{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T22:26:32Z","timestamp":1787955992937,"version":"build-2784847793"},"reference-count":185,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019065","name":"Tianjin Science and Technology Program","doi-asserted-by":"publisher","award":["22JCQNJC00490"],"award-info":[{"award-number":["22JCQNJC00490"]}],"id":[{"id":"10.13039\/501100019065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204962"],"award-info":[{"award-number":["82204962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019066","name":"Tianjin Municipal Transportation Commission Science and Technology Development Plan Project","doi-asserted-by":"publisher","award":["2024ZD005"],"award-info":[{"award-number":["2024ZD005"]}],"id":[{"id":"10.13039\/501100019066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115864","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T17:01:40Z","timestamp":1763658100000},"page":"115864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"P2","title":["Role of metabolic reprogramming in colorectal cancer and pharmacologic intervention"],"prefix":"10.1016","volume":"168","author":[{"given":"Yi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbing","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingtian","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianbin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0005","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","article-title":"Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN","volume":"72","author":"Morgan","year":"2023","journal-title":"Gut"},{"issue":"8","key":"10.1016\/j.intimp.2025.115864_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16081530","article-title":"Colorectal Cancer: epidemiology, risk factors, and prevention","volume":"16","author":"Roshandel","year":"2024","journal-title":"Cancers (Basel)."},{"issue":"7","key":"10.1016\/j.intimp.2025.115864_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14071732","article-title":"Colorectal Cancer: a review of carcinogenesis, global epidemiology, current challenges, risk factors, preventive and treatment strategies","volume":"14","author":"Hossain","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0020","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12935-025-03872-1","article-title":"The role of physical activity and epigenetic changes in colorectal cancer prevention","volume":"25","author":"Sun","year":"2025","journal-title":"Cancer Cell Int."},{"issue":"47","key":"10.1016\/j.intimp.2025.115864_bb0025","doi-asserted-by":"crossref","first-page":"8179","DOI":"10.1039\/D4AY01716A","article-title":"Early colorectal cancer detection: a serum analysis platform combining SERS and machine learning","volume":"16","author":"Zhu","year":"2024","journal-title":"Anal. Methods"},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0030","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The Warburg effect: how does it benefit Cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.intimp.2025.115864_bb0035","article-title":"SOX2 promotes vasculogenic mimicry by accelerating glycolysis via the lncRNA AC005392.2-GLUT1 axis in colorectal cancer","volume":"14(12):791","author":"Huang","year":"2023","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.intimp.2025.115864_bb0040","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1002\/jcsm.13079","article-title":"Atractylenolide I ameliorates cancer cachexia through inhibiting biogenesis of IL-6 and tumour-derived extracellular vesicles","volume":"13","author":"Fan","year":"2022","journal-title":"J. Cachexia. Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0045","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1038\/s41467-024-50138-x","article-title":"Inhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer","volume":"15","author":"Zhou","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41420-025-02670-y","article-title":"Mitochondrial metabolic reprogramming in colorectal cancer: mechanisms of resistance and future clinical interventions","volume":"11","author":"Qiu","year":"2025","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2025.115864_bb0055","article-title":"Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation","volume":"9(13):eadf0927","author":"Bala","year":"2023","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0060","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40170-025-00394-2","article-title":"S-adenosylmethionine metabolism shapes CD8(+) T cell functions in colorectal cancer","volume":"13","author":"Yang","year":"2025","journal-title":"Cancer Metab."},{"issue":"10","key":"10.1016\/j.intimp.2025.115864_bb0065","doi-asserted-by":"crossref","first-page":"5842","DOI":"10.1111\/jcmm.15254","article-title":"Metabolic reprogramming-associated genes predict overall survival for rectal cancer","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2025.115864_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2023.147263","article-title":"Prognosis-related metabolic genes in the development of colorectal cancer progress and perspective","volume":"862","author":"Miao","year":"2023","journal-title":"Gene"},{"issue":"9","key":"10.1016\/j.intimp.2025.115864_bb0075","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/s41419-022-05245-2","article-title":"N6-methyladenosine modification of circ_0003215 suppresses the pentose phosphate pathway and malignancy of colorectal cancer through the miR-663b\/DLG4\/G6PD axis","volume":"13","author":"Chen","year":"2022","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15384047.2022.2108690","article-title":"Crosstalk between PI3K\/Akt and Wnt\/beta-catenin pathways promote colorectal cancer progression regardless of mutational status","volume":"23","author":"Fleming-de-Moraes","year":"2022","journal-title":"Cancer Biol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0085","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12943-024-02086-9","article-title":"Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1(high)CD206(+) pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis","volume":"23","author":"Zhou","year":"2024","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0090","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1002\/jcp.30566","article-title":"Engineered exosomes for co-delivery of PGM5-AS1 and oxaliplatin to reverse drug resistance in colon cancer","volume":"237","author":"Hui","year":"2022","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115864_bb0095","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/j.apsb.2024.04.024","article-title":"KHK-A promotes fructose-dependent colorectal cancer liver metastasis by facilitating the phosphorylation and translocation of PKM2","volume":"14","author":"Peng","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0100","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41392-022-01096-7","article-title":"DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2","volume":"7","author":"Zhao","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/s41388-021-02071-2","article-title":"Deubiquitinase OTUB2 exacerbates the progression of colorectal cancer by promoting PKM2 activity and glycolysis","volume":"41","author":"Yu","year":"2022","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.intimp.2025.115864_bb0110","doi-asserted-by":"crossref","first-page":"4235","DOI":"10.1016\/j.celrep.2020.03.005","article-title":"C-Src promotes tumorigenesis and tumor progression by activating PFKFB3","volume":"30","author":"Ma","year":"2020","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.intimp.2025.115864_bb0115","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41419-024-06958-2","article-title":"HIF1A-AS2 promotes the metabolic reprogramming and progression of colorectal cancer via miR-141-3p\/FOXC1 axis","volume":"15","author":"Zhong","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2025.115864_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154509","article-title":"Mitochondrial remodeling in colorectal cancer initiation, progression, metastasis, and therapy: a review","volume":"246","author":"Abdelmaksoud","year":"2023","journal-title":"Pathol. Res. Pract."