{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:24:16Z","timestamp":1786991056082,"version":"build-2736575974"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023ZD16"],"award-info":[{"award-number":["ZR2023ZD16"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2025M772006"],"award-info":[{"award-number":["2025M772006"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82220108005"],"award-info":[{"award-number":["82220108005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115942","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:49:27Z","timestamp":1764722967000},"page":"115942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Dual suppression of AKT\/MAPK signaling and activation of Nrf2 by methylnissolin attenuates osteoclastogenesis and prevents postmenopausal osteoporosis"],"prefix":"10.1016","volume":"169","author":[{"given":"Yanbin","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijian","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaohui","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqing","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2025.115942_bb0005","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/med.22081","article-title":"Estrogen deficiency-mediated osteoimmunity in postmenopausal osteoporosis","volume":"45","author":"Yao","year":"2025","journal-title":"Med. Res. Rev."},{"issue":"6","key":"10.1016\/j.intimp.2025.115942_bb0010","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1007\/s11914-021-00702-x","article-title":"Osteocytes and estrogen deficiency","volume":"19","author":"McNamara","year":"2021","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.intimp.2025.115942_bb0015","doi-asserted-by":"crossref","first-page":"1551542","DOI":"10.3389\/fimmu.2025.1551542","article-title":"From death to birth: how osteocyte death promotes osteoclast formation","volume":"16","author":"Zhao","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115942_bb0020","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.semcdb.2021.05.014","article-title":"Interaction between bone and immune cells: implications for postmenopausal osteoporosis","volume":"123","author":"Fischer","year":"2022","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2025.115942_bb0025","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3389\/fcell.2020.00433","article-title":"Cathepsin K: the action in and beyond bone","volume":"8","author":"Dai","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115942_bb0030","first-page":"676","article-title":"Postmenopausal osteoporosis. Reply","volume":"390","author":"Walker","year":"2024","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.intimp.2025.115942_bb0035","doi-asserted-by":"crossref","first-page":"8570","DOI":"10.1002\/jcp.27833","article-title":"Prospect of mesenchymal stem cells in therapy of osteoporosis: a review","volume":"234","author":"Aghebati-Maleki","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115942_bb0040","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/s12276-024-01157-7","article-title":"Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases","volume":"56","author":"Takegahara","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2025.115942_bb0045","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202402646R","article-title":"Prussian blue nanoparticles prevent RANKL-induced osteoclastogenesis by scavenging ROS and inactivating NF-kappaB\/MAPK signaling pathways","volume":"39","author":"Yang","year":"2025","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.intimp.2025.115942_bb0050","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s12016-025-09046-1","article-title":"Osteoimmunology: crosstalk between T cells and osteoclasts in osteoporosis","volume":"68","author":"Lu","year":"2025","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115942_bb0055","article-title":"Posttranslational modification in bone homeostasis and osteoporosis","volume":"6","author":"Lin","year":"2025","journal-title":"MedComm (2020)"},{"issue":"6","key":"10.1016\/j.intimp.2025.115942_bb0060","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/JCMA.0000000000001096","article-title":"Suppression of bone resorption by Mori Radicis Cortex through NFATc1 and c-Fos signaling-mediated inhibition of osteoclast differentiation","volume":"87","author":"Hong","year":"2024","journal-title":"J. Chin. Med. Assoc."},{"key":"10.1016\/j.intimp.2025.115942_bb0065","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.freeradbiomed.2023.12.043","article-title":"Redox signaling and antioxidant defense in osteoclasts","volume":"212","author":"Tao","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.intimp.2025.115942_bb0070","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s11914-023-00824-4","article-title":"Inflammatory processes affecting bone health and repair","volume":"21","author":"Torres","year":"2023","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.intimp.2025.115942_bb0075","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.95083","article-title":"Current perspectives on the multiple roles of osteoclasts: mechanisms of osteoclast-osteoblast communication and potential clinical implications","volume":"13","author":"Daponte","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.intimp.2025.115942_bb0080","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12929-015-0212-5","article-title":"Role of Nrf2 in bone metabolism","volume":"22","author":"Sun","year":"2015","journal-title":"J. Biomed. