{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:51:38Z","timestamp":1792216298755,"version":"4.4.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020625","name":"Saveetha Institute of Medical and Technical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.intimp.2025.115581","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:01:23Z","timestamp":1758704483000},"page":"115581","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Green synthesis of copper oxide nanoparticles from Calotropis gigantea of antimicrobial, antidiabetic, and toxicity evaluation in zebrafish"],"prefix":"10.1016","volume":"166","author":[{"given":"Azhagu Madhavan","family":"Sivalingam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115581_bb0005","doi-asserted-by":"crossref","unstructured":"C. Jayalekshmi, N.M. Das, R.J.O.O.R. Periakaruppan, Bioactive compounds of Calotropis gigantea for cancer treatment, (2024) 100336.","DOI":"10.1016\/j.oor.2024.100336"},{"issue":"15","key":"10.1016\/j.intimp.2025.115581_bb0010","doi-asserted-by":"crossref","first-page":"9398","DOI":"10.1021\/acs.jafc.4c10898","article-title":"Crystal Structure of Papain-Like Cysteine Protease, Calotropain FI, Purified from the Latex of Calotropis gigantea","volume":"73","author":"Jamdar","year":"2025","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/j.intimp.2025.115581_bb0015","article-title":"Nanoemulsion based on Calotropis procera seed oil to delivery of betulinic acid: in vitro release kinetics, in vivo toxicity and MTT assay in PC3 cells","volume":"106","author":"de Sousa","year":"2025","journal-title":"5"},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0020","doi-asserted-by":"crossref","first-page":"16284","DOI":"10.1038\/s41598-017-16581-1","article-title":"Mechanistic insight to ROS and Apoptosis regulated cytotoxicity inferred by green synthesized CuO nanoparticles from Calotropis gigantea to embryonic zebrafish","volume":"7","author":"Kumari","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115581_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2024.119180","article-title":"Angiogenic protein profiling, phytochemical screening and in silico anti-cancer targets validation of stem, leaves, fruit, and seeds of Calotropis procera in human liver and breast cancer cell lines","volume":"256","author":"Khan","year":"2024","journal-title":"Environ. Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s11671-025-04225-7","article-title":"Comparative toxicity and environmental impact assessments of sonochemically-synthesized CuO and Zn-doped CuO nanoparticles using zebrafish and LCA tools","volume":"20","author":"Negrini","year":"2025","journal-title":"Discover Nano"},{"issue":"9","key":"10.1016\/j.intimp.2025.115581_bb0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10653-024-02104-1","article-title":"A comparative study of in vivo toxicity in zebrafish embryos synthesized CuO nanoparticles characterized from Salacia reticulata","volume":"46","author":"Sivalingam","year":"2024","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.intimp.2025.115581_bb0040","article-title":"Therapeutic potential of lipopeptide biosurfactant-fabricated copper oxide nanoparticles: mechanistic insight into their biocompatibility using zebra fish, current research","volume":"7","author":"Bhuyan","year":"2024","journal-title":"Biotechnology"},{"key":"10.1016\/j.intimp.2025.115581_bb0045","article-title":"Copper II oxide nanoparticles (CuONPs) alter metabolic markers and swimming activity in zebra-fish (Danio rerio)","volume":"257","author":"de Oliveira Eiras","year":"2022","journal-title":"Comp. Biochem. Physiol., Part C: Toxicol. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115581_bb0050","series-title":"A comprehensive study on characterization of biosynthesized copper-oxide nanoparticles, their capabilities as anticancer and antibacterial agents, and predicting optimal docking poses into the cavity of S. aureus DHFR","first-page":"e0319791","volume":"20","author":"Gad","year":"2025"},{"key":"10.1016\/j.intimp.2025.115581_bb0055","article-title":"Sustainable fabrication of Ti alloy-coated NiO\/ag bimetallic nanoparticles incorporated with Calotropis gigantea fiber: A dual-purpose material for efficient environmental pollutant degradation and advanced biomedical applications","volume":"60","author":"Ramachandran","year":"2025","journal-title":"Surf Interfaces"},{"key":"10.1016\/j.intimp.2025.115581_bb0060","series-title":"Structures, Eco-sustainable shear reinforcement in reinforced concrete beams with Calotropis gigantea fiber","first-page":"1","author":"Suresh","year":"2025"},{"key":"10.1016\/j.intimp.2025.115581_bb0065","series-title":"HPLC-MS standardization and validation methods for determination of calactin content in dichloromethane fraction of Calotropis gigantea (L.) Dryand.