{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:40:28Z","timestamp":1793212828972,"version":"4.5.0"},"reference-count":150,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.intimp.2025.115994","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:14:50Z","timestamp":1765037690000},"page":"115994","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["ALOX15: a key regulator in the pathogenesis and therapy of chronic rhinosinusitis with nasal polyps"],"prefix":"10.1016","volume":"169","author":[{"given":"Zhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl S29","key":"10.1016\/j.intimp.2025.115994_bb0005","first-page":"1","article-title":"European position paper on rhinosinusitis and nasal polyps 2020","volume":"58","author":"Fokkens","year":"2020","journal-title":"Rhinology"},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0010","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1038\/s41467-024-47176-w","article-title":"Incident allergic diseases in post-COVID-19 condition: multinational cohort studies from South Korea, Japan and the UK","volume":"15","author":"Oh","year":"2024","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.intimp.2025.115994_bb0015","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.jaip.2022.01.016","article-title":"Epidemiology of chronic rhinosinusitis: prevalence and risk factors","volume":"10","author":"Sedaghat","year":"2022","journal-title":"J. Allergy Clin. Immunol. Practice"},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0020","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.jaci.2011.08.004","article-title":"Chronic rhinosinusitis: epidemiology and medical management","volume":"128","author":"Hamilos","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3 Suppl","key":"10.1016\/j.intimp.2025.115994_bb0025","first-page":"S44","article-title":"Nasal polyp in Iranian Traditional Medicine & Conventional Medicine","volume":"41","author":"Emtiazi","year":"2016","journal-title":"Iran. J. Med. Sci."},{"key":"10.1016\/j.intimp.2025.115994_bb0030","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-pathol-052016-100401","article-title":"Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis","volume":"12","author":"Schleimer","year":"2017","journal-title":"Annu. Rev. Pathol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0035","first-page":"565","article-title":"Chronic Rhinosinusitis with Nasal Polyps. The journal of allergy and clinical immunology","volume":"4","author":"Stevens","year":"2016","journal-title":"In practice"},{"issue":"9","key":"10.1016\/j.intimp.2025.115994_bb0040","doi-asserted-by":"crossref","first-page":"877","DOI":"10.4065\/74.9.877","article-title":"The diagnosis and incidence of allergic fungal sinusitis","volume":"74","author":"Ponikau","year":"1999","journal-title":"Mayo Clin. Proc."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0045","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/sinusitis1010076","article-title":"Medical management of chronic rhinosinusitis in adults","volume":"1","author":"Malaty","year":"2016","journal-title":"Sinusitis"},{"issue":"6","key":"10.1016\/j.intimp.2025.115994_bb0050","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2500\/ajr.2008.22.3228","article-title":"Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis","volume":"22","author":"Kern","year":"2008","journal-title":"Am. J. Rhinol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0055","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jaci.2020.01.020","article-title":"Biologics for chronic rhinosinusitis with nasal polyps","volume":"145","author":"Bachert","year":"2020","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0060","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/all.16064","article-title":"Updated epithelial barrier dysfunction in chronic rhinosinusitis: targeting pathophysiology and treatment response of tight junctions","volume":"79","author":"Huang","year":"2024","journal-title":"Allergy"},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0065","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016311","article-title":"Lipid mediators in the resolution of inflammation","volume":"7","author":"Serhan","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"7720","key":"10.1016\/j.intimp.2025.115994_bb0070","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/s41586-018-0449-8","article-title":"Allergic inflammatory memory in human respiratory epithelial progenitor cells","volume":"560","author":"Ordovas-Montanes","year":"2018","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.bjorl.2024.101410","article-title":"Identification of core gene in chronic rhinosinusitis with nasal polyps and correlations with inflammation-related genes","volume":"90","author":"Yang","year":"2024","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"10.1016\/j.intimp.2025.115994_bb0080","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.plipres.2018.09.002","article-title":"The evolutionary hypothesis of reaction specificity of mammalian ALOX15 orthologs","volume":"72","author":"Kuhn","year":"2018","journal-title":"Prog. Lipid Res."},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0085","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.bbalip.2014.10.002","article-title":"Mammalian lipoxygenases and their biological relevance","volume":"1851","author":"Kuhn","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.gene.2015.07.073","article-title":"Structural and functional biology of arachidonic acid 15-lipoxygenase-1 (ALOX15)","volume":"573","author":"Ivanov","year":"2015","journal-title":"Gene"},{"issue":"9","key":"10.1016\/j.intimp.2025.115994_bb0095","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1164\/rccm.200811-1744OC","article-title":"Interleukin-13-induced MUC5AC is regulated by 15-lipoxygenase 1 pathway in human bronchial epithelial cells","volume":"179","author":"Zhao","year":"2009","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0100","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.alit.2019.05.001","article-title":"Aspirin-exacerbated respiratory disease (AERD): current understanding of AERD","volume":"68","author":"Taniguchi","year":"2019","journal-title":"Allergol. Int. Off. J. Jpn. Soc. Allergol."