},{"issue":"11","key":"10.1016\/j.intimp.2025.115864_bb0125","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1136\/gutjnl-2020-322780","article-title":"F. Nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer","volume":"70","author":"Hong","year":"2021","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0130","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1038\/s41467-022-29085-y","article-title":"A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine","volume":"13","author":"Sebastian","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115864_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114301","article-title":"4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer","volume":"159","author":"Yang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115864_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.893677","article-title":"Effect of TP53 deficiency and KRAS signaling on the bioenergetics of colon cancer cells in response to different substrates: a single cell study","volume":"10","author":"Kealey","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12051293","article-title":"Common and differential traits of the membrane Lipidome of Colon Cancer cell lines and their secreted vesicles: impact on studies using cell lines","volume":"12","author":"Bestard-Escalas","year":"2020","journal-title":"Cancers (Basel)."},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9041095","article-title":"Decreased triacylglycerol content and elevated contents of cell membrane lipids in colorectal Cancer tissue: a Lipidomic study","volume":"9","author":"Mika","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2025.115864_bb0155","article-title":"Acetyl-CoA carboxylases and diseases. Front","volume":"12","author":"Wang","year":"2022","journal-title":"Oncol"},{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0160","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MOL.0000000000000390","article-title":"ATP-citrate lyase: genetics, molecular biology and therapeutic target for dyslipidemia","volume":"28","author":"Burke","year":"2017","journal-title":"Curr. Opin. Lipidol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0165","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jcb.30347","article-title":"Lipid metabolism reprogramming in colorectal cancer","volume":"124","author":"Chen","year":"2023","journal-title":"J. Cell. Biochem."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0170","article-title":"Statins as anti-tumor agents: a paradigm for repurposed drugs","volume":"7","author":"Tripathi","year":"2024","journal-title":"Cancer Rep (Hoboken)."},{"issue":"16","key":"10.1016\/j.intimp.2025.115864_bb0175","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15164100","article-title":"Emergence of lipid droplets in the mechanisms of carcinogenesis and therapeutic responses","volume":"15","author":"Delmas","year":"2023","journal-title":"Cancers (Basel)."},{"issue":"12","key":"10.1016\/j.intimp.2025.115864_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.115006","article-title":"Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non-cell-autonomous manner","volume":"43","author":"Choi","year":"2024","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0185","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1002\/1878-0261.12917","article-title":"Enhancing cancer-associated fibroblast fatty acid catabolism within a metabolically challenging tumor microenvironment drives colon cancer peritoneal metastasis","volume":"15","author":"Peng","year":"2021","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0190","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/s41421-022-00515-x","article-title":"Reprogramming of palmitic acid induced by dephosphorylation of ACOX1 promotes beta-catenin palmitoylation to drive colorectal cancer progression","volume":"9","author":"Zhang","year":"2023","journal-title":"Cell Discov."},{"key":"10.1016\/j.intimp.2025.115864_bb0195","doi-asserted-by":"crossref","first-page":"1564213","DOI":"10.3389\/fimmu.2025.1564213","article-title":"Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor","volume":"16","author":"Wu","year":"2025","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0200","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41417-023-00711-1","article-title":"SPHK1 potentiates colorectal cancer progression and metastasis via regulating autophagy mediated by TRAF6-induced ULK1 ubiquitination","volume":"31","author":"Chen","year":"2024","journal-title":"Cancer Gene Ther."},{"issue":"7","key":"10.1016\/j.intimp.2025.115864_bb0205","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1016\/j.celrep.2019.07.044","article-title":"Pro-survival lipid Sphingosine-1-phosphate metabolically programs T cells to limit anti-tumor activity","volume":"28","author":"Chakraborty","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.intimp.2025.115864_bb0210","series-title":"Understanding Sphingolipids Metabolism in Colorectal Cancer","author":"Pedro Nuno Brand\u00e3o","year":"2022"},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/biom10040632","article-title":"Ceramides profile identifies patients with more advanced stages of colorectal Cancer","volume":"10","author":"Markowski","year":"2020","journal-title":"Biomolecules"},{"issue":"10","key":"10.1016\/j.intimp.2025.115864_bb0220","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1039\/D1AN02239C","article-title":"Diagnostic value of serum sphingolipids in patients with colorectal cancer","volume":"147","author":"Pan","year":"2022","journal-title":"Analyst"},{"key":"10.1016\/j.intimp.2025.115864_bb0225","doi-asserted-by":"crossref","first-page":"1594419","DOI":"10.3389\/fphar.2025.1594419","article-title":"ACSL4 at the helm of the lipid peroxidation ship: a deep-sea exploration towards ferroptosis","volume":"16","author":"Jiang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115864_bb0230","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2147\/CMAR.S274631","article-title":"Apatinib promotes Ferroptosis in colorectal Cancer cells by targeting ELOVL6\/ACSL4 signaling","volume":"13","author":"Tian","year":"2021","journal-title":"Cancer Manag. Res."},{"issue":"12","key":"10.1016\/j.intimp.2025.115864_bb0235","article-title":"Lipid handling protein gene expression in colorectal Cancer: CD36 and targeting miRNAs","volume":"12","author":"Niculae","year":"2022","journal-title":"Life (Basel)."