{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T18:38:55Z","timestamp":1784054335194,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115900","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T19:42:12Z","timestamp":1763754132000},"page":"115900","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"P2","title":["Bomidin prevents inflammatory responses in macrophages by inhibiting toll-like receptor 4\/nuclear factor-\u03baB activation and blocking metabolic reprogramming to alleviate periodontal inflammation"],"prefix":"10.1016","volume":"168","author":[{"given":"Shanshan","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongping","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixiang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunbo","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.intimp.2025.115900_bb0005","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11906-021-01140-x","article-title":"Periodontitis, blood pressure, and the risk and control of arterial hypertension: epidemiological, clinical, and pathophysiological aspects-review of the literature and clinical trials","volume":"23","author":"Surma","year":"2021","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.intimp.2025.115900_bb0010","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763334","article-title":"Polarized macrophages in periodontitis: characteristics, function, and molecular signaling","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115900_bb0015","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.biomaterials.2019.03.039","article-title":"Gold nanoparticles modulate the crosstalk between macrophages and periodontal ligament cells for periodontitis treatment","volume":"206","author":"Ni","year":"2019","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.intimp.2025.115900_bb0020","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","article-title":"Toll-like receptors and the control of immunity","volume":"180","author":"Fitzgerald","year":"2020","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2025.115900_bb0025","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1600-051X.2009.01370.x","article-title":"TLR4 as a risk factor for periodontal disease: a reappraisal","volume":"36","author":"Ozturk","year":"2009","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115900_bb0030","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13045-023-01478-6","article-title":"Metabolism, metabolites, and macrophages in cancer","volume":"16","author":"Li","year":"2023","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2025.115900_bb0035","doi-asserted-by":"crossref","first-page":"1199751","DOI":"10.3389\/fimmu.2023.1199751","article-title":"Glycolytic reprogramming in macrophages and MSCs during inflammation","volume":"14","author":"Li","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115900_bb0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the Warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.intimp.2025.115900_bb0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.canlet.2020.05.034","article-title":"Beyond glycolysis: hypoxia signaling as a master regulator of alternative metabolic pathways and the implications in clear cell renal cell carcinoma","volume":"489","author":"Bacigalupa","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2025.115900_bb0050","doi-asserted-by":"crossref","first-page":"1403915","DOI":"10.3389\/fcimb.2024.1403915","article-title":"Revisiting the role of hypoxia-inducible factors and nuclear factor erythroid 2-related factor 2 in regulating macrophage inflammation and metabolism","volume":"14","author":"Ting","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2025.115900_bb0055","article-title":"HIF1\u03b1-induced glycolysis metabolism is essential to the activation of inflammatory macrophages","volume":"2017","author":"Wang","year":"2017"},{"issue":"1","key":"10.1016\/j.intimp.2025.115900_bb0060","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13578-021-00560-1","article-title":"The YAP\/HIF-1\u03b1\/miR-182\/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation","volume":"11","author":"Zhou","year":"2021","journal-title":"Cell Biosci."},{"key":"10.1016\/j.intimp.2025.115900_bb0065","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.3389\/fmicb.2019.02866","article-title":"Mechanisms of action for antimicrobial peptides with antibacterial and antibiofilm functions","volume":"10","author":"Raheem","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.intimp.2025.115900_bb0070","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.actbio.2019.12.025","article-title":"Topical antimicrobial peptide formulations for wound healing: current developments and future prospects","volume":"103","author":"Thapa","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.intimp.2025.115900_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115227","article-title":"The antimicrobial peptide chensinin-1b alleviates the inflammatory response by targeting the TLR4\/NF-\u03baB signaling pathway and inhibits Pseudomonas aeruginosa infection and LPS-mediated sepsis","volume":"165","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"17","key":"10.1016\/j.intimp.2025.115900_bb0080","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.3390\/ijms21175973","article-title":"Therapeutic potential of cathelicidin peptide LL-37, an antimicrobial agent, in a murine sepsis model","volume":"21","author":"Nagaoka","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115900_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111423","article-title":"Bomidin attenuates inflammation of periodontal ligament stem cells and periodontitis in mice via inhibiting ferroptosis","volume":"127","author":"Wu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"21","key":"10.1016\/j.intimp.2025.115900_bb0090","doi-asserted-by":"crossref","first-page":"19791","DOI":"10.1021\/acs.jmedchem.4c02157","article-title":"Antibacterial, antibiofilm, and anti-inflammatory effects of a novel thrombin-derived peptide in Sepsis models: insights into underlying mechanisms","volume":"67","author":"Kumar","year":"2024","journal-title":"J. Med. Chem."