{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:24:47Z","timestamp":1789705487265,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012580","name":"Natural Science Foundation of Tianjin Science and Technology Correspondent Project","doi-asserted-by":"publisher","award":["23JCZDJC00540"],"award-info":[{"award-number":["23JCZDJC00540"]}],"id":[{"id":"10.13039\/501100012580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170399"],"award-info":[{"award-number":["82170399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.intimp.2025.115678","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T15:49:38Z","timestamp":1760543378000},"page":"115678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["MSC-derived exosomes carrying sFgl2 alleviate acute rejection of mouse heart transplantation by regulating macrophage polarization"],"prefix":"10.1016","volume":"167","author":[{"given":"Guo-Shan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Tong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hao","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115678_bb0005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/164_2021_552","article-title":"Immunosuppression and heart transplantation","volume":"272","author":"Sutaria","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115678_bb0010","doi-asserted-by":"crossref","first-page":"1242478","DOI":"10.3389\/fimmu.2023.1242478","article-title":"Developments in kidney xenotransplantation","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115678_bb0015","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11894-020-0747-9","article-title":"The complex interplay between inflammatory bowel disease and malignancy","volume":"22","author":"Kimmel","year":"2020","journal-title":"Curr. Gastroenterol. Rep."},{"key":"10.1016\/j.intimp.2025.115678_bb0020","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/164_2021_546","article-title":"Immunosuppression and kidney transplantation","volume":"272","author":"Kamal","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115678_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14040791","volume":"14","author":"Deo","year":"2022","journal-title":"Pharmaceutics"},{"issue":"17","key":"10.1016\/j.intimp.2025.115678_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231710023","article-title":"Immunomodulatory mechanisms of mesenchymal stem cells and their potential clinical applications","volume":"23","author":"Huang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115678_bb0035","doi-asserted-by":"crossref","first-page":"1448597","DOI":"10.3389\/fimmu.2024.1448597","article-title":"1,25-dihydroxyvitamin-D(3) distinctly impacts the paracrine and cell-to-cell contact interactions between hPDL-MSCs and CD4(+) T lymphocytes","volume":"15","author":"Behm","year":"2024","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2025.115678_bb0040","doi-asserted-by":"crossref","first-page":"948","DOI":"10.52586\/4999","article-title":"Potential roles of mesenchymal stem cells and their exosomes in the treatment of COVID-19","volume":"26","author":"Cheng","year":"2021","journal-title":"Front Biosci (Landmark Ed)"},{"issue":"19","key":"10.1016\/j.intimp.2025.115678_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/cells13191604","article-title":"Innovative strategies for liver transplantation: the role of mesenchymal stem cells and their cell-free derivatives","volume":"13","author":"Akabane","year":"2024","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.intimp.2025.115678_bb0050","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s13770-021-00334-3","article-title":"Mesenchymal stem cell transplantation for ischemic diseases: mechanisms and challenges","volume":"18","author":"Van Nguyen","year":"2021","journal-title":"Tissue Eng Regen Med"},{"key":"10.1016\/j.intimp.2025.115678_bb0055","article-title":"The unique immunomodulatory properties of MSC-derived exosomes in organ transplantation","volume":"12","author":"Zheng","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0060","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s13287-025-04398-z","article-title":"CD73-expressing endometrial regenerative cell-derived exosomes mitigate acute cardiac allograft rejection through regulating adenosine metabolism in mice","volume":"16","author":"Sun","year":"2025","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0065","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nri2206","article-title":"Fcgamma receptors as regulators of immune responses","volume":"8","author":"Nimmerjahn","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115678_bb0070","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1002\/eji.200838338","article-title":"The FGL2-FcgammaRIIB pathway: a novel mechanism leading to immunosuppression","volume":"38","author":"Liu","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2025.115678_bb0075","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/978-0-387-33012-9_76","article-title":"Identification of the receptor for FGL2 and implications for susceptibility to mouse hepatitis virus (MHV-3)-induced fulminant hepatitis","volume":"581","author":"Liu","year":"2006","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0080","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/s41598-024-51217-1","article-title":"FGL2 promotes tumour growth and attenuates infiltration of activated immune cells in melanoma and ovarian cancer models","volume":"14","author":"Galpin","year":"2024","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2025.115678_bb0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119686","article-title":"Fibrinogen-like protein 2\/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells","volume":"10","author":"B\u00e9zie","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0090","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s13287-020-01752-1","article-title":"Mesenchymal stem cells transfected with sFgl2 inhibit the acute rejection of heart transplantation in mice by regulating macrophage activation","volume":"11","author":"Gao","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.intimp.2025.115678_bb0095","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0100","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1186\/s12951-021-00894-5","article-title":"Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis","volume":"19","author":"Hu","year":"2021","journal-title":"J Nanobiotechnology"},{"issue":"10","key":"10.1016\/j.intimp.2025.115678_bb0105","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/S1053-2498(01)00309-6","article-title":"The technique for heterotopic cardiac transplantation in mice: experience of 3000 operations by one surgeon","volume":"20","author":"Niimi","year":"2001","journal-title":"J. Heart Lung Transplant."