{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T15:19:28Z","timestamp":1771514368138,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["2019XYMP-16"],"award-info":[{"award-number":["2019XYMP-16"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021A03004"],"award-info":[{"award-number":["CI2021A03004"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115955","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T17:36:22Z","timestamp":1765474582000},"page":"115955","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A comprehensive strategy of network pharmacology and molecular docking reveals Danshenol a as a main active component of Huoluoxiaolingdan in ameliorating acute myocardial infarction"],"prefix":"10.1016","volume":"169","author":[{"given":"Tao","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guifang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Die","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.intimp.2025.115955_bb0005","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1001\/jama.2022.0358","article-title":"Diagnosis and treatment of acute coronary syndromes: a review","volume":"327","author":"Bhatt","year":"2022","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.intimp.2025.115955_bb0010","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1038\/s41467-022-33631-z","article-title":"Dusp6 deficiency attenuates neutrophil-mediated cardiac damage in the acute inflammatory phase of myocardial infarction","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2025.115955_bb0015","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00395-022-00974-z","article-title":"Imatinib attenuates reperfusion injury in a rat model of acute myocardial infarction","volume":"118","author":"Konijnenberg","year":"2023","journal-title":"Basic Res. Cardiol."},{"issue":"22","key":"10.1016\/j.intimp.2025.115955_bb0020","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1016\/j.jacc.2024.02.056","article-title":"Reperfusion injury in patients with acute myocardial infarction: JACC scientific statement","volume":"83","author":"Welt","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.intimp.2025.115955_bb0025","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.2147\/DDDT.S357483","article-title":"Network pharmacology-based strategy combined with molecular docking and in vitro validation study to explore the underlying mechanism of Huo Luo Xiao Ling dan in treating atherosclerosis","volume":"16","author":"Sun","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2025.115955_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154538","article-title":"Mechanism of action of Daqinjiao decoction in treating cerebral small vessel disease explored using network pharmacology and molecular docking technology","volume":"108","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.intimp.2025.115955_bb0035","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1093\/bjd\/ljae234","article-title":"Using network pharmacology to discover potential drugs for hypertrophic scars","volume":"191","author":"Zhang","year":"2024","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2025.115955_bb0040","first-page":"13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2025.115955_bb0045","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/jdi.13628","article-title":"Application of weighted gene co-expression network analysis to identify novel key genes in diabetic nephropathy","volume":"13","author":"Wang","year":"2022","journal-title":"J Diabetes Investig."},{"key":"10.1016\/j.intimp.2025.115955_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105454","article-title":"Mechanisms underlying the therapeutic effects of Qingfeiyin in treating acute lung injury based on GEO datasets, network pharmacology and molecular docking","volume":"145","author":"Wang","year":"2022","journal-title":"Comput. Biol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.115955_bb0055","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinformatics."},{"issue":"D1","key":"10.1016\/j.intimp.2025.115955_bb0060","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"14","key":"10.1016\/j.intimp.2025.115955_bb0065","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1111\/jcmm.17787","article-title":"Integration of molecular docking, molecular dynamics and network pharmacology to explore the multi-target pharmacology of fenugreek against diabetes","volume":"27","author":"Luo","year":"2023","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2025.115955_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.156021","article-title":"Paeoniflorin inhibited GSDMD to alleviate ANIT-induced cholestasis via pyroptosis signaling pathway","volume":"134","author":"Ma","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2025.115955_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155993","article-title":"Longxuetongluo capsule alleviate ischemia\/reperfusion induced cardiomyocyte apoptosis through modulating oxidative stress and mitochondrial dysfunction","volume":"134","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.intimp.2025.115955_bb0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrcardio.2014.28","article-title":"The inflammatory response in myocardial injury, repair, and remodelling","volume":"11","author":"Frangogiannis","year":"2014","journal-title":"Nat. Rev. Cardiol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115955_bb0085","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-022-00925-z","article-title":"Signaling pathways and targeted therapy for myocardial infarction","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"5","key":"10.1016\/j.intimp.2025.115955_bb0090","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1074\/jbc.TM118.006295","article-title":"Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and -2","volume":"294","author":"Smith","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.115955_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2025.106964","article-title":"Beta-sitosterol regulates PTGS1 to inhibit gastric cancer cell proliferation and angiogenesis","volume":"177","author":"Wang","year":"2025","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"47","key":"10.1016\/j.intimp.2025.115955_bb0100","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi8454","article-title":"Partial in vivo reprogramming enables injury-free intestinal regeneration via autonomous Ptgs1 induction","volume":"9","author":"Kim","year":"2023","journal-title":"Sci. Adv."},{"issue":"19","key":"10.1016\/j.intimp.2025.115955_bb0105","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000038031","article-title":"Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: a 4-year follow-up study","volume":"103","author":"Zhang","year":"2024","journal-title":"Medicine (Baltimore)"},{"issue":"8","key":"10.1016\/j.intimp.2025.115955_bb0110","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1111\/bph.14167","article-title":"Eicosanoids, prostacyclin and cyclooxygenase in the cardiovascular system","volume":"176","author":"Mitchell","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2025.115955_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118158","article-title":"Network pharmacology analysis and experimental verification of the antithrombotic active compounds of trichosanthis pericarpium (Gualoupi) in treating coronary heart disease","volume":"329","author":"Xia","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115955_bb0120","doi-asserted-by":"crossref","first-page":"6914","DOI":"10.1038\/s41467-024-51109-y","article-title":"Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver","volume":"15","author":"Aich","year":"2024","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.intimp.2025.115955_bb0125","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1002\/jnr.24934","article-title":"Is cyclooxygenase-1 involved in neuroinflammation?","volume":"99","author":"Ghazanfari","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.intimp.2025.115955_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.neo.2024.100991","article-title":"Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways","volume":"51","author":"Ni","year":"2024","journal-title":"Neoplasia"},{"key":"10.1016\/j.intimp.2025.115955_bb0135","doi-asserted-by":"crossref","DOI":"10.2174\/0118715303382831250712200617","article-title":"Danshenol a mediates the proliferation and differentiation of adipocytes in thyroid-associated ophthalmopathy","author":"Chen","year":"2025","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"issue":"1","key":"10.1016\/j.intimp.2025.115955_bb0140","doi-asserted-by":"crossref","first-page":"12953","DOI":"10.1038\/s41598-017-13072-1","article-title":"Danshenol a inhibits TNF-alpha-induced expression of intercellular adhesion molecule-1 (ICAM-1) mediated by NOX4 in endothelial cells","volume":"7","author":"Zhao","year":"2017","journal-title":"Sci. Rep."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925019435?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925019435?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T14:31:31Z","timestamp":1771511491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925019435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":28,"alternative-id":["S1567576925019435"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115955","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive strategy of network pharmacology and molecular docking reveals Danshenol a as a main active component of Huoluoxiaolingdan in ameliorating acute myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115955","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115955"}}