},{"issue":"11","key":"10.1016\/j.intimp.2025.115994_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/biom10111568","article-title":"Enhanced 15-lipoxygenase 1 production is related to periostin expression and eosinophil recruitment in eosinophilic chronic rhinosinusitis","volume":"10","author":"Imoto","year":"2020","journal-title":"Biomolecules"},{"issue":"13","key":"10.1016\/j.intimp.2025.115994_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28135032","article-title":"Specialized pro-resolving lipid mediators: endogenous roles and pharmacological activities in infections","volume":"28","author":"Rasquel-Oliveira","year":"2023","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.intimp.2025.115994_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107879","article-title":"Resolution of inflammation: an organizing principle in biology and medicine","volume":"227","author":"Panigrahy","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0120","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.smim.2015.03.004","article-title":"The resolution code of acute inflammation: novel pro-resolving lipid mediators in resolution","volume":"27","author":"Serhan","year":"2015","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.intimp.2025.115994_bb0125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.plipres.2018.11.001","article-title":"Emerging role of 12\/15-Lipoxygenase (ALOX15) in human pathologies","volume":"73","author":"Singh","year":"2019","journal-title":"Prog. Lipid Res."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0130","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3390\/biom11050717","article-title":"Regulation of tissue inflammation by 12-lipoxygenases","volume":"11","author":"Kulkarni","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0135","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/eer3.5","article-title":"IL-4\/IL-13 pathway in nasal type 2 inflammation: the central role and targeted therapy","volume":"1","author":"Zhu","year":"2024","journal-title":"Eye & ENT Res."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0140","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0145","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1172\/JCI115110","article-title":"Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells","volume":"87","author":"Nadel","year":"1991","journal-title":"J. Clin. Invest."},{"issue":"7948","key":"10.1016\/j.intimp.2025.115994_bb0150","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41586-022-05660-7","article-title":"Neonatal imprinting of alveolar macrophages via neutrophil-derived 12-HETE","volume":"614","author":"Pernet","year":"2023","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.intimp.2025.115994_bb0155","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.bbalip.2007.06.001","article-title":"Expression of 15-lipoxygenase type-1 in human mast cells","volume":"1771","author":"Gulliksson","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2025.115994_bb0160","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13223-020-00480-8","article-title":"Predictive significance of arachidonate 15-lipoxygenase for eosinophilic chronic rhinosinusitis with nasal polyps","volume":"16","author":"Liang","year":"2020","journal-title":"Allergy, Asthma Clin. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0165","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/s41588-018-0314-6","article-title":"A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis","volume":"51","author":"Kristjansson","year":"2019","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0170","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0005-2760(96)00107-5","article-title":"The molecular biology of mammalian lipoxygenases and the quest for eicosanoid functions using lipoxygenase-deficient mice","volume":"1304","author":"Funk","year":"1996","journal-title":"Biochim. Biophys. Acta"},{"issue":"16","key":"10.1016\/j.intimp.2025.115994_bb0175","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.1111\/j.1742-4658.2008.06570.x","article-title":"Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma","volume":"275","author":"Claesson","year":"2008","journal-title":"FEBS J."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0180","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.jaci.2019.06.037","article-title":"15-Lipoxygenase 1 in nasal polyps promotes CCL26\/eotaxin 3 expression through extracellular signal-regulated kinase activation","volume":"144","author":"Li","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.115994_bb0185","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fmed.2017.00136","article-title":"Regulation of eosinophil and group 2 innate lymphoid cell trafficking in asthma","volume":"4","author":"Larose","year":"2017","journal-title":"Front. Med."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0190","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016303","article-title":"The chemokine system in innate immunity","volume":"7","author":"Sokol","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.0212074","article-title":"CCL26\/eotaxin-3 is more effective to induce the migration of eosinophils of asthmatics than CCL11\/eotaxin-1 and CCL24\/eotaxin-2","volume":"94","author":"Provost","year":"2013","journal-title":"J. Leukoc. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0200","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1073\/pnas.261462598","article-title":"The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness","volume":"99","author":"Humbles","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0205","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jaci.2020.04.031","article-title":"Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease","volume":"147","author":"Stevens","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0210","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jaci.2006.02.046","article-title":"Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals","volume":"118","author":"Takayama","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"issue":"Suppl","key":"10.1016\/j.intimp.2025.115994_bb0215","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.alit.2015.04.012","article-title":"Recent developments regarding periostin in bronchial asthma","volume":"64","author":"Izuhara","year":"2015","journal-title":"Allergol. Int.: Off. J. Jpn. Soc. Allergol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0220","doi-asserted-by":"crossref","first-page":"11450","DOI":"10.1038\/s41598-018-29612-2","article-title":"Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps","volume":"8","author":"Ninomiya","year":"2018","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0225","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1513\/AnnalsATS.201609-720OC","article-title":"Serum Periostin as a biomarker for comorbid chronic rhinosinusitis in patients with asthma","volume":"14","author":"Asano","year":"2017","journal-title":"Ann. Am. Thoracic Soc."},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0230","doi-asserted-by":"crossref","first-page":"L104","DOI":"10.1152\/ajplung.00090.2023","article-title":"Hematopoietic 12\/15-lipoxygenase activity negatively contributes to fungal-associated allergic asthma","volume":"325","author":"Makullah","year":"2023","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"3\u20134","key":"10.1016\/j.intimp.2025.115994_bb0235","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.prostaglandins.2008.12.003","article-title":"On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma","volume":"89","author":"Claesson","year":"2009","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0240","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jaci.2020.08.036","article-title":"A substantial neutrophilic inflammation as regular part of severe type 2 chronic rhinosinusitis with nasal polyps","volume":"147","author":"Delemarre","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0245","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jaci.2021.03.024","article-title":"Rethinking neutrophils and eosinophils in chronic rhinosinusitis","volume":"148","author":"Delemarre","year":"2021","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0250","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1016\/j.jaci.2021.11.023","article-title":"Elevation of activated neutrophils in chronic rhinosinusitis with nasal polyps","volume":"149","author":"Poposki","year":"2022","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0255","doi-asserted-by":"crossref","first-page":"R166","DOI":"10.1186\/cc11518","article-title":"Eliminating or blocking 12\/15-lipoxygenase reduces neutrophil recruitment in mouse models of acute lung injury","volume":"16","author":"Rossaint","year":"2012","journal-title":"Crit. Care (London, England)"},{"issue":"7","key":"10.1016\/j.intimp.2025.115994_bb0260","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/BF00429983","article-title":"In vitro inhibition of leukotriene B4 formation by exogeneous 5-lipoxygenase inhibitors is associated with enhanced generation of 15-hydroxy-eicosatetraenoic acid (15-HETE) by human neutrophils","volume":"280","author":"Fogh","year":"1988","journal-title":"Arch. Dermatol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0265","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1159\/000535560","article-title":"Biological roles of 5-oxo-6,8,11,14-eicosatetraenoic acid and the OXE receptor in allergic diseases: collegium Internationale Allergologicum Update 2024","volume":"185","author":"Lin","year":"2024","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0270","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbalip.2014.10.008","article-title":"Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid","volume":"1851","author":"Powell","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"issue":"8","key":"10.1016\/j.intimp.2025.115994_bb0275","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202424","article-title":"Comparison of eight 15-lipoxygenase (LO) inhibitors on the biosynthesis of 15-LO metabolites by human neutrophils and eosinophils","volume":"13","author":"Archambault","year":"2018","journal-title":"PLoS ONE"},{"issue":"12","key":"10.1016\/j.intimp.2025.115994_bb0280","doi-asserted-by":"crossref","first-page":"6148","DOI":"10.1073\/pnas.94.12.6148","article-title":"Discovery of a second 15S-lipoxygenase in humans","volume":"94","author":"Brash","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"42","key":"10.1016\/j.intimp.2025.115994_bb0285","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1021\/acs.biochem.0c00622","article-title":"Role of human 15-lipoxygenase-2 in the biosynthesis of the lipoxin intermediate, 5S,15S-diHpETE, implicated with the altered positional specificity of human 