{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:04:03Z","timestamp":1790805843787,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","award":["yjrckyqdj-2024-04"],"award-info":[{"award-number":["yjrckyqdj-2024-04"]}],"id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022817","name":"Lanzhou University Second Hospital","doi-asserted-by":"publisher","award":["2021jyjbgs-02"],"award-info":[{"award-number":["2021jyjbgs-02"]}],"id":[{"id":"10.13039\/100022817","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009590","name":"Gansu Education Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102431"],"award-info":[{"award-number":["82102431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["23JRRA1001"],"award-info":[{"award-number":["23JRRA1001"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115798","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:10:46Z","timestamp":1762639846000},"page":"115798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["TMEM176A drives anti-apoptotic signaling through TGM2-mediated ERK activation in gastric cancer"],"prefix":"10.1016","volume":"168","author":[{"given":"Yating","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqiang","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yucai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Futian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2025.115798_bb0005","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10555-020-09925-3","article-title":"Gastric cancer: a comprehensive review of current and future treatment strategies","volume":"39","author":"Sexton","year":"2020","journal-title":"Cancer Metastasis Rev."},{"issue":"1","key":"10.1016\/j.intimp.2025.115798_bb0010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","article-title":"Gastric cancer treatment: recent progress and future perspectives","volume":"16","author":"Guan","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115798_bb0015","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1046\/j.1523-1755.2002.00300.x","article-title":"Gene expression profile of renal proximal tubules regulated by proteinuria","volume":"61","author":"Nakajima","year":"2002","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.intimp.2025.115798_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009369","article-title":"Phylogenetic analysis of the MS4A and TMEM176 gene families","volume":"5","author":"Zuccolo","year":"2010","journal-title":"PLoS ONE"},{"issue":"3","key":"10.1016\/j.intimp.2025.115798_bb0025","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1189\/jlb.1109738","article-title":"Tmem176B and Tmem176A are associated with the immature state of dendritic cells","volume":"88","author":"Condamine","year":"2010","journal-title":"J. Leukoc. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115798_bb0030","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.4049\/jimmunol.169.2.1102","article-title":"Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies","volume":"169","author":"Wang","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.115798_bb0035","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.2147\/OTT.S179725","article-title":"Potential targets of TMEM176A in the growth of glioblastoma cells","volume":"11","author":"Liu","year":"2018","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.intimp.2025.115798_bb0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13148-018-0570-4","article-title":"Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma","volume":"10","author":"Li","year":"2018","journal-title":"Clin. Epigenetics"},{"issue":"7","key":"10.1016\/j.intimp.2025.115798_bb0045","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.acthis.2011.12.006","article-title":"Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology","volume":"114","author":"Cuajungco","year":"2012","journal-title":"Acta Histochem."},{"issue":"3","key":"10.1016\/j.intimp.2025.115798_bb0050","first-page":"3906","article-title":"Downregulation of TMEM176A suppresses cell growth and proliferation in non-small cell lung cancer","volume":"10","author":"Shang","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.intimp.2025.115798_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.795844","article-title":"Comprehensive analysis of expression and prognostic value of MS4As in glioma","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Genet."},{"issue":"161","key":"10.1016\/j.intimp.2025.115798_bb0060","first-page":"145","article-title":"TMEM176A acts as a tumor suppressor gene in pancreatic cancer by inhibiting ERK signaling","volume":"30","author":"Guo","year":"2020","journal-title":"Discov. Med."},{"issue":"7","key":"10.1016\/j.intimp.2025.115798_bb0065","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/15592294.2017.1341027","article-title":"Methylation of TMEM176A is an independent prognostic marker and is involved in human colorectal cancer development","volume":"12","author":"Gao","year":"2017","journal-title":"Epigenetics"},{"issue":"9","key":"10.1016\/j.intimp.2025.115798_bb0070","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.it.2021.07.002","article-title":"The tetraspan MS4A family in homeostasis, immunity, and disease","volume":"42","author":"Mattiola","year":"2021","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115798_bb0075","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1515\/med-2018-0028","article-title":"Distinct expression and prognostic value of MS4A in gastric cancer","volume":"13","author":"Sun","year":"2018","journal-title":"Open Med."