{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T04:36:11Z","timestamp":1778214971398,"version":"3.51.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017683","name":"Dalian Science and Technology Innovation Fund","doi-asserted-by":"publisher","award":["2025JJ11PT006"],"award-info":[{"award-number":["2025JJ11PT006"]}],"id":[{"id":"10.13039\/501100017683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204629"],"award-info":[{"award-number":["82204629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012131","name":"Department of Science and Technology of Liaoning Province","doi-asserted-by":"publisher","award":["2024JH2\/102600066"],"award-info":[{"award-number":["2024JH2\/102600066"]}],"id":[{"id":"10.13039\/501100012131","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115910","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T22:01:00Z","timestamp":1763848860000},"page":"115910","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P2","title":["Dual-targeted hybrid micelles mediated by VCAM-1 suppress synovial angiogenesis in rheumatoid arthritis"],"prefix":"10.1016","volume":"168","author":[{"given":"Yuanyuan","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruibo","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runchao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10416","key":"10.1016\/j.intimp.2025.115910_bb0005","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"issue":"10055","key":"10.1016\/j.intimp.2025.115910_bb0010","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.intimp.2025.115910_bb0015","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1159\/000493390","article-title":"Rheumatoid arthritis: a brief overview of the treatment","volume":"27","author":"Bullock","year":"2018","journal-title":"Med. Princ. Pract."},{"issue":"2","key":"10.1016\/j.intimp.2025.115910_bb0020","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/rheumatology\/38.2.103","article-title":"Angiogenesis and arthritis","volume":"38","author":"Walsh","year":"1999","journal-title":"Rheumatology (Oxford)"},{"issue":"7","key":"10.1016\/j.intimp.2025.115910_bb0025","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.3390\/ijms19072012","article-title":"Implications of angiogenesis involvement in arthritis","volume":"19","author":"MacDonald","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115910_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174500","article-title":"Angiogenesis as a potential treatment strategy for rheumatoid arthritis","volume":"910","author":"Wang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115910_bb0035","doi-asserted-by":"crossref","first-page":"23","DOI":"10.15586\/aei.v50i4.591","article-title":"Polyphyllin I alleviates lipopolysaccharide-induced inflammation reduces pyroptosis in BEAS-2B and HPAEC cells by inhibiting NF-\u03baB signaling","volume":"50","author":"Mao","year":"2022","journal-title":"Allergol Immunopathol (Madr)"},{"key":"10.1016\/j.intimp.2025.115910_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155135","article-title":"Polyphyllin I induced ferroptosis to suppress the progression of hepatocellular carcinoma through activation of the mitochondrial dysfunction via Nrf2\/HO-1\/GPX4 axis","volume":"122","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.intimp.2025.115910_bb0045","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1111\/apm.13353","article-title":"Polyphyllin I, a strong antifungal compound against Candida albicans","volume":"131","author":"Zhang","year":"2023","journal-title":"APMIS"},{"issue":"10","key":"10.1016\/j.intimp.2025.115910_bb0050","doi-asserted-by":"crossref","first-page":"644","DOI":"10.21037\/atm-20-3371","article-title":"The protective effect of polyphyllin I on myocardial ischemia\/reperfusion injury in rats","volume":"8","author":"Huang","year":"2020","journal-title":"Ann Transl Med."},{"key":"10.1016\/j.intimp.2025.115910_bb0055","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.3389\/fimmu.2018.02091","article-title":"Polyphyllin I ameliorates collagen-induced arthritis by suppressing the inflammation response in macrophages through the NF-\u03baB pathway","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115910_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110750","article-title":"Inhibitory effects of Paris saponin I, II, VI and VII on HUVEC cells through regulation of VEGFR2, PI3K\/AKT\/mTOR, Src\/eNOS, PLC\u03b3\/ERK\/MERK, and JAK2-STAT3 pathways","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.intimp.2025.115910_bb0065","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/acs.molpharmaceut.0c00295","article-title":"Nanomedicine for the treatment of rheumatoid arthritis","volume":"18","author":"Jeong","year":"2021","journal-title":"Mol. Pharm."