15-lipoxygenase-1","volume":"59","author":"Perry","year":"2020","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0290","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1172\/JCI78490","article-title":"12\/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function","volume":"125","author":"Rothe","year":"2015","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.intimp.2025.115994_bb0295","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.4049\/jimmunol.169.10.5638","article-title":"Dendritic cell-associated lectin-1: a novel dendritic cell-associated, C-type lectin-like molecule enhances T cell secretion of IL-4","volume":"169","author":"Ryan","year":"2002","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0300","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/all.14287","article-title":"Cold-inducible RNA-binding protein contributes to tissue remodeling in chronic rhinosinusitis with nasal polyps","volume":"76","author":"Shi","year":"2021","journal-title":"Allergy"},{"issue":"9","key":"10.1016\/j.intimp.2025.115994_bb0305","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell. Physiol."},{"issue":"9","key":"10.1016\/j.intimp.2025.115994_bb0310","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.4049\/jimmunol.173.9.5810","article-title":"CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure","volume":"173","author":"Pivarcsi","year":"2004","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"issue":"7","key":"10.1016\/j.intimp.2025.115994_bb0315","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011450","article-title":"Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis","volume":"5","author":"Plager","year":"2010","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0320","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jaci.2011.08.021","article-title":"Increased expression of CC chemokine ligand 18 in patients with chronic rhinosinusitis with nasal polyps","volume":"129","author":"Peterson","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0325","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/s12026-019-09072-0","article-title":"Monocytes of newly diagnosed juvenile DM1 patients are prone to differentiate into regulatory IL-10(+) M2 macrophages","volume":"67","author":"Juhas","year":"2019","journal-title":"Immunol. Res."},{"key":"10.1016\/j.intimp.2025.115994_bb0330","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.3389\/fimmu.2018.01906","article-title":"A novel function for 15-lipoxygenases in cholesterol homeostasis and CCL17 production in human macrophages","volume":"9","author":"Snodgrass","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115994_bb0335","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3389\/fphar.2019.00719","article-title":"Regulation and functions of 15-lipoxygenases in human macrophages","volume":"10","author":"Snodgrass","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"12","key":"10.1016\/j.intimp.2025.115994_bb0340","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrendo.2017.91","article-title":"SREBP-regulated lipid metabolism: convergent physiology - divergent pathophysiology","volume":"13","author":"Shimano","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0345","first-page":"81","article-title":"Predicting difficult-to-treat chronic rhinosinusitis by noninvasive biological markers","volume":"59","author":"Guo","year":"2021","journal-title":"Rhinology"},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0350","first-page":"1501","article-title":"Identification and validation of ferroptosis-related genes for chronic rhinosinusitis with nasal polyps","volume":"280","author":"Huang","year":"2023","journal-title":"Eur. Arch. Oto-rhino-laryngol.: Off. J. Eur. Fed. Oto-Rhino-Laryngol. Soc. (EUFOS): Affil. Germ. Soc. Oto-Rhino-Laryngol. - Head Neck Surg."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0355","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cell.2017.09.044","article-title":"PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals","volume":"171","author":"Wenzel","year":"2017","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0360","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/s41589-019-0462-8","article-title":"Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death","volume":"16","author":"Kapralov","year":"2020","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0365","doi-asserted-by":"crossref","DOI":"10.1172\/JCI151685","article-title":"15LO1 dictates glutathione redox changes in asthmatic airway epithelium to worsen type 2 inflammation","volume":"132","author":"Nagasaki","year":"2022","journal-title":"J. Clin. Invest."},{"issue":"10","key":"10.1016\/j.intimp.2025.115994_bb0370","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1038\/s41590-022-01312-0","article-title":"Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis","volume":"23","author":"Wang","year":"2022","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0375","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jaci.2012.02.046","article-title":"Glandular mast cells with distinct phenotype are highly elevated in chronic rhinosinusitis with nasal polyps","volume":"130","author":"Takabayashi","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"issue":"56","key":"10.1016\/j.intimp.2025.115994_bb0380","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abb7221","article-title":"Human airway mast cells proliferate and acquire distinct inflammation-driven phenotypes during type 2 inflammation","volume":"6","author":"Dwyer","year":"2021","journal-title":"Sci. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0385","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1073\/pnas.0710127105","article-title":"Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells","volume":"105","author":"Feltenmark","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.intimp.2025.115994_bb0390","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1159\/000539309","article-title":"Eosinophil-epithelial cell interactions in asthma","volume":"185","author":"Steffan","year":"2024","journal-title":"Int. Arch. Allergy Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0395","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1172\/JCI124606","article-title":"Epithelial cell-derived cytokines: more than just signaling the alarm","volume":"129","author":"Roan","year":"2019","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.intimp.2025.115994_bb0400","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1165\/rcmb.2017-0031OC","article-title":"Preferential generation of 15-HETE-PE induced by IL-13 regulates goblet cell differentiation in human airway epithelial cells","volume":"57","author":"Zhao","year":"2017","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0405","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4193\/Rhino16.215","article-title":"Periostin as a marker of mucosal remodelling in chronic rhinosinusitis","volume":"55","author":"Ebenezer","year":"2017","journal-title":"Rhinology"},{"key":"10.1016\/j.intimp.2025.115994_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2024.04.019","article-title":"ALOX15(+) M2 macrophages contribute to epithelial remodeling in eosinophilic chronic rhinosinusitis with nasal polyps","author":"Liu","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2025.115994_bb0415","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1165\/rcmb.2007-0443OC","article-title":"Mice lacking 12\/15-lipoxygenase have attenuated airway allergic inflammation and remodeling","volume":"39","author":"Andersson","year":"2008","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"25","key":"10.1016\/j.intimp.2025.115994_bb0420","doi-asserted-by":"crossref","first-page":"14376","DOI":"10.1073\/pnas.1921618117","article-title":"PEBP1 acts as a rheostat between prosurvival autophagy and ferroptotic death in asthmatic epithelial cells","volume":"117","author":"Zhao","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0425","doi-asserted-by":"crossref","DOI":"10.1172\/JCI155884","article-title":"The role of 15 lipoxygenase 1 in asthma comes into focus","volume":"132","author":"Boyce","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2025.115994_bb0430","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.16239","article-title":"A review on the relationship between Arachidonic acid 15-Lipoxygenase (ALOX15) and diabetes mellitus","volume":"11","author":"He","year":"2023","journal-title":"PeerJ"},{"issue":"6","key":"10.1016\/j.intimp.2025.115994_bb0435","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1111\/all.13726","article-title":"Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis","volume":"74","author":"Miyata","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2025.115994_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2020.106477","article-title":"Dysregulated metabolism of polyunsaturated fatty acids in eosinophilic allergic diseases","volume":"150","author":"Miyata","year":"2020","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.intimp.2025.115994_bb0445","series-title":"Regulation of arachidonic acid pathway and eosinophilic inflammation in chronic rhinosinusitis\/nasal polyposis. Potential role of Staphylococcus aureus enterotoxin","author":"Perez","year":"2006"},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0450","doi-asserted-by":"crossref","first-page":"C1249","DOI":"10.1152\/ajpcell.2000.279.4.C1249","article-title":"15(S)-HETE modulates LTB(4) production and neutrophil chemotaxis in chronic bronchitis","volume":"279","author":"Profita","year":"2000","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0455","first-page":"449","article-title":"Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro","volume":"126","author":"Marom","year":"1982","journal-title":"Am. Rev. Respir. Dis."},{"issue":"6","key":"10.1016\/j.intimp.2025.115994_bb0460","first-page":"917","article-title":"15-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion","volume":"131","author":"Johnson","year":"1985","journal-title":"Am. Rev. Respir. Dis."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0465","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1124\/jpet.300.3.868","article-title":"Leukotriene B4 production in human mononuclear phagocytes is modulated by interleukin-4-induced 15-lipoxygenase","volume":"300","author":"Profita","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2025.115994_bb0470","doi-asserted-by":"crossref","first-page":"5152","DOI":"10.1073\/pnas.091076998","article-title":"IL-4 determines eicosanoid formation in dendritic cells by down-regulation of 5-lipoxygenase and up-regulation of 15-lipoxygenase 1 expression","volume":"98","author":"Spanbroek","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0475","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/imm.12888","article-title":"Human dendritic cell subsets: an update","volume":"154","author":"Collin","year":"2018","journal-title":"Immunology"},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0480","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.plipres.2006.02.003","article-title":"Inflammation and immune regulation by 12\/15-lipoxygenases","volume":"45","author":"K\u00fchn","year":"2006","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.intimp.2025.115994_bb0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102528","article-title":"12\/15-Lipoxygenase choreographs the resolution of IgG-mediated skin inflammation","volume":"115","author":"Sezin","year":"2020","journal-title":"J. Autoimmun."