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2025.115942_bb0085","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/med.21504","article-title":"The underlying pathophysiology and therapeutic approaches for osteoporosis","volume":"38","author":"Awasthi","year":"2018","journal-title":"Med. Res. Rev."},{"issue":"21","key":"10.1016\/j.intimp.2025.115942_bb0090","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11216434","article-title":"A mini review on osteoporosis: from biology to pharmacological management of bone loss","volume":"11","author":"Chin","year":"2022","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115942_bb0095","article-title":"Bisphosphonates for osteoporosis in people with cystic fibrosis","volume":"1","author":"Jeffery","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.intimp.2025.115942_bb0100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1749-6632.2010.05768.x","article-title":"Bisphosphonate-related osteonecrosis of the jaw: an overview","volume":"1218","author":"Ruggiero","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2025.115942_bb0105","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1210\/endrev\/bnae010","article-title":"Targeting cell senescence and senolytics: novel interventions for age-related endocrine dysfunction","volume":"45","author":"Suda","year":"2024","journal-title":"Endocr. Rev."},{"issue":"12","key":"10.1016\/j.intimp.2025.115942_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12124042","article-title":"Managing early onset osteoporosis: the impact of premature ovarian insufficiency on bone health","volume":"12","author":"Meczekalski","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2025.115942_bb0115","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.2147\/DDDT.S518508","article-title":"A natural compound methylnissolin: physicochemical properties, pharmacological activities, pharmacokinetics and resource development","volume":"19","author":"Lin","year":"2025","journal-title":"Drug Des. Devel. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2025.115942_bb0120","first-page":"346","article-title":"Review, revision, and prospect of list of substances with both edible and medicinal values in China","volume":"50","author":"Sun","year":"2025","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.intimp.2025.115942_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.839885","article-title":"Comparative efficacy of Xianling Gubao capsules in improving bone mineral density in postmenopausal osteoporosis: a network meta-analysis","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.intimp.2025.115942_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2019.153063","article-title":"Gushukang inhibits osteocyte apoptosis and enhances BMP-2\/Smads signaling pathway in ovariectomized rats","volume":"64","author":"Chai","year":"2019","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.intimp.2025.115942_bb0135","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.62347\/GCDD8292","article-title":"Xianling Gubao capsules improve oral health, alveolar bone defects, and bone density in patients with periodontitis","volume":"17","author":"Zhou","year":"2025","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.intimp.2025.115942_bb0140","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-0716-2736-5_4","article-title":"Flow cytometry and cell cycle analysis: an overview","volume":"2579","author":"Rieger","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.intimp.2025.115942_bb0145","doi-asserted-by":"crossref","first-page":"4811","DOI":"10.2147\/DDDT.S328238","article-title":"Oroxin B attenuates ovariectomy-induced bone loss by suppressing osteoclast formation and activity","volume":"15","author":"Huang","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2025.115942_bb0150","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1038\/s12276-023-01085-y","article-title":"CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1\/HSP90beta complex","volume":"55","author":"Chen","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2025.115942_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.645140","article-title":"Inhibitory effects of rhaponticin on osteoclast formation and resorption by targeting RANKL-induced NFATc1 and ROS activity","volume":"12","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115942_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157279","article-title":"Farrerol alleviates microbiota dysbiosis-associated osteoporosis in IBD by inhibiting PI3K-AKT\/MAPK signaling pathways","volume":"148","author":"Yin","year":"2025","journal-title":"Phytomedicine"},{"issue":"11","key":"10.1016\/j.intimp.2025.115942_bb0165","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrrheum.2011.130","article-title":"New targets for intervention in the treatment of postmenopausal osteoporosis","volume":"7","author":"Lewiecki","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115942_bb0170","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00198-024-07340-w","article-title":"Assessment of trabecular bone Hounsfield units in the lumbar spine for osteoporosis evaluation in individuals aged 65 and above: a review","volume":"36","author":"Alharthy","year":"2025","journal-title":"Osteoporos. Int."