},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0110","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s13287-023-03550-x","article-title":"sFgl2 gene-modified MSCs regulate the differentiation of CD4(+) T cells in the treatment of autoimmune hepatitis","volume":"14","author":"Ji","year":"2023","journal-title":"Stem Cell Res Ther"},{"issue":"6","key":"10.1016\/j.intimp.2025.115678_bb0115","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1016\/j.jaci.2022.06.021","article-title":"Allosteric inhibition of SHP2 rescues functional T-cell abnormalities in SAP deficiency","volume":"150","author":"Panchal","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.115678_bb0120","doi-asserted-by":"crossref","first-page":"2405698","DOI":"10.1155\/2018\/2405698","article-title":"B7-H1 expression is required for human endometrial regenerative cells in the prevention of transplant vasculopathy in mice","volume":"2018","author":"Ye","year":"2018","journal-title":"Stem Cells Int."},{"issue":"18","key":"10.1016\/j.intimp.2025.115678_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12185938","article-title":"Preventing rejection of the kidney transplant","volume":"12","author":"Malhotra","year":"2023","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0130","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s11658-024-00645-y","article-title":"Endometrial regeneration cell-derived exosomes loaded with siSLAMF6 inhibit cardiac allograft rejection through the suppression of desialylation modification","volume":"29","author":"Xu","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0135","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s13287-022-02982-1","article-title":"IL-37 overexpression promotes endometrial regenerative cell-mediated inhibition of cardiac allograft rejection","volume":"13","author":"Qin","year":"2022","journal-title":"Stem Cell Res Ther"},{"issue":"11","key":"10.1016\/j.intimp.2025.115678_bb0140","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1089\/hum.2016.057","article-title":"NK cell regulatory property is involved in the protective role of MSC-derived extracellular vesicles in renal ischemic reperfusion injury","volume":"27","author":"Zou","year":"2016","journal-title":"Hum. Gene Ther."},{"issue":"4","key":"10.1016\/j.intimp.2025.115678_bb0145","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1007\/s10787-023-01189-x","article-title":"Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4(+) T cells in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"31","author":"Ma","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2025.115678_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112825","article-title":"IGF2 contributes to the immunomodulatory effects of exosomes from endometrial regenerative cells on experimental colitis","volume":"140","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0155","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41368-021-00150-4","article-title":"Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell\/Treg balance in inflamed periodontium","volume":"13","author":"Zhang","year":"2021","journal-title":"Int. J. Oral Sci."},{"issue":"2","key":"10.1016\/j.intimp.2025.115678_bb0160","doi-asserted-by":"crossref","first-page":"851","DOI":"10.14336\/AD.2023.0719-1","article-title":"Mesenchymal stem cell-derived exosomes promote recovery of the facial nerve injury through regulating macrophage M1 and M2 polarization by targeting the P38 MAPK\/NF-\u039ab pathway","volume":"15","author":"Xue","year":"2024","journal-title":"Aging Dis."},{"issue":"11","key":"10.1016\/j.intimp.2025.115678_bb0165","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1177\/0963689718805375","article-title":"Exosomes derived from IDO1-overexpressing rat bone marrow mesenchymal stem cells promote Immunotolerance of cardiac allografts","volume":"27","author":"He","year":"2018","journal-title":"Cell Transplant."},{"issue":"7","key":"10.1016\/j.intimp.2025.115678_bb0170","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1111\/ajt.14706","article-title":"Serelaxin induces Notch1 signaling and alleviates hepatocellular damage in orthotopic liver transplantation","volume":"18","author":"Kageyama","year":"2018","journal-title":"Am. J. Transplant."},{"issue":"9","key":"10.1016\/j.intimp.2025.115678_bb0175","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.4049\/jimmunol.1004076","article-title":"Blockade of notch ligand \u03b41 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation","volume":"187","author":"Riella","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.115678_bb0180","doi-asserted-by":"crossref","first-page":"274","DOI":"10.3389\/fimmu.2018.00274","article-title":"Tolerogenic dendritic cells in solid organ transplantation: where do we stand?","volume":"9","author":"Mar\u00edn","year":"2018","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2025.115678_bb0185","doi-asserted-by":"crossref","first-page":"3641","DOI":"10.1016\/j.transproceed.2014.09.093","article-title":"Infusion of dendritic cells carrying donor lymphocytes treated with 8-methoxypsoralen and ultraviolet A light induces CD19+ IL-10+ regulatory B cells and promotes skin allograft survival","volume":"46","author":"Wei","year":"2014","journal-title":"Transplant. Proc."},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0190","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/cmi.2014.52","article-title":"Tolerogenic dendritic cells and their applications in transplantation","volume":"12","author":"Li","year":"2015","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.intimp.2025.115678_bb0195","doi-asserted-by":"crossref","first-page":"1113560","DOI":"10.3389\/fimmu.2023.1113560","article-title":"The immunomodulation role of Th17 and Treg in renal transplantation","volume":"14","author":"Huang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115678_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.535012","article-title":"Clinical and basic research Progress on Treg-induced immune tolerance in liver transplantation","volume":"12","author":"Ni","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0205","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.immuni.2019.12.006","article-title":"Signaling through the inhibitory fc receptor Fc\u03b3RIIB induces CD8(+) T cell apoptosis to limit T cell immunity","volume":"52","author":"Morris","year":"2020","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0210","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s42003-021-02018-z","article-title":"Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu","volume":"4","author":"Hou","year":"2021","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.intimp.2025.115678_bb0215","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1038\/s41467-018-04695-7","article-title":"Soluble E-cadherin promotes tumor angiogenesis and localizes to exosome surface","volume":"9","author":"Tang","year":"2018","journal-title":"Nat. Commun."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925016698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925016698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:33:42Z","timestamp":1765456422000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925016698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":43,"alternative-id":["S1567576925016698"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115678","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MSC-derived exosomes carrying sFgl2 alleviate acute rejection of mouse heart transplantation by regulating macrophage polarization","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115678"}}