{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:35:42Z","timestamp":1787974542484,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303077"],"award-info":[{"award-number":["82303077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401150"],"award-info":[{"award-number":["82401150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115863","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:36:42Z","timestamp":1763642202000},"page":"115863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P2","title":["zDHHC-mediated palmitoylation modification patterns and tumor immune microenvironment infiltration characterization in pancreatic cancer"],"prefix":"10.1016","volume":"168","author":[{"given":"Cong","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yi","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2025.115863_bb0005","first-page":"17","article-title":"Cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.intimp.2025.115863_bb0010","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1136\/gutjnl-2017-314828","article-title":"Resection of pancreatic cancer in Europe and USA: an international large-scale study highlighting large variations","volume":"68","author":"Huang","year":"2019","journal-title":"Gut"},{"issue":"9","key":"10.1016\/j.intimp.2025.115863_bb0015","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrc.2016.66","article-title":"Pancreatic cancer biology and genetics from an evolutionary perspective","volume":"16","author":"Makohon-Moore","year":"2016","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2025.115863_bb0020","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/s43018-022-00479-7","article-title":"Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes","volume":"4","author":"Hyeon","year":"2023","journal-title":"Nat. Cancer"},{"issue":"8","key":"10.1016\/j.intimp.2025.115863_bb0025","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.7150\/ijbs.72244","article-title":"Emerging roles of protein palmitoylation and its modifying enzymes in cancer cell signal transduction and cancer therapy","volume":"18","author":"Liu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2025.115863_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114567","article-title":"Targeting ZDHHC9 potentiates anti-programmed death-ligand 1 immunotherapy of pancreatic cancer by modifying the tumor microenvironment","volume":"161","author":"Lin","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"10","key":"10.1016\/j.intimp.2025.115863_bb0035","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1038\/s41587-023-02030-0","article-title":"A palmitoyl transferase chemical-genetic system to map ZDHHC-specific S-acylation","volume":"42","author":"Ocasio","year":"2024","journal-title":"Nat. Biotechnol."},{"issue":"8","key":"10.1016\/j.intimp.2025.115863_bb0040","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/j.apsb.2020.03.008","article-title":"ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression","volume":"10","author":"Yuan","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"7","key":"10.1016\/j.intimp.2025.115863_bb0045","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1158\/2159-8290.CD-23-0428","article-title":"Senescence defines a distinct subset of myofibroblasts that orchestrates immunosuppression in pancreatic cancer","volume":"14","author":"Belle","year":"2024","journal-title":"Cancer Discov."},{"key":"10.1016\/j.intimp.2025.115863_bb0050","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1038\/s41467-023-38578-3","article-title":"Transcriptional control of pancreatic cancer immunosuppression by metabolic enzyme CD73 in a tumor-autonomous and -autocrine manner","volume":"14,1","author":"Tang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115863_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216149","article-title":"scRNA-Seq and imaging mass cytometry analyses unveil iNKT cells-mediated anti-tumor immunity in pancreatic cancer liver metastasis","volume":"561","author":"Yi","year":"2023","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.intimp.2025.115863_bb0060","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1053\/j.gastro.2016.09.060","article-title":"Hypermutation in pancreatic Cancer","volume":"152","author":"Humphris","year":"2017","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.intimp.2025.115863_bb0065","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/s41575-019-0245-4","article-title":"Role of oncogenic KRAS in the diagnosis, prognosis and treatment of pancreatic cancer","volume":"17","author":"Buscail","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"3124122","key":"10.1016\/j.intimp.2025.115863_bb0070","first-page":"15","article-title":"Systematic analysis of molecular subtypes based on the expression