},{"issue":"3","key":"10.1016\/j.intimp.2025.115910_bb0070","doi-asserted-by":"crossref","first-page":"316","DOI":"10.4103\/RPS.RPS_40_25","article-title":"Synthesis and in vitro evaluation of novel pH-triggered biocompatible folate-chondroitin sulfate-dexamethasone copolymers for delivery of tofacitinib in rheumatoid arthritis","volume":"20","author":"Ansarypour","year":"2025","journal-title":"Res Pharm Sci."},{"key":"10.1016\/j.intimp.2025.115910_bb0075","article-title":"Hyaluronic acid-anchored nanoparticles co-delivering emodin and siRNA confers protection against rheumatoid arthritis via macrophage polarization","volume":"33","author":"Qin","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.intimp.2025.115910_bb0080","doi-asserted-by":"crossref","first-page":"8967","DOI":"10.2147\/IJN.S516434","article-title":"DS-modified Paeoniflorin pH-responsive lipid-polymer hybrid nanoparticles for targeted macrophage polarization in a rat model of rheumatoid arthritis","volume":"20","author":"Zhang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.intimp.2025.115910_bb0085","article-title":"Eucommia ulmoides polysaccharides attenuate rabbit osteoarthritis by regulating the function of macrophages","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115910_bb0090","doi-asserted-by":"crossref","first-page":"29647","DOI":"10.1038\/s41598-024-80859-4","article-title":"Eucommia ulmoides Oliver polysaccharide alleviates glucocorticoid-induced osteoporosis by stimulating bone formation via ERK\/BMP-2\/SMAD signaling","volume":"14","author":"Song","year":"2024","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2025.115910_bb0095","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/14728222.2023.2187778","article-title":"Targeting VCAM-1: a therapeutic opportunity for vascular damage","volume":"27","author":"Troncoso","year":"2023","journal-title":"Expert Opin. Ther. Targets"},{"issue":"8","key":"10.1016\/j.intimp.2025.115910_bb0100","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2217\/nnm-2023-0282","article-title":"VCAM-1-targeted nanoparticles to diagnose, monitor and treat atherosclerosis","volume":"19","author":"Castro","year":"2024","journal-title":"Nanomedicine (London)"},{"key":"10.1016\/j.intimp.2025.115910_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119047","article-title":"Engineered DNA nanodrugs alleviate inflammation in inflammatory arthritis","volume":"577","author":"Wang","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.intimp.2025.115910_bb0110","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1684\/ecn.2023.0481","article-title":"Acetylcholine suppresses LPS-induced endothelial cell activation by inhibiting the MAPK and NF-\u03baB pathways","volume":"33","author":"Li","year":"2022","journal-title":"Eur. Cytokine Netw."},{"key":"10.1016\/j.intimp.2025.115910_bb0115","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.lfs.2015.06.015","article-title":"Biochanin a inhibits lipopolysaccharide-induced inflammation in human umbilical vein endothelial cells","volume":"136","author":"Ming","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2025.115910_bb0120","article-title":"Fluorescent nanocarriers targeting VCAM-1 for early detection of senescent endothelial cells","volume":"34","author":"Belcastro","year":"2021","journal-title":"Nanomedicine"},{"issue":"12","key":"10.1016\/j.intimp.2025.115910_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083805","article-title":"Characterization of VCAM-1-binding peptide-functionalized quantum dots for molecular imaging of inflamed endothelium","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2025.115910_bb0130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mvr.2016.04.003","article-title":"Potential of mZD7349-conjugated PLGA nanoparticles for selective targeting of vascular cell-adhesion molecule-1 in inflamed endothelium","volume":"106","author":"Imanparast","year":"2016","journal-title":"Microvasc. Res."