},{"issue":"10","key":"10.1016\/j.intimp.2025.115900_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.108043","article-title":"Dental pulp stem cells accelerate wound healing through CCL2-induced M2 macrophages polarization","volume":"26","author":"Yang","year":"2023","journal-title":"iScience"},{"issue":"41","key":"10.1016\/j.intimp.2025.115900_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202101505","article-title":"Quercetin-loaded ceria nanocomposite potentiate dual-directional immunoregulation via macrophage polarization against periodontal inflammation","volume":"17","author":"Wang","year":"2021","journal-title":"Small (Weinheim an der Bergstrasse, Germany)"},{"issue":"21","key":"10.1016\/j.intimp.2025.115900_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111401","article-title":"Mechanism of antimicrobial peptides: antimicrobial, anti-inflammatory and antibiofilm activities","volume":"22","author":"Luo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"W1","key":"10.1016\/j.intimp.2025.115900_bb0110","doi-asserted-by":"crossref","first-page":"W365","DOI":"10.1093\/nar\/gkad414","article-title":"nCoVDock2: a docking server to predict the binding modes between COVID-19 targets and its potential ligands","volume":"51","author":"Liu","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"7242","key":"10.1016\/j.intimp.2025.115900_bb0115","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1038\/nature07830","article-title":"The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex","volume":"458","author":"Park","year":"2009","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2025.115900_bb0120","first-page":"362","article-title":"Imperatorin interferes with LPS binding to the TLR4 co-receptor and activates the Nrf2 antioxidative pathway in RAW264.7 murine macrophage cells","volume":"10","author":"Huang","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"32","key":"10.1016\/j.intimp.2025.115900_bb0125","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.3748\/wjg.v28.i32.4600","article-title":"Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1\u03b1-mediated glycolysis in hepatocellular carcinoma","volume":"28","author":"Zhou","year":"2022","journal-title":"World J. Gastroenterol."},{"issue":"10","key":"10.1016\/j.intimp.2025.115900_bb0130","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2850","article-title":"Measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) in culture cells for assessment of the energy metabolism","volume":"8","author":"Plitzko","year":"2018","journal-title":"Bio-protocol"},{"issue":"2","key":"10.1016\/j.intimp.2025.115900_bb0135","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.kint.2024.05.016","article-title":"Lactate: a missing link between metabolism and inflammation in CKD progression?","volume":"106","author":"Nishima","year":"2024","journal-title":"Kidney Int."},{"issue":"7","key":"10.1016\/j.intimp.2025.115900_bb0140","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.115900_bb0145","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41392-023-01499-0","article-title":"Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms","volume":"8","author":"Jia","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2025.115900_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011612","article-title":"Development of an antibody fused with an antimicrobial peptide targeting Pseudomonas aeruginosa: a new approach to prevent and treat bacterial infections","volume":"19","author":"Johnson","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.intimp.2025.115900_bb0155","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.pharmthera.2017.04.002","article-title":"Antimicrobial peptides: role in human disease and potential as immunotherapies","volume":"178","author":"de la Fuente-N\u00fa\u00f1ez","year":"2017","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2025.115900_bb0160","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3390\/biom14030320","article-title":"LL-37: structures, antimicrobial activity, and influence on amyloid-related diseases","volume":"14","author":"Bhattacharjya","year":"2024","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.intimp.2025.115900_bb0165","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s40168-023-01673-0","article-title":"Antimicrobial peptides modulate lung injury by altering the intestinal microbiota","volume":"11","author":"Abdelgawad","year":"2023","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.intimp.2025.115900_bb0170","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12602-021-09857-6","article-title":"Functional mechanism of antimicrobial peptide bomidin and its safety for Macrobrachium rosenbergii","volume":"14","author":"Zhang","year":"2022","journal-title":"Probiot. Antimicrob. Proteins"},{"key":"10.1016\/j.intimp.2025.115900_bb0175","article-title":"Bomidin: an optimized antimicrobial peptide with broad antiviral activity against enveloped viruses","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115900_bb0180","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1016\/j.bpj.2011.04.041","article-title":"Biophysical mechanisms of endotoxin neutralization by cationic amphiphilic peptides","volume":"100","author":"Kaconis","year":"2011","journal-title":"Biophys. J."