(Niu jiao gua) stem bark and its application in prediction of anticancer activities","volume":"11","author":"Kaewpaeng","year":"2025"},{"key":"10.1016\/j.intimp.2025.115581_bb0070","series-title":"Unravelling the in vivo biotoxicity of a green-biofabricated graphene oxide\u2013microplastic hybrid mediated by proximal intrinsic atomic interactions","author":"Sinha","year":"2025"},{"key":"10.1016\/j.intimp.2025.115581_bb0075","series-title":"Improved synthesis of Cu2O NPs and ascorbic acid-modified derivatives for adsorption of brilliant Cresyl blue: Surface and reusability studies","first-page":"2358","volume":"17","author":"Zeghdi","year":"2024"},{"key":"10.1016\/j.intimp.2025.115581_bb0080","doi-asserted-by":"crossref","unstructured":"A.M. Sivalingam, A.J.M.P. Pandian, antihyperglycemic activity of polyphenolic metabolites and biosynthesized silver nanoparticles from pedalium murex: characterization and application of antioxidant and uropathogenic antimicrobial activities, (2025) 107620.","DOI":"10.1016\/j.micpath.2025.107620"},{"issue":"5","key":"10.1016\/j.intimp.2025.115581_bb0085","doi-asserted-by":"crossref","first-page":"6567","DOI":"10.1007\/s13399-022-02743-3","article-title":"In vitro antioxidant activities of copper mixed oxide (CuO\/Cu2O) nanoparticles produced from the leaves of Phoenix dactylifera L","volume":"14","author":"Djamila","year":"2024","journal-title":"Biomass Convers. Biorefinery"},{"key":"10.1016\/j.intimp.2025.115581_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbsr.2024.100707","article-title":"Biosynthesis of ZnO nanocomposites from Mentha spicata applications of antioxidant, antimicrobial and genotoxicity advances in MCF-7 cell line","volume":"46","author":"Sivalingam","year":"2024","journal-title":"Sensing Bio-Sensing Res."},{"key":"10.1016\/j.intimp.2025.115581_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbsr.2025.100843","article-title":"Biological characterization of synthesized iron nanoparticles (FeNPs) from Avicennia marina for phenol red removal","volume":"49","author":"Sivalingam","year":"2025","journal-title":"Sensing Bio-Sensing Res."},{"key":"10.1016\/j.intimp.2025.115581_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2024.106635","article-title":"Identification and characterization of silver nanoparticles from Erythrina indica and its antioxidant and Uropathogenic antimicrobial properties","volume":"190","author":"Sivalingam","year":"2024","journal-title":"Microb. Pathog."},{"issue":"8","key":"10.1016\/j.intimp.2025.115581_bb0105","first-page":"1637","article-title":"Toxicity and immunomodulatory efficacy of biosynthesized silver myconanosomes on pathogenic microbes and macrophage cells","volume":"46","author":"Fatima","year":"2018","journal-title":"Artificial Cells, Nanomedicine, and Biotechnology"},{"key":"10.1016\/j.intimp.2025.115581_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcab.2024.103043","article-title":"An investigation on antidiabetic competence of Ferula assafoetida mediated AgNPs on diabetic (STZ) induced albino rats","volume":"56","author":"Subramaniam","year":"2024","journal-title":"Biocatal. Agric. Biotechnol."},{"key":"10.1016\/j.intimp.2025.115581_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2024.120390","article-title":"Efficient production of lignin nanoparticle colloids and their feasibility for eco-friendly dyeing of natural and synthetic textile fabrics","volume":"225","author":"Pereira","year":"2025","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.intimp.2025.115581_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.cplett.2022.139493","article-title":"Green synthesis of silver nanoparticles using fruits extracts of Syzygium cumini and their bioactivity","volume":"795","author":"Chakravarty","year":"2022","journal-title":"Chem. Phys. Lett."},{"key":"10.1016\/j.intimp.2025.115581_bb0125","volume":"8","author":"Sivalingam","year":"2024","journal-title":"Applications, characterization of silver nanoparticles (AgNPs) synthesized using polyphenolic compounds from Phyllanthus emblica L.and their impact on cytotoxicity in human cell lines"},{"key":"10.1016\/j.intimp.2025.115581_bb0130","series-title":"Synthesis, Green-synthesized chromium oxide nanoparticles using pomegranate husk extract: multifunctional bioactivity in antioxidant potential, lipase and amylase inhibition, and cytotoxicity","volume":"14","author":"Cheah","year":"2025"},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0135","doi-asserted-by":"crossref","first-page":"30198","DOI":"10.1038\/s41598-024-81384-0","article-title":"Oxidative stress-induced cytotoxicity of HCC2998 colon carcinoma cells by ZnO nanoparticles synthesized from Calophyllum teysmannii","volume":"14","author":"Subramaniam","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115581_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.140750","article-title":"In vitro study of antibacterial and anticancer activities of biosynthesized ag-doped ZnO nanoparticles from Anisochilus Carnosus, Nephelium Lappaceum, Calotropis Gigantea","volume":"1323","author":"Vandhana","year":"2025","journal-title":"J. Mol. Struct."