},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/biom11030417","article-title":"Lipidomic signatures for colorectal Cancer diagnosis and progression using UPLC-QTOF-ESI(+)MS","volume":"11","author":"Rachieriu","year":"2021","journal-title":"Biomolecules"},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0245","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2023.13106","article-title":"Metabolomics analyses of cancer tissue from patients with colorectal cancer","volume":"28","author":"Kang","year":"2023","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0250","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1039\/D1MO00022E","article-title":"Tissue metabolic profiling reveals major metabolic alteration in colorectal cancer","volume":"17","author":"Shen","year":"2021","journal-title":"Mol Omics."},{"issue":"46","key":"10.1016\/j.intimp.2025.115864_bb0255","doi-asserted-by":"crossref","first-page":"6443","DOI":"10.1038\/s41388-021-02023-w","article-title":"CEMIP, a novel adaptor protein of OGT, promotes colorectal cancer metastasis through glutamine metabolic reprogramming via reciprocal regulation of beta-catenin","volume":"40","author":"Hua","year":"2021","journal-title":"Oncogene"},{"issue":"16","key":"10.1016\/j.intimp.2025.115864_bb0260","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1038\/s41388-023-02632-7","article-title":"L-2hydroxyglutaric acid rewires amino acid metabolism in colorectal cancer via the mTOR-ATF4 axis","volume":"42","author":"Tabata","year":"2023","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0265","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.cell.2021.02.021","article-title":"In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions","volume":"184","author":"Huang","year":"2021","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0270","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12964-022-00909-0","article-title":"Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment","volume":"20","author":"Ma","year":"2022","journal-title":"Cell Commun. Signal"},{"issue":"Pt A","key":"10.1016\/j.intimp.2025.115864_bb0275","article-title":"Indoleamine 2,3-dioxygenase-1 involves in CD8(+)T cell exhaustion in glioblastoma via regulating tryptophan levels","volume":"142","author":"Zhou","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2025.115864_bb0280","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00262-024-03706-5","article-title":"Rocaglamide promotes infiltration and differentiation of T cells and coordinates with PD-1 inhibitor to overcome checkpoint resistance in multiple tumor models","volume":"73","author":"Luo","year":"2024","journal-title":"Cancer Immunol. Immunother."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0285","doi-asserted-by":"crossref","first-page":"233","DOI":"10.62347\/ZSOO2247","article-title":"Role of amino acid metabolism in tumor immune microenvironment of colorectal cancer","volume":"15","author":"Zhu","year":"2025","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.intimp.2025.115864_bb0290","doi-asserted-by":"crossref","first-page":"10287","DOI":"10.2147\/OTT.S273107","article-title":"Study of the relationship between serum amino acid metabolism and lymph node metastasis in patients with colorectal Cancer","volume":"13","author":"Liu","year":"2020","journal-title":"Onco. Targets. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0295","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.radonc.2016.01.014","article-title":"Myeloid-derived suppressor cells reveal radioprotective properties through arginase-induced l-arginine depletion","volume":"119","author":"Leonard","year":"2016","journal-title":"Radiother. Oncol."},{"issue":"20","key":"10.1016\/j.intimp.2025.115864_bb0300","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.1038\/s41388-020-1262-z","article-title":"Phosphorylation of BCKDK of BCAA catabolism at Y246 by Src promotes metastasis of colorectal cancer","volume":"39","author":"Tian","year":"2020","journal-title":"Oncogene"},{"key":"10.1016\/j.intimp.2025.115864_bb0305","doi-asserted-by":"crossref","first-page":"1430352","DOI":"10.3389\/fimmu.2024.1430352","article-title":"Exploiting branched-chain amino acid metabolism and NOTCH3 expression to predict and target colorectal cancer progression","volume":"15","author":"Shen","year":"2024","journal-title":"Front. Immunol."},{"issue":"17","key":"10.1016\/j.intimp.2025.115864_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179286","article-title":"S-Adenosylmethionine increases the sensitivity of human colorectal Cancer cells to 5-fluorouracil by inhibiting P-glycoprotein expression and NF-kappaB activation","volume":"22","author":"Mosca","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2025.115864_bb0315","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1158\/0008-5472.CAN-20-1541","article-title":"Exogenous and endogenous sources of serine contribute to Colon Cancer metabolism, growth, and resistance to 5-fluorouracil","volume":"81","author":"Montrose","year":"2021","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0320","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.tranon.2016.03.006","article-title":"Increased expression of PHGDH and prognostic significance in colorectal Cancer","volume":"9","author":"Jia","year":"2016","journal-title":"Transl. Oncol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0325","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41419-023-05849-2","article-title":"HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA\/LIMK-1\/CFL-1","volume":"14","author":"Han","year":"2023","journal-title":"Cell Death Dis."},{"issue":"27","key":"10.1016\/j.intimp.2025.115864_bb0330","doi-asserted-by":"crossref","first-page":"6318","DOI":"10.12998\/wjcc.v11.i27.6318","article-title":"Characteristics of amino acid metabolism in colorectal cancer","volume":"11","author":"Xu","year":"2023","journal-title":"World J. Clin. Cases"},{"issue":"24","key":"10.1016\/j.intimp.2025.115864_bb0335","doi-asserted-by":"crossref","DOI":"10.3390\/cells11244106","article-title":"The role of amino acid metabolism of tumor associated macrophages in the development of colorectal Cancer","volume":"11","author":"Jiang","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0340","doi-asserted-by":"crossref","first-page":"2348441","DOI":"10.1080\/19490976.2024.2348441","article-title":"Commensal microbiota-derived metabolite agmatine triggers inflammation to promote colorectal tumorigenesis","volume":"16","author":"Lu","year":"2024","journal-title":"Gut Microbes"},{"issue":"7","key":"10.1016\/j.intimp.2025.115864_bb0345","doi-asserted-by":"crossref","DOI":"10.3390\/metabo11070456","article-title":"A metabolic model of intestinal secretions: the link between human microbiota and colorectal Cancer