{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:39:13Z","timestamp":1771522753440,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270676"],"award-info":[{"award-number":["82270676"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115842","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T04:52:09Z","timestamp":1764391929000},"page":"115842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["C498-0670 ameliorates severe acute pancreatitis through dual modulation of NF-\u03baB and STAT3 signaling pathways"],"prefix":"10.1016","volume":"168","author":[{"given":"Hongqing","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2025.115842_bb0005","doi-asserted-by":"crossref","first-page":"G573","DOI":"10.1152\/ajpgi.00285.2020","article-title":"Severe acute pancreatitis: capillary permeability model linking systemic inflammation to multiorgan failure","volume":"319","author":"Komara","year":"2020","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115842_bb0010","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1053\/j.gastro.2024.02.052","article-title":"Diagnosis and Management of Acute Pancreatitis","volume":"167","author":"Trikudanathan","year":"2024","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.intimp.2025.115842_bb0015","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1053\/j.gastro.2018.12.041","article-title":"Organ failure due to systemic injury in acute pancreatitis","volume":"156","author":"Garg","year":"2019","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2025.115842_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2024.10.030","article-title":"Practical management of severe acute pancreatitis","volume":"133","author":"Hamesch","year":"2025","journal-title":"Eur. J. Intern. Med."},{"issue":"8","key":"10.1016\/j.intimp.2025.115842_bb0025","doi-asserted-by":"crossref","DOI":"10.1093\/bjs\/znae170","article-title":"Severe acute pancreatitis","volume":"111","author":"S\u00f8reide","year":"2024","journal-title":"Br. J. Surg."},{"issue":"23","key":"10.1016\/j.intimp.2025.115842_bb0030","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.3748\/wjg.v16.i23.2867","article-title":"Inflammation and immunosuppression in severe acute pancreatitis","volume":"16","author":"Kyl\u00e4np\u00e4\u00e4","year":"2010","journal-title":"World J. Gastroenterol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115842_bb0035","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2119\/molmed.2014.00117","article-title":"Cell death and DAMPs in acute pancreatitis","volume":"20","author":"Kang","year":"2014","journal-title":"Mol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2025.115842_bb0040","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1053\/gast.1996.v110.agast960639","article-title":"Cytokines and acute pancreatitis","volume":"110","author":"Kusske","year":"1996","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.intimp.2025.115842_bb0045","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gutjnl-2011-300771","article-title":"Tumour necrosis factor \u03b1 secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice","volume":"62","author":"Sendler","year":"2013","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.intimp.2025.115842_bb0050","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1159\/000214191","article-title":"Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis","volume":"9","author":"Aoun","year":"2009","journal-title":"Pancreatology"},{"issue":"15","key":"10.1016\/j.intimp.2025.115842_bb0055","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.3748\/wjg.v16.i15.1845","article-title":"Different profiles of cytokine expression during mild and severe acute pancreatitis","volume":"16","author":"Dambrauskas","year":"2010","journal-title":"World J. Gastroenterol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115842_bb0060","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI64931","article-title":"IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethality","volume":"123","author":"Zhang","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2025.115842_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1279539","article-title":"Immune response mechanisms in acute and chronic pancreatitis: strategies for therapeutic intervention","volume":"14","author":"Glaubitz","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115842_bb0070","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s10753-011-9406-5","article-title":"Fractalkine upregulates inflammation through CX3CR1 and the jak-Stat pathway in severe acute pancreatitis rat model","volume":"35","author":"Huang","year":"2012","journal-title":"Inflammation"},{"issue":"15","key":"10.1016\/j.intimp.2025.115842_bb0075","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.1073\/pnas.1714102115","article-title":"IRF9 and unphosphorylated STAT2 cooperate with NF-\u03baB to drive IL6 expression","volume":"115","author":"Nan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.intimp.2025.115842_bb0080","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cytogfr.2009.11.005","article-title":"Dangerous liaisons: STAT3 and NF-kappaB collaboration and crosstalk in cancer","volume":"21","author":"Grivennikov","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"issue":"2","key":"10.1016\/j.intimp.2025.115842_bb0085","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/gast.2002.31060","article-title":"NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response","volume":"122","author":"Chen","year":"2002","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.intimp.2025.115842_bb0090","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jaci.2024.09.020","article-title":"JAK-STAT signaling pathway, immunodeficiency, inflammation, immune dysregulation, and inborn errors of immunity","volume":"155","author":"Samra","year":"2025","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.115842_bb0095","doi-asserted-by":"crossref","first-page":"1132265","DOI":"10.3389\/fimmu.2023.1132265","article-title":"Bioactive compound C498-0670 alleviates LPS-induced sepsis via JAK\/STAT and NF\u03baB signaling pathways","volume":"14","author":"Xu","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115842_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2025.177314","article-title":"Octreotide