},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0145","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s40203-025-00331-7","article-title":"Anthelmintic activity of calotropis gigantea: in silico investigation on novel target site nematode kinases","volume":"13","author":"Gopalakrishnan","year":"2025","journal-title":"Silico Pharmacology"},{"issue":"4","key":"10.1016\/j.intimp.2025.115581_bb0150","article-title":"Latex extract as an effective green corrosion inhibitor for mild steel in acidic medium","volume":"20","author":"Salman","year":"2025","journal-title":"Exp. Quantum Chem."},{"key":"10.1016\/j.intimp.2025.115581_bb0155","series-title":"Evaluation of potential and in-vitro antioxidant activity of mangrove leaves Avicennia marina ethanolic extract","first-page":"32","volume":"6","author":"Azhagu Madhavan","year":"2021"},{"issue":"2","key":"10.1016\/j.intimp.2025.115581_bb0160","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s10924-023-02976-x","article-title":"Plant extract-mediated synthesis of CuO nanoparticles from lemon Peel extract and their modification with polyethylene glycol for enhancing photocatalytic and antioxidant activities","volume":"32","author":"Kir","year":"2024","journal-title":"J. Polym. Environ."},{"key":"10.1016\/j.intimp.2025.115581_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2020.136521","article-title":"Green synthesized MgO nanoparticles infer biocompatibility by reducing in vivo molecular nanotoxicity in embryonic zebrafish through arginine interaction elicited apoptosis","volume":"713","author":"Verma","year":"2020","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.intimp.2025.115581_bb0170","series-title":"Therapeutic efficacy of Phyllanthus emblica-coated iron oxide nanoparticles in A549 lung cancer cell line","first-page":"2355","volume":"14","author":"Thoidingjam","year":"2019"},{"key":"10.1016\/j.intimp.2025.115581_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2022.113542","article-title":"Toxicity of green synthesized TiO2 nanoparticles (TiO2 NPs) on zebra fish","volume":"212","author":"Jafari","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.intimp.2025.115581_bb0180","series-title":"Green synthesis of ZnO nanoparticles using the mangosteen (Garcinia mangostana L.) leaf extract: Comparative preliminary in vitro antibacterial study","volume":"13","author":"Chan","year":"2024"},{"key":"10.1016\/j.intimp.2025.115581_bb0185","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1016\/j.jmrt.2022.08.028","article-title":"Synthesis, characterization, and preliminary in vitro antibacterial evaluation of ZnO nanoparticles derived from soursop (Annona muricata L.) leaf extract as a green reducing agent","volume":"20","author":"Selvanathan","year":"2022","journal-title":"J. Mater. Res. Technol."},{"key":"10.1016\/j.intimp.2025.115581_bb0190","series-title":"Microwave-assisted green synthesis, characterization, and in vitro antibacterial activity of NiO nanoparticles obtained from lemon peel extract","volume":"13","author":"Heng","year":"2024"},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0195","first-page":"3931","article-title":"Synthesis of chitosan\/PVA\/copper oxide nanocomposite using Anacardium occidentale extract and evaluating its antioxidant, antibacterial","volume":"15","author":"Rajkumar","year":"2025","journal-title":"Anti-Inflammatory Cytotoxic Activities"},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0200","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1021\/acsomega.4c08287","article-title":"Toxicity assessment of biogenic gold nanoparticles on crop seeds and zebrafish embryos: implications for agricultural and aquatic ecosystems, ACS","volume":"10","author":"Botteon","year":"2025","journal-title":"Omega"},{"issue":"3","key":"10.1016\/j.intimp.2025.115581_bb0205","first-page":"684","article-title":"Application of Fourier transform infrared (FTIR)","volume":"30","author":"Pasieczna-Patkowska","year":"2025","journal-title":"Spectroscopy Characterization Green Synthesized