},{"issue":"7","key":"10.1016\/j.intimp.2025.115798_bb0080","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.3390\/cells10071842","article-title":"Role of transglutaminase 2 in cell death, survival, and fibrosis","volume":"10","author":"Tatsukawa","year":"2021","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.intimp.2025.115798_bb0085","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.3390\/ijms25052797","article-title":"The role of transglutaminase 2 in cancer: an update","volume":"25","author":"Zaltron","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2025.115798_bb0090","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3858\/emm.2010.42.9.063","article-title":"Transglutaminase 2 inhibits apoptosis induced by calcium overload through down-regulation of bax","volume":"42","author":"Cho","year":"2010","journal-title":"Exp. Mol. Med."},{"issue":"25","key":"10.1016\/j.intimp.2025.115798_bb0095","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.1038\/s41388-021-01847-w","article-title":"Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53","volume":"40","author":"Malkomes","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2025.115798_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1485258","article-title":"Transglutaminase 2 in breast cancer metastasis and drug resistance","volume":"12","author":"Li","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115798_bb0105","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1111\/jcmm.12361","article-title":"Elongation factor-2 kinase regulates TG2\/\u03b21 integrin\/Src\/uPAR pathway and epithelial\u2013mesenchymal transition mediating pancreatic cancer cell invasion","volume":"18","author":"Ashour","year":"2014","journal-title":"J. Cell. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115798_bb0110","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.231134","article-title":"Tissue transglutaminase 2 regulates tumor cell tensional homeostasis by increasing contractility","volume":"133","author":"Bordeleau","year":"2020","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.intimp.2025.115798_bb0115","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0092-8674(00)80405-5","article-title":"Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery","volume":"91","author":"Datta","year":"1997","journal-title":"Cell"},{"issue":"5392","key":"10.1016\/j.intimp.2025.115798_bb0120","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.282.5392.1318","article-title":"Regulation of cell death protease caspase-9 by phosphorylation","volume":"282","author":"Cardone","year":"1998","journal-title":"Science"},{"issue":"7092","key":"10.1016\/j.intimp.2025.115798_bb0125","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature04870","article-title":"Nuclear factor-\u03baB in cancer development and progression","volume":"441","author":"Karin","year":"2006","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2025.115798_bb0130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115798_bb0135","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1186\/s12967-024-05998-8","article-title":"The role of MAPK pathway in gastric cancer: unveiling molecular crosstalk and therapeutic prospects","volume":"22","author":"Yuan","year":"2024","journal-title":"J. Transl. Med."},{"issue":"8","key":"10.1016\/j.intimp.2025.115798_bb0140","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nmeth.3047","article-title":"Improved vectors and genome-wide libraries for CRISPR screening","volume":"11","author":"Sanjana","year":"2014","journal-title":"Nat. Methods"},{"issue":"9","key":"10.1016\/j.intimp.2025.115798_bb0145","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/jcp.48.9.876","article-title":"A \u201cquickscore\u201d method for immunohistochemical semiquantitation: validation for oestrogen receptor in breast carcinomas","volume":"48","author":"Detre","year":"1995","journal-title":"J. Clin. Pathol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115798_bb0150","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.intimp.2025.115798_bb0155","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/nprot.2006.238","article-title":"Analysis of apoptosis by propidium iodide staining and flow cytometry","volume":"1","author":"Riccardi","year":"2006","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.intimp.2025.115798_bb0160","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1083\/jcb.66.1.188","article-title":"Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining","volume":"66","author":"Krishan","year":"1975","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115798_bb0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nprot.2007.30","article-title":"In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro","volume":"2","author":"Liang","year":"2007","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.intimp.2025.115798_bb0170","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.119.3.493","article-title":"Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation","volume":"119","author":"Gavrieli","year":"1992","journal-title":"J. Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115798_bb0175","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/ijc.2910570422","article-title":"Inhibition of growth of MKN45 human gastric carcinoma xenografts in nude mice by treatment with bombesin\/gastrin-releasing-peptide antagonist (RC-3095) and somatostatin analogue RC-160","volume":"57","author":"Pinski","year":"1994","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.intimp.2025.115798_bb0180","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s10120-011-0102-9","article-title":"In vitro and in vivo antitumor activity of cetuximab in human gastric cancer cell lines in relation to epidermal growth factor receptor expression and mutational phenotype","volume":"15","author":"Hotz","year":"2012","journal-title":"Gastric Cancer"},{"issue":"18","key":"10.1016\/j.intimp.2025.115798_bb0185","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.3748\/wjg.v12.i18.2890","article-title":"Anticancer effect of jinlongshe granules on in situ-transplanted human MKN-45 gastric cancer in nude mice and xenografted sarcoma 180 in Kunming mice and its mechanism","volume":"12","author":"Yu","year":"2006","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.intimp.2025.115798_bb0190","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.21873\/invivo.11669","article-title":"Establishment of peritoneal and hepatic metastasis mouse xenograft models using gastric cancer cell lines","volume":"33","author":"Miwa","year":"2019","journal-title":"In Vivo"},{"issue":"6","key":"10.1016\/j.intimp.2025.115798_bb0195","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3390\/cells8060585","article-title":"Establishment of novel gastric cancer patient-derived xenografts and cell lines: pathological comparison between primary tumor, patient-derived, and cell-line derived xenografts","volume":"8","author":"Kuwata","year":"2019","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.intimp.2025.115798_bb0200","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"6509","key":"10.1016\/j.intimp.2025.115798_bb0205","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Consortium GT","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.intimp.2025.115798_bb0210","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115798_bb0215","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"issue":"43","key":"10.1016\/j.intimp.2025.115798_bb0220","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.115798_bb0225","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s10549-009-0674-9","article-title":"An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients","volume":"123","author":"Gy\u00f6rffy","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"issue":"6","key":"10.1016\/j.intimp.2025.115798_bb0230","first-page":"501","article-title":"Regression modeling strategies","volume":"64","author":"Nunez","year":"2011","journal-title":"Rev. Esp. Cardiol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115798_bb0235","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/pro.3978","article-title":"The BioGRID database: a comprehensive biomedical resource of curated protein, genetic, and chemical interactions","volume":"30","author":"Oughtred","year":"2021","journal-title":"Protein Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115798_bb0240","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1034\/j.1600-065X.2003.00048.x","article-title":"Caspase-activation pathways in apoptosis and immunity","volume":"193","author":"Creagh","year":"2003","journal-title":"Immunol. Rev."},{"issue":"9","key":"10.1016\/j.intimp.2025.115798_bb0245","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nrm2952","article-title":"Mitochondria and cell death: outer membrane permeabilization and beyond","volume":"11","author":"Tait","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115798_bb0250","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.171","article-title":"JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry","volume":"3","author":"Perelman","year":"2012","journal-title":"Cell Death Dis."},{"issue":"3","key":"10.1016\/j.intimp.2025.115798_bb0255","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1080\/07853890600551037","article-title":"Targeting the ERK signaling pathway in cancer therapy","volume":"38","author":"Kohno","year":"2006","journal-title":"Ann. Med."},{"issue":"41","key":"10.1016\/j.intimp.2025.115798_bb0260","doi-asserted-by":"crossref","first-page":"70035","DOI":"10.18632\/oncotarget.19550","article-title":"Epigenetic silencing of TMEM176A promotes esophageal squamous cell cancer development","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"issue":"17","key":"10.1016\/j.intimp.2025.115798_bb0265","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.2217\/epi-2021-0217","article-title":"Methylation of TMEM176A, a key ERK signaling regulator, is a novel synthetic lethality marker of ATM inhibitors in human lung cancer","volume":"13","author":"Li","year":"2021","journal-title":"Epigenomics"},{"key":"10.1016\/j.intimp.2025.115798_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1038429","article-title":"The intracellular cation channel TMEM176B as a dual immunoregulator","volume":"10","author":"Hill","year":"2022","journal-title":"Front. Cell Dev. Biol."}],"updated-by":[{"DOI":"10.1016\/j.intimp.2025.115850","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000}},{"DOI":"10.1016\/j.intimp.2025.115850","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000}}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925017862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925017862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:38:30Z","timestamp":1781897910000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925017862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":54,"alternative-id":["S1567576925017862"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115798","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TMEM176A drives anti-apoptotic signaling through TGM2-mediated ERK activation in gastric cancer","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115798"}}