{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T15:58:23Z","timestamp":1790870303682,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100025010","name":"Dipartimento di Scienze del Farmaco, Universit\u00e0 degli Studi di Padova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100025010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023983","name":"Babasaheb Bhimrao Ambedkar University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023983","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115797","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T08:36:48Z","timestamp":1762591008000},"page":"115797","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"P1","title":["Bezafibrate, a Pan PPAR agonist, attenuates experimental rheumatoid arthritis via PPAR dependent modulation of inflammatory pathways with emphasis on PPAR \u03b3 activity"],"prefix":"10.1016","volume":"168","author":[{"given":"Alpana","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishabh","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anand","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115797_bb0005","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"10","key":"10.1016\/j.intimp.2025.115797_bb0010","doi-asserted-by":"crossref","first-page":"e594","DOI":"10.1016\/S2665-9913(23)00211-4","article-title":"Global, regional, and national burden of rheumatoid arthritis, 1990\u20132020, and projections to 2050: a systematic analysis of the global burden of disease study 2021","volume":"5","author":"Black","year":"2023","journal-title":"Lancet Rheumatol."},{"issue":"Pt A","key":"10.1016\/j.intimp.2025.115797_bb0015","article-title":"Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis","volume":"125","author":"Chaudhary","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115797_bb0020","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/cells9092073","article-title":"Osteoblast-Osteoclast Communication and Bone Homeostasis","volume":"9","author":"Kim","year":"2020","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.intimp.2025.115797_bb0025","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1007\/s00210-024-03529-2","article-title":"Chronic stress-mediated dysregulations in inflammatory, immune and oxidative circuitry impairs the therapeutic response of methotrexate in experimental autoimmune disease models","volume":"398","author":"Chaudhary","year":"2025","journal-title":"Naunyn Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2025.115797_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103101","article-title":"Once-monthly hemin suppresses inflammatory and autoreactive CD4+ T cell responses to robustly ameliorate experimental rheumatoid arthritis","volume":"24","author":"Sun","year":"2021","journal-title":"iScience"},{"issue":"2","key":"10.1016\/j.intimp.2025.115797_bb0035","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.plipres.2005.12.002","article-title":"From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions","volume":"45","author":"Feige","year":"2006","journal-title":"Prog. Lipid Res."},{"issue":"6662","key":"10.1016\/j.intimp.2025.115797_bb0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/34178","article-title":"The peroxisome proliferator-activated receptor-\u03b3 is a negative regulator of macrophage activation","volume":"391","author":"Ricote","year":"1998","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2025.115797_bb0045","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.pharmthera.2005.08.007","article-title":"Peroxisome proliferator-activated receptors and inflammation","volume":"110","author":"Moraes","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2025.115797_bb0050","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41401-022-00957-9","article-title":"PPAR-\u03b3 alleviates the inflammatory response in TNF-\u03b1-induced fibroblast-like synoviocytes by binding to p53 in rheumatoid arthritis","volume":"44","author":"Li","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"issue":"14","key":"10.1016\/j.intimp.2025.115797_bb0055","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B","article-title":"Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function","volume":"19","author":"Morris","year":"1998","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.intimp.2025.115797_bb0060","first-page":"2","article-title":"SwissDock, a protein-small molecule docking web service based on EADock DSS","volume":"39(SUPPL","author":"Grosdidier","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"9","key":"10.1016\/j.intimp.2025.115797_bb0065","doi-asserted-by":"crossref","first-page":"4066","DOI":"10.1021\/acs.jmedchem.5b00104","article-title":"pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures","volume":"58","author":"Pires","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.intimp.2025.115797_bb0070","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115797_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.111114","article-title":"Withaferin a alleviates inflammation in animal models of arthritis by inhibiting the NF-\u03baB pathway and cytokine release","volume":"398","author":"Alenazi","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.intimp.2025.115797_bb0080","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.biopha.2018.07.143","article-title":"Modulatory effect of eugenol on arginase, nucleotidase, and adenosine deaminase activities of platelets in a carrageenan-induced arthritis rat model: a possible anti-arthritic mechanism of eugenol","volume":"106","author":"Adefegha","year":"2018","journal-title":"Biomed Pharmacother [Internet]"},{"issue":"1","key":"10.1016\/j.intimp.2025.115797_bb0085","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1309\/E5R9P5YPHXFE3198","article-title":"Differences in erythrocyte sedimentation rates using the Westergren method and a centrifugation method","volume":"130","author":"Shelat","year":"2008","journal-title":"Am J Clin Pathol [Internet]."},{"issue":"3","key":"10.1016\/j.intimp.2025.115797_bb0090","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of the superoxide anion radical in the autoxidation of Pyrogallol and a convenient assay for superoxide dismutase","volume":"47","author":"Marklund","year":"1974","journal-title":"Eur. J. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2025.115797_bb0095","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.intimp.2025.115797_bb0100","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0003-2697(72)90132-7","article-title":"Colorimetric assay of catalase","volume":"47","author":"Sinha","year":"1972","journal-title":"Anal. Biochem."},{"issue":"2","key":"10.1016\/j.intimp.2025.115797_bb0105","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0005-2760(65)90118-9","article-title":"Mechanisms of lipid peroxide formation in tissues Role of metals and haematin proteins in the catalysis of the oxidation of unsaturated fatty acids","volume":"98","author":"Wills","year":"1965","journal-title":"Biochim Biophys Acta (BBA)\/Lipids Lipid Metab [Internet]"},{"issue":"1\u20132","key":"10.1016\/j.intimp.2025.115797_bb0110","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.intimp.2025.115797_bb0115","series-title":"Histopathology specimens [internet]","first-page":"433","article-title":"Joint space, bone, soft tissues, and special techniques","author":"Davis","year":"2013"},{"issue":"1","key":"10.1016\/j.intimp.2025.115797_bb0120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41413-018-0016-9","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"6","author":"Guo","year":"2018","journal-title":"Bone Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925017850?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925017850?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:40:57Z","timestamp":1781898057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925017850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":24,"alternative-id":["S1567576925017850"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115797","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bezafibrate, a Pan PPAR agonist, attenuates experimental rheumatoid arthritis via PPAR dependent modulation of inflammatory pathways with emphasis on PPAR \u03b3 activity","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115797","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115797"}}