{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:20:24Z","timestamp":1794000024191,"version":"4.8.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2023Y9284"],"award-info":[{"award-number":["2023Y9284"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2024Y9081"],"award-info":[{"award-number":["2024Y9081"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017357","name":"Science and Technology Projects of Fujian Province","doi-asserted-by":"publisher","award":["2023Y9320"],"award-info":[{"award-number":["2023Y9320"]}],"id":[{"id":"10.13039\/100017357","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017954","name":"Fujian Provincial Department of Finance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J08250"],"award-info":[{"award-number":["2024J08250"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J011105"],"award-info":[{"award-number":["2024J011105"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024Y0033"],"award-info":[{"award-number":["2024Y0033"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023J011159"],"award-info":[{"award-number":["2023J011159"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023J011846"],"award-info":[{"award-number":["2023J011846"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J011017"],"award-info":[{"award-number":["2024J011017"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","award":["2024QNA002"],"award-info":[{"award-number":["2024QNA002"]}],"id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","award":["2024GGA090"],"award-info":[{"award-number":["2024GGA090"]}],"id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","award":["2025QNGGA003"],"award-info":[{"award-number":["2025QNGGA003"]}],"id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014125","name":"Fujian Provincial Health Commission","doi-asserted-by":"publisher","award":["2024GGB02"],"award-info":[{"award-number":["2024GGB02"]}],"id":[{"id":"10.13039\/501100014125","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115888","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:41:17Z","timestamp":1763970077000},"page":"115888","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"P2","title":["Fasudil targets the RhoA\/ROCK-NLRP3 axis to attenuate aristolochic acid-induced renal pyroptosis: translational validation by in vivo molecular imaging"],"prefix":"10.1016","volume":"168","author":[{"given":"Mei-zhu","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-feng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-yan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-jun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-hai","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-fang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-ping","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan-dan","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-sheng","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu-ting","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-wei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2025.115888_bb0005","doi-asserted-by":"crossref","first-page":"579","DOI":"10.23876\/j.krcp.22.211","article-title":"Overview of aristolochic acid nephropathy: an update","volume":"42","author":"Zhou","year":"2023","journal-title":"Kidney Res Clin Pract"},{"issue":"2","key":"10.1016\/j.intimp.2025.115888_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020297","article-title":"An integrated view of aristolochic acid nephropathy: update of the literature","volume":"18","author":"Jadot","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"23","key":"10.1016\/j.intimp.2025.115888_bb0015","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1056\/NEJM200006083422301","article-title":"Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)","volume":"342","author":"Nortier","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2025.115888_bb0020","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0300-483X(02)00486-9","article-title":"Renal interstitial fibrosis and urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi)","volume":"181-182","author":"Nortier","year":"2002","journal-title":"Toxicology"},{"issue":"6","key":"10.1016\/j.intimp.2025.115888_bb0025","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/sj.jes.7500489","article-title":"Evaluation of the hypothesis that Balkan endemic nephropathy is caused by drinking water exposure to contaminants leaching from Pliocene coal deposits","volume":"16","author":"Voice","year":"2006","journal-title":"J. Expo. Sci. Environ. Epidemiol."},{"issue":"9","key":"10.1016\/j.intimp.2025.115888_bb0030","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1021\/acs.chemrestox.0c00229","article-title":"Determination of aristolochic acids in vegetables: nephrotoxic and carcinogenic environmental pollutants contaminating a broad swath of the food supply and driving incidence of Balkan endemic nephropathy","volume":"33","author":"Au","year":"2020","journal-title":"Chem. Res. Toxicol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115888_bb0035","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1021\/acs.est.9b05337","article-title":"Occurrence and environmental stability of aristolochic acids in groundwater collected from Serbia: links to human exposure and Balkan endemic nephropathy","volume":"54","author":"Tung","year":"2020","journal-title":"Environ. Sci. Technol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115888_bb0040","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ."},{"issue":"4","key":"10.1016\/j.intimp.2025.115888_bb0045","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1159\/000499685","article-title":"Caspase-11 mediates Pyroptosis of tubular epithelial cells and septic acute kidney injury","volume":"44","author":"Ye","year":"2019","journal-title":"Kidney Blood Press. Res."},{"issue":"10","key":"10.1016\/j.intimp.2025.115888_bb0050","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41419-018-1023-x","article-title":"Caspase-11-mediated tubular epithelial pyroptosis underlies contrast-induced acute kidney injury","volume":"9","author":"Zhang","year":"2018","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2025.115888_bb0055","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.kint.2019.04.035","article-title":"The cleavage of gasdermin D by caspase-11 promotes tubular epithelial cell pyroptosis and urinary IL-18 excretion in acute kidney injury","volume":"96","author":"Miao","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.intimp.2025.115888_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113881","article-title":"Autophagy promotes GSDME-mediated pyroptosis via intrinsic and extrinsic apoptotic pathways in cobalt chloride-induced hypoxia reoxygenation-acute kidney injury","volume":"242","author":"Liu","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/j.intimp.2025.115888_bb0065","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/cbin.12258","article-title":"Carnosol alleviates cisplatin-induced acute kidney injury by regulating apoptosis and pyroptosis","volume":"49","author":"Li","year":"2025","journal-title":"Cell Biol. Int."},{"issue":"1","key":"10.1016\/j.intimp.2025.115888_bb0070","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s12967-023-04350-w","article-title":"Identification of pyroptosis-related genes and potential drugs in diabetic nephropathy","volume":"21","author":"Yan","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115888_bb0075","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s13577-019-00306-9","article-title":"Hirsutella sinensis inhibits NLRP3 inflammasome activation to block aristolochic acid-induced renal tubular epithelial cell transdifferentiation","volume":"33","author":"Yu","year":"2020","journal-title":"Hum. Cell"},{"key":"10.1016\/j.intimp.2025.115888_bb0080","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.3389\/fimmu.2019.02277","article-title":"Interleukin-22 attenuated renal tubular injury in aristolochic acid nephropathy via suppressing activation of NLRP3 inflammasome","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115888_bb0085","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41419-021-03431-2","article-title":"Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation","volume":"12","author":"Xia","year":"2021","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2025.115888_bb0090","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/21541248.2021.1932402","article-title":"Rho GTPases in kidney physiology and diseases","volume":"13","author":"Steichen","year":"2022","journal-title":"Small GTPases"},{"key":"10.1016\/j.intimp.2025.115888_bb0095","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev.biochem.68.1.459","article-title":"Regulation of the cytoskeleton and cell adhesion by the rho family GTPases in mammalian cells","volume":"68","author":"Kaibuchi","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.intimp.2025.115888_bb0100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.biopha.2017.12.063","article-title":"CXCL16\/ROCK1 signaling pathway exacerbates acute kidney injury induced by ischemia-reperfusion","volume":"98","author":"Liang","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2025.115888_bb0105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molimm.2021.07.022","article-title":"ROCK1 regulates sepsis-induced acute kidney injury via TLR2-mediated endoplasmic reticulum stress\/pyroptosis axis","volume":"138","author":"Wang","year":"2021","journal-title":"Mol. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115888_bb0110","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/bcpt.12895","article-title":"Rho kinase inhibitor, Fasudil, attenuates contrast-induced acute kidney injury","volume":"122","author":"Wang","year":"2018","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115888_bb0115","doi-asserted-by":"crossref","first-page":"F1088","DOI":"10.1152\/ajprenal.90746.2008","article-title":"Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling","volume":"296","author":"Meyer-Schwesinger","year":"2009","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"43","key":"10.1016\/j.intimp.2025.115888_bb0120","doi-asserted-by":"crossref","first-page":"18294","DOI":"10.1021\/jacs.1c08898","article-title":"An activatable near-infrared fluorescence probe for in vivo imaging of acute kidney injury by targeting phosphatidylserine and Caspase-3","volume":"143","author":"Weng","year":"2021","journal-title":"J. Am. Chem. Soc."},{"issue":"1","key":"10.1016\/j.intimp.2025.115888_bb0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s10020-024-01020-5","article-title":"Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy","volume":"30","author":"Liu","year":"2024","journal-title":"Mol. Med."