{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:47:13Z","timestamp":1790045233017,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272256"],"award-info":[{"award-number":["82272256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115856","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:34:02Z","timestamp":1763634842000},"page":"115856","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["Protective mechanism of zinc ions in spinal cord injury treatment: regulation of mitochondrial function and reduction of apoptosis via TNF-\u03b1 pathway inhibition"],"prefix":"10.1016","volume":"168","author":[{"given":"Mingyu","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daoyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengtao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dake","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zipeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xifan","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haosen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115856_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.906704","article-title":"Methane single cell protein: potential to secure a global protein supply against catastrophic food shocks","volume":"10","author":"Garcia Martinez","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"issue":"19","key":"10.1016\/j.intimp.2025.115856_bb0010","doi-asserted-by":"crossref","first-page":"3811","DOI":"10.1021\/acs.jafc.7b00357","article-title":"Ameliorative effect of Ecklonia cava polyphenol extract on renal inflammation associated with aberrant energy metabolism and oxidative stress in high fat diet-induced obese mice","volume":"65","author":"Eo","year":"2017","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.intimp.2025.115856_bb0015","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3748\/wjg.v23.i1.76","article-title":"miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism","volume":"23","author":"Jin","year":"2017","journal-title":"World J. Gastroenterol."},{"issue":"Pt 2","key":"10.1016\/j.intimp.2025.115856_bb0020","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/brain\/awr339","article-title":"Transplanted neural stem\/precursor cells instruct phagocytes and reduce secondary tissue damage in the injured spinal cord","volume":"135","author":"Cusimano","year":"2012","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.intimp.2025.115856_bb0025","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s12974-018-1085-9","article-title":"Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury","volume":"15","author":"Cusimano","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.intimp.2025.115856_bb0030","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/NRR.NRR-D-24-00802","article-title":"Maraviroc promotes recovery from traumatic brain injury in mice by suppression of neuroinflammation and activation of neurotoxic reactive astrocytes","volume":"18","author":"Liu","year":"2023","journal-title":"Neural Regen. Res."},{"issue":"8","key":"10.1016\/j.intimp.2025.115856_bb0035","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1007\/s10495-015-1139-8","article-title":"Microglia activation and interaction with neuronal cells in a biochemical model of mevalonate kinase deficiency","volume":"20","author":"Tricarico","year":"2015","journal-title":"Apoptosis"},{"issue":"1","key":"10.1016\/j.intimp.2025.115856_bb0040","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13287-023-03284-w","article-title":"Inflammatory stimulation of astrocytes affects the expression of miRNA-22-3p within NSCs-EVs regulating remyelination by targeting KDM3A","volume":"14","author":"Han","year":"2023","journal-title":"Stem Cell Res Ther"},{"issue":"4","key":"10.1016\/j.intimp.2025.115856_bb0045","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s12298-017-0462-7","article-title":"Plant growth under water\/salt stress: ROS production; antioxidants and significance of added potassium under such conditions","volume":"23","author":"Ahanger","year":"2017","journal-title":"Physiol. Mol. Biol. Plants"},{"issue":"4","key":"10.1016\/j.intimp.2025.115856_bb0050","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/s41574-021-00626-7","article-title":"Mitochondrial and metabolic dysfunction in ageing and age-related diseases","volume":"18","author":"Amorim","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115856_bb0055","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1159\/000477891","article-title":"Effect of TNF-alpha inhibition on bone marrow-derived mesenchymal stem cells in neurological function recovery after spinal cord injury via the Wnt signaling pathway in a rat model","volume":"42","author":"Peng","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2025.115856_bb0060","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12929-017-0398-9","article-title":"Preclinical and clinical aspects of TNF-alpha and its receptors TNFR1 and TNFR2 in breast cancer","volume":"24","author":"Martinez-Reza","year":"2017","journal-title":"J. Biomed. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115856_bb0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s12974-023-02784-z","article-title":"Co-modulation of TNFR1 and TNFR2 in an animal model of multiple sclerosis","volume":"20","author":"Fiedler","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.intimp.2025.115856_bb0070","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s10495-008-0219-4","article-title":"Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3","volume":"13","author":"Ndebele","year":"2008","journal-title":"Apoptosis"},{"issue":"8","key":"10.1016\/j.intimp.2025.115856_bb0075","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1021\/acsami.0c15727","article-title":"Polymer\/aptamer-integrated gold Nanoconstruct suppresses the inflammatory process by scavenging ROS and Capturing pro-inflammatory cytokine TNF-alpha","volume":"13","author":"Kim","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"10","key":"10.1016\/j.intimp.2025.115856_bb0080","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/s41419-020-03122-4","article-title":"High-fat diet promotes renal injury by inducing oxidative stress and mitochondrial dysfunction","volume":"11","author":"Sun","year":"2020","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2025.115856_bb0085","article-title":"LDHB deficiency promotes mitochondrial dysfunction mediated oxidative stress and neurodegeneration in adult mouse brain","volume":"11","author":"Park","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2025.115856_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.755862","article-title":"Co-exposure of cardiomyocytes to IFN-gamma and TNF-alpha induces mitochondrial dysfunction and nitro-oxidative stress: implications for the pathogenesis of chronic Chagas disease cardiomyopathy","volume":"12","author":"Nunes","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115856_bb0095","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13020-023-00755-3","article-title":"Bushen-Yizhi formula ameliorates mitochondrial dysfunction and oxidative stress via AMPK\/Sirt1 signaling pathway in D-gal-induced aging rats","volume":"18","author":"Liao","year":"2023","journal-title":"Chin. Med."},{"issue":"5","key":"10.1016\/j.intimp.2025.115856_bb0100","doi-asserted-by":"crossref","first-page":"H2726","DOI":"10.1152\/ajpheart.00376.2007","article-title":"TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol","volume":"293","author":"Mariappan","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115856_bb0105","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41419-024-06579-9","article-title":"TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits","volume":"15","author":"Zhang","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2025.115856_bb0110","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2024.05.037","article-title":"Zinc ions regulate mitochondrial quality control in neurons under oxidative stress and reduce PANoptosis in spinal cord injury models via the Lgals3-Bax pathway","volume":"221","author":"Bai","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2025.115856_bb0115","doi-asserted-by":"crossref","DOI":"10.1177\/20417314221143059","article-title":"Biomaterials delivery strategies to repair spinal cord injury by modulating macrophage phenotypes","volume":"13","author":"Xia","year":"2022","journal-title":"J Tissue Eng"},{"issue":"1","key":"10.1016\/j.intimp.2025.115856_bb0120","first-page":"449","article-title":"Cinnamaldehyde protects against oxidative stress and inhibits the TNF-alpha-induced inflammatory response in human umbilical vein endothelial cells","volume":"46","author":"Kim","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2025.115856_bb0125","doi-asserted-by":"crossref","first-page":"568","DOI":"10.3389\/fphar.2020.00568","article-title":"Tanshinone IIA suppresses proliferation and inflammatory cytokine production of synovial fibroblasts from rheumatoid arthritis patients induced by TNF-alpha and attenuates the inflammatory response in AIA mice","volume":"11","author":"Du","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2025.115856_bb0130","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1007\/s12035-016-0014-0","article-title":"Physical exercise attenuates experimental autoimmune encephalomyelitis by inhibiting peripheral immune response and blood-brain barrier disruption","volume":"54","author":"Souza","year":"2017","journal-title":"Mol. Neurobiol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115856_bb0135","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1007\/s12035-016-9910-6","article-title":"Propitious therapeutic modulators to prevent blood-spinal cord barrier disruption in spinal cord injury","volume":"54","author":"Kumar","year":"2017","journal-title":"Mol. Neurobiol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:45:23Z","timestamp":1781898323000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925018442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"alternative-id":["S1567576925018442"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115856","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective mechanism of zinc ions in spinal cord injury treatment: regulation of mitochondrial function and reduction of apoptosis via TNF-\u03b1 pathway inhibition","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115856","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115856"}}