Nanoparticles"},{"issue":"3","key":"10.1016\/j.intimp.2025.115581_bb0210","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/s10971-024-06608-1","article-title":"Gallic acid assisted synthesis of novel CuO\/Ni\/Fe3O4 nanocomposite for catalytic CO2 methanation and photocatalytic hydrogen generation","volume":"113","author":"Salmi","year":"2025","journal-title":"J. Sol-Gel Sci. Technol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0215","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1038\/s41598-023-32938-1","article-title":"Removal of hydrocarbons and heavy metals from petroleum water by modern green nanotechnology methods","volume":"13","author":"Bouafia","year":"2023","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2025.115581_bb0220","doi-asserted-by":"crossref","first-page":"102092","DOI":"10.1016\/j.jksus.2022.102092","article-title":"Green and chemical synthesis of CuO nanoparticles: A comparative study for several in vitro bioactivities and in vivo toxicity in zebrafish embryos","volume":"34","author":"Sabeena","year":"2022","journal-title":"J. King Saud Univ \u2013 Sci."},{"key":"10.1016\/j.intimp.2025.115581_bb0225","series-title":"Green synthesis and characterization of CuO\/ZnO nanocomposite using Musa acuminata leaf extract for cytotoxic studies on colorectal cancer cells (HCC2998)","volume":"13","author":"Wong","year":"2024"},{"key":"10.1016\/j.intimp.2025.115581_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2025.115936","article-title":"Encapsulation of oleanolic acid into cyclodextrin metal-organic frameworks by co-crystallization: preparation, structure characterization and its effect on a zebrafish larva NAFLD model","volume":"204","author":"Li","year":"2025","journal-title":"Food Res. Int."},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0235","doi-asserted-by":"crossref","DOI":"10.1093\/ijfood\/vvaf051","article-title":"Enhanced antioxidant, anti-inflammatory, and photocatalytic properties of \u03b1-tocopherol-coated copper oxide nanoparticles: synthesis, characterisation, and multifunctional applications","volume":"60","author":"Barani","year":"2025","journal-title":"Int. J. Food Sci. Technol."},{"key":"10.1016\/j.intimp.2025.115581_bb0240","first-page":"383","article-title":"Bactericidal potential of dual-ionic honeycomb-like ZnO-CuO nanocomposites from Calotropis gigantea against prominent pathogen associated with skin and surgical wound infections: Staphylococcus aureus","volume":"4","author":"Govindasamy","year":"2021","journal-title":"Materials Sci. Energy Technol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115581_bb0245","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s10876-023-02519-3","article-title":"One post biosynthesis of novel ternary nanocomposite ZnO\/CuO\/Cu2MgO3 for enhancing photocatalytic degradation of Bromocresol green in wastewater","volume":"35","author":"Tabet","year":"2024","journal-title":"J. Clust. Sci."},{"key":"10.1016\/j.intimp.2025.115581_bb0250","series-title":"Plant extract-mediated green synthesized CuO nanoparticles for environmental and microbial remediation: A review covering basic understandings to mechanistic study","author":"Mobarak","year":"2025"},{"key":"10.1016\/j.intimp.2025.115581_bb0255","series-title":"Green synthesis and characterization of cuo nanoparticles derived from papaya peel extract for the photocatalytic degradation of palm oil mill effluent (POME)","first-page":"796","volume":"13","author":"Phang","year":"2021"},{"key":"10.1016\/j.intimp.2025.115581_bb0260","series-title":"Phytochemical mediated synthesis of CuO nanoparticles and its evaluation for electrocatalytic oxygen reduction reaction activity","first-page":"e202501100","volume":"10","author":"Yadav","year":"2025"},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0265","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s12010-024-05031-0","article-title":"Phytomediated copper oxide nanoparticles derived from the fronds of Adiantum venustum D.Don: evaluation of their biomedical potential","volume":"197","author":"Kimta","year":"2025","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.intimp.2025.115581_bb0270","series-title":"Biodiversity, synthesis, characterization and antibacterial activity evaluation of CuO NPs and B-CuO NPs obtained from Livistona chinensis leaf extract","first-page":"e202401596","volume":"22","author":"Veg","year":"2025"},{"key":"10.1016\/j.intimp.2025.115581_bb0275","series-title":"Enhanced photocatalytic activity and antiviral evaluation of CuO@ Fe2O3 NC for amoxicillin degradation and SARS-CoV-2 treatment","first-page":"445101","volume":"34","author":"Legmairi","year":"2023"},{"issue":"3","key":"10.1016\/j.intimp.2025.115581_bb0280","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11243-024-00574-x","article-title":"Novel CuO\u2013SiO2 nanocomposites: synthesis, kinetics, recyclability, high stability and photocatalytic efficiency for rose Bengal dye removal","volume":"49","author":"Gharbi","year":"2024","journal-title":"Transit. Met. Chem."