases?","volume":"73","author":"Orvain","year":"2021","journal-title":"Arthritis Rheumatol. (Hoboken, NJ)."},{"issue":"3","key":"10.1016\/j.intimp.2025.115528_bb0200","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3109\/03009742.2013.846407","article-title":"Circulating Th17 and Th1 cells expressing CD161 are associated with disease activity in rheumatoid arthritis","volume":"43","author":"Miao","year":"2014","journal-title":"Scand. J. Rheumatol."},{"issue":"7811","key":"10.1016\/j.intimp.2025.115528_bb0205","article-title":"Percentages of CD4+CD161+ and CD4-CD8-CD161+ T cells in the synovial fluid are correlated with disease activity in rheumatoid arthritis","volume":"2015","author":"Miao","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"2","key":"10.1016\/j.intimp.2025.115528_bb0210","first-page":"318","article-title":"The mechanism of action of tofacitinib - an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis","volume":"34","author":"Hodge","year":"2016","journal-title":"Clin. Exp. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115528_bb0215","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13045-025-01677-3","article-title":"CAR-NK cell therapy: latest updates from the 2024 ASH annual meeting","volume":"18","author":"Kong","year":"2025","journal-title":"J. Hematol. Oncol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115528_bb0220","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41571-020-0426-7","article-title":"Exploring the NK cell platform for cancer immunotherapy","volume":"18","author":"Myers","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"June","key":"10.1016\/j.intimp.2025.115528_bb0225","first-page":"1","article-title":"A phase I study of locoregional high-dose autologous natural killer cell therapy with hepatic arterial infusion chemotherapy in patients with locally advanced hepatocellular carcinoma","volume":"13","author":"Bae","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115528_bb0230","article-title":"In vivo AAV-SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy","author":"Peng","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"10","key":"10.1016\/j.intimp.2025.115528_bb0235","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1136\/annrheumdis-2020-217798","article-title":"Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-\u03b3 treatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis","volume":"79","author":"He","year":"2020","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.intimp.2025.115528_bb0240","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/cei.12891","article-title":"Association of NKG2D gene variants with susceptibility and severity of rheumatoid arthritis","volume":"187","author":"Mariaselvam","year":"2017","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115528_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/genes9020064","article-title":"Influence of NKG2D genetic variants on response to anti-TNF agents in patients with rheumatoid arthritis","volume":"9","author":"Iwaszko","year":"2018","journal-title":"Genes (Basel)"},{"issue":"3","key":"10.1016\/j.intimp.2025.115528_bb0250","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2683","article-title":"Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study","volume":"11","author":"Kirsten","year":"2009","journal-title":"Arthritis Res. Ther."},{"issue":"11","key":"10.1016\/j.intimp.2025.115528_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007444","article-title":"Macrophage activation by IFN-\u03b3 triggers restriction of phagosomal copper from intracellular pathogens","volume":"14","author":"Shen","year":"2018","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.intimp.2025.115528_bb0260","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41598-018-37448-z","article-title":"High percentages and activity of synovial fluid NK cells present in patients with advanced stage active rheumatoid arthritis","volume":"9","author":"Yamin","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.115528_bb0265","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1038\/s41598-020-62654-z","article-title":"Phenotypic and functional characterization of natural killer cells in rheumatoid arthritis-regulation with interleukin-15","volume":"10","author":"Lin","year":"2020","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.intimp.2025.115528_bb0270","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.4049\/jimmunol.173.10.6418","article-title":"CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation","volume":"173","author":"Dalbeth","year":"2004","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115528_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/genes11050492","article-title":"Differentially expressed genes of natural killer cells can distinguish rheumatoid arthritis patients from healthy controls","volume":"11","author":"Elemam","year":"2020","journal-title":"Genes (Basel)"},{"issue":"March","key":"10.1016\/j.intimp.2025.115528_bb0280","article-title":"Natural killer cells infiltration in the joints exacerbates collagen-induced arthritis","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"issue":"23","key":"10.1016\/j.intimp.2025.115528_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.182390","article-title":"NK cell subsets define sustained remission in rheumatoid arthritis","volume":"9","author":"Coyle","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.intimp.2025.115528_bb0290","first-page":"83","article-title":"NK cell count as predictor of clinical response in patients with rheumatoid arthritis treated with rituximab","volume":"6","author":"Lurati","year":"2012","journal-title":"Biologics"},{"issue":"2","key":"10.1016\/j.intimp.2025.115528_bb0295","first-page":"241","article-title":"Rituximab increases peripheral natural killer cells in patients with rheumatoid arthritis","volume":"35","author":"Giollo","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"issue":"March","key":"10.1016\/j.intimp.2025.115528_bb0300","article-title":"NK cells in autoimmune diseases: protective or pathogenic?","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115528_bb0305","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2119\/molmed.2014.00252","article-title":"Enrichment of genetic variants for rheumatoid arthritis within T-cell and NK-cell enhancer regions","volume":"21","author":"Freudenberg","year":"2015","journal-title":"Mol. Med."},{"issue":"6","key":"10.1016\/j.intimp.2025.115528_bb0310","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3899\/jrheum.150644","article-title":"Altered natural killer cell subsets in seropositive arthralgia and early rheumatoid arthritis are associated with autoantibody status","volume":"43","author":"Chalan","year":"2016","journal-title":"J. Rheumatol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115528_bb0315","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.autrev.2013.10.010","article-title":"Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases","volume":"13","author":"Antonelli","year":"2014","journal-title":"Autoimmun. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2025.115528_bb0320","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/art.41958","article-title":"Effect of JAK inhibition on the induction of proinflammatory HLA-DR+CD90+ rheumatoid arthritis synovial fibroblasts by interferon-\u03b3","volume":"74","author":"Zhao","year":"2022","journal-title":"Arthritis Rheumatol. (Hoboken, NJ)"},{"key":"10.1016\/j.intimp.2025.115528_bb0325","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.addr.2018.12.005","article-title":"Targeting the CD40-CD40L pathway in autoimmune diseases: humoral immunity and beyond","volume":"141","author":"Karnell","year":"2019","journal-title":"Adv. Drug Deliv. Rev."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692501519X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692501519X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T15:21:38Z","timestamp":1763047298000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692501519X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":65,"alternative-id":["S156757692501519X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115528","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting CD161 inhibitory receptors enhances NK cell-mediated changes in synovial fibroblast function in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115528"}}