profile of immune-related genes in pancreatic cancer","volume":"2022","author":"Ke","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"10","key":"10.1016\/j.intimp.2025.115863_bb0075","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/ijc.34208","article-title":"Metabolomic analyses redefine the biological classification of pancreatic cancer and correlate with clinical outcomes","volume":"151","author":"Guo","year":"2022","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.115863_bb0080","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.13308","article-title":"Protein palmitoylation in cancer: molecular functions and therapeutic potential","volume":"17","author":"Zhou","year":"2023","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.intimp.2025.115863_bb0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-0716-2035-9_7","article-title":"Regulation of cell polarity by posttranslational protein palmitoylation","volume":"2438","author":"Chen","year":"2022","journal-title":"Methods Mol. Biol. (Clifton, N.J.)"},{"issue":"6","key":"10.1016\/j.intimp.2025.115863_bb0090","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1158\/1535-7163.MCT-20-0717","article-title":"Small molecule inhibitors of TEAD auto-palmitoylation selectively inhibit proliferation and tumor growth of NF2-deficient mesothelioma","volume":"20","author":"Tang","year":"2021","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.intimp.2025.115863_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2022.101097","article-title":"Pathological implication of protein post-translational modifications in cancer","volume":"86","author":"Pan","year":"2022","journal-title":"Mol. Aspects Med."},{"issue":"24","key":"10.1016\/j.intimp.2025.115863_bb0100","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1200\/JCO.21.02616","article-title":"Immunologic strategies in pancreatic cancer: making cold tumors hot","volume":"40","author":"Ullman","year":"2022","journal-title":"J. Clin. Oncol."},{"issue":"8016","key":"10.1016\/j.intimp.2025.115863_bb0105","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41586-024-07373-5","article-title":"ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D","volume":"630","author":"Du","year":"2024","journal-title":"Nature"},{"issue":"315\u2013328","key":"10.1016\/j.intimp.2025.115863_bb0110","first-page":"29","article-title":"Palmitoylated antigens for the induction of anti-tumor CD8+ T cells and enhanced tumor recognition","volume":"21","author":"Stolk","year":"2021","journal-title":"Mol. Ther. Oncol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115863_bb0115","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/s41551-019-0375-6","article-title":"Inhibiting PD-L1 palmitoylation enhances T-cell immune responses against tumours","volume":"3","author":"Yao","year":"2019","journal-title":"Nat. Biomed. Eng."},{"issue":"51","key":"10.1016\/j.intimp.2025.115863_bb0120","doi-asserted-by":"crossref","first-page":"25688","DOI":"10.1073\/pnas.1912671116","article-title":"Palmitoylation of BMPR1a regulates neural stem cell fate","volume":"116","author":"Wegleiter","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.intimp.2025.115863_bb0125","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.stem.2023.11.011","article-title":"A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS","volume":"31","author":"Duan","year":"2024","journal-title":"Cell Stem Cell"},{"issue":"7592","key":"10.1016\/j.intimp.2025.115863_bb0130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature16965","article-title":"Genomic analyses identify molecular subtypes of pancreatic cancer","volume":"531","author":"Bailey","year":"2016","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.intimp.2025.115863_bb0135","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.cmet.2019.02.001","article-title":"Macrophage-released pyrimidines inhibit gemcitabine therapy in pancreatic cancer","volume":"29","author":"Halbrook","year":"2019","journal-title":"Cell Metab."},{"issue":"3","key":"10.1016\/j.intimp.2025.115863_bb0140","first-page":"409","article-title":"Association of DCBLD2 upregulation with tumor progression and poor survival in colorectal cancer","volume":"43","author":"He","year":"2020","journal-title":"Cell. Oncol. (Dordrecht, Netherlands)"},{"issue":"6","key":"10.1016\/j.intimp.2025.115863_bb0145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/WNR.0000000000001611","article-title":"Transmembrane protein DCBLD2 is correlated with poor prognosis and affects phenotype by regulating epithelial-mesenchymal transition in human glioblastoma cells","volume":"32","author":"Cheng","year":"2021","journal-title":"Neuroreport"},{"issue":"6","key":"10.1016\/j.intimp.2025.115863_bb0150","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3390\/cancers13061403","article-title":"DCBLD2 mediates epithelial-mesenchymal transition-induced metastasis by cisplatin in lung adenocarcinoma","volume":"13","author":"Chen","year":"2021","journal-title":"Cancers"},{"issue":"8","key":"10.1016\/j.intimp.2025.115863_bb0155","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/cdd.2014.228","article-title":"LAMC2 enhances the metastatic potential of lung adenocarcinoma","volume":"22","author":"Moon","year":"2015","journal-title":"Cell Death Differ."