},{"issue":"1","key":"10.1016\/j.intimp.2025.115900_bb0185","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrmicro1068","article-title":"LPS, TLR4 and infectious disease diversity","volume":"3","author":"Miller","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.intimp.2025.115900_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114291","article-title":"Toll-like receptor 4 (TLR4) inhibitors: current research and prospective","volume":"235","author":"Zhang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"9","key":"10.1016\/j.intimp.2025.115900_bb0195","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1021\/jm401006s","article-title":"Toll-like receptor 4 (TLR4) modulation by synthetic and natural compounds: an update","volume":"57","author":"Peri","year":"2014","journal-title":"J. Med. Chem."},{"issue":"35","key":"10.1016\/j.intimp.2025.115900_bb0200","doi-asserted-by":"crossref","first-page":"27431","DOI":"10.1039\/C4RA16731G","article-title":"Structure of a TLR4-interacting SPA4 peptide","volume":"5","author":"Awasthi","year":"2015","journal-title":"RSC Adv."},{"issue":"8","key":"10.1016\/j.intimp.2025.115900_bb0205","doi-asserted-by":"crossref","first-page":"659","DOI":"10.4049\/immunohorizons.2100067","article-title":"Mechanism of anti-inflammatory activity of TLR4-interacting SPA4 peptide","volume":"5","author":"Awasthi","year":"2021","journal-title":"ImmunoHorizons"},{"issue":"7","key":"10.1016\/j.intimp.2025.115900_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2023.119521","article-title":"NAT10 regulates the LPS-induced inflammatory response via the NOX2-ROS-NF-\u03baB pathway in macrophages","volume":"1870","author":"Zhang","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"Pt 3","key":"10.1016\/j.intimp.2025.115900_bb0215","article-title":"Flavonoid extract from propolis alleviates periodontitis by boosting periodontium regeneration and inflammation resolution via regulating TLR4\/MyD88\/NF-\u03baB and RANK\/NF-\u03baB pathway","volume":"319","author":"Tang","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115900_bb0220","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.7150\/thno.51777","article-title":"Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"issue":"14","key":"10.1016\/j.intimp.2025.115900_bb0225","article-title":"Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany)"},{"key":"10.1016\/j.intimp.2025.115900_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112933","article-title":"Natural compound phloretin restores periodontal immune homeostasis via HIF-1\u03b1-regulated PI3K\/Akt and glycolysis in macrophages","volume":"141","author":"Zeng","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.115900_bb0235","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3389\/fimmu.2019.01462","article-title":"The metabolic signature of macrophage responses","volume":"10","author":"Viola","year":"2019","journal-title":"Front. Immunol."},{"issue":"23","key":"10.1016\/j.intimp.2025.115900_bb0240","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1007\/s00018-021-03978-5","article-title":"Metabolic regulation of RA macrophages is distinct from RA fibroblasts and blockade of glycolysis alleviates inflammatory phenotype in both cell types","volume":"78","author":"Umar","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2025.115900_bb0245","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12950-017-0151-x","article-title":"Higher phagocytic activity of thioglycollate-elicited peritoneal macrophages is related to metabolic status of the cells","volume":"14","author":"Pavlou","year":"2017","journal-title":"J. Inflamm. (London, England)"},{"issue":"4","key":"10.1016\/j.intimp.2025.115900_bb0250","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.3892\/ijo.2015.2887","article-title":"Antimicrobial peptide FF\/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile","volume":"46","author":"Kuroda","year":"2015","journal-title":"Int. J. Oncol."},{"issue":"6","key":"10.1016\/j.intimp.2025.115900_bb0255","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1084\/jem.182.6.1683","article-title":"A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter","volume":"182","author":"Melillo","year":"1995","journal-title":"J. Exp. Med."},{"issue":"7444","key":"10.1016\/j.intimp.2025.115900_bb0260","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2025.115900_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110514","article-title":"Formaldehyde exacerbates asthma in mice through the potentiation of HIF-1\u03b1-mediated pro-inflammatory responses in pulmonary macrophages","volume":"379","author":"Ma","year":"2023","journal-title":"Chem. Biol. Interact."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T14:16:02Z","timestamp":1766153762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925018880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":53,"alternative-id":["S1567576925018880"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115900","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bomidin prevents inflammatory responses in macrophages by inhibiting toll-like receptor 4\/nuclear factor-\u03baB activation and blocking metabolic reprogramming to alleviate periodontal inflammation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115900","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115900"}}