},{"issue":"5","key":"10.1016\/j.intimp.2025.115942_bb0175","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1142\/S0192415X24500526","article-title":"Insight of Chinese herbal medicine in treating osteoporosis: achievements from 2013 to 2023","volume":"52","author":"Tan","year":"2024","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.intimp.2025.115942_bb0180","article-title":"Expert consensus on the bone repair strategy for osteoporotic fractures in China","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.intimp.2025.115942_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111598","article-title":"Mechanisms of ferroptosis in bone disease: a new target for osteoporosis treatment","volume":"127","author":"Wang","year":"2025","journal-title":"Cell. Signal."},{"issue":"3","key":"10.1016\/j.intimp.2025.115942_bb0190","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.amjmed.2023.11.018","article-title":"Medication-related osteonecrosis of the jaw: a cross-sectional study on the prevalence of cutaneous manifestations and the primary care physician\u2019s role in its early diagnosis","volume":"137","author":"Whitefield","year":"2024","journal-title":"Am. J. Med."},{"issue":"5","key":"10.1016\/j.intimp.2025.115942_bb0195","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41584-023-00935-3","article-title":"Mechanisms underlying the long-term and withdrawal effects of denosumab therapy on bone","volume":"19","author":"Ferrari","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"issue":"13","key":"10.1016\/j.intimp.2025.115942_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26133852","article-title":"Cytoprotection against oxidative stress by methylnissolin-3-O-beta-d-glucopyranoside from Astragalus membranaceus mainly via the activation of the Nrf2\/HO-1 pathway","volume":"26","author":"Wu","year":"2021","journal-title":"Molecules"},{"issue":"13","key":"10.1016\/j.intimp.2025.115942_bb0205","article-title":"Dual beneficial effects of methylnissolin-3-O-beta-d-glucopyranoside on obesity-induced inflammatory responses in adipocyte-macrophage co-culture","volume":"11","author":"Lee","year":"2022","journal-title":"Plants (Basel)"},{"key":"10.1016\/j.intimp.2025.115942_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157472","article-title":"Bisabolangelone targets CSF1R to impede osteoclastogenesis and attenuate estrogen-deficiency bone loss","volume":"148","author":"Mo","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.115942_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157293","article-title":"Specnuezhenide attenuates rheumatoid arthritis bone destruction via dual regulation of osteoclast-osteoblast balance through KEAP1\/NRF2 signaling","volume":"148","author":"Yao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.115942_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.818462","article-title":"Cathepsin K(+) non-osteoclast cells in the skeletal system: function, models, identity, and therapeutic implications","volume":"10","author":"Zou","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115942_bb0225","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41413-025-00433-0","article-title":"Mouse model of anti-RANKL discontinuation reveals reduced bone mass and quality through disruption of bone remodeling","volume":"13","author":"Ishikawa","year":"2025","journal-title":"Bone Res."},{"key":"10.1016\/j.intimp.2025.115942_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101842","article-title":"Physiological functions of podosomes: from structure and function to therapy implications in osteoclast biology of bone resorption","volume":"85","author":"Chen","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"11","key":"10.1016\/j.intimp.2025.115942_bb0235","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.7150\/ijms.108763","article-title":"Unraveling the role of N6-methylation modification: from bone biology to osteoporosis","volume":"22","author":"Liu","year":"2025","journal-title":"Int. J. Med. Sci."