},{"key":"10.1016\/j.intimp.2025.115581_bb0285","article-title":"Eco-friendly synthesis of chitosan NPs from Fioria vitifolia (L.) L: potential to antibacterial, antioxidant, cytotoxicity properties of HepG2 cells and their evaluation of safety on zebrafish embryo","volume":"25","author":"Imath","year":"2025","journal-title":"Res. Eng. Des."},{"key":"10.1016\/j.intimp.2025.115581_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcrysgro.2024.127917","article-title":"Biogenic synthesis of porous CuO nanoparticles: synergistic effects in photocatalytic dye degradation and electrochemical energy storage applications","volume":"649","author":"Beevi Sharafudheen","year":"2025","journal-title":"J. Cryst. Growth"},{"issue":"21","key":"10.1016\/j.intimp.2025.115581_bb0295","first-page":"6379","article-title":"Muntingia calabura leaves mediated green synthesis of CuO Nanorods: exploiting phytochemicals for unique","volume":"14","author":"Selvanathan","year":"2021","journal-title":"Morphology"},{"issue":"20","key":"10.1016\/j.intimp.2025.115581_bb0300","first-page":"3589","article-title":"Effect of calcination temperature on structural, morphological and optical properties of copper oxide nanostructures derived from Garcinia mangostana L","volume":"12","author":"Chan","year":"2022","journal-title":"Leaf Extract"},{"issue":"15","key":"10.1016\/j.intimp.2025.115581_bb0305","first-page":"5421","article-title":"Impact of diverse parameters on the physicochemical characteristics of green-synthesized zinc oxide\u2013copper oxide nanocomposites derived from an aqueous extract of Garcinia mangostana L","volume":"16","author":"Chan","year":"2023","journal-title":"Leaf"},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0310","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s13369-023-08495-0","article-title":"Biogenic ZnO\/CuO\/Fe2O3 nanocomposite: A groundbreaking approach for enhanced degradation capabilities and reusability in dye removal applications","volume":"49","author":"Serouti","year":"2024","journal-title":"Arab. J. Sci. Eng."},{"key":"10.1016\/j.intimp.2025.115581_bb0315","series-title":"Application of Nanoradioprotective Agents in Cancer Therapy, Harnessing Materials for X-ray Based Cancer Therapy and Imaging","first-page":"175","author":"Mozafari","year":"2022"},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0320","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.sjbs.2021.09.013","article-title":"Ali Raza Shah, novel biosynthesis, characterization and bio-catalytic potential of green algae (Spirogyra hyalina) mediated silver nanomaterials","volume":"29","author":"Abdullah","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.intimp.2025.115581_bb0325","series-title":"In vitro and in vivo applications of Euphorbia wallichii shoot extract-mediated gold nanospheres","first-page":"101","volume":"10","author":"Ullah","year":"2021"},{"key":"10.1016\/j.intimp.2025.115581_bb0330","doi-asserted-by":"crossref","unstructured":"H. Jan, M. Shah, A. Andleeb, S. Faisal, A. Khattak, M. Rizwan, S. Drouet, C. Hano, B.H.J.O.M. Abbasi, C. Longevity, Plant-based synthesis of zinc oxide nanoparticles (ZnO-NPs) using aqueous leaf extract of aquilegia pubiflora: Their antiproliferative activity against HepG2 Cells Inducing Reactive Oxygen species and other In Vitro Properties, 2021(1) 4786227.","DOI":"10.1155\/2021\/4786227"},{"key":"10.1016\/j.intimp.2025.115581_bb0335","series-title":"Fagonia cretica-mediated synthesis of manganese oxide (MnO2) nanomaterials their characterization and evaluation of their bio-catalytic and enzyme inhibition potential for maintaining flavor and texture in apples","first-page":"558","volume":"12","author":"Faisal","year":"2022"},{"issue":"30","key":"10.1016\/j.intimp.2025.115581_bb0340","doi-asserted-by":"crossref","first-page":"27439","DOI":"10.1021\/acsomega.3c02932","article-title":"Enterobacter hormaechei-driven novel biosynthesis of tin oxide nanoparticles and evaluation of their anti-aging, cytotoxic, and enzyme inhibition potential","volume":"8","author":"Rizwan","year":"2023","journal-title":"ACS Omega"},{"issue":"17","key":"10.1016\/j.intimp.2025.115581_bb0345","first-page":"6364","article-title":"Multifunctional Spirogyra-hyalina-mediated barium oxide nanoparticles (BaONPs)","volume":"28","author":"Abdullah","year":"2023","journal-title":"Synthesis and Applications"},{"issue":"13-15","key":"10.1016\/j.intimp.2025.115581_bb0350","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1089\/ars.2022.0107","article-title":"Advances in antioxidant nanomedicines for imaging and therapy of Alzheimer\u2019s disease","volume":"40","author":"Hasan","year":"2023","journal-title":"Antioxid. Redox Signal."