{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:07:58Z","timestamp":1793333278254,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515010829"],"award-info":[{"award-number":["2022A1515010829"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202201010976"],"award-info":[{"award-number":["202201010976"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202201020197"],"award-info":[{"award-number":["202201020197"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["202201020108"],"award-info":[{"award-number":["202201020108"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.intimp.2025.115703","type":"journal-article","created":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T02:50:51Z","timestamp":1760842251000},"page":"115703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Salidroside alleviates senile osteoporosis in SAMP8 mice by inhibiting the ferroptosis of bone marrow stromal cells via PI3K\/AKT\/mTOR signaling pathway"],"prefix":"10.1016","volume":"167","author":[{"given":"Zhun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouyu","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2025.115703_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052701","article-title":"Age related osteoporosis: targeting cellular senescence","volume":"23","author":"F\u00f6ger-Samwald","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115703_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/AITC202401160","article-title":"Osteoporosis","volume":"177","author":"Ensrud","year":"2024","journal-title":"Ann. Intern. Med."},{"issue":"4","key":"10.1016\/j.intimp.2025.115703_bb0015","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41584-024-01094-9","article-title":"Evidence-based guideline for the management of osteoporosis in men","volume":"20","author":"Fuggle","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115703_bb0020","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11914-024-00867-1","article-title":"Diagnosing osteoporosis in diabetes-a systematic review on BMD and fractures","volume":"22","author":"Brandt","year":"2024","journal-title":"Curr. Osteoporos. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.115703_bb0025","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/s12967-024-05191-x","article-title":"Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis","volume":"22","author":"Chen","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2025.115703_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102201","article-title":"Ferroptosis: mechanisms and role in diabetes mellitus and its complications","volume":"94","author":"Liu","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2025.115703_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.910675","article-title":"Research Progress of Ferroptosis regulatory network and bone remodeling in osteoporosis","volume":"10","author":"Yan","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/j.intimp.2025.115703_bb0040","doi-asserted-by":"crossref","first-page":"1492610","DOI":"10.3389\/fendo.2024.1492610","article-title":"Mechanism and application prospect of ferroptosis inhibitors in improving osteoporosis","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.intimp.2025.115703_bb0045","doi-asserted-by":"crossref","first-page":"2634431","DOI":"10.1155\/2022\/2634431","article-title":"Ferroptosis: a new regulatory mechanism in osteoporosis","volume":"2022","author":"Liu","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2025.115703_bb0050","series-title":"Food and chemical toxicology\u202f: an international journal published for the British Industrial Biological Research Association","first-page":"499","article-title":"Salidroside stimulates osteoblast differentiation through BMP signaling pathway","volume":"62","author":"Chen","year":"2013"},{"key":"10.1016\/j.intimp.2025.115703_bb0055","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.ejphar.2017.12.025","article-title":"Osteoprotective effects of salidroside in ovariectomized mice and diabetic mice","volume":"819","author":"Chen","year":"2018","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115703_bb0060","article-title":"Salidroside protects against osteoporosis in ovariectomized rats by inhibiting oxidative stress and promoting osteogenesis via Nrf2 activation","volume":"99","author":"Wang","year":"2022","journal-title":"Phytomedicine\u202f: international journal of phytotherapy and phytopharmacology"},{"key":"10.1016\/j.intimp.2025.115703_bb0065","article-title":"Salidroside alleviates cognitive impairment by inhibiting ferroptosis via activation of the Nrf2\/GPX4 axis in SAMP8 mice","volume":"114","author":"Yang","year":"2023","journal-title":"Phytomedicine\u202f: international journal of phytotherapy and phytopharmacology"},{"key":"10.1016\/j.intimp.2025.115703_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176244","article-title":"Icariin inhibits osteoblast ferroptosis via Nrf2\/HO-1 signaling and enhances healing of osteoporotic fractures","volume":"965","author":"Xiang","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115703_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.938520","article-title":"Tocopherol attenuates the oxidative stress of BMSCs by inhibiting ferroptosis through the PI3k\/AKT\/mTOR pathway","volume":"10","author":"Lan","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.intimp.2025.115703_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2019.12.008","article-title":"Natural products targeting the PI3K-Akt-mTOR signaling pathway in cancer: a novel therapeutic