{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T04:04:46Z","timestamp":1763697886132,"version":"3.45.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010950","name":"Department of Science and Technology of Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["LHGJ20220014","LHGJ20220288","242102310230"],"award-info":[{"award-number":["LHGJ20220014","LHGJ20220288","242102310230"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.intimp.2025.115627","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T06:54:04Z","timestamp":1759301644000},"page":"115627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["TLR2\/NF-\u03baB signaling could oversee the function of CD56bright NK cells in patients afflicted with severe fever and thrombocytopenia syndrome (SFTS)"],"prefix":"10.1016","volume":"166","author":[{"given":"Meng-Meng","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Ran","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Bo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le-Le","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"16","key":"10.1016\/j.intimp.2025.115627_bb0005","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1056\/NEJMoa1010095","article-title":"Fever with thrombocytopenia associated with a novel bunyavirus in China","volume":"364","author":"Yu","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.intimp.2025.115627_bb0010","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/S1473-3099(18)30312-8","article-title":"Risk factors for death in severe fever with thrombocytopenia syndrome","volume":"18","author":"Yu","year":"2018","journal-title":"Lancet Infect. Dis."},{"issue":"4","key":"10.1016\/j.intimp.2025.115627_bb0015","article-title":"Immune modulation and immune-mediated pathogenesis of emerging Tickborne Banyangviruses","volume":"7","author":"Mendoza","year":"2019","journal-title":"Vaccines (Basel)"},{"issue":"2","key":"10.1016\/j.intimp.2025.115627_bb0020","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1089\/vbz.2011.0758","article-title":"Person-to-person transmission of severe fever with thrombocytopenia syndrome virus","volume":"12","author":"Liu","year":"2012","journal-title":"Vector Borne Zoonotic Dis."},{"issue":"5","key":"10.1016\/j.intimp.2025.115627_bb0025","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1128\/JVI.06192-11","article-title":"The ecology, genetic diversity, and phylogeny of Huaiyangshan virus in China","volume":"86","author":"Zhang","year":"2012","journal-title":"J. Virol."},{"key":"10.1016\/j.intimp.2025.115627_bb0030","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijid.2016.11.418","article-title":"Decreased myeloid dendritic cells indicate a poor prognosis in patients with severe fever with thrombocytopenia syndrome","volume":"54","author":"Zhang","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.intimp.2025.115627_bb0035","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijid.2015.12.009","article-title":"Decreased monocyte subsets and TLR4-mediated functions in patients with acute severe fever with thrombocytopenia syndrome (SFTS)","volume":"43","author":"Peng","year":"2016","journal-title":"Int. J. Infect. Dis."},{"issue":"10","key":"10.1016\/j.intimp.2025.115627_bb0040","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.vaccine.2015.01.051","article-title":"Characterization of immunological responses in patients with severe fever with thrombocytopenia syndrome: a cohort study in China","volume":"33","author":"Lu","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2025.115627_bb0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ijid.2017.02.017","article-title":"Dynamic changes of laboratory parameters and peripheral blood lymphocyte subsets in severe fever with thrombocytopenia syndrome patients","volume":"58","author":"Liu","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.intimp.2025.115627_bb0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.clim.2018.07.009","article-title":"CD4 T cell loss and Th2 and Th17 bias are associated with the severity of severe fever with thrombocytopenia syndrome (SFTS)","volume":"195","author":"Li","year":"2018","journal-title":"Clin. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115627_bb0055","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s12250-020-00224-3","article-title":"Depletion but activation of CD56(dim)CD16(+)NK cells in acute infection with severe fever with thrombocytopenia syndrome virus","volume":"35","author":"Li","year":"2020","journal-title":"Virol. Sin."},{"issue":"11","key":"10.1016\/j.intimp.2025.115627_bb0060","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","article-title":"The biology of human natural killer-cell subsets","volume":"22","author":"Cooper","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.intimp.2025.115627_bb0065","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3389\/fimmu.2014.00390","article-title":"NK cell subset redistribution during the course of viral infections","volume":"5","author":"Lugli","year":"2014","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2025.115627_bb0070","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/ACI.0b013e3280106b65","article-title":"Human natural killer cell deficiencies","volume":"6","author":"Orange","year":"2006","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.115627_bb0075","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev-immunol-032712-100001","article-title":"Control of human viral infections by natural killer cells","volume":"31","author":"Jost","year":"2013","journal-title":"Annu. Rev. Immunol."