},{"issue":"7293","key":"10.1016\/j.intimp.2025.115994_bb0490","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0495","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/cea.12462","article-title":"Group 2 innate lymphoid cells (ILC2s) are increased in chronic rhinosinusitis with nasal polyps or eosinophilia","volume":"45","author":"Ho","year":"2015","journal-title":"Clin. Exp. Allergy: J. Br. Soc. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.115994_bb0500","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.687192","article-title":"12\/15-lipoxygenase regulates IL-33-induced eosinophilic airway inflammation in mice","volume":"12","author":"Miyata","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115994_bb0505","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.850494","article-title":"Comprehensive analysis of nasal polyps reveals a more pronounced type 2 transcriptomic profile of epithelial cells and mast cells in aspirin-exacerbated respiratory disease","volume":"13","author":"Bangert","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.115994_bb0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106982","article-title":"Lipoxin-mediated signaling: ALX\/FPR2 interaction and beyond","volume":"197","author":"S\u00e1nchez-Garc\u00eda","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"34","key":"10.1016\/j.intimp.2025.115994_bb0515","doi-asserted-by":"crossref","first-page":"23679","DOI":"10.1074\/jbc.274.34.23679","article-title":"Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate","volume":"274","author":"Brash","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.intimp.2025.115994_bb0520","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1002\/alr.22218","article-title":"Deficiency in interleukin-10 production by M2 macrophages in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"8","author":"Wang","year":"2018","journal-title":"International forum of allergy & rhinology"},{"issue":"8","key":"10.1016\/j.intimp.2025.115994_bb0525","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1080\/1744666X.2023.2232554","article-title":"Inflammation resolution and specialized pro-resolving lipid mediators in chronic rhinosinusitis","volume":"19","author":"Robinson","year":"2023","journal-title":"Expert Rev. Clin. Immunol."},{"issue":"24","key":"10.1016\/j.intimp.2025.115994_bb0530","doi-asserted-by":"crossref","DOI":"10.1172\/JCI142883","article-title":"The resolvin D1 receptor GPR32 transduces inflammation resolution and atheroprotection","volume":"131","author":"Arnardottir","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"8","key":"10.1016\/j.intimp.2025.115994_bb0535","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.4049\/jimmunol.1501701","article-title":"Resolvin D1 polarizes primary human macrophages toward a proresolution phenotype through GPR32","volume":"196","author":"Schmid","year":"2016","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"key":"10.1016\/j.intimp.2025.115994_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2022.101605","article-title":"Specialized pro-resolving mediators as modulators of immune responses","volume":"59","author":"Julliard","year":"2022","journal-title":"Semin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0545","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41467-023-43554-y","article-title":"15-Lipoxygenase promotes resolution of inflammation in lymphedema by controlling T(reg) cell function through IFN-\u03b2","volume":"15","author":"Zamora","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2025.115994_bb0550","doi-asserted-by":"crossref","first-page":"463","DOI":"10.2147\/JAA.S237463","article-title":"The role of mast cells in aspirin-exacerbated respiratory disease (AERD) pathogenesis: implications for future therapeutics","volume":"13","author":"Kuruvilla","year":"2020","journal-title":"J. Asthma Allergy"},{"issue":"6","key":"10.1016\/j.intimp.2025.115994_bb0555","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1016\/j.jaci.2018.12.1018","article-title":"Induction of human regulatory innate lymphoid cells from group 2 innate lymphoid cells by retinoic acid","volume":"143","author":"Morita","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0560","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085085","article-title":"Interleukin-4-mediated 15-lipoxygenase-1 trans-activation requires UTX recruitment and H3K27me3 demethylation at the promoter in A549 cells","volume":"9","author":"Han","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2025.115994_bb0565","first-page":"104","article-title":"Epigenetics in immune development and in allergic and autoimmune diseases","author":"Martino","year":"2014","journal-title":"J. Reprod. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0570","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1398-9995.2010.02514.x","article-title":"Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics","volume":"66","author":"Cheong","year":"2011","journal-title":"Allergy"},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0575","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.jaci.2016.07.036","article-title":"The nasal methylome and childhood atopic asthma","volume":"139","author":"Yang","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0580","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.redox.2013.11.001","article-title":"Functional characterization of genetic enzyme variations in human lipoxygenases","volume":"1","author":"Horn","year":"2013","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0585","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1002\/humu.20273","article-title":"Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1","volume":"27","author":"Wittwer","year":"2006","journal-title":"Hum. Mutat."