progression","volume":"11","author":"Salahshouri","year":"2021","journal-title":"Metabolites"},{"issue":"10","key":"10.1016\/j.intimp.2025.115864_bb0350","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1002\/1878-0261.12999","article-title":"Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1","volume":"15","author":"Kandasamy","year":"2021","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0355","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41467-019-14224-9","article-title":"Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D)","volume":"11","author":"Kennedy","year":"2020","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0360","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1053\/j.gastro.2022.11.014","article-title":"Dysregulated amino acid sensing drives colorectal Cancer growth and metabolic reprogramming leading to Chemoresistance","volume":"164","author":"Solanki","year":"2023","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0365","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12943-020-01235-0","article-title":"Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p\/miR-506-3p- TGF-beta1 axis","volume":"19","author":"Shang","year":"2020","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0370","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13045-020-00991-2","article-title":"Tumor-derived exosomal miR-934 induces macrophage M2 polarization to promote liver metastasis of colorectal cancer","volume":"13","author":"Zhao","year":"2020","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0375","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s13045-021-01210-2","article-title":"Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p\/CTBP2\/E-cadherin axis in colorectal cancer","volume":"14","author":"He","year":"2021","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2025.115864_bb0380","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.927811","article-title":"Hsa_Circ_0066351 acts as a prognostic and immunotherapeutic biomarker in colorectal Cancer","volume":"13","author":"Gao","year":"2022","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115864_bb0385","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1002\/1878-0261.12796","article-title":"CircFNDC3B sequestrates miR-937-5p to derepress TIMP3 and inhibit colorectal cancer progression","volume":"14","author":"Zeng","year":"2020","journal-title":"Mol. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0390","doi-asserted-by":"crossref","first-page":"5395","DOI":"10.1038\/s41467-018-07810-w","article-title":"Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis","volume":"9","author":"Zeng","year":"2018","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.intimp.2025.115864_bb0395","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.595","article-title":"EMT-cancer cells-derived exosomal miR-27b-3p promotes circulating tumour cells-mediated metastasis by modulating vascular permeability in colorectal cancer","volume":"11","author":"Dou","year":"2021","journal-title":"Clin. Transl. Med."},{"issue":"10","key":"10.1016\/j.intimp.2025.115864_bb0400","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1002\/cam4.3840","article-title":"miR-140-3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2","volume":"10","author":"Liu","year":"2021","journal-title":"Cancer Med."},{"issue":"18","key":"10.1016\/j.intimp.2025.115864_bb0405","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.7150\/thno.44419","article-title":"Hypoxia induced exosomal circRNA promotes metastasis of colorectal Cancer via targeting GEF-H1\/RhoA axis","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0410","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bbrc.2020.04.142","article-title":"Matrine reduces the secretion of exosomal circSLC7A6 from cancer-associated fibroblast to inhibit tumorigenesis of colorectal cancer by regulating CXCR5","volume":"527","author":"Gu","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0415","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12967-020-02648-7","article-title":"Exosomal LncRNA LINC00659 transferred from cancer-associated fibroblasts promotes colorectal cancer cell progression via miR-342-3p\/ANXA2 axis","volume":"19","author":"Zhou","year":"2021","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0420","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/hep.32009","article-title":"Hypoxia-inducible exosomes facilitate liver-tropic Premetastatic niche in colorectal Cancer","volume":"74","author":"Sun","year":"2021","journal-title":"Hepatology"},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0425","doi-asserted-by":"crossref","DOI":"10.3390\/biom15040510","article-title":"Interactions between non-coding RNAs and HIF-1alpha in the context of colorectal Cancer","volume":"15","author":"Gong","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.intimp.2025.115864_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101203","article-title":"Loss of mitochondrial aconitase promotes colorectal cancer progression via SCD1-mediated lipid remodeling","volume":"48","author":"You","year":"2021","journal-title":"Mol Metab."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0435","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1186\/s12967-024-05847-8","article-title":"Role of ENO1 and its targeted therapy in tumors","volume":"22","author":"Li","year":"2024","journal-title":"J. Transl. Med."},{"issue":"28","key":"10.1016\/j.intimp.2025.115864_bb0440","article-title":"Metabolic recoding of NSUN2-mediated m(5)C modification promotes the progression of colorectal Cancer via the NSUN2\/YBX1\/m(5)C-ENO1 positive feedback loop","volume":"11","author":"Chen","year":"2024","journal-title":"Adv Sci (Weinh)."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0445","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/imm.13871","article-title":"Metabolic reprogramming in Cancer: implications for immunosuppressive microenvironment","volume":"174","author":"Aden","year":"2025","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0450","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.cmet.2022.12.003","article-title":"Immunoediting instructs tumor metabolic reprogramming to support immune evasion","volume":"35","author":"Tsai","year":"2023","journal-title":"Cell Metab."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0455","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.cmet.2021.03.002","article-title":"Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8(+) T cell immunity","volume":"33","author":"He","year":"2021","journal-title":"Cell Metab."},{"issue":"44","key":"10.1016\/j.intimp.2025.115864_bb0460","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2408354121","article-title":"O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic glycolysis and immune evasion in colorectal cancer","volume":"121","author":"Zhu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0465","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/s41388-019-1035-8","article-title":"Dichloroacetate restores colorectal cancer chemosensitivity through the p53\/miR-149-3p\/PDK2-mediated glucose metabolic pathway","volume":"39","author":"Liang","year":"2020","journal-title":"Oncogene"},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0470","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14051281","article-title":"Metformin and ICG-001 act synergistically to abrogate Cancer stem cells-mediated Chemoresistance in colorectal Cancer by promoting apoptosis and autophagy","volume":"14","author":"Roy","year":"2022","journal-title":"Cancers (Basel)."