},{"issue":"26","key":"10.1016\/j.intimp.2025.115627_bb0080","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJM198906293202605","article-title":"Severe herpesvirus infections in an adolescent without natural killer cells","volume":"320","author":"Biron","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2025.115627_bb0085","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev-immunol-100219-020937","article-title":"Regulatory T cell development","volume":"38","author":"Savage","year":"2020","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.115627_bb0090","first-page":"10","article-title":"SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-\u03baB pathway","author":"Khan","year":"2021","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.intimp.2025.115627_bb0095","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1182\/blood-2006-06-027136","article-title":"Innate immunity against vaccinia virus is mediated by TLR2 and requires TLR-independent production of IFN-beta","volume":"109","author":"Zhu","year":"2007","journal-title":"Blood"},{"issue":"16","key":"10.1016\/j.intimp.2025.115627_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e35950","article-title":"TLR2\/NF-\u043aB signaling may control expansion and function of regulatory T cells in patients with severe fever with thrombocytopenia syndrome (SFTS)","volume":"10","author":"Li","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.intimp.2025.115627_bb0105","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/978-1-60761-362-6_23","article-title":"Functional analysis of human NK cells by flow cytometry","volume":"612","author":"Bryceson","year":"2010","journal-title":"Methods Mol. Biol."},{"issue":"52","key":"10.1016\/j.intimp.2025.115627_bb0110","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000005708","article-title":"A simple and practical score model for predicting the mortality of severe fever with thrombocytopenia syndrome patients","volume":"95","author":"Xiong","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"10.1016\/j.intimp.2025.115627_bb0115","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.bjid.2013.05.011","article-title":"Clinical and laboratory characteristics of severe fever with thrombocytopenia syndrome in Chinese patients","volume":"18","author":"Weng","year":"2014","journal-title":"Braz. J. Infect. Dis."},{"issue":"7","key":"10.1016\/j.intimp.2025.115627_bb0120","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/infdis\/jis452","article-title":"Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome","volume":"206","author":"Sun","year":"2012","journal-title":"J. Infect. Dis."},{"issue":"8","key":"10.1016\/j.intimp.2025.115627_bb0125","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.4049\/jimmunol.178.8.4947","article-title":"CD56brightCD16- killer Ig-like receptor- NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation","volume":"178","author":"Romagnani","year":"2007","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115627_bb0130","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-3083.2006.01883.x","article-title":"Induction of CD16+ CD56bright NK cells with antitumour cytotoxicity not only from CD16- CD56bright NK cells but also from CD16- CD56dim NK cells","volume":"65","author":"Takahashi","year":"2007","journal-title":"Scand. J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115627_bb0135","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/eji.201343868","article-title":"Peripheral blood CD56(bright) NK cells respond to stem cell factor and adhere to its membrane-bound form after upregulation of c-kit","volume":"44","author":"Pradier","year":"2014","journal-title":"Eur. J. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2025.115627_bb0140","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.4049\/jimmunol.173.10.6418","article-title":"CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation","volume":"173","author":"Dalbeth","year":"2004","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115627_bb0145","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.4049\/jimmunol.1502570","article-title":"Human CD56bright NK cells: an update","volume":"196","author":"Michel","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.115627_bb0150","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jaut.2016.04.003","article-title":"Dysregulation of regulatory CD56(bright) NK cells\/T cells interactions in multiple sclerosis","volume":"72","author":"Laroni","year":"2016","journal-title":"J. Autoimmun."},{"issue":"16","key":"10.1016\/j.intimp.2025.115627_bb0155","doi-asserted-by":"crossref","first-page":"8388","DOI":"10.1128\/JVI.00612-12","article-title":"Suppression of the interferon and NF-\u03baB responses by severe fever with thrombocytopenia syndrome virus","volume":"86","author":"Qu","year":"2012","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115627_bb0160","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01815-23","article-title":"Interaction between the SFTSV envelope glycoprotein Gn and STING inhibits the formation of the STING-TBK1 complex and suppresses the NF-\u03baB signaling pathway","volume":"98","author":"Jia","year":"2024","journal-title":"J. Virol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115627_bb0165","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a000034","article-title":"The NF-kappaB family of transcription factors and its regulation","volume":"1","author":"Oeckinghaus","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115627_bb0170","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s10787-020-00773-9","article-title":"The role and therapeutic potential of NF-kappa-B pathway in severe COVID-19 patients","volume":"29","author":"Hariharan","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"1","key":"10.1016\/j.intimp.2025.115627_bb0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2025.115627_bb0180","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000811","article-title":"Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection","volume":"6","author":"Martinez","year":"2010","journal-title":"PLoS Pathog."},{"issue":"7","key":"10.1016\/j.intimp.2025.115627_bb0185","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70134","article-title":"Extracellular vesicles derived from Streptococcus anginosus aggravate lupus nephritis by triggering TLR2-MyD88-NF-\u03baB Signalling in NK cells","volume":"14","author":"Gong","year":"2025","journal-title":"J. Extracell Vesicles"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925016182?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925016182?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T03:56:02Z","timestamp":1763697362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925016182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":37,"alternative-id":["S1567576925016182"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115627","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLR2\/NF-\u03baB signaling could oversee the function of CD56bright NK cells in patients afflicted with severe fever and thrombocytopenia syndrome (SFTS)","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115627","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115627"}}