},{"issue":"12","key":"10.1016\/j.intimp.2025.115994_bb0590","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/ng.3985","article-title":"Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology","volume":"49","author":"Ferreira","year":"2017","journal-title":"Nat. Genet."},{"issue":"8","key":"10.1016\/j.intimp.2025.115994_bb0595","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1073\/pnas.96.8.4378","article-title":"Effects of mutant p53 expression on human 15-lipoxygenase-promoter activity and murine 12\/15-lipoxygenase gene expression: evidence that 15-lipoxygenase is a mutator gene","volume":"96","author":"Kelavkar","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.intimp.2025.115994_bb0600","article-title":"Epigenetic modifications in chronic rhinosinusitis with and without nasal polyps","volume":"13","author":"Li","year":"2022","journal-title":"Front. Genet."},{"issue":"46","key":"10.1016\/j.intimp.2025.115994_bb0605","doi-asserted-by":"crossref","first-page":"31341","DOI":"10.1074\/jbc.M803729200","article-title":"Chromatin modification requirements for 15-lipoxygenase-1 transcriptional reactivation in colon cancer cells","volume":"283","author":"Zuo","year":"2008","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0610","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/alr.22243","article-title":"Inhibition of arachidonate 15-lipoxygenase reduces the epithelial-mesenchymal transition in eosinophilic chronic rhinosinusitis with nasal polyps","volume":"9","author":"Yan","year":"2019","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.intimp.2025.115994_bb0615","doi-asserted-by":"crossref","first-page":"529","DOI":"10.37349\/eaa.2024.00063","article-title":"Deciphering the role of 12\/15-lipoxygenase in asthma: insights into mitochondrial dysfunction and therapeutic implications","author":"Greeshma","year":"2024","journal-title":"Explor. Asthma Allergy"},{"key":"10.1016\/j.intimp.2025.115994_bb0620","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114052","article-title":"Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: a single-center, randomized, double-blind, placebo-controlled, single-dose phase I study","volume":"274","author":"Dong","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0625","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/cpdd.1203","article-title":"First-in-human studies of pharmacokinetics and safety of utreloxastat (PTC857), a novel 15-lipooxygenase inhibitor for the treatment of amyotrophic lateral sclerosis","volume":"12","author":"Gao","year":"2023","journal-title":"Clin. Pharmacol. Drug Dev."},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0630","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0062916","article-title":"Baicalein reduces airway injury in allergen and IL-13 induced airway inflammation","volume":"8","author":"Mabalirajan","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.intimp.2025.115994_bb0635","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.12659\/MSM.915080","article-title":"Emodin alleviates the airway inflammation of cough variant asthma in mice by regulating the notch pathway","volume":"25","author":"Hua","year":"2019","journal-title":"Med. Sci. Monit.: Int. Med. J. Exp. Clin. Res."},{"issue":"7","key":"10.1016\/j.intimp.2025.115994_bb0640","article-title":"PD146176 affects human EA.hy926 endothelial cell function by differentially modulating oxylipin production of LOX, COX and CYP epoxygenase","volume":"1867","author":"Du","year":"2022","journal-title":"Biochimica et biophysica acta. Mol. Cell Biol. Lipids"},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0645","doi-asserted-by":"crossref","DOI":"10.3390\/cimb47030181","article-title":"The therapeutic potential of baicalin and baicalein in breast cancer: a systematic review of mechanisms and efficacy","volume":"47","author":"Zieniuk","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0650","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s13346-020-00891-5","article-title":"Intranasal drug delivery: opportunities and toxicologic challenges during drug development","volume":"12","author":"Keller","year":"2022","journal-title":"Drug Del. Transl. Res."},{"issue":"8","key":"10.1016\/j.intimp.2025.115994_bb0655","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1080\/17425247.2024.2392790","article-title":"The effects of airway disease on the deposition of inhaled drugs","volume":"21","author":"Darquenne","year":"2024","journal-title":"Expert Opin. Drug Del."},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0660","first-page":"64","article-title":"The argument against the use of dupilumab in patients with limited polyp burden in chronic rhinosinusitis with nasal polyposis (CRSwNP)","volume":"52","author":"Hardison","year":"2023","journal-title":"J. Otolaryngol. - Head Neck Surg. = Le Journal d\u2019oto-rhino-laryngologie et de chirurgie cervico-faciale"},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0665","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1055\/s-2001-11532","article-title":"Inhibitory effect of baicalein, a flavonoid in Scutellaria Root, on eotaxin production by human dermal fibroblasts","volume":"67","author":"Nakajima","year":"2001","journal-title":"Planta Med."