},{"issue":"7","key":"10.1016\/j.intimp.2025.115910_bb0135","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.3390\/ijms23073824","article-title":"VCAM-1 targeted Lipopolyplexes as vehicles for efficient delivery of shRNA-Runx2 to osteoblast-differentiated Valvular interstitial cells; implications in calcific valve disease treatment","volume":"23","author":"Voicu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.intimp.2025.115910_bb0140","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.3390\/molecules25153437","article-title":"Anti-VCAM-1 and anti-IL4R\u03b1 aptamer-conjugated super paramagnetic Iron oxide nanoparticles for enhanced breast Cancer diagnosis and therapy","volume":"25","author":"Chinnappan","year":"2020","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.intimp.2025.115910_bb0145","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3390\/ijms23020905","article-title":"Rheumatoid arthritis: pathogenic roles of diverse immune cells","volume":"23","author":"Jang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115910_bb0150","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jot.2021.01.003","article-title":"Treatment of collagen-induced arthritis rat model by using notch signalling inhibitor","volume":"28","author":"Chen","year":"2021","journal-title":"J Orthop Translat."},{"key":"10.1016\/j.intimp.2025.115910_bb0155","article-title":"Promising therapeutic targets for treatment of rheumatoid arthritis","volume":"12","author":"Huang","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115910_bb0160","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11010-022-04492-3","article-title":"Rheumatoid arthritis: advances in treatment strategies","volume":"478","author":"Prasad","year":"2023","journal-title":"Mol. Cell. Biochem."},{"issue":"11","key":"10.1016\/j.intimp.2025.115910_bb0165","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202300678","article-title":"Genetically engineered biomimetic nanoparticles for targeted delivery of mRNA to treat rheumatoid arthritis","volume":"7","author":"Chen","year":"2023","journal-title":"Small Methods"},{"key":"10.1016\/j.intimp.2025.115910_bb0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jot.2023.05.004","article-title":"HIF-1\u03b1 dependent RhoA as a novel therapeutic target to regulate rheumatoid arthritis fibroblast-like synoviocytes migration in vitro and in vivo","volume":"40","author":"Chen","year":"2023","journal-title":"J Orthop Translat."},{"issue":"10","key":"10.1016\/j.intimp.2025.115910_bb0175","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1002\/art.41748","article-title":"Notch-1 and Notch-3 mediate hypoxia-induced activation of synovial fibroblasts in rheumatoid arthritis","volume":"73","author":"Chen","year":"2021","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2025.115910_bb0180","article-title":"pH-sensitive nano-polyelectrolyte complexes with arthritic macrophage-targeting delivery of triptolide","volume":"632","author":"Li","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.intimp.2025.115910_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120390","article-title":"Targeted silver nanoparticles for rheumatoid arthritis therapy via macrophage apoptosis and re-polarization","volume":"264","author":"Yang","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2025.115910_bb0190","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.ijbiomac.2019.08.145","article-title":"Fabrication of strontium Eucommia ulmoides polysaccharides and in vitro evaluation of their osteoimmunomodulatory property","volume":"140","author":"Deng","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.115910_bb0195","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ijbiomac.2022.05.048","article-title":"Surface modification of polyetheretherketone (PEEK) to enhance osteointegration by grafting strontium Eucommia ulmoides polysaccharides","volume":"211","author":"Mengdi","year":"2022","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115910_bb0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s40824-023-00361-2","article-title":"Surface modifications of titanium dental implants with strontium eucommia ulmoides to enhance osseointegration and suppress inflammation","volume":"27","author":"Sun","year":"2023","journal-title":"Biomater Res."},{"issue":"7","key":"10.1016\/j.intimp.2025.115910_bb0205","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/1061186X.2022.2053539","article-title":"A pH-driven indomethacin-loaded nanomedicine for effective rheumatoid arthritis therapy by combining with photothermal therapy","volume":"30","author":"Hu","year":"2022","journal-title":"J. Drug Target."},{"key":"10.1016\/j.intimp.2025.115910_bb0210","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mvr.2016.04.003","article-title":"Potential of mZD7349-conjugated PLGA nanoparticles for selective targeting of vascular cell-adhesion molecule-1 in inflamed endothelium","volume":"106","author":"Imanparast","year":"2016","journal-title":"Microvasc. Res."