},{"key":"10.1016\/j.intimp.2025.115864_bb0475","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.862889","article-title":"Zebrafish avatars of rectal cancer patients validate the radiosensitive effect of metformin","volume":"12","author":"Costa","year":"2022","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115864_bb0480","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16071399","article-title":"Inhibition of carbohydrate metabolism potentiated by the therapeutic effects of oxidative phosphorylation inhibitors in Colon Cancer cells","volume":"16","author":"Guo","year":"2024","journal-title":"Cancers (Basel)."},{"issue":"21","key":"10.1016\/j.intimp.2025.115864_bb0485","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1158\/0008-5472.CAN-23-0323","article-title":"Fasting-mimicking diet drives antitumor immunity against colorectal Cancer by reducing IgA-producing cells","volume":"83","author":"Zhong","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2025.115864_bb0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104496","article-title":"Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells","volume":"90","author":"Liu","year":"2023","journal-title":"EBioMedicine"},{"issue":"9","key":"10.1016\/j.intimp.2025.115864_bb0495","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1158\/0008-5472.CAN-24-1940","article-title":"Arginine deprivation induces quiescence and confers vulnerability to Ferroptosis in colorectal Cancer","volume":"85","author":"Lin","year":"2025","journal-title":"Cancer Res"},{"issue":"9","key":"10.1016\/j.intimp.2025.115864_bb0500","article-title":"Insights into the role of microRNAs in colorectal Cancer (CRC)","volume":"12","author":"Wai Hon","year":"2020","journal-title":"Metabolism. Cancers (Basel)."},{"key":"10.1016\/j.intimp.2025.115864_bb0505","first-page":"10","article-title":"Downregulation of miR-423-5p contributes to the Radioresistance in colorectal Cancer cells. Front","author":"Shang","year":"2021","journal-title":"Oncol"},{"issue":"10","key":"10.1016\/j.intimp.2025.115864_bb0510","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1038\/s41416-022-01965-6","article-title":"Sensitisation of cancer cells to radiotherapy by serine and glycine starvation","volume":"127","author":"Falcone","year":"2022","journal-title":"Br. J. Cancer"},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0515","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1002\/2211-5463.13137","article-title":"SREBP1\/FASN\/cholesterol axis facilitates radioresistance in colorectal cancer","volume":"11","author":"Jin","year":"2021","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.intimp.2025.115864_bb0520","doi-asserted-by":"crossref","first-page":"1216911","DOI":"10.3389\/fonc.2023.1216911","article-title":"Metformin is a metabolic modulator and radiosensitiser in rectal cancer","volume":"13","author":"Buckley","year":"2023","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115864_bb0525","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/s41419-023-05999-3","article-title":"New insights into the responder\/nonresponder divide in rectal cancer: damage-induced type I IFNs dictate treatment efficacy and can be targeted to enhance radiotherapy","volume":"14","author":"Uccello","year":"2023","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0530","doi-asserted-by":"crossref","first-page":"180","DOI":"10.2174\/1871523018666190718161928","article-title":"Protection from radiation-induced damage in rat\u2019s ileum and Colon by combined regimens of melatonin and metformin: a histopathological study","volume":"19","author":"Najafi","year":"2020","journal-title":"Antiinflamm Antiallergy Agents Med Chem."},{"issue":"6","key":"10.1016\/j.intimp.2025.115864_bb0535","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065356","article-title":"Combinatorial network of transcriptional and miRNA regulation in colorectal Cancer","volume":"24","author":"Kumar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0540","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10863-015-9612-1","article-title":"Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer","volume":"47","author":"Sun","year":"2015","journal-title":"J. Bioenerg. Biomembr."},{"key":"10.1016\/j.intimp.2025.115864_bb0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2024.104896","article-title":"Analysis of anti-tumor effect and mechanism of GLS1 inhibitor CB-839 in colorectal cancer using a stroma-abundant tumor model","volume":"137","author":"Miyamoto","year":"2024","journal-title":"Exp. Mol. Pathol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115864_bb0550","doi-asserted-by":"crossref","DOI":"10.1172\/JCI137845","article-title":"Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma","volume":"131","author":"Capece","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0555","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.7150\/ijbs.101921","article-title":"Chloroquine suppresses colorectal Cancer progression via targeting CHKA and PFKM to inhibit the PI3K\/AKT pathway and the Warburg effect","volume":"21","author":"Liu","year":"2025","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0560","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/s41419-025-07334-4","article-title":"DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer","volume":"16","author":"Zhao","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0565","doi-asserted-by":"crossref","DOI":"10.3390\/cimb47010067","article-title":"Targeting SLC4A4: a novel approach in colorectal Cancer drug repurposing","volume":"47","author":"Pawar","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"issue":"24","key":"10.1016\/j.intimp.2025.115864_bb0570","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1158\/0008-5472.CAN-21-2273","article-title":"ANGPTL4-mediated promotion of glycolysis facilitates the colonization of fusobacterium nucleatum in colorectal Cancer","volume":"81","author":"Zheng","year":"2021","journal-title":"Cancer Res."},{"issue":"50","key":"10.1016\/j.intimp.2025.115864_bb0575","doi-asserted-by":"crossref","first-page":"6736","DOI":"10.1038\/s41388-021-02063-2","article-title":"NeuroD1 promotes tumor cell proliferation and tumorigenesis by directly activating the pentose phosphate pathway in colorectal carcinoma","volume":"40","author":"Li","year":"2021","journal-title":"Oncogene"},{"issue":"16","key":"10.1016\/j.intimp.2025.115864_bb0580","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23169442","article-title":"Augmented therapeutic potential of EC-synthetic Retinoids in Caco-2 Cancer cells using an in vitro approach","volume":"23","author":"Abdelaal","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0585","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1158\/0008-5472.CAN-20-1517","article-title":"2-hydroxylation of fatty acids represses colorectal tumorigenesis and metastasis via the YAP transcriptional Axis","volume":"81","author":"Sun","year":"2021","journal-title":"Cancer Res."},{"issue":"29","key":"10.1016\/j.intimp.2025.115864_bb0590","article-title":"Metabolism-based molecular subtyping endows effective ketogenic therapy in p53-mutant Colon Cancer","volume":"9","author":"Tang","year":"2022","journal-title":"Adv Sci (Weinh)."