},{"issue":"2","key":"10.1016\/j.intimp.2025.115581_bb0355","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11051-023-05675-9","article-title":"Nanoparticle and nanomaterial involvement during the wound healing process: an update in the field","volume":"25","author":"P\u00e9rez-D\u00edaz","year":"2023","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.intimp.2025.115581_bb0360","series-title":"Investigating Chemopreventive and Chemotherapeutic Applications of Cannabinoids in Prostate cancer","author":"O'Reilly","year":"2022"},{"key":"10.1016\/j.intimp.2025.115581_bb0365","series-title":"Nanomedicine,, biotechnology, Molecular investigation to RNA and protein based interaction induced in vivo biocompatibility of phytofabricated AuNP with embryonic zebrafish","first-page":"671","volume":"46","author":"Verma","year":"2018"},{"key":"10.1016\/j.intimp.2025.115581_bb0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.125574","article-title":"Biotechnological potential of a cysteine protease (CpCP3) from Calotropis procera latex for cheesemaking","volume":"307","author":"Silva","year":"2020","journal-title":"Food Chem."},{"issue":"1","key":"10.1016\/j.intimp.2025.115581_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jfutfo.2024.01.001","article-title":"Recent advcances on plant-based bioengineered nanoparticles using secondary metabolites and their potential in lung cancer management","volume":"5","author":"Islam","year":"2025","journal-title":"J. Future Foods"},{"key":"10.1016\/j.intimp.2025.115581_bb0380","first-page":"1","article-title":"Evaluating the toxicity profile of green-synthesized ferric nanoparticles using Madhuca indica in a zebrafish model, Biomed","volume":"2","author":"Behera","year":"2025","journal-title":"Biomed. Mater. Devices"},{"key":"10.1016\/j.intimp.2025.115581_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137425","article-title":"Formulation of Asiatic acid-loaded polymeric chitosan-based hydrogel for effective MRSA infection control and enhanced wound healing in zebrafish models","volume":"293","author":"Kandaswamy","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.115581_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.chphi.2025.100849","article-title":"Fe2O3-type iron oxide nanoparticles from Aerva lanata leaf extract exhibit antibiofilm, discriminatory toxicity in cancer cells, and theranostic against oxidative stress in zebrafish","volume":"10","author":"Nagaraj","year":"2025","journal-title":"Chem. Phys. Impact"},{"key":"10.1016\/j.intimp.2025.115581_bb0395","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1007\/s10811-025-03535-8","article-title":"Impact of dietary supplementation with Synechococcus elongatus PCC 7942 expressing a \u03b2-glucosidase from Amazonian soil on the physiology of zebrafish (Danio rerio) fed a soybean meal-rich diet","volume":"3","author":"Hernandez","year":"2025","journal-title":"J. Appl. Phycol"},{"key":"10.1016\/j.intimp.2025.115581_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.107349","article-title":"In vivo host-pathogen dynamics and immune responses to Piscirickettsia salmonis using the zebrafish model","volume":"200","author":"Ortiz-Sever\u00edn","year":"2025","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.intimp.2025.115581_bb0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.107374","article-title":"Uncovering the pathogenic mechanisms of Cronobacter turicensis: A dual transcriptomics study using a zebrafish larvae model","volume":"202","author":"Cosentino","year":"2025","journal-title":"Microb. Pathog."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925015723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925015723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T03:47:49Z","timestamp":1763696869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925015723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":81,"alternative-id":["S1567576925015723"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115581","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Green synthesis of copper oxide nanoparticles from Calotropis gigantea of antimicrobial, antidiabetic, and toxicity evaluation in zebrafish","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115581","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115581"}}