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Ethnopharmacol."},{"key":"10.1016\/j.intimp.2025.115652_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155488","article-title":"The antitumor effects of herbal medicine Triphala on oral cancer by inactivating PI3K\/Akt signaling pathway: based on the network pharmacology, molecular docking, in vitro and in vivo experimental validation","volume":"128","author":"Hu","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.115652_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.120946","article-title":"Urinary exosomes-based engineered Nanovectors for Homologously targeted chemo-Chemodynamic prostate Cancer therapy via abrogating EGFR\/AKT\/NF-kB\/IkB signaling","volume":"275","author":"Pan","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2025.115652_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121645","article-title":"Targeting HMGB1\/PI3K\/Akt and NF-\u03baB\/Nrf-2 signaling pathways by vildagliptin mitigates testosterone-induced benign prostate hyperplasia in rats","volume":"322","author":"El-Sahar","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.115652_bb0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156405","article-title":"Modified Shenqi Dihuang decoction inhibits prostate cancer metastasis by disrupting TCA cycle energy metabolism via NF-kB\/p65-mediated OGDH regulation","volume":"138","author":"Zhang","year":"2025","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.intimp.2025.115652_bb0395","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096824","article-title":"Development and validation of an animal model of prostate inflammation-induced chronic pelvic pain: evaluating from inflammation of the prostate to pain behavioral modifications","volume":"9","author":"Zeng","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.intimp.2025.115652_bb0400","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s10787-008-8051-6","article-title":"Development and characterisation of a novel animal model of prostate inflammation-induced chronic pelvic pain","volume":"17","author":"Radhakrishnan","year":"2009","journal-title":"Inflammopharmacology"},{"issue":"03","key":"10.1016\/j.intimp.2025.115652_bb0405","first-page":"268","article-title":"Animal models of autoimmune prostatitis and their evaluation criteria","volume":"22","author":"Shen Jiaming","year":"2016","journal-title":"Nat. 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