},{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0595","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s10142-024-01356-5","article-title":"Targeting nucleotide metabolic pathways in colorectal cancer by integrating scRNA-seq, spatial transcriptome, and bulk RNA-seq data","volume":"24","author":"Zhao","year":"2024","journal-title":"Funct. Integr. Genomics"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0600","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1038\/s41598-023-29958-2","article-title":"Modulation of AMPK\/ TET2\/ 5-hmC axis in response to metabolic alterations as a novel pathway for obesity-related colorectal cancer development","volume":"13","author":"Kon","year":"2023","journal-title":"Sci. Rep."},{"issue":"15","key":"10.1016\/j.intimp.2025.115864_bb0605","doi-asserted-by":"crossref","first-page":"13095","DOI":"10.1021\/acsomega.2c00527","article-title":"N-carbamoyl alanine-mediated selective targeting for CHEK2-null colorectal Cancer","volume":"7","author":"Ahmad","year":"2022","journal-title":"ACS Omega"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0610","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1038\/s41419-025-07781-z","article-title":"SLC44A2 negatively regulates mitochondrial fatty acid oxidation to suppress colorectal progression by blocking the MUL1-CPT2 interaction","volume":"16","author":"Yang","year":"2025","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0615","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/s41467-025-56748-3","article-title":"Regorafenib plus sintilimab as a salvage treatment for microsatellite stable metastatic colorectal cancer: a single-arm, open-label, phase II clinical trial","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.intimp.2025.115864_bb0620","doi-asserted-by":"crossref","first-page":"3595","DOI":"10.7150\/thno.51265","article-title":"Vitamin C activates pyruvate dehydrogenase (PDH) targeting the mitochondrial tricarboxylic acid (TCA) cycle in hypoxic KRAS mutant colon cancer","volume":"11","author":"Cenigaonandia-Campillo","year":"2021","journal-title":"Theranostics"},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0625","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2022.188797","article-title":"Colorectal cancer: metabolic interactions reshape the tumor microenvironment","volume":"1877","author":"Chen","year":"2022","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"issue":"7851","key":"10.1016\/j.intimp.2025.115864_bb0630","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41586-020-03045-2","article-title":"Metabolic support of tumour-infiltrating regulatory T cells by lactic acid","volume":"591","author":"Watson","year":"2021","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.intimp.2025.115864_bb0635","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108500","article-title":"Lactate limits T cell proliferation via the NAD(H) redox state","volume":"33","author":"Quinn","year":"2020","journal-title":"Cell Rep."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0640","first-page":"107","article-title":"Treating colorectal Cancer with immunotherapy: implications for single versus combination therapy","volume":"16","author":"Karki","year":"2020","journal-title":"Curr. Colorectal Cancer Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0645","doi-asserted-by":"crossref","first-page":"1906500","DOI":"10.1080\/2162402X.2021.1906500","article-title":"PPARgamma induces PD-L1 expression in MSS+ colorectal cancer cells","volume":"10","author":"Gutting","year":"2021","journal-title":"Oncoimmunology"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0650","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12964-024-01848-8","article-title":"Acetylcysteine synergizes PD-1 blockers against colorectal cancer progression by promoting TCF1(+)PD1(+)CD8(+) T cell differentiation","volume":"22","author":"Zhou","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0655","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3892\/ol.2022.13628","article-title":"Interference with pathways activated by topoisomerase inhibition alters the surface expression of PD-L1 and MHC I in colon cancer cells","volume":"25","author":"Hassan","year":"2023","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0660","article-title":"Inhibition of glutamate-to-glutathione flux promotes tumor antigen presentation in colorectal Cancer cells","volume":"12","author":"Yu","year":"2025","journal-title":"Adv Sci (Weinh)."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0665","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1038\/s41467-022-33285-x","article-title":"USP14 promotes tryptophan metabolism and immune suppression by stabilizing IDO1 in colorectal cancer","volume":"13","author":"Shi","year":"2022","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0670","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13040950","article-title":"Immunogenic cell death and metabolic reprogramming in Cancer: mechanisms, synergies, and innovative therapeutic strategies","volume":"13","author":"Jiang","year":"2025","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0675","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41590-022-01132-2","article-title":"Immunogenic cell stress and death","volume":"23","author":"Kroemer","year":"2022","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0680","doi-asserted-by":"crossref","first-page":"198","DOI":"10.17305\/bjbms.2022.8286","article-title":"Intrinsic resistance and efficacy of immunotherapy in microsatellite instability-high colorectal cancer: a systematic review and meta-analysis","volume":"23","author":"Wang","year":"2023","journal-title":"Biomol Biomed."},{"key":"10.1016\/j.intimp.2025.115864_bb0685","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.canlet.2020.08.033","article-title":"Arctigenin disrupts NLRP3 inflammasome assembly in colonic macrophages via downregulating fatty acid oxidation to prevent colitis-associated cancer","volume":"491","author":"Qiao","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2025.115864_bb0690","doi-asserted-by":"crossref","first-page":"1360745","DOI":"10.3389\/fonc.2024.1360745","article-title":"In silico evaluation of anti-colorectal cancer inhibitors by resveratrol derivatives targeting Armadillo repeats domain of APC: molecular docking and molecular dynamics simulation","volume":"14","author":"Akash","year":"2024","journal-title":"Front. Oncol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0695","doi-asserted-by":"crossref","first-page":"904","DOI":"10.7150\/ijms.93903","article-title":"Natural product Quercetin-3-methyl ether promotes colorectal Cancer cell apoptosis by downregulating intracellular polyamine signaling","volume":"21","author":"Zeng","year":"2024","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.intimp.2025.115864_bb0700","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117529","article-title":"Gingerenone a induces ferroptosis in colorectal cancer via targeting suppression of SLC7A11 signaling pathway","volume":"180","author":"Xiao","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0705","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1002\/ptr.7735","article-title":"Targeting lipid metabolism with natural products: a novel strategy for gastrointestinal cancer therapy","volume":"37","author":"Guo","year":"2023","journal-title":"Phytother. Res."