},{"issue":"Pt 1","key":"10.1016\/j.intimp.2025.115888_bb0130","article-title":"Ulinastatin attenuates renal ischemia-reperfusion injury by inhibiting NLRP3 inflammasome-triggered pyroptosis","volume":"143","author":"Huang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115888_bb0135","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12964-024-01556-3","article-title":"Acetyl-CoA synthetase 2 induces pyroptosis and inflammation of renal epithelial tubular cells in sepsis-induced acute kidney injury by upregulating the KLF5\/NF-kappaB pathway","volume":"22","author":"Lu","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"8","key":"10.1016\/j.intimp.2025.115888_bb0140","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2025.115888_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2020.105789","article-title":"Vitamin D\/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3\/Caspase-1\/GSDMD pyroptosis pathway","volume":"206","author":"Jiang","year":"2021","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.intimp.2025.115888_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119466","article-title":"Hydrogen sulfide reduces pyroptosis and alleviates ischemia-reperfusion-induced acute kidney injury by inhibiting NLRP3 inflammasome","volume":"284","author":"Ni","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.115888_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105531","article-title":"\u03b1Klotho protein has therapeutic activity in contrast-induced acute kidney injury by limiting NLRP3 inflammasome-mediated pyroptosis and promoting autophagy","volume":"167","author":"Zhu","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.115888_bb0160","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.kint.2023.12.007","article-title":"Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury","volume":"105","author":"Li","year":"2024","journal-title":"Kidney Int."},{"issue":"7661","key":"10.1016\/j.intimp.2025.115888_bb0165","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115888_bb0170","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biopha.2018.01.014","article-title":"MicroRNA-145 alleviates high glucose-induced proliferation and migration of vascular smooth muscle cells through targeting ROCK1","volume":"99","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.intimp.2025.115888_bb0175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.yexcr.2016.02.004","article-title":"Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic caspase 3","volume":"341","author":"Liu","year":"2016","journal-title":"Exp. Cell Res."},{"issue":"4","key":"10.1016\/j.intimp.2025.115888_bb0180","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.bbadis.2017.01.021","article-title":"ROCK1\/p53\/NOXA signaling mediates cardiomyocyte apoptosis in response to high glucose in vitro and vivo","volume":"1863","author":"Su","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"8","key":"10.1016\/j.intimp.2025.115888_bb0185","doi-asserted-by":"crossref","first-page":"F899","DOI":"10.1152\/ajprenal.00362.2014","article-title":"Signaling rho-kinase mediates inflammation and apoptosis in T cells and renal tubules in cisplatin nephrotoxicity","volume":"308","author":"Nozaki","year":"2015","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115888_bb0190","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jphs.2020.10.002","article-title":"Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro","volume":"145","author":"Xiang","year":"2021","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2025.115888_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.738121","article-title":"Renal ROCK activation and its pharmacological inhibition in patients with diabetes","volume":"12","author":"Matoba","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115888_bb0200","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41419-023-05680-9","article-title":"Honokiol suppresses the aberrant interactions between renal resident macrophages and tubular epithelial cells in lupus nephritis through the NLRP3\/IL-33\/ST2 axis","volume":"14","author":"Ma","year":"2023","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2025.115888_bb0205","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.kint.2024.10.026","article-title":"TRAIL induces podocyte PANoptosis via death receptor 5 in diabetic kidney disease","volume":"107","author":"Lv","year":"2025","journal-title":"Kidney Int."},{"issue":"Pt 1","key":"10.1016\/j.intimp.2025.115888_bb0210","article-title":"Omega-3 polyunsaturated fatty acids alleviate hyperuricemic nephropathy by inhibiting renal pyroptosis through GPR120","volume":"230","author":"Yang","year":"2024","journal-title":"Biochem. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018764?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018764?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:13:29Z","timestamp":1777619609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925018764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"alternative-id":["S1567576925018764"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115888","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fasudil targets the RhoA\/ROCK-NLRP3 axis to attenuate aristolochic acid-induced renal pyroptosis: translational validation by in vivo molecular imaging","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115888","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115888"}}