{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:20:57Z","timestamp":1793748057350,"version":"4.6.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82560036"],"award-info":[{"award-number":["82560036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20224BAB216037"],"award-info":[{"award-number":["20224BAB216037"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20232BAB216037"],"award-info":[{"award-number":["20232BAB216037"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20232BAB206053"],"award-info":[{"award-number":["20232BAB206053"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["20252BAC240524"],"award-info":[{"award-number":["20252BAC240524"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115976","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T10:08:54Z","timestamp":1764842934000},"page":"115976","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Integrated m6A reader network in acute myeloid leukemia: prognostic modeling, immune modulation, and functional validation of YTHDF3"],"prefix":"10.1016","volume":"169","author":[{"given":"Fangmin","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.115976_bb0005","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/ajh.26822","article-title":"Acute myeloid leukemia: 2023 update on diagnosis, risk-stratification, and management","volume":"98","author":"Shimony","year":"2023","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.intimp.2025.115976_bb0010","first-page":"46","article-title":"Acute myeloid leukemia management and research in 2025","volume":"75","author":"Kantarjian","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.intimp.2025.115976_bb0015","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1053\/j.seminhematol.2018.08.001","article-title":"Genetic and epigenetic determinants of AML pathogenesis","volume":"56","author":"Cai","year":"2019","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.intimp.2025.115976_bb0020","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.tig.2022.10.004","article-title":"Genetic and epigenetic defects of the RNA modification machinery in cancer","volume":"39","author":"Orsolic","year":"2023","journal-title":"Trends Genet."},{"key":"10.1016\/j.intimp.2025.115976_bb0025","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12943-019-1109-9","article-title":"Functions of N6-methyladenosine and its role in cancer","volume":"18","author":"He","year":"2019","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2025.115976_bb0030","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12943-020-01204-7","article-title":"The potential role of RNA N6-methyladenosine in Cancer progression","volume":"19","author":"Wang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2025.115976_bb0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40164-022-00298-7","article-title":"Role of m6A writers, erasers and readers in cancer","volume":"11","author":"Fang","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.intimp.2025.115976_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2023.117783","article-title":"Exosome-shuttled FTO from BM-MSCs contributes to cancer malignancy and chemoresistance in acute myeloid leukemia by inducing m6A-demethylation: a nano-based investigation","volume":"244","author":"Kou","year":"2024","journal-title":"Environ. Res."},{"key":"10.1016\/j.intimp.2025.115976_bb0045","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8301888","article-title":"M(6)A-related angiogenic genes to construct prognostic signature, reveal immune and oxidative stress landscape, and screen drugs in hepatocellular carcinoma","volume":"2022","author":"Qu","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2025.115976_bb0050","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.gendis.2022.02.014","article-title":"N6-methyladenosine modified LINC00901 promotes pancreatic cancer progression through IGF2BP2\/MYC axis","volume":"10","author":"Peng","year":"2023","journal-title":"Genes Dis"},{"key":"10.1016\/j.intimp.2025.115976_bb0055","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12943-020-01220-7","article-title":"METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer","volume":"19","author":"Chen","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2025.115976_bb0060","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.stem.2017.11.016","article-title":"METTL14 inhibits hematopoietic stem\/progenitor differentiation and promotes leukemogenesis via mRNA m(6)a modification","volume":"22","author":"Weng","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.intimp.2025.115976_bb0065","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1158\/0008-5472.CAN-21-4249","article-title":"The RNA m6A reader YTHDF1 is required for acute myeloid Leukemia progression","volume":"83","author":"Hong","year":"2023","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2025.115976_bb0070","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s12276-022-00735-x","article-title":"The m6A reader IGF2BP3 promotes acute myeloid leukemia progression by enhancing RCC2 stability","volume":"54","author":"Zhang","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2025.115976_bb0075","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics: A J. Integrat. Biol."},{"key":"10.1016\/j.intimp.2025.115976_bb0080","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.intimp.2025.115976_bb0085","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.intimp.2025.115976_bb0090","first-page":"1572","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinf. (Oxf.)"},{"key":"10.1016\/j.intimp.2025.115976_bb0095","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.intimp.2025.115976_bb0100","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbab260","article-title":"oncoPredict: an R package for predicting in vivo or cancer patient drug response and biomarkers from cell line screening data","volume":"22","author":"Maeser","year":"2021","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.intimp.2025.115976_bb0105","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.stem.2019.03.021","article-title":"Targeting the RNA m(6)a reader YTHDF2 selectively compromises Cancer stem cells in acute myeloid Leukemia","volume":"25","author":"Paris","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.intimp.2025.115976_bb0110","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12943-021-01447-y","article-title":"METTL3\/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N(6)-methyladenosine modification of PD-L1 mRNA in breast cancer","volume":"21","author":"Wan","year":"2022","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2025.115976_bb0115","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s12195-025-00863-0","article-title":"Macrophage polarization profiling in dynamic culture system","volume":"18","author":"Y\u0131lmaz","year":"2025","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.intimp.2025.115976_bb0120","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13072-025-00575-9","article-title":"Crosstalk between metabolism and epigenetics during macrophage polarization","volume":"18","author":"Zhang","year":"2025","journal-title":"Epigenet. Chromatin"},{"key":"10.1016\/j.intimp.2025.115976_bb0125","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1172\/JCI99317","article-title":"Contribution of NK cells to immunotherapy mediated by PD-1\/PD-L1 blockade","volume":"128","author":"Hsu","year":"2018","journal-title":"J. Clin. Invest."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925019642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925019642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:10:54Z","timestamp":1777619454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925019642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":25,"alternative-id":["S1567576925019642"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115976","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated m6A reader network in acute myeloid leukemia: prognostic modeling, immune modulation, and functional validation of YTHDF3","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115976","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115976"}}