},{"issue":"7","key":"10.1016\/j.intimp.2025.115864_bb0710","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/s41418-023-01178-1","article-title":"Curcumin activates a ROS\/KEAP1\/NRF2\/miR-34a\/b\/c cascade to suppress colorectal cancer metastasis","volume":"30","author":"Liu","year":"2023","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0715","doi-asserted-by":"crossref","DOI":"10.1002\/biof.2137","article-title":"Suppression of colorectal cancer growth: interplay between curcumin and metformin through DMT1 downregulation and ROS-mediated pathways","volume":"51","author":"Chuang","year":"2025","journal-title":"Biofactors"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0720","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41420-023-01622-8","article-title":"Targeting survivin with Tanshinone IIA inhibits tumor growth and overcomes chemoresistance in colorectal cancer","volume":"9","author":"Cao","year":"2023","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2025.115864_bb0725","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fphar.2020.00273","article-title":"Atractylenolide I induces apoptosis and suppresses glycolysis by blocking the JAK2\/STAT3 signaling pathway in colorectal Cancer cells","volume":"11","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115864_bb0730","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.588079","article-title":"A holistic view of Berberine inhibiting intestinal carcinogenesis in conventional mice based on microbiome-metabolomics analysis","volume":"11","author":"Chen","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0735","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e23533","article-title":"An exploration of the effect of Chinese herbal compound on the occurrence and development of large intestine cancer and intestinal flora","volume":"10","author":"Liu","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.intimp.2025.115864_bb0740","doi-asserted-by":"crossref","first-page":"4319551","DOI":"10.1155\/2023\/4319551","article-title":"The efficacy and mechanism of Qinghua Jianpi recipe in inhibiting Canceration of colorectal adenoma based on inflammatory Cancer transformation","volume":"2023","author":"Liu","year":"2023","journal-title":"J. Immunol. Res."},{"issue":"5","key":"10.1016\/j.intimp.2025.115864_bb0745","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s00432-024-05763-w","article-title":"Modified Lichong decoction intervenes in colorectal cancer by modulating the intestinal flora and the Wnt\/beta-catenin signaling pathway","volume":"150","author":"Liu","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"46","key":"10.1016\/j.intimp.2025.115864_bb0750","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000031690","article-title":"Exploring the mechanism of Tengli Kangliu decoction in the prevention and treatment of colorectal cancer precancerous based on network pharmacology","volume":"101","author":"Liu","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.intimp.2025.115864_bb0755","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3389\/fonc.2020.00746","article-title":"Administration of Metabiotics Extracted from Probiotic Lactobacillus rhamnosus MD 14 inhibit experimental colorectal carcinogenesis by targeting Wnt\/beta-catenin pathway","volume":"10","author":"Sharma","year":"2020","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0760","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1038\/s41467-019-12594-8","article-title":"5-fluorouracil treatment induces characteristic T>G mutations in human cancer","volume":"10","author":"Christensen","year":"2019","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.intimp.2025.115864_bb0765","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3892\/etm.2022.11321","article-title":"Oxaliplatin induces ferroptosis and oxidative stress in HT29 colorectal cancer cells by inhibiting the Nrf2 signaling pathway","volume":"23","author":"Liu","year":"2022","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0770","doi-asserted-by":"crossref","first-page":"24674","DOI":"10.1038\/s41598-025-92436-4","article-title":"ABCE1 facilitates tumour progression via aerobic glycolysis and inhibits cell death in human colorectal cancer cells through the p53 signalling pathway","volume":"15","author":"Natarajan","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0775","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40170-022-00286-9","article-title":"Global metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress","volume":"10","author":"Marx","year":"2022","journal-title":"Cancer Metab."},{"issue":"6","key":"10.1016\/j.intimp.2025.115864_bb0780","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.7150\/ijbs.76704","article-title":"SIRT1 promotes glucolipid metabolic conversion to facilitate tumor development in colorectal carcinoma","volume":"19","author":"Wei","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0785","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40170-021-00260-x","article-title":"Lipopolysaccharide promotes metastasis via acceleration of glycolysis by the nuclear factor-kappaB\/snail\/hexokinase3 signaling axis in colorectal cancer","volume":"9","author":"Wu","year":"2021","journal-title":"Cancer Metab."},{"issue":"14","key":"10.1016\/j.intimp.2025.115864_bb0790","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23147673","article-title":"S-Adenosylmethionine inhibits colorectal Cancer cell migration through Mirna-mediated targeting of notch signaling pathway","volume":"23","author":"Borzacchiello","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0795","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1038\/s41598-025-87728-8","article-title":"ACOX1 activates autophagy via the ROS\/mTOR pathway to suppress proliferation and migration of colorectal cancer","volume":"15","author":"Shi","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0800","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1186\/s12885-025-13532-2","article-title":"Up-regulation of m(6)a writer METTL14 inhibits tumorigenesis by suppressing glycolysis in colorectal cancer","volume":"25","author":"Li","year":"2025","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.intimp.2025.115864_bb0805","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002503","article-title":"Single-cell RNA sequencing reveals distinct cellular factors for response to immunotherapy targeting CD73 and PD-1 in colorectal cancer","volume":"9","author":"Kim","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0810","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12964-024-02016-8","article-title":"FOXC1-mediated serine metabolism reprogramming enhances colorectal cancer growth and 5-FU resistance under serine restriction","volume":"23","author":"Chen","year":"2025","journal-title":"Cell Commun. Signal"},{"issue":"2","key":"10.1016\/j.intimp.2025.115864_bb0815","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26020664","article-title":"Energy metabolism and Stemness and the role of Lauric acid in reversing 5-fluorouracil resistance in colorectal Cancer cells","volume":"26","author":"Fujiwara-Tani","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115864_bb0820","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.115074","article-title":"A serum metabolomics study based on LC-MS: Chemosensitization effects of Rauvolfia vomitoria Afzel. Combined with 5- fluorouracil on colorectal cancer mice","volume":"221","author":"Wang","year":"2022","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0825","article-title":"An immunometabolism subtyping system identifies S100A9(+) macrophage as an immune therapeutic target in colorectal cancer based on multiomics analysis","volume":"4","author":"Bao","year":"2023","journal-title":"Cell Rep Med."