},{"issue":"5","key":"10.1016\/j.intimp.2025.115863_bb0160","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00432-024-05720-7","article-title":"LAMC2 regulates the proliferation, invasion, and metastasis of gastric cancer via PI3K\/Akt signaling pathway","volume":"150","author":"Cheng","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115863_bb0165","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/carcin\/bgab011","article-title":"LAMC2 promotes cancer progression and gemcitabine resistance through modulation of EMT and ATP-binding cassette transporters in pancreatic ductal adenocarcinoma","volume":"42","author":"Okada","year":"2021","journal-title":"Carcinogenesis"},{"issue":"5","key":"10.1016\/j.intimp.2025.115863_bb0170","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/hep.32419","article-title":"Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC","volume":"76","author":"Suthen","year":"2022","journal-title":"Hepatology (Baltimore, Md.)"},{"key":"10.1016\/j.intimp.2025.115863_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110235","article-title":"Collagen-induced DDR1 upregulates CXCL5 to promote neutrophil extracellular traps formation and Treg infiltration in breast cancer","volume":"120","author":"Li","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115863_bb0180","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12943-019-1077-0","article-title":"ASPH-notch axis guided exosomal delivery of prometastatic secretome renders breast cancer multi-organ metastasis","volume":"18","author":"Lin","year":"2019","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.intimp.2025.115863_bb0185","first-page":"2537","article-title":"Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture","volume":"11","author":"Lin","year":"2021","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.intimp.2025.115863_bb0190","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ebiom.2018.05.004","article-title":"Hydroxylase activity of ASPH promotes hepatocellular carcinoma metastasis through epithelial-to-mesenchymal transition pathway","volume":"31","author":"Zou","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2025.115863_bb0195","doi-asserted-by":"crossref","DOI":"10.1177\/1533033820921248","article-title":"KRT6A promotes EMT and cancer stem cell transformation in lung adenocarcinoma","volume":"19","author":"Yang","year":"2020","journal-title":"Technol. Cancer Res. Treat."},{"issue":"694071","key":"10.1016\/j.intimp.2025.115863_bb0200","first-page":"21","article-title":"KRT6A promotes lung cancer cell growth and invasion through MYC-regulated pentose phosphate pathway","volume":"9","author":"Che","year":"2021","journal-title":"Front. Cell Devel. Biol."},{"issue":"8","key":"10.1016\/j.intimp.2025.115863_bb0205","first-page":"7060","article-title":"Keratin 6A (KRT6A) promotes radioresistance, invasion, and metastasis in lung cancer via p53 signaling pathway","volume":"16","author":"Xu","year":"2024","journal-title":"Aging"},{"issue":"3","key":"10.1016\/j.intimp.2025.115863_bb0210","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/jcp.26013","article-title":"The emerging role of NPNT in tissue injury repair and bone homeostasis","volume":"233","author":"Sun","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2025.115863_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146436","article-title":"Integrated analysis identified NPNT as a potential key regulator in tumor metastasis of hepatocellular carcinoma","volume":"825","author":"Huang","year":"2022","journal-title":"Gene"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692501851X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692501851X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:15:30Z","timestamp":1766153730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692501851X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":43,"alternative-id":["S156757692501851X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115863","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"zDHHC-mediated palmitoylation modification patterns and tumor immune microenvironment infiltration characterization in pancreatic cancer","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115863","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115863"}}