strategy","volume":"80","author":"Tewari","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.intimp.2025.115703_bb0085","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/j.biopha.2018.04.184","article-title":"Salidroside protects hypoxia-induced injury by up-regulation of miR-210 in rat neural stem cells","volume":"103","author":"Yan","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.intimp.2025.115703_bb0090","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13581","article-title":"AAV-mediated expression of secreted and transmembrane \u03b1Klotho isoforms rescues relevant aging hallmarks in senescent SAMP8 mice","volume":"21","author":"Roig-Soriano","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2025.115703_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.568423","article-title":"Salidroside attenuates cognitive dysfunction in senescence-accelerated mouse prone 8 (SAMP8) mice and modulates inflammation of the gut-brain Axis","volume":"11","author":"Xie","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2025.115703_bb0100","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","article-title":"Ferroptosis at the intersection of lipid metabolism and cellular signaling","volume":"82","author":"Liang","year":"2022","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.intimp.2025.115703_bb0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13045-019-0720-y","article-title":"Ferroptosis, a new form of cell death: opportunities and challenges in cancer","volume":"12","author":"Mou","year":"2019","journal-title":"J. Hematol. Oncol."},{"issue":"12","key":"10.1016\/j.intimp.2025.115703_bb0110","doi-asserted-by":"crossref","first-page":"9814","DOI":"10.3390\/ijms24129814","article-title":"Single-cell RNA-sequencing reveals the skeletal cellular dynamics in bone repair and osteoporosis","volume":"24","author":"Wu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115703_bb0115","doi-asserted-by":"crossref","first-page":"1288993","DOI":"10.3389\/fmed.2023.1288993","article-title":"Targeting cellular senescence in senile osteoporosis: therapeutic potential of traditional Chinese medicine","volume":"10","author":"Zhang","year":"2023","journal-title":"Front. Med."},{"issue":"3","key":"10.1016\/j.intimp.2025.115703_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21030708","article-title":"An update on the Progress of isolation, culture, storage, and clinical application of human bone marrow mesenchymal stem\/stromal cells","volume":"21","author":"Chu","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2025.115703_bb0125","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1038\/s41596-023-00836-5","article-title":"Purification and functional characterization of novel human skeletal stem cell lineages","volume":"18","author":"Hoover","year":"2023","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.intimp.2025.115703_bb0130","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3390\/ijms21010349","article-title":"Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells","volume":"21","author":"Qadir","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115703_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101915","article-title":"Sirt3-mediated mitophagy regulates AGEs-induced BMSCs senescence and senile osteoporosis","volume":"41","author":"Guo","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2025.115703_bb0140","doi-asserted-by":"crossref","first-page":"1210627","DOI":"10.3389\/fendo.2023.1210627","article-title":"Research progress on the role of lncRNA-miRNA networks in regulating adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporosis","volume":"14","author":"An","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115703_bb0145","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jot.2014.12.002","article-title":"Steroid-associated osteonecrosis: epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview)","volume":"3","author":"Xie","year":"2015","journal-title":"Journal of orthopaedic translation."},{"issue":"9","key":"10.1016\/j.intimp.2025.115703_bb0150","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","article-title":"Mitophagy in degenerative joint diseases","volume":"17","author":"Sun","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.intimp.2025.115703_bb0155","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41413-022-00198-w","article-title":"Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis","volume":"10","author":"Yang","year":"2022","journal-title":"Bone research"},{"issue":"11","key":"10.1016\/j.intimp.2025.115703_bb0160","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1002\/iub.2656","article-title":"Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study","volume":"74","author":"Jiang","year":"2022","journal-title":"IUBMB Life"},{"issue":"2","key":"10.1016\/j.intimp.2025.115703_bb0165","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2025.115703_bb0170","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"issue":"7","key":"10.1016\/j.intimp.2025.115703_bb0175","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.intimp.2025.115703_bb0180","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.7150\/ijbs.83348","article-title":"The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks","volume":"19","author":"Li","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"14","key":"10.1016\/j.intimp.2025.115703_bb0185","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1182\/blood-2009-12-260083","article-title":"Bone loss caused by iron overload in a murine model: importance of oxidative