},{"issue":"8","key":"10.1016\/j.intimp.2025.115864_bb0830","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1080\/1061186X.2022.2071909","article-title":"Targeting cellular energy metabolism- mediated ferroptosis by small molecule compounds for colorectal cancer therapy","volume":"30","author":"Wang","year":"2022","journal-title":"J. Drug Target."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0835","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3892\/etm.2022.11758","article-title":"Calorie restriction remodels gut microbiota and suppresses tumorigenesis of colorectal cancer in mice","volume":"25","author":"Dai","year":"2023","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0840","article-title":"Modulation of intestinal metabolites by calorie restriction and its association with gut microbiota in a xenograft model of colorectal cancer. Discover","volume":"15","author":"Zhang","year":"2024","journal-title":"Oncology"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0845","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12885-020-6513-4","article-title":"Immunogenomic pathways associated with cytotoxic lymphocyte infiltration and survival in colorectal cancer","volume":"20","author":"Shen","year":"2020","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0850","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13030425","article-title":"Cysteine and folate metabolism are targetable vulnerabilities of metastatic colorectal Cancer","volume":"13","author":"Tarrago-Celada","year":"2021","journal-title":"Cancers (Basel)."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0855","doi-asserted-by":"crossref","first-page":"9155","DOI":"10.1038\/s41598-025-94306-5","article-title":"The synergistic antitumour effect of Carrimycin combined with 5-fluorouracil on colorectal cancer","volume":"15","author":"Shi","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0860","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1186\/s12957-023-03222-3","article-title":"The efficacy and safety of anti-EGFR target agents in patients with potentially resectable metastatic colorectal cancer: a meta-analysis of randomized controlled trials","volume":"21","author":"Wang","year":"2023","journal-title":"World J. Surg. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0865","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s12885-024-12064-5","article-title":"Regulation of metastatic potential by drug repurposing and mitochondrial targeting in colorectal cancer cells","volume":"24","author":"Mathur","year":"2024","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0870","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s12885-024-12142-8","article-title":"Single-cell transcriptional signature-based drug repurposing and in vitro evaluation in colorectal cancer","volume":"24","author":"Mahdi-Esferizi","year":"2024","journal-title":"BMC Cancer"},{"issue":"4","key":"10.1016\/j.intimp.2025.115864_bb0875","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/procel\/pwad038","article-title":"Drug repurposing screening and mechanism analysis based on human colorectal cancer organoids","volume":"15","author":"Mao","year":"2024","journal-title":"Protein Cell"},{"issue":"3","key":"10.1016\/j.intimp.2025.115864_bb0880","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.3390\/curroncol30030196","article-title":"Mapping immune correlates and Surfaceome genes in BRAF mutated colorectal cancers","volume":"30","author":"Morafraile","year":"2023","journal-title":"Curr. Oncol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115864_bb0885","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007840","article-title":"Methylglyoxal from gut microbes boosts radiosensitivity and radioimmunotherapy in rectal cancer by triggering endoplasmic reticulum stress and cGAS-STING activation","volume":"11","author":"Zhou","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"8","key":"10.1016\/j.intimp.2025.115864_bb0890","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24087082","article-title":"Energy metabolism is altered in Radioresistant rectal Cancer","volume":"24","author":"Buckley","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0895","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e12515","article-title":"Metabolomic analysis of circulating tumor cells derived liver metastasis of colorectal cancer","volume":"9","author":"Li","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.intimp.2025.115864_bb0900","doi-asserted-by":"crossref","first-page":"1422281","DOI":"10.3389\/fphar.2024.1422281","article-title":"The critical role of glutamine and fatty acids in the metabolic reprogramming of anoikis-resistant melanoma cells","volume":"15","author":"Peppicelli","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0905","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/s41598-024-84300-8","article-title":"Glycosylation gene expression profiles enable prognosis prediction for colorectal cancer","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.115864_bb0910","first-page":"178","article-title":"Artificial intelligence in metabolomics: a current review","author":"Chi","year":"2024","journal-title":"Trends Analyt Chem."},{"issue":"10221","key":"10.1016\/j.intimp.2025.115864_bb0915","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0140-6736(19)32998-8","article-title":"Deep learning for prediction of colorectal cancer outcome: a discovery and validation study","volume":"395","author":"Skrede","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2025.115864_bb0920","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41540-025-00494-1","article-title":"Merging metabolic modeling and imaging for screening therapeutic targets in colorectal cancer","volume":"11","author":"Tavakoli","year":"2025","journal-title":"NPJ Syst Biol Appl."},{"key":"10.1016\/j.intimp.2025.115864_bb0925","article-title":"Transcriptome analysis reveals a reprogramming energy metabolism-related signature to improve prognosis in colon cancer","volume":"8","author":"Zhang","year":"2020","journal-title":"PeerJ"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:32:56Z","timestamp":1768401176000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925018521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":185,"alternative-id":["S1567576925018521"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115864","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of metabolic reprogramming in colorectal cancer and pharmacologic intervention","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115864"}}