attenuates experimental severe acute pancreatitis through inhibiting pyroptosis and modulating intestinal homeostasis","volume":"994","author":"Zhao","year":"2025","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115842_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116854","article-title":"Pinocembrin\u2019s protective effect against acute pancreatitis in a rat model: the correlation between TLR4\/NF-\u03baB\/NLRP3 and miR-34a-5p\/SIRT1\/Nrf2\/HO-1 pathways","volume":"176","author":"Ali","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115842_bb0110","doi-asserted-by":"crossref","unstructured":"G. Rompianesi, A. Hann, O. Komolafe, S.P. Pereira, B.R. Davidson, K.S. Gurusamy, Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis, Cochrane Database Syst. Rev. 4(4) (2017) Cd012010.","DOI":"10.1002\/14651858.CD012010.pub2"},{"issue":"15","key":"10.1016\/j.intimp.2025.115842_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21155386","article-title":"NLRP3 inflammasome-mediated inflammation in acute pancreatitis","volume":"21","author":"Ferrero-Andr\u00e9s","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2025.115842_bb0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41575-018-0087-5","article-title":"Global epidemiology and holistic prevention of pancreatitis","volume":"16","author":"Petrov","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115842_bb0125","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1053\/j.gastro.2019.01.268","article-title":"Early intra-acinar events in pathogenesis of pancreatitis","volume":"156","author":"Saluja","year":"2019","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.intimp.2025.115842_bb0130","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1053\/j.gastro.2018.11.081","article-title":"Genetics, cell biology, and pathophysiology of pancreatitis","volume":"156","author":"Mayerle","year":"2019","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.intimp.2025.115842_bb0135","doi-asserted-by":"crossref","first-page":"e664","DOI":"10.1097\/CCM.0000000000001639","article-title":"Effects of tocilizumab on experimental severe acute pancreatitis and associated acute lung injury","volume":"44","author":"Chen","year":"2016","journal-title":"Crit. Care Med."},{"issue":"42","key":"10.1016\/j.intimp.2025.115842_bb0140","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2213744119","article-title":"Blockade of the protease ADAM17 ameliorates experimental pancreatitis","volume":"119","author":"Saad","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.intimp.2025.115842_bb0145","doi-asserted-by":"crossref","DOI":"10.1590\/acb370706","article-title":"NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis","volume":"37","author":"Shen","year":"2022","journal-title":"Acta Cir. Bras."},{"issue":"8","key":"10.1016\/j.intimp.2025.115842_bb0150","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1021\/acs.molpharmaceut.3c00238","article-title":"Biomimetic nanoparticles loaded with Ulinastatin for the targeted treatment of acute pancreatitis","volume":"20","author":"Chen","year":"2023","journal-title":"Mol. Pharm."},{"issue":"43","key":"10.1016\/j.intimp.2025.115842_bb0155","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017644","article-title":"Efficacy of ulinastatin for the treatment of patients with severe acute pancreatitis","volume":"98","author":"Yao","year":"2019","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.intimp.2025.115842_bb0160","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jcrc.2018.01.021","article-title":"Role of Ulinastatin, a trypsin inhibitor, in severe acute pancreatitis in critical care setting: a retrospective analysis","volume":"45","author":"Lagoo","year":"2018","journal-title":"J. Crit. Care"},{"issue":"4","key":"10.1016\/j.intimp.2025.115842_bb0165","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/00325481.2022.2136390","article-title":"Trends and recent developments in pharmacotherapy of acute pancreatitis","volume":"135","author":"Hey-Hadavi","year":"2023","journal-title":"Postgrad. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115842_bb0170","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41392-024-01757-9","article-title":"NF-\u03baB in biology and targeted therapy: new insights and translational implications","volume":"9","author":"Guo","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2025.115842_bb0175","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pan.2016.05.001","article-title":"NF-\u03baB in acute pancreatitis: mechanisms and therapeutic potential","volume":"16","author":"Jakkampudi","year":"2016","journal-title":"Pancreatology"},{"issue":"Pt A","key":"10.1016\/j.intimp.2025.115842_bb0180","article-title":"Bufalin alleviates inflammatory response and oxidative stress in experimental severe acute pancreatitis through activating Keap1-Nrf2\/HO-1 and inhibiting NF-\u03baB pathways","volume":"142","author":"Niu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115842_bb0185","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/s41590-024-01804-1","article-title":"JAK-STAT signaling maintains homeostasis in T cells and macrophages","volume":"25","author":"Fortelny","year":"2024","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2025.115842_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115135","article-title":"Old drugs with new applications: tofacitinib-mediated inhibition of M1-like macrophage polarization in acute pancreatitis by the JAK\/STAT and emerging NOD-like receptor pathways","volume":"162","author":"Dai","year":"2025","journal-title":"Int. Immunopharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T16:58:58Z","timestamp":1771520338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925018302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":38,"alternative-id":["S1567576925018302"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115842","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C498-0670 ameliorates severe acute pancreatitis through dual modulation of NF-\u03baB and STAT3 signaling pathways","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115842","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115842"}}