},{"issue":"2","key":"10.1016\/j.intimp.2025.115910_bb0215","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/bit.21885","article-title":"Polymeric particles conjugated with a ligand to VCAM-1 exhibit selective, avid, and focal adhesion to sites of atherosclerosis","volume":"101","author":"Deosarkar","year":"2008","journal-title":"Biotechnol. Bioeng."},{"issue":"3","key":"10.1016\/j.intimp.2025.115910_bb0220","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/02652048.2011.552989","article-title":"Preparation and in vitro evaluation of anti-VCAM-1-fab\u2019-conjugated liposomes for the targeted delivery of the poorly water-soluble drug celecoxib","volume":"28","author":"Kang","year":"2011","journal-title":"J. Microencapsul."},{"key":"10.1016\/j.intimp.2025.115910_bb0225","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cbi.2017.12.024","article-title":"Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis","volume":"281","author":"Phull","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"36","key":"10.1016\/j.intimp.2025.115910_bb0230","doi-asserted-by":"crossref","first-page":"47206","DOI":"10.1021\/acsami.4c09080","article-title":"Mesenchymal stem cell-based biomimetic liposome for targeted treatment of rheumatoid arthritis","volume":"16","author":"Ma","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.intimp.2025.115910_bb0235","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biomaterials.2017.03.044","article-title":"Dextran sulfate nanoparticles as a theranostic nanomedicine for rheumatoid arthritis","volume":"131","author":"Heo","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2025.115910_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174500","article-title":"Angiogenesis as a potential treatment strategy for rheumatoid arthritis","volume":"910","author":"Wang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2025.115910_bb0245","doi-asserted-by":"crossref","first-page":"16118","DOI":"10.1021\/acsnano.2c04491","article-title":"Porous silicon-based nanomedicine for simultaneous Management of Joint Inflammation and Bone Erosion in rheumatoid arthritis","volume":"16","author":"Jeong","year":"2022","journal-title":"ACS Nano"},{"key":"10.1016\/j.intimp.2025.115910_bb0250","article-title":"ROS-scavenging hydrogen nanotherapy simultaneously targets inflammation and pain in rheumatoid arthritis","volume":"33","author":"Wu","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"3","key":"10.1016\/j.intimp.2025.115910_bb0255","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/ar746","article-title":"CD44 in rheumatoid arthritis","volume":"5","author":"Naor","year":"2003","journal-title":"Arthritis Res. Ther."},{"issue":"11","key":"10.1016\/j.intimp.2025.115910_bb0260","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/art.1780341115","article-title":"Measurement of an adhesion molecule as an indicator of inflammatory disease activity. Up-regulation of the receptor for hyaluronate (CD44) in rheumatoid arthritis","volume":"34","author":"Haynes","year":"1991","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.intimp.2025.115910_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2022.155835","article-title":"Moxibustion regulates the polarization of macrophages through the IL-4\/STAT6 pathway in rheumatoid arthritis","volume":"152","author":"Zhong","year":"2022","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2025.115910_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in rheumatoid arthritis synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115910_bb0275","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1089\/dna.2022.0509","article-title":"A single-cell RNA-sequencing analysis of distinct subsets of synovial macrophages in rheumatoid arthritis","volume":"42","author":"Li","year":"2023","journal-title":"DNA Cell Biol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115910_bb0280","first-page":"961","article-title":"The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis","volume":"17","author":"Afuwape","year":"2002","journal-title":"Histol. Histopathol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925018983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:01:54Z","timestamp":1771513314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925018983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":56,"alternative-id":["S1567576925018983"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115910","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-targeted hybrid micelles mediated by VCAM-1 suppress synovial angiogenesis in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115910","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115910"}}