stress","volume":"116","author":"Tsay","year":"2010","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.intimp.2025.115703_bb0190","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1021\/acs.jafc.2c05632","article-title":"A novel anti-osteoporosis mechanism of VK2: interfering with Ferroptosis via AMPK\/SIRT1 pathway in type 2 diabetic osteoporosis","volume":"71","author":"Jin","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2025.115703_bb0195","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.phymed.2018.10.031","article-title":"Salidroside stimulates the Sirt1\/PGC-1\u03b1 axis and ameliorates diabetic nephropathy in mice","volume":"54","author":"Xue","year":"2019","journal-title":"Phytomedicine\u202f: international journal of phytotherapy and phytopharmacology"},{"key":"10.1016\/j.intimp.2025.115703_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113170","article-title":"Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via SIRT1-dependent regulation of ROS and mitochondrial function","volume":"231","author":"Shan","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.intimp.2025.115703_bb0205","doi-asserted-by":"crossref","first-page":"32131","DOI":"10.1038\/srep32131","article-title":"Protective effect of salidroside against bone loss via hypoxia-inducible factor-1\u03b1 pathway-induced angiogenesis","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.115703_bb0210","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13020-022-00634-3","article-title":"Salidroside attenuates neuronal ferroptosis by activating the Nrf2\/HO1 signaling pathway in a\u03b2(1-42)-induced Alzheimer\u2019s disease mice and glutamate-injured HT22 cells","volume":"17","author":"Yang","year":"2022","journal-title":"Chin. Med."},{"key":"10.1016\/j.intimp.2025.115703_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114245","article-title":"Salidroside facilitates therapeutic angiogenesis in diabetic hindlimb ischemia by inhibiting ferroptosis","volume":"159","author":"Wang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115703_bb0220","article-title":"Natural products attenuate PI3K\/Akt\/mTOR signaling pathway: a promising strategy in regulating neurodegeneration","volume":"91","author":"Fakhri","year":"2021","journal-title":"Phytomedicine\u202f: international journal of phytotherapy and phytopharmacology"},{"key":"10.1016\/j.intimp.2025.115703_bb0225","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ijbiomac.2021.02.029","article-title":"SIRT3 ameliorates osteoarthritis via regulating chondrocyte autophagy and apoptosis through the PI3K\/Akt\/mTOR pathway","volume":"175","author":"Xu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.115703_bb0230","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.biopha.2017.01.130","article-title":"Inhibition of PI3K\/AKT\/mTOR signaling pathway promotes autophagy of articular chondrocytes and attenuates inflammatory response in rats with osteoarthritis","volume":"89","author":"Xue","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115703_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpb.2021.110632","article-title":"Review: Schistosoma mansoni phosphatidylinositol 3 kinase (PI3K)\/Akt\/mechanistic target of rapamycin (mTOR) signaling pathway","volume":"256","author":"Abou-El-Naga","year":"2021","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.intimp.2025.115703_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109726","article-title":"Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K\/Akt\/mTOR pathway","volume":"122","author":"Rong","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.intimp.2025.115703_bb0245","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1111\/cns.13548","article-title":"Acyl-CoA synthetase long chain family member 4 plays detrimental role in early brain injury after subarachnoid hemorrhage in rats by inducing ferroptosis","volume":"27","author":"Qu","year":"2021","journal-title":"CNS Neurosci. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2025.115703_bb0250","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41589-021-00751-4","article-title":"A compendium of kinetic modulatory profiles identifies ferroptosis regulators","volume":"17","author":"Conlon","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.intimp.2025.115703_bb0255","doi-asserted-by":"crossref","first-page":"8223737","DOI":"10.1155\/2022\/8223737","article-title":"Melatonin inhibits the Ferroptosis pathway in rat bone marrow mesenchymal stem cells by activating the PI3K\/AKT\/mTOR signaling Axis to attenuate steroid-induced osteoporosis","volume":"2022","author":"Li","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"7","key":"10.1016\/j.intimp.2025.115703_bb0260","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41419-022-05065-4","article-title":"Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis","volume":"13","author":"Cheng","year":"2022","journal-title":"Cell Death Dis."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925016947?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925016947?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:39:03Z","timestamp":1765456743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925016947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":52,"alternative-id":["S1567576925016947"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115703","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salidroside alleviates senile osteoporosis in SAMP8 mice by inhibiting the ferroptosis of bone marrow stromal cells via PI3K\/AKT\/mTOR signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115703"}}