},{"issue":"9","key":"10.1016\/j.intimp.2025.115994_bb0670","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.4049\/jimmunol.0803874","article-title":"Ym1\/2 promotes Th2 cytokine expression by inhibiting 12\/15(S)-lipoxygenase: identification of a novel pathway for regulating allergic inflammation","volume":"182","author":"Cai","year":"2009","journal-title":"J. Immunol. (Baltimore, Md.: 1950)"},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0675","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2478\/acph-2020-0009","article-title":"Beneficial effects of baicalein on a model of allergic rhinitis","volume":"70","author":"Liu","year":"2020","journal-title":"Acta Pharmaceutica (Zagreb, Croatia)"},{"issue":"7","key":"10.1016\/j.intimp.2025.115994_bb0680","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1016\/j.fct.2012.03.076","article-title":"Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma","volume":"50","author":"Chu","year":"2012","journal-title":"Food Chem. Toxicol.: Int. J. Publ. Br. Ind. Biol. Res. Assoc."},{"issue":"6","key":"10.1016\/j.intimp.2025.115994_bb0685","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11655-014-1898-z","article-title":"Protective effect of emodin against airway inflammation in the ovalbumin-induced mouse model","volume":"21","author":"Wang","year":"2015","journal-title":"Chin. J. Integr. Med."},{"issue":"8","key":"10.1016\/j.intimp.2025.115994_bb0690","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/aps.2017.147","article-title":"Emodin alleviates alternatively activated macrophage and asthmatic airway inflammation in a murine asthma model","volume":"39","author":"Song","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2025.115994_bb0695","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106855","article-title":"Emodin ameliorates ovalbumin-induced airway remodeling in mice by suppressing airway smooth muscle cells proliferation","volume":"88","author":"Liu","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0700","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0021-9150(97)00204-9","article-title":"A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit","volume":"136","author":"Bocan","year":"1998","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.intimp.2025.115994_bb0705","doi-asserted-by":"crossref","first-page":"F105","DOI":"10.1152\/ajprenal.00214.2021","article-title":"15-Lipoxygenase worsens renal fibrosis, inflammation, and metabolism in a murine model of ureteral obstruction","volume":"322","author":"Montford","year":"2022","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"7","key":"10.1016\/j.intimp.2025.115994_bb0710","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1002\/jcb.24098","article-title":"Involvement of 15-lipoxygenase in the inflammatory arthritis","volume":"113","author":"Wu","year":"2012","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2025.115994_bb0715","article-title":"Altered tissue specialized pro-resolving mediators in chronic rhinosinusitis. Prostaglandins, leukotrienes, and essential fatty acids","volume":"164","author":"Vickery","year":"2021"},{"issue":"34","key":"10.1016\/j.intimp.2025.115994_bb0720","doi-asserted-by":"crossref","first-page":"14246","DOI":"10.1073\/pnas.1018075108","article-title":"15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells","volume":"108","author":"Zhao","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.intimp.2025.115994_bb0725","doi-asserted-by":"crossref","first-page":"74","DOI":"10.5415\/apallergy.0000000000000187","article-title":"Predictive significance of 15(S)-hydroxyeicosatetraenoic acid for eosinophilic chronic rhinosinusitis with nasal polyps","volume":"15","author":"Li","year":"2025","journal-title":"Asia Pacific Allergy"},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0730","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1177\/1945892420978957","article-title":"A nomogram combing peripheral parameters for estimation of CRSwNP recurrence","volume":"35","author":"Du","year":"2021","journal-title":"Am. J. Rhinol. Allergy"},{"issue":"5","key":"10.1016\/j.intimp.2025.115994_bb0735","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1080\/14712598.2021.1901881","article-title":"Dupilumab for the treatment of chronic rhinosinusitis with nasal polyposis","volume":"21","author":"Fokkens","year":"2021","journal-title":"Expert. Opin. Biol. Ther."},{"issue":"3","key":"10.1016\/j.intimp.2025.115994_bb0740","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jaci.2024.05.030","article-title":"Nasal brushing molecular endotyping distinguishes patients with chronic rhinosinusitis with nasal polyps with better response to dupilumab","volume":"154","author":"Gayvert","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2025.115994_bb0745","article-title":"Dupilumab dampens mucosal type 2 response during acetylsalicylic acid challenge in N-ERD patients","author":"Eckl-Dorna","year":"2024","journal-title":"Clin. Exp. Allergy"},{"issue":"4","key":"10.1016\/j.intimp.2025.115994_bb0750","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/s12276-025-01440-1","article-title":"SLC27A2 marks lipid peroxidation in nasal epithelial cells driven by type 2 inflammation in chronic rhinosinusitis with nasal polyps","volume":"57","author":"Park","year":"2025","journal-title":"Exp. Mol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925019824?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925019824?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T16:13:15Z","timestamp":1768061595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925019824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":150,"alternative-id":["S1567576925019824"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115994","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ALOX15: a key regulator in the pathogenesis and therapy of chronic rhinosinusitis with nasal polyps","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.115994","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115994"}}