},{"issue":"20","key":"10.1016\/j.intimp.2025.115942_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015342","article-title":"Extracellular signal-regulated kinases play essential but contrasting roles in osteoclast differentiation","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2025.115942_bb0245","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.freeradbiomed.2025.10.284","article-title":"Corosolic acid modulates RANKL-triggered signaling to suppress osteoclastogenesis and ovariectomy-induced bone loss","volume":"241","author":"Zhao","year":"2025","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2025.115942_bb0250","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.freeradbiomed.2025.06.043","article-title":"Idebenone attenuates RANKL-induced osteoclastogenesis and improves bone mass in ovariectomized mice","volume":"238","author":"Yu","year":"2025","journal-title":"Free Radic. Biol. Med."},{"issue":"15","key":"10.1016\/j.intimp.2025.115942_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153792","article-title":"Extracellular signal-regulated kinase: a regulator of cell growth, inflammation, chondrocyte and bone cell receptor-mediated gene expression","volume":"20","author":"Lu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2025.115942_bb0260","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1080\/1061186X.2021.2013488","article-title":"Effects and mechanisms of natural plant active compounds for the treatment of osteoclast-mediated bone destructive diseases","volume":"30","author":"Xu","year":"2022","journal-title":"J. Drug Target."},{"issue":"10","key":"10.1016\/j.intimp.2025.115942_bb0265","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/jbmr.3810","article-title":"Specific RANK cytoplasmic motifs drive osteoclastogenesis","volume":"34","author":"Li","year":"2019","journal-title":"J. Bone Miner. Res."},{"issue":"37","key":"10.1016\/j.intimp.2025.115942_bb0270","doi-asserted-by":"crossref","first-page":"20383","DOI":"10.1021\/acs.jafc.4c02982","article-title":"Tetrahydroberberine prevents ovariectomy-induced bone loss by inhibiting RANKL-induced osteoclastogenesis and promoting osteoclast apoptosis","volume":"72","author":"Wu","year":"2024","journal-title":"J. Agric. Food Chem."},{"issue":"2","key":"10.1016\/j.intimp.2025.115942_bb0275","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1128\/MCB.06361-11","article-title":"Selective signaling by Akt1 controls osteoblast differentiation and osteoblast-mediated osteoclast development","volume":"32","author":"Mukherjee","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.intimp.2025.115942_bb0280","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2025.1536851","article-title":"Identification of a key environment-responsive gene mediating environmental impact on postmenopausal osteoporosis","volume":"13","author":"Wan","year":"2025","journal-title":"Front. Public Health"},{"key":"10.1016\/j.intimp.2025.115942_bb0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114834","article-title":"Oxidative stress: a common pathological state in a high-risk population for osteoporosis","volume":"163","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"17","key":"10.1016\/j.intimp.2025.115942_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241713327","article-title":"Role of the Nrf2 signaling pathway in ovarian aging: potential mechanism and protective strategies","volume":"24","author":"Gao","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2025.115942_bb0295","article-title":"Transcriptomic characterization reveals mitochondrial involvement in Nrf2\/Keap1-mediated osteoclastogenesis","volume":"13","author":"Sakai","year":"2024","journal-title":"Antioxidants (Basel)"},{"issue":"Pt 2","key":"10.1016\/j.intimp.2025.115942_bb0300","article-title":"VSIG4 inhibits RANKL-induced osteoclastogenesis by enhancing Nrf2-dependent antioxidant response against reactive oxygen species production","volume":"260","author":"Miao","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.intimp.2025.115942_bb0305","article-title":"Three classes of antioxidant defense systems and the development of postmenopausal osteoporosis","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2025.115942_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107686","article-title":"A sinomenine derivative alleviates bone destruction in collagen-induced arthritis mice by suppressing mitochondrial dysfunction and oxidative stress via the NRF2\/HO-1\/NQO1 signaling pathway","volume":"215","author":"Guo","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2025.115942_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114299","article-title":"Nicorandil-based hydrogel promotes bone defect reconstruction by targeting Hmox1","volume":"245","author":"Wang","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925019307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925019307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:00:25Z","timestamp":1771513225000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925019307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":63,"alternative-id":["S1567576925019307"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115942","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual suppression of AKT\/MAPK signaling and activation of Nrf2 by methylnissolin attenuates osteoclastogenesis and prevents postmenopausal osteoporosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115942"}}